JP2016528165A5 - - Google Patents
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- Publication number
- JP2016528165A5 JP2016528165A5 JP2016509176A JP2016509176A JP2016528165A5 JP 2016528165 A5 JP2016528165 A5 JP 2016528165A5 JP 2016509176 A JP2016509176 A JP 2016509176A JP 2016509176 A JP2016509176 A JP 2016509176A JP 2016528165 A5 JP2016528165 A5 JP 2016528165A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- alkyl
- aliphatic hydrocarbon
- composition according
- cyclo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000001931 aliphatic group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
- 125000004423 acyloxy group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 239000011593 sulfur Substances 0.000 claims 3
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 2
- WIUGSPUQKXSPDJ-JDFMTEHDSA-N (e)-7-[(1r,2r)-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopentyl]hept-2-enoic acid Chemical compound CCCCC(F)(F)C(=O)CC[C@H]1CCC(=O)[C@@H]1CCCC\C=C\C(O)=O WIUGSPUQKXSPDJ-JDFMTEHDSA-N 0.000 claims 1
- CTQWVWWSERVGET-HZPDHXFCSA-N 7-[(1r,2r)-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopentyl]heptanoic acid Chemical group CCCCC(F)(F)C(=O)CC[C@H]1CCC(=O)[C@@H]1CCCCCCC(O)=O CTQWVWWSERVGET-HZPDHXFCSA-N 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361868750P | 2013-08-22 | 2013-08-22 | |
| US61/868,750 | 2013-08-22 | ||
| US201361918124P | 2013-12-19 | 2013-12-19 | |
| US61/918,124 | 2013-12-19 | ||
| PCT/JP2014/072508 WO2015025980A1 (en) | 2013-08-22 | 2014-08-21 | Method for treating neuropathic pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016528165A JP2016528165A (ja) | 2016-09-15 |
| JP2016528165A5 true JP2016528165A5 (cg-RX-API-DMAC7.html) | 2017-09-28 |
| JP6641263B2 JP6641263B2 (ja) | 2020-02-05 |
Family
ID=52480928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016509176A Expired - Fee Related JP6641263B2 (ja) | 2013-08-22 | 2014-08-21 | 神経障害性疼痛の処置方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20150057351A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3035925A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6641263B2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015025980A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108366984A (zh) | 2015-09-22 | 2018-08-03 | 灰色视觉公司 | 用于治疗眼部病症的化合物和组合物 |
| BR112019011961A2 (pt) * | 2017-01-06 | 2019-11-05 | Clexio Bioscienses Ltd | formulação tópica, método para prover tratamento não-sistêmico prolongado para dor em um indivíduo humano necessitando do mesmo, método para formar um depósito subcutâneo de detomidina ou um sal do mesmo em um indivíduo humano, formulação tópica e método para prover o tratamento para dor em um indivíduo humano necessitando do mesmo |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1322749C (en) | 1987-01-28 | 1993-10-05 | Ryuzo Ueno | Prostaglandins of the d series, and tranquilizers and soporifics containing the same |
| US5166174A (en) | 1987-01-28 | 1992-11-24 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti-ulcers containing same |
| US5221763A (en) | 1987-04-30 | 1993-06-22 | R-Tech Ueno, Ltd. | Prostaglandins of the F series |
| TW249226B (cg-RX-API-DMAC7.html) | 1990-04-04 | 1995-06-11 | Aderk Ueno Kk | |
| CA2150287C (en) | 1994-06-03 | 2004-08-10 | Ryuji Ueno | Agent for treating hepato-biliary diseases |
| WO1997047595A1 (en) | 1996-06-10 | 1997-12-18 | R-Tech Ueno, Ltd. | Endothelin antagonist |
| NZ523851A (en) * | 2000-07-21 | 2004-09-24 | Ortho Mcneil Pharm Inc | A method for use of carbamate enantiomers in preventing or treating neuropathic pain and cluster and migraine headache-associated pain |
| JPWO2002066030A1 (ja) * | 2001-02-22 | 2004-06-17 | 小野薬品工業株式会社 | ジクロフェナクとオルノプロスチルからなる医薬組成物 |
| BR0212233A (pt) * | 2001-08-31 | 2004-10-05 | Sucampo Ag | Abridor de canal de cloreto |
| KR100837019B1 (ko) * | 2004-05-11 | 2008-06-10 | 인사이트 코포레이션 | 케모카인 수용체 조절제로서3-(4-헤테로아릴사이클로헥실아미노)사이클로펜탄카복스아마이드 |
| DE602006018583D1 (de) * | 2005-03-04 | 2011-01-13 | Sucampo Ag | Verfahren und zusammensetzung zur behandlung von peripheren gefässkrankheiten |
| US20090030072A1 (en) * | 2007-07-03 | 2009-01-29 | Sucampo Ag | Pharmaceutical combination of opioid and prostaglandin compound |
| JP2010106019A (ja) * | 2008-10-02 | 2010-05-13 | Kanazawa Univ | リマプロストを含有してなる癌化学療法に起因する末梢神経障害予防、治療および／または症状軽減剤 |
| US20110034424A1 (en) * | 2009-06-30 | 2011-02-10 | Sucampo Ag | Method for the long term nsaid use |
| MX359697B (es) * | 2011-08-05 | 2018-10-08 | Sucampo Ag | Metodo para tratar esquizofrenia. |
-
2014
- 2014-08-20 US US14/464,232 patent/US20150057351A1/en not_active Abandoned
- 2014-08-21 WO PCT/JP2014/072508 patent/WO2015025980A1/en not_active Ceased
- 2014-08-21 JP JP2016509176A patent/JP6641263B2/ja not_active Expired - Fee Related
- 2014-08-21 EP EP14838126.2A patent/EP3035925A4/en not_active Withdrawn
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