JP2016533368A5 - - Google Patents
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- Publication number
- JP2016533368A5 JP2016533368A5 JP2016523968A JP2016523968A JP2016533368A5 JP 2016533368 A5 JP2016533368 A5 JP 2016533368A5 JP 2016523968 A JP2016523968 A JP 2016523968A JP 2016523968 A JP2016523968 A JP 2016523968A JP 2016533368 A5 JP2016533368 A5 JP 2016533368A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- cycloalkyl
- salt
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 15
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 201000000980 schizophrenia Diseases 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 101000934342 Mus musculus T-cell surface glycoprotein CD5 Proteins 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 230000007278 cognition impairment Effects 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 230000000698 schizophrenic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13188904 | 2013-10-16 | ||
| EP13188904.0 | 2013-10-16 | ||
| PCT/EP2014/072085 WO2015055698A1 (en) | 2013-10-16 | 2014-10-15 | Piperazine derivatives and the use thereof as medicament |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016533368A JP2016533368A (ja) | 2016-10-27 |
| JP2016533368A5 true JP2016533368A5 (OSRAM) | 2017-11-24 |
| JP6483105B2 JP6483105B2 (ja) | 2019-03-13 |
Family
ID=49354583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016523968A Active JP6483105B2 (ja) | 2013-10-16 | 2014-10-15 | ピペラジン誘導体および医薬としてのその使用 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9233953B2 (OSRAM) |
| EP (1) | EP3057963B1 (OSRAM) |
| JP (1) | JP6483105B2 (OSRAM) |
| KR (1) | KR102281284B1 (OSRAM) |
| CN (1) | CN105636961B (OSRAM) |
| AR (1) | AR098037A1 (OSRAM) |
| AU (1) | AU2014336258B2 (OSRAM) |
| BR (1) | BR112016008062B1 (OSRAM) |
| CA (1) | CA2926754C (OSRAM) |
| CL (1) | CL2016000884A1 (OSRAM) |
| DK (1) | DK3057963T3 (OSRAM) |
| EA (1) | EA029313B1 (OSRAM) |
| ES (1) | ES2745555T3 (OSRAM) |
| HU (1) | HUE047044T2 (OSRAM) |
| IL (1) | IL244693B (OSRAM) |
| MX (1) | MX370006B (OSRAM) |
| PH (1) | PH12016500577B1 (OSRAM) |
| PL (1) | PL3057963T3 (OSRAM) |
| TW (1) | TW201609716A (OSRAM) |
| UY (1) | UY35785A (OSRAM) |
| WO (1) | WO2015055698A1 (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106854189A (zh) * | 2015-12-08 | 2017-06-16 | 湖南华腾制药有限公司 | 一种哌嗪化合物的合成方法 |
| CN107778257A (zh) * | 2016-08-29 | 2018-03-09 | 湖南华腾制药有限公司 | 一种哌嗪衍生物的合成方法 |
| CN106977463A (zh) * | 2017-05-31 | 2017-07-25 | 湖南华腾制药有限公司 | 一种联苯取代哌嗪衍生物的合成方法 |
| CN107417679A (zh) * | 2017-08-04 | 2017-12-01 | 河南农业大学 | 1,3‑唑类取代吡嗪类化合物的制备方法 |
| CA3166938A1 (en) | 2020-01-09 | 2021-07-15 | Disc Medicine, Inc. | Methods of treating erythropoietic protoporphyria, x-linked protoporphyria, or congenital erythropoietic porphyria with glycine transport inhibitors |
| CN117050051A (zh) * | 2023-08-14 | 2023-11-14 | 上海药坦药物研究开发有限公司 | 一种2-溴-1-（5-碘噻吩-2-基）-乙酮的纯化方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0224084D0 (en) * | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| GB0505085D0 (en) | 2005-03-11 | 2005-04-20 | Glaxo Group Ltd | Compounds |
| JP2008536950A (ja) * | 2005-04-18 | 2008-09-11 | ニューロジェン・コーポレーション | 置換ヘテロアリールのｃｂ１拮抗薬 |
| US9346809B2 (en) * | 2009-07-08 | 2016-05-24 | Leo Pharma A/S | Heterocyclic compounds as JAK receptor and protein tyrosine kinase inhibitors |
-
2014
- 2014-10-14 US US14/513,918 patent/US9233953B2/en active Active
- 2014-10-15 WO PCT/EP2014/072085 patent/WO2015055698A1/en not_active Ceased
- 2014-10-15 PL PL14784235T patent/PL3057963T3/pl unknown
- 2014-10-15 HU HUE14784235A patent/HUE047044T2/hu unknown
- 2014-10-15 AR ARP140103834A patent/AR098037A1/es unknown
- 2014-10-15 AU AU2014336258A patent/AU2014336258B2/en active Active
- 2014-10-15 BR BR112016008062-9A patent/BR112016008062B1/pt active IP Right Grant
- 2014-10-15 TW TW103135739A patent/TW201609716A/zh unknown
- 2014-10-15 CN CN201480056368.8A patent/CN105636961B/zh active Active
- 2014-10-15 ES ES14784235T patent/ES2745555T3/es active Active
- 2014-10-15 JP JP2016523968A patent/JP6483105B2/ja active Active
- 2014-10-15 KR KR1020167012860A patent/KR102281284B1/ko active Active
- 2014-10-15 CA CA2926754A patent/CA2926754C/en active Active
- 2014-10-15 MX MX2016004847A patent/MX370006B/es active IP Right Grant
- 2014-10-15 EP EP14784235.5A patent/EP3057963B1/en active Active
- 2014-10-15 DK DK14784235.5T patent/DK3057963T3/da active
- 2014-10-15 EA EA201600323A patent/EA029313B1/ru not_active IP Right Cessation
- 2014-10-16 UY UY0001035785A patent/UY35785A/es unknown
-
2016
- 2016-03-21 IL IL244693A patent/IL244693B/en active IP Right Grant
- 2016-03-30 PH PH12016500577A patent/PH12016500577B1/en unknown
- 2016-04-14 CL CL2016000884A patent/CL2016000884A1/es unknown
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