JP2016536369A - 抗ｖｅｇｆ ｄａｒｐｉｎを用いた眼の容態の治療方法 - Google Patents

抗ｖｅｇｆ ｄａｒｐｉｎを用いた眼の容態の治療方法 Download PDF

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Publication number
JP2016536369A
JP2016536369A JP2016552455A JP2016552455A JP2016536369A JP 2016536369 A JP2016536369 A JP 2016536369A JP 2016552455 A JP2016552455 A JP 2016552455A JP 2016552455 A JP2016552455 A JP 2016552455A JP 2016536369 A JP2016536369 A JP 2016536369A
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doses
days
dose
interval
administered
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Japanese (ja)
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JP2016536369A5 (https=
Inventor
トーマス ホーマン
トーマス ホーマン
ジャネット チータム
ジャネット チータム
スコット ホイットカップ
スコット ホイットカップ
エリック リッパ
エリック リッパ
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Allergan Inc
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Allergan Inc
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Publication of JP2016536369A publication Critical patent/JP2016536369A/ja
Publication of JP2016536369A5 publication Critical patent/JP2016536369A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2016552455A 2013-11-05 2014-11-04 抗ｖｅｇｆ ｄａｒｐｉｎを用いた眼の容態の治療方法 Pending JP2016536369A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361900246P 2013-11-05 2013-11-05
US61/900,246 2013-11-05
US201462016620P 2014-06-24 2014-06-24
US62/016,620 2014-06-24
PCT/US2014/063951 WO2015069668A1 (en) 2013-11-05 2014-11-04 Method of treating conditions of the eye with an anti-vegf darpin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020106978A Division JP2020169191A (ja) 2013-11-05 2020-06-22 抗ｖｅｇｆ ｄａｒｐｉｎを用いた眼の容態の治療方法

Publications (2)

Publication Number Publication Date
JP2016536369A true JP2016536369A (ja) 2016-11-24
JP2016536369A5 JP2016536369A5 (https=) 2018-02-22

Family

ID=51947485

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016552455A Pending JP2016536369A (ja) 2013-11-05 2014-11-04 抗ｖｅｇｆ ｄａｒｐｉｎを用いた眼の容態の治療方法
JP2020106978A Pending JP2020169191A (ja) 2013-11-05 2020-06-22 抗ｖｅｇｆ ｄａｒｐｉｎを用いた眼の容態の治療方法
JP2022076645A Pending JP2022107628A (ja) 2013-11-05 2022-05-06 抗ｖｅｇｆ ｄａｒｐｉｎを用いた眼の容態の治療方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2020106978A Pending JP2020169191A (ja) 2013-11-05 2020-06-22 抗ｖｅｇｆ ｄａｒｐｉｎを用いた眼の容態の治療方法
JP2022076645A Pending JP2022107628A (ja) 2013-11-05 2022-05-06 抗ｖｅｇｆ ｄａｒｐｉｎを用いた眼の容態の治療方法

Country Status (14)

Country Link
US (4) US20150126458A1 (https=)
EP (2) EP3628324A1 (https=)
JP (3) JP2016536369A (https=)
KR (1) KR20160070164A (https=)
CN (1) CN105960247A (https=)
AU (2) AU2014346921A1 (https=)
CA (1) CA2927012A1 (https=)
DK (1) DK3065761T3 (https=)
ES (1) ES2773317T3 (https=)
HU (1) HUE047910T2 (https=)
PL (1) PL3065761T3 (https=)
PT (1) PT3065761T (https=)
TW (1) TWI729970B (https=)
WO (1) WO2015069668A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007237096C1 (en) 2006-04-07 2012-12-13 EyePoint, Inc. Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof
AU2012323856B2 (en) 2011-10-13 2017-05-25 EyePoint, Inc. Methods for treating Vascular Leak Syndrome and cancer
HUE046134T2 (hu) 2012-05-07 2020-02-28 Allergan Inc Eljárás AMD kezelésére az anti-VEGF terápiára nem reagáló betegekben
US11103552B2 (en) 2018-05-10 2021-08-31 Regeneron Pharmaceuticals, Inc. High concentration VEGF receptor fusion protein containing formulations
CN120058958A (zh) 2018-09-24 2025-05-30 视点制药公司 靶向HPTP-β（VE-PTP）和VEGF的多特异性抗体
SG11202112925PA (en) * 2019-06-04 2021-12-30 Molecular Partners Ag Recombinant fap binding proteins and their use
CN118718181A (zh) 2019-06-05 2024-10-01 里珍纳龙药品有限公司 用于精确剂量递送的装置及方法
AU2021356298A1 (en) * 2020-10-07 2023-05-04 Line 6 Biotechnology, Inc Methods and agents for the treatment of ocular disease
CA3197759A1 (en) * 2020-10-08 2022-04-14 Notal Vision Ltd. Oct guided therapy
CN114075290B (zh) * 2022-01-20 2022-04-19 南京鼓楼医院 Cd40靶向结合蛋白、其编码核酸以及用途
USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012507271A (ja) * 2008-11-03 2012-03-29 モレキュラー・パートナーズ・アーゲー Ｖｅｇｆ−ａレセプター相互作用を阻害する結合タンパク質
JP2013531616A (ja) * 2010-04-30 2013-08-08 モレキュラー・パートナーズ・アーゲー Ｖｅｇｆ−ａレセプターの相互作用を阻害する改変結合タンパク質

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100523187C (zh) 1999-06-08 2009-08-05 里珍纳龙药品有限公司 具有改善的药物动力学特性的修饰嵌合多肽
DE60140474D1 (de) 2000-09-08 2009-12-24 Univ Zuerich Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten
US7696320B2 (en) 2004-08-24 2010-04-13 Domantis Limited Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
EP1996937A4 (en) 2006-03-06 2009-04-08 Amunix Inc GENETIC PACKS AND USES THEREOF
US20100144599A1 (en) 2007-02-02 2010-06-10 Bristol-Myers Squibb Company Vegf pathway blockade
ATE502114T1 (de) 2007-06-21 2011-04-15 Univ Muenchen Tech Biologisch aktive proteine mit erhöhter in-vivo- und/oder in-vitro-stabilität
HUE046134T2 (hu) * 2012-05-07 2020-02-28 Allergan Inc Eljárás AMD kezelésére az anti-VEGF terápiára nem reagáló betegekben

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012507271A (ja) * 2008-11-03 2012-03-29 モレキュラー・パートナーズ・アーゲー Ｖｅｇｆ−ａレセプター相互作用を阻害する結合タンパク質
JP2013531616A (ja) * 2010-04-30 2013-08-08 モレキュラー・パートナーズ・アーゲー Ｖｅｇｆ−ａレセプターの相互作用を阻害する改変結合タンパク質

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AM J OPHTALMOL, vol. 155, no. 4, JPN6018032493, April 2013 (2013-04-01), pages 697 - 704, ISSN: 0004216840 *
ARVO ANNUAL MEETING ABSTRACT SEARCH AND PROGRAM PLANNER, vol. 2011, JPN6018032496, 2011, pages 1655, ISSN: 0004216842 *
PUBMED ABSTRACT PMID:15523197, JPN6019014301, 2006, ISSN: 0004021616 *
プラクティス, vol. 29, no. 2, JPN6018032495, 2012, pages 132 - 133, ISSN: 0004216841 *

Also Published As

Publication number Publication date
US20210008158A1 (en) 2021-01-14
JP2022107628A (ja) 2022-07-22
AU2014346921A1 (en) 2016-06-02
KR20160070164A (ko) 2016-06-17
TW201609125A (zh) 2016-03-16
EP3065761A1 (en) 2016-09-14
EP3628324A1 (en) 2020-04-01
HUE047910T2 (hu) 2020-05-28
AU2020202968A1 (en) 2020-05-21
PT3065761T (pt) 2020-02-21
US20220175881A1 (en) 2022-06-09
US20150126458A1 (en) 2015-05-07
JP2020169191A (ja) 2020-10-15
EP3065761B1 (en) 2020-01-08
DK3065761T3 (da) 2020-02-17
WO2015069668A1 (en) 2015-05-14
CN105960247A (zh) 2016-09-21
TWI729970B (zh) 2021-06-11
US20170157207A1 (en) 2017-06-08
PL3065761T3 (pl) 2020-05-18
CA2927012A1 (en) 2015-05-14
ES2773317T3 (es) 2020-07-10

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