JP2017007689A - Laminate for blister pack, and blister pack using the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a laminate for a blister pack, a blister pack using the laminate, more specifically, a laminate for a blister pack for giving a sufficient formability having neither de-lamination nor wrinkles at a blister pack molding time or after the molding time, a blister pack laminate for giving a sufficient formability, and a blister pack using the laminate.SOLUTION: A blister pack laminate comprises at least a base material layer 1, a printing layer 2, an adhesion layer 3, an aluminum foil layer 4 and an absorber layer 5 in the recited order, and the adhesion layer 3 has a Martens hardness of 350 to 500 N/m, in the case where a measurement is made according to ISO14577.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a laminate for blister packs and a blister pack using the same.

  A powdery preparation is enclosed in a thin paper bag or a film bag, and a preparation such as a tablet or a capsule is enclosed in a blister pack called PTP (press-through pack). By pushing the preparation enclosed in the PTP with a finger, the sheet-like lid can be broken and the preparation can be taken out. In addition, the preparation may be enclosed in a blister pack having a shape in which two barrier laminates formed with pockets for containing the preparation are faced and sealed. In the case of this form, the end of the blister pack is cut off and opened, or peeled and opened between the two laminates, so that it can also be used in powdery and liquid preparations.

  The pharmaceutical composition may be altered by absorption of moisture. Therefore, conventionally, a desiccant such as silica gel has been enclosed in an outer bag enclosing a blister pack. However, the operation of putting the desiccant into the outer bag takes time and there is a risk of accidental ingestion or accidental eating. In addition, after opening the exterior bag, the inside of the blister pack cannot be kept at a low humidity, and there is a problem that the deterioration of the preparation proceeds. Furthermore, since some preparations are easily oxidatively decomposed and generate specific odors, there is a demand for absorbing gas such as oxygen and odor in the blister pack.

  On the other hand, patent document 1 is disclosing the technique which improves the long-term stability of a formulation by forming the absorption layer which has an absorber in the inside of a blister pack. Here, first, a dome-shaped pocket portion is formed in a laminate of a base material and an absorption layer which are barrier layers. And the formulation which is a tablet is put into the pocket part, and this is sealed with the lid | cover material. According to this technique, it is considered that it is possible to maintain a dry state, prevent oxidation, and efficiently remove odors without enclosing a desiccant or the like in the outer bag.

  In addition, some preparations are vulnerable to ultraviolet rays, and if the packaging container is transparent, the medicinal components may be deteriorated. On the other hand, for example, Patent Document 2 discloses a technique of forming an aluminum foil layer not only on the cover material on the back side of the blister pack but also on the front side blister pack laminate, so-called aluminum blister packaging. According to this technique, since the aluminum foil layer is formed on the blister pack, the preparation cannot be visually recognized, but the ultraviolet ray can be blocked and the barrier property can be further enhanced.

  In a mode in which the above two technologies are simply combined, when forming a dome-shaped pocket in a blister pack laminate, the ceiling of the dome is torn or cracks are generated in the hem or shoulder. This causes molding problems. In order to cope with this, Patent Document 2 laminates a stiff reinforcing layer using a specific polymer between an aluminum foil layer and an absorbent layer to form a base layer / aluminum foil layer / reinforcing layer / absorbing layer. The laminated body for blister packs to have in order is disclosed.

International Publication No. 2006/115264 International Publication No. 2012/029323

  In the laminated body for blister packs of Patent Document 2, the strength of the entire laminated body is improved by providing a stiff reinforcing layer to reduce molding defects.

  On the other hand, in order to display the contents or the like, a printing layer may be formed between the base material layer and the aluminum foil layer by printing on the base material layer. In this case, since the surface of the printing layer is rough and has irregularities, the adhesion between the printing layer and the aluminum foil layer is deteriorated. Further, since the absorbing layer is made of a thick and soft resin, a film return phenomenon (spring back) after blister pack molding occurs. Therefore, in the conventional blister pack laminate, delamination, wrinkles, etc. occur between the printed layer and the aluminum foil layer depending on the manufacturing conditions, storage environment, pocket size, shape, etc. The present inventors have found that there has been a problem of doing so.

  The present invention has been made against the background of the problems of the prior art, and even when a printing layer is formed between the base material layer and the aluminum foil layer, delamination, wrinkles, etc. occur during and after blister pack molding. It aims at providing the blister pack laminated body which does not generate | occur | produce and gives fully moldability, and the blister pack using the laminated body.

The present inventors have found that the above problems can be solved by the following means.
[1] At least a base material layer, a printed layer, an adhesive layer, an aluminum foil layer, and an absorbent layer are included in this order, and the adhesive layer has a Martens hardness of 350 to 500 N / m ² when measured according to ISO14577. A laminated body for blister packs having a thickness.
[2] The blister pack laminate according to [1], wherein the adhesive layer has a Martens hardness of 400 to 450 N / m ² when measured in accordance with ISO14577.
[3] The blister pack laminate according to [1] or [2], wherein the adhesive layer is a reactive adhesive layer.
[4] The laminate for blister packs according to any one of [1] to [3], wherein the adhesive layer is a urethane-based adhesive layer.
[5] The base material layer includes a resin selected from the group consisting of polyethylene resin, polyvinyl chloride, polyvinylidene chloride, polychlorotrifluoroethylene, polypropylene resin, polyethylene terephthalate, polyamide, and a mixture thereof. The laminated body for blister packs in any one of [1]-[4].
[6] The blister pack laminate according to any one of [1] to [5], wherein the printing layer is made of gravure ink.
[7] Any of [1] to [6], wherein the absorbent layer includes an outer skin layer on the base material layer side, an absorbent holding layer having an absorbent and a binder resin, and an inner skin layer in this order. The laminate for blister packs described in 1.
[8] The blister pack laminate according to any one of [1] to [7], further including a reinforcing layer between the aluminum foil layer and the absorbing layer.
[9] The laminate according to any one of [1] to [8], and a lid member having an aluminum foil layer and a resin layer different from the aluminum foil layer, the absorbent layer of the laminate and the lid A blister pack in which a resin layer of the material is at least partially adhered, and a pocket portion is formed in the laminate so that a pharmaceutical preparation can be stored between the laminate and the lid.
[10] The two laminates according to any one of [1] to [8] are bonded at least partially with the absorption layer facing each other, and a pocket portion is formed in the two laminates. A blister pack in which a pharmaceutical preparation can be stored in the pocket.
[11] A blister pack package comprising the blister pack according to [9] or [10] and the contents stored in the pocket portion.

  According to the present invention, even when a printing layer is formed between the base material layer and the aluminum foil layer, the blister that gives sufficient moldability without delamination, wrinkles, etc. during and after blister pack molding. The laminated body for packs, and the blister pack using the laminated body can be provided.

It is the schematic which shows an example of the blister pack of this invention. It is the schematic which shows the other example of the blister pack of this invention. It is the schematic of the layer structure of the blister pack of this invention.

<Laminated body for blister pack>
The present invention includes at least a base material layer, a printed layer, an adhesive layer, an aluminum foil layer, and an absorbent layer in this order, and the adhesive layer has a Martens of 350 to 500 N / m ² when measured according to ISO14577. The present invention relates to a laminate for blister packs having hardness. Moreover, the laminated body for blister packs of this invention may have a reinforcement layer between the aluminum foil layer and the absorption layer in order to improve the moldability of the laminated body for blister packs. For example, as shown in FIG. 1, the laminated body 10 for blister packs of this invention has the base material layer 1, the printing layer 2, the adhesive layer 3, the aluminum foil layer 4, the optional reinforcement layer 5, and the absorption layer 6. FIG. .

  Examples of a method for bonding at least two layers of the aluminum foil layer, the optional reinforcing layer, and the absorption layer include a dry laminating method and a sand laminating method. The dry laminating method is a method in which an adhesive is applied and dried, and then pressurized, and the adhesive is cured and bonded. The sand laminating method is a method in which a resin or an adhesive resin constituting each melted layer is extruded and bonded between a base material and a film to be bonded.

  The blister pack laminate is formed with a pocket for storing contents such as a preparation. Examples of the molding method for molding the pocket portion include a flat plate type pneumatic molding method, a plug assist pressure molding method, a drum type vacuum molding method, and a plug molding method. Among these, a plug molding method using a columnar rod (plug material) made of an ultrahigh molecular weight polyethylene resin having a viscosity average molecular weight of 1 million or more and having a rounded tip is preferable for forming a pocket.

(Base material layer)
The resin used for the base material layer is not particularly limited as long as it provides a suitable barrier property and moldability to the laminate for blister packs. For example, polyethylene resin, polyvinyl chloride, polyvinylidene chloride, polychlorotrifluoroethylene, polypropylene resin, polyethylene terephthalate, polyamide (for example, nylon (registered trademark), nylon 6, nylon 6,6, nylon MXD6), etc. And mixtures thereof. Preferably, those that prevent entry of moisture from the outside and excellent in moisture resistance are preferable, and polypropylene resins, polyamides, and polyethylene terephthalate are particularly preferable.

  In this specification, the polyethylene-based resin is a resin containing a repeating unit of an ethylene group in a polymer main chain of 30 mol% or more, 40 mol% or more, 50 mol% or more, 60 mol% or more, 70 mol% or more, or 80 mol% or more. For example, low density polyethylene (LDPE), linear low density polyethylene (LLDPE), medium density polyethylene (MDPE), high density polyethylene (HDPE), ethylene-acrylic acid copolymer (EAA), ethylene-methacrylic Acid copolymer (EMAA), ethylene-ethyl acrylate copolymer (EEA), ethylene-methyl acrylate copolymer (EMA), ethylene vinyl acetate copolymer (EVA), carboxylic acid-modified polyethylene, carboxylic acid-modified ethylene vinyl Acetate copolymer and the same Derivatives, as well as selected from the group consisting of mixtures.

  In this specification, a polypropylene resin is a resin containing a propylene group repeating unit in a polymer main chain of 30 mol% or more, 40 mol% or more, 50 mol% or more, 60 mol% or more, 70 mol% or more, or 80 mol% or more. Examples include polypropylene (PP) homopolymer, random polypropylene (random PP), block polypropylene (block PP), chlorinated polypropylene, carboxylic acid-modified polypropylene, and derivatives thereof, and mixtures thereof.

  The thickness of the base material layer is preferably 10 μm or more, 20 μm or more, or 30 μm or more, and preferably 300 μm or less, 200 μm or less, or 100 μm or less.

(Print layer)
A printing layer is a layer formed by printing on a base material layer, Comprising: It is a layer provided between a base material layer and an aluminum foil layer. The printed layer can be provided as a functional layer for antistatic, ultraviolet absorption, ultraviolet shielding, etc., in addition to the pattern and characters attached to the packaging material. Therefore, the printing layer is not limited to a layer representing a pattern, characters, etc., and may be a colorless and transparent layer made of only a medium or a resin (vehicle), for example. It can also be set as the layer which consists of two layers of the layer showing etc.

  The printing layer can be formed by a known method such as gravure printing, offset printing, screen printing, etc., but a volatile drying type ink having a quick drying property can be used, and high speed printing can be performed by a winding type rotary printing press. From such a viewpoint, it is preferable to form by gravure printing.

  It does not specifically limit as gravure ink, A general thing can be used. Specifically, for example, natural resins such as shellacs, rosins, rosin-modified maleic acid and derivatives thereof; nitrified cotton (nitrocellulose), cellulose acetate and other cellulose derivatives; polyamide resins; chlorinated rubber, Chlorinated rubber and rubber derivatives such as cyclized rubber; Vinyl chloride resins such as vinyl acetate vinyl chloride copolymer; Polyolefins such as ethylene vinyl acetate copolymer and polypropylene chlorinated products; Copolymers of acrylic acid and acrylic esters Acrylic resins such as copolymers; Urethane resins; High acid number rosin-modified maleic acid resins containing carboxyl groups, styrene maleic resins, acrylic resins, shellac, casein, acrylic resins or emulsions of urethane resins, etc. Gravure inks containing water-soluble resin as a resin component That.

  The thickness of the printing layer varies depending on each printing method, the ink to be used, and the number of colors to be used, but is usually 0.1 to 30 μm, preferably about 0.5 to 10 μm.

(Aluminum foil layer)
The aluminum foil layer is used for imparting moisture and gas barrier properties. This may be a pure aluminum-based aluminum foil or an aluminum alloy-based aluminum foil. The thickness of the aluminum foil layer is preferably 7 μm or more, 10 μm or more, or 20 μm or more, and 60 μm or less, 50 μm or less, or 40 μm or less in order to give appropriate moldability and elasticity to the blister pack laminate. .

(Reinforcing layer)
A reinforcement layer is a layer used arbitrarily in order to improve the moldability of the laminated body for blister packs. The reinforcing layer may be composed of polyvinyl chloride, saturated or unsaturated polyester (for example, polyethylene terephthalate, polybutylene terephthalate), polyamide, and mixtures thereof. The thickness of the reinforcing layer is preferably 10 μm or more, 15 μm or more, or 25 μm or more, and 60 μm or less, or 50 μm or less. In the present invention, the reinforcing layer described in Patent Document 2 can be used as the reinforcing layer.

(Absorption layer)
The absorption layer is a layer having an absorptive function, and the long-term stability of the contents can be improved by this layer. The absorbent layer may be a single absorbent holding layer containing an absorbent and a binder resin, but preferably the outer skin layer, the absorbent holding layer containing the absorbent and the binder resin, and the inner skin layer in this order. Including. In this case, the absorbent contained in the absorbent holding layer is prevented from being detached during use, and the absorbent layer can be easily produced, so that it is sandwiched between the upper and lower skin layers.

  The outer skin layer is a layer used on the side (outside) opposite to the side containing the contents of the blister pack, and the inner skin layer is a layer used on the side (inside) containing the contents. As shown in FIG. 1, the absorbent layer 6 is laminated with the base material layer 1, the printing layer 2, the adhesive layer 3, the aluminum foil layer 4, and the optional reinforcing layer 5 in the blister pack laminate 10 of the present invention. Can be used. Further, for example, as shown in FIG. 3, the absorbent layer 6 includes an outer skin layer 6a, an absorbent holding layer 6b, and an inner skin layer 6c.

  The absorbent layer of the absorbent holding layer single layer can be manufactured by extrusion molding such as inflation method, T-die method, co-extrusion, or injection molding. In addition, an absorption layer having a three-layer structure including an outer skin layer, an absorbent holding layer, and an inner skin layer can be produced by a multilayer inflation method. This is a method for producing a multilayer film by extruding a plurality of resins into a tube shape at the same time by a plurality of extruders and sending the air into the tubes to inflate them. Also, the absorbent holding layer is formed into a film or sheet by extrusion or injection molding such as inflation method, T-die method, coextrusion, etc., and the outer skin layer and inner skin layer are formed into a film by a known method. Then, an absorbent layer having a three-layer structure can be produced by laminating the absorbent holding layer.

  The thickness of the absorbing layer is preferably 50 μm or more, 60 μm or more, or 70 μm or more, and preferably 200 μm or less, 100 μm or less, 90 μm or less, or 80 μm or less from the viewpoint of obtaining appropriate moldability and elasticity.

<Inner skin layer and outer skin layer>
The inner skin layer and the outer skin layer mainly contain a resin and may contain a smaller amount of absorbent than the absorbent retaining layer, but the absorbent may be detached during the production and use of the blister pack. In consideration of the ease of production of the absorbent layer, it is preferable not to contain an absorbent. Examples of the resin used for the inner skin layer and the outer skin layer include polyethylene resin, polypropylene resin, polymethylpentene, saturated polyester, polyvinyl chloride, polystyrene, polycarbonate, polyamide, thermoplastic elastomer, and mixtures thereof. It is done.

  The thicknesses of the inner skin layer and the outer skin layer are preferably 5 μm or more, 10 μm or more, or 20 μm or more, and preferably 50 μm or less, or 40 μm or less from the viewpoint of obtaining appropriate moldability and elasticity.

<Absorbent retention layer>
The absorbent holding layer has a structure in which an absorbent is dispersed in a binder resin. The absorbent holding layer functions as a layer that absorbs moisture, organic gas, and inorganic gas in the blister pack.

  Absorbents that can be used in the absorbent holding layer include inorganic absorbents, for example, chemical adsorbents such as calcium oxide, calcium chloride, calcium sulfate, magnesium sulfate, and sodium sulfate, and aluminum oxide, quicklime, silica gel, and inorganic molecular sieves. Physical adsorbents such as Examples of inorganic molecular sieves include, but are not limited to, aluminosilicate minerals, clays, porous glass, microporous activated carbon, zeolite, activated carbon, or compounds having an open structure capable of diffusing small molecules such as water. Can be mentioned. Such an inorganic absorbent can obtain high absorbency even in a low humidity region, and absorbs moisture slightly contained in the blister pack even under such a low relative humidity environment. It is particularly preferable to use an absorbent that can exhibit high absorbability.

  As zeolite, natural zeolite, artificial zeolite, synthetic zeolite and the like can be used. Zeolite is a porous granular material used to separate substances according to the difference in molecular size, and has a structure with uniform pores. Therefore, water (steam, water vapor), organic gas, inorganic gas, etc. can be absorbed. An example of the synthetic zeolite is a molecular sieve. Among these, a molecular sieve having a pore (absorption port) diameter of 0.3 nm to 1 nm can be used. In general, molecular sieves having pore sizes of 0.3 nm, 0.4 nm, 0.5 nm, and 1 nm are referred to as molecular sieve 3A, molecular sieve 4A, molecular sieve 5A, and molecular sieve 13X, respectively. The average particle size of the molecular sieve (particle size at an integrated value of 50% in the particle size distribution determined by the laser diffraction / scattering method) is, for example, about 10 μm. In the present invention, these zeolites can be properly used in accordance with the object to be absorbed and the properties of the contents.

  In particular, when absorbing an organic gas, it is preferable to use a hydrophobic zeolite. Hydrophobic zeolite is a generic term for a so-called high silica zeolite in which aluminum atoms in the crystal skeleton of the zeolite are reduced by dealumination to increase the silica-alumina ratio. Hydrophobic zeolite is a zeolite that loses its affinity for polar substances such as water and absorbs nonpolar substances more strongly, and more easily absorbs organic gases and the like. As the hydrophobic molecular sieve which is an example of the hydrophobic zeolite, those having a pore diameter of 0.6 to 0.9 nm can be used, and examples include Abscents 1000, Abscents 2000, Abscents 3000 (above Union Showa Co., Ltd.) and the like. The pore diameter can be confirmed by structural analysis by X-ray diffraction. The average particle size of the hydrophobic zeolite (particle size at an integrated value of 50% in the particle size distribution determined by the laser diffraction / scattering method) is, for example, 3 to 5 μm.

  The absorbent is more than 0% by weight, 10% by weight, 20% by weight, 30% by weight, 40% by weight, or 50% by weight with respect to the weight of the absorbent holding layer from the viewpoint of absorption capacity. In the above range, it can be contained in the absorbent retaining layer, and in the range of 70% by weight or less, 60% by weight or less, 50% by weight or less, or 40% by weight or less from the viewpoint of dispersibility in the binder resin and moldability. Can be contained in the absorbent retaining layer.

  Binder resins that can be used for the absorbent-holding layer include organic binders such as polyethylene resins, polypropylene resins, saturated or unsaturated polyesters, ionomers, polyvinyl chloride (PVC), polystyrene, and derivatives thereof, and these Of the mixture.

  The thickness of the absorbent holding layer is preferably 10 μm or more, 20 μm or more, or 30 μm or more from the viewpoint of absorption capability, moldability, and elasticity, and is 500 μm or less, 300 μm or less, 200 μm or less, 150 μm or less, 100 μm, or It is preferable that it is 60 micrometers or less.

(Adhesive layer)
The laminate for blister packs of the present invention has an adhesive layer between the printed layer and the aluminum foil layer in order to bond at least between the printed layer and the aluminum foil layer. Moreover, the laminated body for blister packs of this invention may have an adhesive layer between any other two layers.

  The adhesive that may be used for the adhesive layer of the present invention is not limited as long as it adheres each layer. For example, when classified by an adhesive mechanism, a solvent-volatile adhesive that adheres by evaporation of the solvent, once melted Examples thereof include a hot-melt adhesive that adheres when it returns to solid by cooling, and a pressure-sensitive adhesive that adheres by applying pressure. Specific examples include a butyl rubber adhesive, an olefin adhesive, and a vinyl chloride adhesive.

In addition, a reactive adhesive can be used. The reactive adhesive cures and adheres when the components contained in the adhesive change due to a chemical reaction. Examples of reactive adhesives include urethane adhesives and acrylic adhesives. In the case of a reactive adhesive that mixes two liquids, it can be used, for example, by a combination of a polyol, polyamine, or the like as a main agent and an epoxy, polyisocyanate, or the like as a curing agent. The coating amount is about 0.5 to 10.0 g / m ² . If the coating amount is too small, the adhesive strength may be insufficient. On the other hand, if the coating amount is too large, no further improvement in the adhesive strength is observed, which is undesirable in terms of moisture resistance and economy.

Adhesive layer having between the print layer and the aluminum foil layer, Martens hardness when measured in accordance with ISO14577 is, 350 N / ^{m 2} or more, 360N / ^{m 2} or more, 370N / ^{m 2} or more, 380 N / m ² or more, preferably 390 N / ^{m 2} or more, or 400 N / ^{m 2} or more,, 500 N / ^{m 2} or less, 490 N / ^{m 2} or less, 480N / ^{m 2} or less, 470N / ^{m 2} or less, 460N / ^{m 2} or less Or 450 N / m ² or less. By using an adhesive layer having a Martens hardness within the above range, it is possible to suppress film return by blister pack molding and spring back after molding, and prevent interlaminar separation between the printed layer and the aluminum foil layer. Can do.

  If an adhesive layer with too low Martens hardness is used, film return due to springback after molding or after molding cannot be suppressed.Therefore, peeling between the printed layer and the aluminum foil layer causes wrinkles and This is not preferable because appearance defects such as lamination occur. Also, if an adhesive layer with too high Martens hardness is used, the adhesive layer breaks during blister pack molding, and film return due to springback after molding cannot be suppressed, so the printed layer and the aluminum foil layer It is not preferable because it is peeled off between them and appearance defects such as wrinkles and delamination occur.

  As a method for adjusting the Martens hardness of the adhesive layer, for example, when a reactive adhesive is used, it can be adjusted by adjusting the ratio of the main agent and the curing agent.

  In the present invention, the Martens hardness of the adhesive layer is such that the adhesive is spin-coated on a glass plate so that the thickness after curing is 1 to 2 μm, dried, and then in accordance with ISO14577. By using an indenter hardness measuring machine (TRH-001, Technicimo Co., Ltd.) as a measuring machine, it can be measured under conditions of an indentation amount of 0.5 mm and an indentation speed of 5.0 μm / s.

(Blister pack and blister pack package)
The blister pack of the present invention includes, for example, the above-described laminated body for blister packs and a lid material. The absorbent layer and the lid material of the blister pack laminate are at least partially bonded. After forming the pocket part for storing the contents such as tablets in the laminated body for blister pack, the contents are stored in the pocket part, and the lid material is adhered to store the contents in the pocket part of the blister pack A blister pack package can be produced.

  The lid member includes, for example, a thermoplastic resin layer and a metal layer. As the resin layer, a thermoplastic resin can be used. As the metal layer, an aluminum foil such as a pure aluminum foil or an aluminum alloy foil can be used. Preferably, the lid is in a form in which a thermoplastic resin layer is coated on an aluminum foil, and the thermoplastic resin layer of the lid and the layer (absorbing layer) to which the laminate for blister packs adheres have an adhesive property. From the viewpoint of enhancing, the same resin can be included. Alternatively, an aluminum foil may be coated with an easy peel resin such as polyolefin polymer alloy, or an easy peel film may be laminated. In this case, the contents can be taken out by peeling at the bonding interface between the blister pack and the lid.

  As another aspect of the blister pack of the present invention, two laminates selected from the above-mentioned laminate for blister packs are bonded at least partially with the absorbent layers facing each other. After forming the pocket for storing the contents such as tablets on both the two blister pack laminates, the contents are stored in the pockets and the absorbent layers of the two blister pack laminates are bonded together. Thus, a blister pack package in which the contents are stored in the pocket portion of the blister pack can be produced.

  The contents of the blister pack of the present invention are not limited as long as they can be deteriorated by contact with the outside air, and examples thereof include foods, cosmetics, medical devices, electronic components, and the like. In addition to pharmaceutical preparations, preparations include detergents, agricultural chemicals and the like.

  FIG. 1 is a schematic view of a blister pack 100. Here, the cover material 7 is bonded to the laminated body 10 for blister pack in which the base material layer 1, the printing layer 2, the adhesive layer 3, the aluminum foil layer 4, the optional reinforcing layer 5, and the absorbent layer 6 are laminated in this order. The contents 300 are contained in a dome-shaped pocket formed in the laminate 10.

  FIG. 2 is a schematic view of a blister pack 200 according to another embodiment. The absorbent layers of the two blister pack laminates 10 are bonded to each other, and the contents 300 are contained in the pocket portions formed in the laminate 10.

  FIG. 3 is a schematic view of the layer structure of the blister pack 100 of the present invention. In this figure, the end portion of the blister pack 100 where the pocket portion is not formed is shown. In this order, the base layer 1, the printing layer 2, the adhesive layer 3, the aluminum foil layer 4, the optional reinforcing layer 5, and A lid 7 is bonded to a blister pack laminate 10 in which an absorbent layer 6 is laminated. The absorbent layer 6 is composed of an outer skin layer 6a, an absorbent holding layer 6b, and an inner skin layer 6c, and the lid member 7 is composed of a thermoplastic resin layer 7a and a metal layer 7b.

Example 1
(Production of absorption layer)
Resin pellets of linear low density polyethylene (LLDPE) (Evolue SP2520, Prime Polymer Co., Ltd.) were prepared as materials for the inner and outer skin layers. As materials for the absorbent holding layer, ethylene-methacrylic acid-modified polyethylene (Nucleel AN42115C, Mitsui DuPont Co., Ltd.) and the absorbent zeolite (Molecular Sieve 3A, Union Showa) are put into a kneading extruder, and the resin is heated and melted. Then, the mixture was extruded and cooled by an extruder to obtain resin pellets for the absorbent holding layer. The content of zeolite in the resin pellet for the absorbent retaining layer was 53% by weight of the weight of the pellet. And the film used as an absorption layer was formed into a film by co-extrusion molding by an air-cooling type inflation molding machine using the resin pellets for the inner and outer skin layers and the resin pellets for the absorbent holding layer. The thickness of the obtained absorption layer was 10 μm for the inner skin layer, 30 μm for the absorbent retaining layer, and 20 μm for the outer skin layer. Inflation molding was performed by a three-layer inflation molding machine (TUL-600R, Plako Corporation) at a resin temperature of 170 ° C. and a take-up speed of 10 m / min.

(Production of laminate)
A printing layer is provided on one side of a PET film (E5102, Toyobo Co., Ltd.) having a thickness of 25 μm so that the printed film thickness after drying is 1 to 2 μm by gravure printing, and the adhesive layer is applied to the printing layer side by bar coating. After applying and drying, a laminate a was obtained by laminating the aluminum foil on a rough surface (matt surface).

Here, the main agent (Takelac (trademark) A525S, Mitsui Chemicals, Inc.) and the curing agent (Takenate (trademark) A50, Mitsui Chemicals, Inc.) are respectively used as the adhesive used for the adhesive layer of the laminate a. A urethane adhesive containing a weight ratio of 2 was used. In addition, the coating amount of the adhesive was 3 to 4 g / m ² .

  An adhesive layer was applied to one side of a PET film (PCBC, Unitika Ltd.) having a thickness of 12 μm by bar coating, and laminated on the glossy surface of the aluminum foil of the laminate a. Then, the laminated body b was obtained by storing for 14 days in 40 degreeC environment, and performing aging.

  An adhesive layer was applied to the surface of the laminate b having a thickness of 12 μm by bar coating, and an absorbent layer was laminated to obtain a laminate c. Then, the sample for evaluation was obtained by performing aging by storing for 3 days in an environment of 40 ° C.

As the adhesive used for the adhesive layers of the laminates b and c, the main agent (Takelac (trademark) A525S, Mitsui Chemicals) and the curing agent (Takenate (trademark) A50, Mitsui Chemicals) are each 9: 1. A urethane-based adhesive contained in a weight ratio was used. In addition, the coating amount of the adhesive agent between each layer was 3-4 g / m < ² >.

  The layer structure of the sample for evaluation of Example 1 is shown in Table 1.

(Example 2)
As the adhesive used for the adhesive layer of the laminate a, the main agent (Takelac (trademark) A525S, Mitsui Chemicals, Inc.) and the curing agent (Takenate (trademark) A50, Mitsui Chemicals, Inc.) each have a weight of 9: 1.3. A sample for evaluation was obtained in the same procedure as in Example 1 except that the urethane-based adhesive contained in the ratio was used. The layer structure of the sample for evaluation of Example 2 is shown in Table 1.

(Example 3)
As the adhesive used for the adhesive layer of the laminate a, the main agent (Takelac (trademark) A525S, Mitsui Chemicals, Inc.) and the curing agent (Takenate (trademark) A50, Mitsui Chemicals, Inc.) each have a weight of 9: 1.4. A sample for evaluation was obtained in the same procedure as in Example 1 except that the urethane-based adhesive contained in the ratio was used. The layer structure of the sample for evaluation of Example 3 is shown in Table 1.

(Comparative Example 1)
As the adhesive used for the adhesive layer of the laminate a, the main agent (Takelac (trademark) A525S, Mitsui Chemicals, Inc.) and the curing agent (Takenate (trademark) A50, Mitsui Chemicals, Inc.) are each in a weight ratio of 9: 1. A sample for evaluation was obtained in the same procedure as in Example 1 except that the urethane-based adhesive contained was used. Table 1 shows the layer structure of the sample for evaluation of Comparative Example 1.

(Comparative Example 2)
As the adhesive used for the adhesive layer of the laminate a, the main agent (Takelac (trademark) A525S, Mitsui Chemicals) and the curing agent (Takenate (trademark) A50, Mitsui Chemicals) each have a weight of 9: 1.1. A sample for evaluation was obtained in the same procedure as in Example 1 except that the urethane-based adhesive contained in the ratio was used. Table 1 shows the layer structure of the sample for evaluation in Comparative Example 2.

(Comparative Example 3)
As the adhesive used for the adhesive layer of the laminate a, the main agent (Takelac (trademark) A525S, Mitsui Chemicals) and the curing agent (Takenate (trademark) A50, Mitsui Chemicals) each have a weight of 9: 1.5. A sample for evaluation was obtained in the same procedure as in Example 1 except that the urethane-based adhesive contained in the ratio was used. Table 1 shows the layer structure of the sample for evaluation in Comparative Example 3.

(Comparative Example 4)
As the adhesive used for the adhesive layer of the laminate a, the main agent (Takelac (trademark) A525S, Mitsui Chemicals, Inc.) and the curing agent (Takenate (trademark) A50, Mitsui Chemicals, Inc.) each have a weight of 9: 1.6. A sample for evaluation was obtained in the same procedure as in Example 1 except that the urethane-based adhesive contained in the ratio was used. Table 1 shows the layer structure of the sample for evaluation in Comparative Example 4.

(Evaluation 1: Molding test)
A pocket part of a pharmaceutical preparation having a depth of 5.0 mm was molded at room temperature on the evaluation samples of Examples 1 to 3 and Comparative Examples 1 to 4. A high-speed hydraulic press (HYP505H) manufactured by Nippon Automatic Machine Co., Ltd. was used as the molding machine. The plug material is ultra high molecular weight polyethylene resin (product name: Newlite (trademark) NL-W, Sakushin Kogyo Co., Ltd.) having a viscosity average molecular weight of 5.5 million, the plug diameter is 13 mm, the molding speed is 200 mm / s, and the molding is performed. The pressure was 7.7 MPa and the indentation holding time was 1 second. Here, after the periphery of the part to be molded is fixed while pressure is applied, the stacked body is formed into a dome shape by pushing out the plug (convex part) for a set length.

  Here, the case where there were no visual defects such as cracks, scratches, dents, delamination, etc. in the molded pocket part was marked with ○, and the appearance defects such as cracks, scratches, dents, delamination, etc. in the molded pocket part. When x occurred visually, it was set as x. The results are shown in Table 1.

(Evaluation 2: Heating test)
The samples after the molding tests of Examples 1 to 3 and Comparative Examples 1 to 4 were left in an oven at 150 ° C. for 15 seconds, and the appearance was visually observed. Here, the case where the appearance of defects such as cracks, scratches, wrinkles, delamination, etc. did not occur visually in the pocket part formed around the heating test and its peripheral part was marked with ○, and the pocket part formed around the heating test and its peripheral part In the case where appearance defects such as cracks, scratches, wrinkles, delamination, etc. occurred visually, the case was evaluated as x. The results are shown in Table 1.

(Evaluation 3: Storage test)
The samples after the molding tests of Examples 1 to 3 and Comparative Examples 1 to 4 were left in an environment of a temperature of 40 ° C. and a relative humidity of 75% for 14 days, and the appearance was visually observed. Here, when the appearance of defects such as cracks, scratches, dents, delamination, etc. did not occur in the pocket portion molded after the storage test and its peripheral portion, the pocket portion and the peripheral portion formed after the storage test were marked as ◯. In the case where defects in appearance such as cracks, scratches, dents, delamination, etc. occurred visually, the case was evaluated as x. The results are shown in Table 1.

(Evaluation 4: Evaluation of hardness of adhesive)
After spin-coating the adhesive used in Examples 1 to 3 and Comparative Examples 1 to 4 on a glass plate so that the thickness after curing is 1 to 2 μm, the Martens hardness is determined in accordance with ISO14577. It was measured. Using a tabletop nanoindenter hardness measuring machine (TRH-001, Technicimo Co., Ltd.) as a measuring machine, the indentation amount was 0.5 mm and the indentation speed was 5.0 μm / s. The results are shown in Table 1.

  As can be seen from the results in Table 1, Examples 1 to 3 using adhesives having preferred Martens hardness as compared to Comparative Examples 1 to 4 using adhesives having Martens hardness that is too small or too large. Thus, no appearance defects such as scratches, dents, and delamination occurred during and after molding.

  This is because, by using an adhesive having a preferable hardness, it is possible to suppress film return due to springback during molding and after molding between the printed layer and the aluminum foil, so that appearance defects such as dents and delamination are not caused. It is thought that it will not occur. On the other hand, when an adhesive having a too high Martens hardness is used, the adhesive cracks during molding between the printed layer and the aluminum foil, and the film return after molding cannot be suppressed. It is considered that appearance defects such as the above occur.

100, 200 Blister pack 300 Contents 10 Blister pack laminate 1 Base layer 2 Print layer 3 Adhesive layer 4 Aluminum foil layer 5 Reinforcement layer 6 Absorbing layer 7 Lid 6a Outer skin layer 6b Absorbent retaining layer 6c Inner skin layer 7a Thermoplastic resin layer 7b Metal layer

Claims (11)

At least a base material layer, a printing layer, an adhesive layer, an aluminum foil layer, and an absorption layer are included in this order, and the adhesive layer has a Martens hardness of 350 to 500 N / m ² when measured according to ISO14577. , Blister pack laminate. The blister pack laminate according to claim 1, wherein the adhesive layer has a Martens hardness of 400 to 450 N / m ² when measured in accordance with ISO14577.   The blister pack laminate according to claim 1 or 2, wherein the adhesive layer is a layer of a reactive adhesive.   The laminated body for blister packs as described in any one of Claims 1-3 whose said contact bonding layer is a layer of a urethane type adhesive agent.   The said base material layer contains resin selected from the group which consists of a polyethylene-type resin, a polyvinyl chloride, a polyvinylidene chloride, a polychlorotrifluoroethylene, a polypropylene-type resin, a polyethylene terephthalate, polyamide, and these mixtures. The laminated body for blister packs as described in any one of -4.   The laminated body for blister packs as described in any one of Claims 1-5 in which the said printing layer consists of gravure ink.   The said absorption layer contains the outer skin layer by the side of the said base material layer, the absorber holding layer which has an absorber and binder resin, and the inner skin layer in this order. Blister pack laminate.   The laminated body for blister packs as described in any one of Claims 1-7 which further has a reinforcement layer between the said aluminum foil layer and the said absorption layer.   The laminate according to any one of claims 1 to 8, and a lid member having an aluminum foil layer and a resin layer different from the aluminum foil layer, the absorbent layer of the laminate and the resin of the lid member A blister pack in which a layer is adhered at least partially, and a pocket is formed in the laminate so that a pharmaceutical preparation can be stored between the laminate and the lid.   The two laminates according to any one of claims 1 to 8 are bonded at least partially with the absorption layer facing each other, and a pocket portion is formed in the two laminates to form the pocket. Blister pack that can store pharmaceutical preparations in the part.   The blister pack package which has the blister pack of Claim 9 or 10, and the content accommodated in the said pocket part.

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