JP2016533317A - 多発性嚢胞腎の予防及び/又は治療薬 - Google Patents
多発性嚢胞腎の予防及び/又は治療薬 Download PDFInfo
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- JP2016533317A JP2016533317A JP2016507943A JP2016507943A JP2016533317A JP 2016533317 A JP2016533317 A JP 2016533317A JP 2016507943 A JP2016507943 A JP 2016507943A JP 2016507943 A JP2016507943 A JP 2016507943A JP 2016533317 A JP2016533317 A JP 2016533317A
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- tolvaptan
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- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 125000006328 iso-butylcarbonyl group Chemical group [H]C([H])([H])C([H])(C(*)=O)C([H])([H])[H] 0.000 description 1
- 125000005929 isobutyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])OC(*)=O 0.000 description 1
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 description 1
- 125000005928 isopropyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(OC(*)=O)C([H])([H])[H] 0.000 description 1
- 229950003188 isovaleryl diethylamide Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229940117841 methacrylic acid copolymer Drugs 0.000 description 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 125000004718 n-hexylthio group Chemical group C(CCCCC)S* 0.000 description 1
- 125000006252 n-propylcarbonyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 description 1
- 125000005185 naphthylcarbonyl group Chemical group C1(=CC=CC2=CC=CC=C12)C(=O)* 0.000 description 1
- 125000005933 neopentyloxycarbonyl group Chemical group 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 206010029446 nocturia Diseases 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 125000000405 phenylalanyl group Chemical group 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
- 229920001993 poloxamer 188 Polymers 0.000 description 1
- 229920001987 poloxamine Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 108700014314 sandostatinLAR Proteins 0.000 description 1
- 229940016590 sarkosyl Drugs 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 125000005930 sec-butyloxycarbonyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(OC(*)=O)C([H])([H])[H] 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
- 229960002167 sodium tartrate Drugs 0.000 description 1
- 235000011004 sodium tartrates Nutrition 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- 229940075620 somatostatin analogue Drugs 0.000 description 1
- 108010043680 somatostatin(7-10) Proteins 0.000 description 1
- 230000003294 somatostatinlike Effects 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 239000012929 tonicity agent Substances 0.000 description 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000002536 vasopressin receptor antagonist Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61K38/00—Medicinal preparations containing peptides
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract
Description
本発明の多発性嚢胞腎の予防及び/又は治療薬は、トルバプタン又はそのプロドラッグを含有する粒子を含む注射用持効性製剤である。これにより、トルバプタンの治療学的に有効な血中濃度を長期間維持することができる。
式(Ia)における、Rで示される保護基を有することのあるヒドロキシ基、保護基を有することのあるメルカプト基、又は保護基を1個若しくは2個有することのあるアミノ基における「保護基」としては特に限定はなく、典型例として、低級アルキル基(例えば、メチル、エチル等のC1−6アルキル基等)、フェニル低級アルキル基(例えば、ベンジル、フェネチル等のフェニルC1−6アルキル基等)、低級アルコキシカルボニル基(例えば、メトキシカルボニル、エトキシカルボニル、tert−ブトキシカルボニル基等のC1−6アルコキシカルボニル基等)等が挙げられる。
(1-1) 基−CO−(CH2)n−COR2
(ここで、nは1〜4の整数を示す。R2は、(2-1)水酸基;(2-2)置換基として水酸基、低級アルカノイル基、低級アルカノイルオキシ基、低級アルコキシカルボニルオキシ基、シクロアルキルオキシカルボニルオキシ基もしくは5−メチル−2−オキソ−1,3−ジオキソール−4−イル基を有することのある低級アルコキシ基;または(2-3)置換基としてヒドロキシ低級アルキル基を有することのあるアミノ基を示す。)
(1-2) 基−CO−(CH2)m−NR3R4
(ここで、mは0〜4の整数を示す。R3は、水素原子または低級アルキル基を示す。R4は、(4-1)水素原子;(4-2)置換基としてハロゲン原子、低級アルキルアミノ基、低級アルコキシカルボニル基もしくは5−メチル−2−オキソ−1,3−ジオキソール−4−イル基を有することのある低級アルキル基;または(4-3)置換基としてハロゲン原子、低級アルカノイルオキシ基もしくは5−メチル−2−オキソ−1,3−ジオキソール−4−イル基を有することのある低級アルコキシカルボニル基を示す。また、R3及びR4は、これらが結合する窒素原子と共に他の窒素原子もしくは酸素原子を介しまたは介することなく互いに結合して5〜6員の飽和複素環を形成してもよい。該複素環上には、(4-4)低級アルキル基(低級アルキル基上に置換基としてヒドロキシ低級アルコキシ基を有していてもよい);(4-5)低級アルコキシカルボニル基;(4-6)アルキルカルボニル基(アルキル基上に置換基としてカルボキシル基もしくは低級アルコキシカルボニル基を有していてもよい);(4-7)アリールカルボニル基;または(4-8)フリルカルボニル基が置換していてもよい。)
(1-3) 基−CO−(CH2)p−O−CO−NR5R6
(ここで、pは1〜4の整数を示す。R5は低級アルキル基を示す。R6は低級アルコキシカルボニル低級アルキル基を示す。)
(1-4) 基−CO−(CH2)q−X−R7
(ここで、qは1〜4の整数を示す。Xは、酸素原子、硫黄原子またはスルホニル基を示す。R7は、カルボキシ低級アルキル基または低級アルコキシカルボニル低級アルキル基を示す。)
(1-5) 基−CO−R8
(ここで、R8は、(8-1)アルキル基上にハロゲン原子、低級アルカノイルオキシ基もしくはフェニル基(該フェニル基は、ヒドロキシ基がベンジル基で置換されていてもよいジヒドロキシホスホリルオキシ基および低級アルキル基で置換されている)が置換していてもよいアルキル基、(8-2)ハロゲン原子、低級アルカノイルオキシ基もしくはジヒドロキシホスホリルオキシ基を置換基として有する低級アルコキシ基、
(8-3)ピリジル基、または(8-4)低級アルコキシフェニル基を示す。)
(1-6) 低級アルキルチオ基、ジヒドロキシホスホリルオキシ基および低級アルカノイルオキシ基からなる群より選ばれた基が置換した低級アルキル基、または
(1-7) 1個以上の保護基を有することのあるアミノ酸残基もしくはペプチド残基]
式(Ib)において、「低級」とは、特に指示がなければ炭素原子1〜6個を意味するものとする。
ソマトスタチンアナログとは、ソマトスタチン、及びソマトスタチンの生理活性に必須のアミノ酸配列(Phe-Trp-Lys-Thr)を含むソマトスタチン様の作用を有する化合物又はその塩を意味する。当該化合物として具体的には、ソマトスタチン、オクトレオチド、パシレオチド、ランレオチド、バプレオチド等が挙げられる。これらのうち1種又は2種以上を用いることができる。好ましくは、オクトレオチド、ランレオチドである。
薬学的に許容される注射用担体は、有効成分であるトルバプタン又はそのプロドラッグを含む粒子、及びソマトスタチンアナログを、水性懸濁液又はゲルの形態に調製するために用いられる。当該注射用担体には、通常、(a)懸濁化剤及び/又は湿潤剤、(b)必要に応じて等張化剤及び/又はバルキング剤、(c)必要に応じて緩衝剤、(d)必要に応じてpH調整剤、(e)必要に応じて粘度増強剤、並びに(f)必要に応じて保存剤が含まれる。
注射用水は、無菌で発熱性物質を含まないものであり、注射液製造又は注射用医薬品の溶解に用いることができるものである。なお、注射用水は、単独で、又はグルコース溶液若しくは塩化ナトリウム溶液等の一般的な注射用溶液(溶解液又は希釈液)の形態で用いることができる。
本発明の多発性嚢胞腎の予防及び/又は治療薬は、トルバプタン又はそのプロドラッグを含有する粒子、及びソマトスタチンアナログを含む注射用持効性製剤である。
本発明の注射用持効性製剤は、配合剤(合剤)及び併用剤のいずれにおいても注射剤の形態であり、水性懸濁液又はゲルの形態で、多発性嚢胞腎の予防及び/又は治療が必要とされる患者の筋肉内又は皮下に投与される。好ましくは、水性懸濁液の形態である。
トルバプタン(ラセミ体)スプレードライ粉末は、WO2008/156217に記載の方法に準じて製造した。
S-トルバプタンの結晶粒子を含む注射用持続性製剤(S-トルバプタン徐放性製剤)を、以下のようにして製造した。
R-トルバプタン結晶 30.0 gを、表1の媒体溶液 76.0gに懸濁した (製剤100mL相当)。懸濁液中にφ1.5 mmジルコニアビーズ 150 gを加え、容器内を攪拌することでビーズミル(湿式粉砕)を行い、R-トルバプタン徐放性製剤を調製した。粒度分布計(SALD-3000J、(株)島津製作所製)で超音波照射時に測定したR-トルバプタンの結晶粒子の平均粒子径は1.9μmであった。その偏光顕微鏡写真を図3に示す。
サンドスタチンLAR筋注用20 mg(ノバルティスファーマ製;表3を参照)にオクトレオチドとして20 mg/mLとなるように表1の媒体溶液1.0 mLで懸濁し、この懸濁液を0.5 mL採取して、製造例2と同様の方法で調製したS-トルバプタンの結晶粒子の製剤0.5 mLと良く混合し、S-トルバプタンの結晶粒子とサンドスタチンLARの合剤を調製した。その偏光顕微鏡写真を図4に示す。
サンドスタチンLAR筋注用20 mgにオクトレオチドとして20 mg/mLとなるように表1の媒体溶液 1.0 mLで懸濁し、この懸濁液を0.5 mL採取して、製造例3と同様の方法で調製したR-トルバプタンの結晶粒子の製剤0.5 mLと良く混合し、R-トルバプタンの結晶粒子とサンドスタチンLARの合剤を調製した。その偏光顕微鏡写真を図5に示す。
オクトレオチド酢酸塩徐放性製剤(粉末状のマイクロスフェア製剤、サンドスタチンLAR)に、専用の希釈液(2mL中に注射用水及び添加物としてカルメロースナトリウム10mg、D-マンニトール12mgを含有する)を添加し懸濁液を調製し、オクトレオチドとして5mg/mLの濃度に調製した。
ランレオチド酢酸塩徐放性製剤は、ソマチュリン皮下注60mg(帝人ファーマ(株))を使用した。当該製剤はゲル製剤であり、ゲル製剤244 mg中にランレオチド酢酸塩71.5 mg(ランレオチドとして60 mg)を含有する。
多発性嚢胞腎における、バソプレシンV2受容体(V2R)拮抗薬であるトルバプタン及びソマトスタチンアナログであるオクトレオチドのそれぞれの単独効果ならびに併用効果について、PKDモデル動物であるpcyマウスを用いて評価した。
(1) コントロール群、
(2) トルバプタン0.1%混餌(製造例1)投与群、
(3) S-トルバプタン徐放性製剤(製造例2)単独投与群 (300 mg/kg sc)、
(4) オクトレオチド酢酸塩徐放性製剤(サンドスタチンLAR)(製造例6)単独投与群(1mg/body sc)、及び
(5) S-トルバプタン徐放性製剤(製造例2)(300 mg/kg sc)及びオクトレオチド酢酸塩徐放性製剤(製造例6)(1 mg/body sc)の併用投与群、
に群分けを行なった(各群N=9)。試験期間中はすべての群にMF飼料を与えた。なお、サンドスタチンLARの顕微鏡写真を図2に示す。
多発性嚢胞腎における、バソプレシン受容体拮抗薬であるトルバプタン及びソマトスタチンアナログであるランレオチドの腎機能に対する単独効果ならびに併用効果について、PKDモデル動物であるPCKラットを用いて評価した。
(1) コントロール群、
(2) R-トルバプタン徐放性製剤(製造例3)単独投与群(100 mg/kg im)、
(3) ランレオチド酢酸塩徐放性製剤(ソマチュリン皮下注、帝人ファーマ(株)製)(製造例7)単独投与群(2.5 mg/body sc)、
(4) R-トルバプタン徐放性製剤(製造例3)及びランレオチド酢酸塩徐放性製剤(製造例7)の併用投与群、
に群分けを行なった(各群N=11〜12)。正常ラットコントロールとしてCrl:CD(SD)を用いた(N=5)。試験期間中は全ての群にMF飼料を与えた。
Claims (21)
- トルバプタン又はそのプロドラッグを含有する粒子及びソマトスタチンアナログを含む注射用持効性製剤であることを特徴とする多発性嚢胞腎の予防及び/又は治療薬。
- 前記トルバプタン又はそのプロドラッグが結晶である、請求項1に記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記トルバプタン又はそのプロドラッグが光学活性体である、請求項1又は2に記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記光学活性のトルバプタン又はそのプロドラッグが、本質的にR体からなるトルバプタン又はそのプロドラッグ、或いは本質的にS体からなるトルバプタン又はそのプロドラッグである、請求項3に記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記トルバプタン又はそのプロドラッグを含有する粒子中のトルバプタン又はそのプロドラッグの含有量が50〜100重量%である、請求項1〜4のいずれかに記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記トルバプタン又はそのプロドラッグを含有する粒子の平均粒子径が約1〜100μmである、請求項1〜5のいずれかに記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記ソマトスタチンアナログが、ソマトスタチン、オクトレオチド、パシレオチド、ランレオチド、バプレオチド、及びそれらの塩からなる群より選ばれる少なくとも1種である、請求項1〜6のいずれかに記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記ソマトスタチンアナログが、マイクロスフェア製剤、又はゲル製剤である、請求項1〜7のいずれかに記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記注射用持効性製剤が、トルバプタン又はそのプロドラッグを含有する粒子及びソマトスタチンアナログを混合してなる注射用持効性製剤である(配合剤)、請求項1〜8のいずれかに記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記注射用持効性製剤が、薬学的に許容される注射用担体を含む、請求項9に記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記注射用持効性製剤が、注射用水を含む、請求項9又は10に記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記注射用持効性製剤が、水性懸濁液の形態であり、当該水性懸濁液中のトルバプタン又はそのプロドラッグの配合量が50mg/mL〜500mg/mLである請求項11に記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記注射用持効性製剤が、皮下投与剤又は筋肉内投与剤である、請求項9〜12のいずれかに記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記注射用持効性製剤が、トルバプタン又はそのプロドラッグを含有する粒子を含む注射用持効性製剤A、及びソマトスタチンアナログを含む注射用持効性製剤Bの組合せからなり、該製剤Aと製剤Bが互いに併用して投与される(併用剤)、請求項1〜8のいずれかに記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記注射用持効性製剤Aが、薬学的に許容される注射用担体を含む、請求項14に記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記注射用持効性製剤Bが、薬学的に許容される注射用担体を含む、請求項14又は15に記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記注射用持効性製剤A及びBが、注射用水を含む、請求項14〜16のいずれかに記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記注射用持効性製剤Aが水性懸濁液の形態であり、当該水性懸濁液中のトルバプタン又はそのプロドラッグの配合量が50mg/mL〜500mg/mLである、請求項14〜17のいずれかに記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記注射用持効性製剤Bが、水性懸濁液又はゲルの形態である、請求項14〜18のいずれかに記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記注射用持効性製剤A及びBが、それぞれ皮下投与剤又は筋肉内投与剤である、請求項14〜19のいずれかに記載の多発性嚢胞腎の予防及び/又は治療薬。
- 前記トルバプタン又はそのプロドラッグがトルバプタンである、請求項1〜20のいずれかに記載の多発性嚢胞腎の予防及び/又は治療薬。
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