JP2016540759A5 - - Google Patents
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- JP2016540759A5 JP2016540759A5 JP2016535047A JP2016535047A JP2016540759A5 JP 2016540759 A5 JP2016540759 A5 JP 2016540759A5 JP 2016535047 A JP2016535047 A JP 2016535047A JP 2016535047 A JP2016535047 A JP 2016535047A JP 2016540759 A5 JP2016540759 A5 JP 2016540759A5
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- timp
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- 239000003795 chemical substances by application Substances 0.000 claims 26
- 238000003556 assay Methods 0.000 claims 22
- 102100029228 Insulin-like growth factor-binding protein 7 Human genes 0.000 claims 10
- 108010008598 insulin-like growth factor binding protein-related protein 1 Proteins 0.000 claims 10
- 210000001124 body fluid Anatomy 0.000 claims 6
- 230000006370 G0 arrest Effects 0.000 claims 5
- 230000037057 G1 phase arrest Effects 0.000 claims 5
- 239000010839 body fluid Substances 0.000 claims 5
- 208000033626 Renal failure acute Diseases 0.000 claims 4
- 201000011040 acute kidney failure Diseases 0.000 claims 4
- 239000000090 biomarker Substances 0.000 claims 4
- 230000006369 cell cycle progression Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 3
- 210000002919 epithelial cell Anatomy 0.000 claims 3
- 210000001985 kidney epithelial cell Anatomy 0.000 claims 3
- 229930105110 Cyclosporin A Natural products 0.000 claims 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 2
- 108010036949 Cyclosporine Proteins 0.000 claims 2
- 101000998548 Yersinia ruckeri Alkaline proteinase inhibitor Proteins 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 2
- 229960001265 ciclosporin Drugs 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 230000001747 exhibiting effect Effects 0.000 claims 2
- 239000000411 inducer Substances 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 239000003475 metalloproteinase inhibitor Substances 0.000 claims 2
- 102100032814 ATP-dependent zinc metalloprotease YME1L1 Human genes 0.000 claims 1
- QEEBRPGZBVVINN-UHFFFAOYSA-N Desacetyl-bufotalin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C1(O)CCC2C=1C=CC(=O)OC=1 QEEBRPGZBVVINN-UHFFFAOYSA-N 0.000 claims 1
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 1
- 102000003972 Fibroblast growth factor 7 Human genes 0.000 claims 1
- 108090000385 Fibroblast growth factor 7 Proteins 0.000 claims 1
- -1 NC381 Chemical compound 0.000 claims 1
- 101800000795 Proadrenomedullin N-20 terminal peptide Proteins 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- BIIVYFLTOXDAOV-YVEFUNNKSA-N alvocidib Chemical compound O[C@@H]1CN(C)CC[C@@H]1C1=C(O)C=C(O)C2=C1OC(C=1C(=CC=CC=1)Cl)=CC2=O BIIVYFLTOXDAOV-YVEFUNNKSA-N 0.000 claims 1
- 229950010817 alvocidib Drugs 0.000 claims 1
- FIHJKUPKCHIPAT-AHIGJZGOSA-N artesunate Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2O[C@@H](OC(=O)CCC(O)=O)[C@@H]4C FIHJKUPKCHIPAT-AHIGJZGOSA-N 0.000 claims 1
- 229960004991 artesunate Drugs 0.000 claims 1
- QEEBRPGZBVVINN-BMPKRDENSA-N bufalin Chemical compound C=1([C@H]2CC[C@]3(O)[C@H]4[C@@H]([C@]5(CC[C@H](O)C[C@H]5CC4)C)CC[C@@]32C)C=CC(=O)OC=1 QEEBRPGZBVVINN-BMPKRDENSA-N 0.000 claims 1
- 238000007675 cardiac surgery Methods 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000022131 cell cycle Effects 0.000 claims 1
- 230000025084 cell cycle arrest Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 210000004351 coronary vessel Anatomy 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 230000001882 diuretic effect Effects 0.000 claims 1
- 229960005167 everolimus Drugs 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 231100000417 nephrotoxicity Toxicity 0.000 claims 1
- 229960002404 palifermin Drugs 0.000 claims 1
- PIRWNASAJNPKHT-SHZATDIYSA-N pamp Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)N)C(C)C)C1=CC=CC=C1 PIRWNASAJNPKHT-SHZATDIYSA-N 0.000 claims 1
- 238000012959 renal replacement therapy Methods 0.000 claims 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims 1
- 229960002855 simvastatin Drugs 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 229940037128 systemic glucocorticoids Drugs 0.000 claims 1
- 229960004066 trametinib Drugs 0.000 claims 1
- LIRYPHYGHXZJBZ-UHFFFAOYSA-N trametinib Chemical compound CC(=O)NC1=CC=CC(N2C(N(C3CC3)C(=O)C3=C(NC=4C(=CC(I)=CC=4)F)N(C)C(=O)C(C)=C32)=O)=C1 LIRYPHYGHXZJBZ-UHFFFAOYSA-N 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 238000007631 vascular surgery Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361911406P | 2013-12-03 | 2013-12-03 | |
| US61/911,406 | 2013-12-03 | ||
| PCT/US2014/068337 WO2015084939A1 (en) | 2013-12-03 | 2014-12-03 | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019202233A Division JP7068256B2 (ja) | 2013-12-03 | 2019-11-07 | 腎損傷および腎不全の診断および予後のための方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016540759A JP2016540759A (ja) | 2016-12-28 |
| JP2016540759A5 true JP2016540759A5 (enExample) | 2018-01-18 |
Family
ID=53274065
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016535047A Pending JP2016540759A (ja) | 2013-12-03 | 2014-12-03 | 腎損傷および腎不全の診断および予後のための方法および組成物 |
| JP2019202233A Active JP7068256B2 (ja) | 2013-12-03 | 2019-11-07 | 腎損傷および腎不全の診断および予後のための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019202233A Active JP7068256B2 (ja) | 2013-12-03 | 2019-11-07 | 腎損傷および腎不全の診断および予後のための方法および組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US10300108B2 (enExample) |
| EP (1) | EP3077819A4 (enExample) |
| JP (2) | JP2016540759A (enExample) |
| CN (2) | CN110007084B (enExample) |
| WO (1) | WO2015084939A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010048346A1 (en) | 2008-10-21 | 2010-04-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| MX342967B (es) | 2009-12-20 | 2016-10-19 | Astute Medical Inc | Metodos y composiciones para la diagnosis y prognosis de lesion renal y falla renal. |
| NZ605698A (en) | 2010-06-23 | 2015-03-27 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP3540440B1 (en) | 2011-12-08 | 2022-09-28 | Astute Medical, Inc. | Methods and uses for evaluating renal injury and renal status |
| JP6681195B2 (ja) | 2013-01-17 | 2020-04-15 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| CN110007084B (zh) | 2013-12-03 | 2022-11-18 | 阿斯图特医药公司 | 用于肾损伤和肾衰竭的诊断和预后的方法和组合物 |
| WO2016164854A1 (en) | 2015-04-09 | 2016-10-13 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| AU2017277305A1 (en) | 2016-06-06 | 2018-12-20 | Astute Medical, Inc. | Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 |
| UA124019C2 (uk) * | 2016-10-05 | 2021-07-07 | Мітобрідж, Інк. | Спосіб лікування гострого пошкодження нирок |
| WO2018081447A1 (en) | 2016-10-26 | 2018-05-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Compositions and methods for reducing the rick of radiocontrast-induced nephropathy |
| EP3532101B1 (en) * | 2016-10-28 | 2021-12-08 | Astute Medical, Inc. | Use of antibodies to timp-2 for the improvement of renal function |
| US10600502B2 (en) * | 2016-12-20 | 2020-03-24 | Astrazeneca Uk Ltd. | Systems and methods for dispensing a statin medication over the counter |
| CN110431422A (zh) | 2017-02-06 | 2019-11-08 | 机敏医药股份有限公司 | 用于肾损伤和肾衰竭的诊断和预后的方法和组合物 |
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| JP2020524714A (ja) | 2017-06-23 | 2020-08-20 | エーケーアイ・セラピューティクス・エーぺーエス | 急性腎障害の予防及び治療のための組成物 |
| IT201900001365A1 (it) * | 2019-01-30 | 2020-07-30 | Torino Politecnico | Sistema di monitoraggio e previsione della diuresi per il calcolo del rischio di insufficienza renale, e relativo metodo |
| CN116870135A (zh) * | 2019-10-12 | 2023-10-13 | 睿诺医疗科技（上海）有限公司 | 肾毒素诱发的肾损伤的治疗和预防 |
| CN116615211A (zh) * | 2020-10-19 | 2023-08-18 | 特拉哈斯霍默医学研究基础设施和服务有限公司 | 尿源性上皮细胞培养物、由此得到的肾球状体以及其制备和使用方法 |
| CN112316150B (zh) * | 2020-12-04 | 2023-04-28 | 深圳市中医院 | 一种用于预防或治疗代谢或损伤相关疾病的药物组合物 |
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| WO2014197729A1 (en) | 2013-06-05 | 2014-12-11 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| KR20160039682A (ko) | 2013-08-07 | 2016-04-11 | 아스튜트 메디컬 인코포레이티드 | 생물학적 샘플에서 개선된 성능을 가지는 timp2에 대한 검정 |
| AU2014346695B2 (en) | 2013-11-06 | 2020-10-15 | Astute Medical, Inc. | Assays for IGFBP7 having improved performance in biological samples |
| CN110007084B (zh) | 2013-12-03 | 2022-11-18 | 阿斯图特医药公司 | 用于肾损伤和肾衰竭的诊断和预后的方法和组合物 |
| WO2016164854A1 (en) | 2015-04-09 | 2016-10-13 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| KR102083104B1 (ko) | 2015-10-08 | 2020-02-28 | 에프. 호프만-라 로슈 아게 | 수술 전 측정시 ａｋｉ 의 위험 예측을 위한 ｉｇｆｂｐ７ |
| AU2017277305A1 (en) | 2016-06-06 | 2018-12-20 | Astute Medical, Inc. | Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 |
| EP3532101B1 (en) | 2016-10-28 | 2021-12-08 | Astute Medical, Inc. | Use of antibodies to timp-2 for the improvement of renal function |
| CN110431422A (zh) | 2017-02-06 | 2019-11-08 | 机敏医药股份有限公司 | 用于肾损伤和肾衰竭的诊断和预后的方法和组合物 |
| WO2018187453A1 (en) | 2017-04-05 | 2018-10-11 | Astute Medical, Inc. | Assays for timp2 having improved performance in biological samples |
| WO2018208684A1 (en) | 2017-05-07 | 2018-11-15 | Astute Medical, Inc. | Use of insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 in the management of renal replacement therapy |
-
2014
- 2014-12-03 CN CN201910275935.3A patent/CN110007084B/zh active Active
- 2014-12-03 US US15/101,118 patent/US10300108B2/en active Active
- 2014-12-03 CN CN201480073639.0A patent/CN105917229B/zh active Active
- 2014-12-03 JP JP2016535047A patent/JP2016540759A/ja active Pending
- 2014-12-03 EP EP14868424.4A patent/EP3077819A4/en active Pending
- 2014-12-03 WO PCT/US2014/068337 patent/WO2015084939A1/en not_active Ceased
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2019
- 2019-05-24 US US16/422,520 patent/US11229676B2/en active Active
- 2019-11-07 JP JP2019202233A patent/JP7068256B2/ja active Active
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2022
- 2022-01-24 US US17/582,999 patent/US20220143133A1/en not_active Abandoned
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