JP2016526875A5 - - Google Patents
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- JP2016526875A5 JP2016526875A5 JP2016514143A JP2016514143A JP2016526875A5 JP 2016526875 A5 JP2016526875 A5 JP 2016526875A5 JP 2016514143 A JP2016514143 A JP 2016514143A JP 2016514143 A JP2016514143 A JP 2016514143A JP 2016526875 A5 JP2016526875 A5 JP 2016526875A5
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- 238000000034 method Methods 0.000 claims description 52
- 101000830596 Homo sapiens Tumor necrosis factor ligand superfamily member 15 Proteins 0.000 claims description 11
- 101000597785 Homo sapiens Tumor necrosis factor receptor superfamily member 6B Proteins 0.000 claims description 11
- 102100024587 Tumor necrosis factor ligand superfamily member 15 Human genes 0.000 claims description 11
- 208000011231 Crohn disease Diseases 0.000 claims description 10
- 206010016654 Fibrosis Diseases 0.000 claims description 10
- 230000004761 fibrosis Effects 0.000 claims description 10
- 102100035284 Tumor necrosis factor receptor superfamily member 6B Human genes 0.000 claims description 7
- 238000003556 assay Methods 0.000 claims description 7
- 238000003205 genotyping method Methods 0.000 claims description 5
- 230000001681 protective effect Effects 0.000 claims description 4
- 238000011477 surgical intervention Methods 0.000 claims description 2
- 230000035945 sensitivity Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361824932P | 2013-05-17 | 2013-05-17 | |
| US61/824,932 | 2013-05-17 | ||
| PCT/US2014/038468 WO2014186750A2 (en) | 2013-05-17 | 2014-05-16 | Variants of tnfsf15 and dcr3 associated with crohn's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018124311A Division JP2018148931A (ja) | 2013-05-17 | 2018-06-29 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016526875A JP2016526875A (ja) | 2016-09-08 |
| JP2016526875A5 true JP2016526875A5 (https=) | 2017-06-15 |
| JP6482533B2 JP6482533B2 (ja) | 2019-03-13 |
Family
ID=51899024
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016514143A Active JP6482533B2 (ja) | 2013-05-17 | 2014-05-16 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
| JP2018124311A Withdrawn JP2018148931A (ja) | 2013-05-17 | 2018-06-29 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
| JP2020096798A Withdrawn JP2020127437A (ja) | 2013-05-17 | 2020-06-03 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
| JP2022093628A Withdrawn JP2022111329A (ja) | 2013-05-17 | 2022-06-09 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
| JP2024213907A Pending JP2025023316A (ja) | 2013-05-17 | 2024-12-06 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018124311A Withdrawn JP2018148931A (ja) | 2013-05-17 | 2018-06-29 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
| JP2020096798A Withdrawn JP2020127437A (ja) | 2013-05-17 | 2020-06-03 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
| JP2022093628A Withdrawn JP2022111329A (ja) | 2013-05-17 | 2022-06-09 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
| JP2024213907A Pending JP2025023316A (ja) | 2013-05-17 | 2024-12-06 | クローン病に関連するｔｎｆｓｆ１５及びｄｃｒ３の変異体 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20160090629A1 (https=) |
| EP (3) | EP3988673A3 (https=) |
| JP (5) | JP6482533B2 (https=) |
| KR (4) | KR102295125B1 (https=) |
| CN (1) | CN105358713B (https=) |
| ES (1) | ES2894963T3 (https=) |
| WO (1) | WO2014186750A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| KR101982899B1 (ko) | 2011-09-30 | 2019-05-27 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | ＴＬ1ａ에 대한 항체 및 그의 용도 |
| KR20230109779A (ko) | 2013-03-27 | 2023-07-20 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전 |
| ES2894963T3 (es) | 2013-05-17 | 2022-02-16 | Cedars Sinai Medical Center | Variantes de TNFSF15 y DcR3 asociadas con la enfermedad de Crohn |
| EP3022295A4 (en) | 2013-07-19 | 2017-03-01 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
| EP3730188B1 (en) | 2015-08-21 | 2024-07-31 | The Children's Hospital of Philadelphia | Compositions and methods for use in combination for the treatment and diagnosis of autoimmune diseases |
| TWI703158B (zh) | 2015-09-18 | 2020-09-01 | 美商希佛隆公司 | 特異性結合tl1a之抗體 |
| KR20240095481A (ko) | 2016-03-17 | 2024-06-25 | 세다르스-신나이 메디칼 센터 | Rnaset2를 통한 염증성 장 질환의 진단 방법 |
| EP3458466B1 (en) * | 2016-05-20 | 2024-08-07 | Cedars-Sinai Medical Center | Diagnosis of inflammatory bowel disease based on genes |
| KR20210057088A (ko) * | 2018-09-07 | 2021-05-20 | 더 칠드런스 호스피탈 오브 필라델피아 | 림프계 장애의 진단 및 치료를 위한 조성물 및 방법 |
| AU2020275413A1 (en) | 2019-05-14 | 2021-12-23 | Cedars-Sinai Medical Center | TL1A patient selection methods, systems, and devices |
| CN121930331A (zh) * | 2019-09-13 | 2026-04-28 | 协和麒麟株式会社 | DcR3变体 |
| AU2021377688A1 (en) * | 2020-11-13 | 2023-06-29 | Cedars-Sinai Medical Center | Methods, systems, and kits for treatment of inflammatory diseases targeting tl1a |
| CN121843714A (zh) | 2023-08-11 | 2026-04-10 | 派拉冈医疗公司 | Tl1a结合抗体及使用方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US20090186034A1 (en) * | 2006-12-19 | 2009-07-23 | Genetech, Inc. | Gene expression markers for inflammatory bowel disease |
| US20100190162A1 (en) | 2007-02-26 | 2010-07-29 | Cedars-Sinai Medical Center | Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease |
| US20100240043A1 (en) | 2007-10-19 | 2010-09-23 | Cedars-Sinai Medical Center | Methods of using genetic variants to diagnose and predict inflammatory bowel disease |
| AU2009215441B2 (en) | 2008-02-19 | 2015-07-02 | The Children's Hospital Of Philadelphia | Identification of pediatric onset inflammatory bowel disease loci and methods of use thereof for the diagnosis and treatment of the same |
| US20120073585A1 (en) | 2009-04-08 | 2012-03-29 | Cedars-Sinai Medical Center | Methods of predicting complication and surgery in crohn's disease |
| WO2010120814A1 (en) * | 2009-04-14 | 2010-10-21 | Prometheus Laboratories Inc. | Inflammatory bowel disease prognostics |
| NZ609363A (en) | 2010-10-18 | 2015-04-24 | Nestec Sa | Methods for determining anti-drug antibody isotypes |
| CA2827609A1 (en) | 2011-02-17 | 2012-11-15 | Nestec S.A. | Assays for detecting autoantibodies to anti-tnf.alpha. drugs |
| WO2012161856A1 (en) | 2011-05-20 | 2012-11-29 | Government Of The United States, As Represented By The Secretary, Department Of Health And Human Services | Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology and antibodies thereof |
| US20140170157A1 (en) | 2011-06-15 | 2014-06-19 | Glaxosmithkline Intellectual Property (No.2) Limited | Method of selecting therapeutic indications |
| EP2565277A1 (en) | 2011-09-05 | 2013-03-06 | Progenika Biopharma, S.A. | Method for predicting radiographic severity in ankylosing spondylitis |
| JP2015502740A (ja) | 2011-10-21 | 2015-01-29 | ネステク ソシエテ アノニム | 炎症性腸疾患の診断を改善するための方法 |
| ES2894963T3 (es) | 2013-05-17 | 2022-02-16 | Cedars Sinai Medical Center | Variantes de TNFSF15 y DcR3 asociadas con la enfermedad de Crohn |
| CR20180365A (es) | 2015-12-16 | 2018-09-28 | Amgen Inc | PROTEÍNAS DE UNIÓN AL ANTÍGENO BISPECÍFICO DE ANTI-TL1A/ANTI-TNF-a Y SUS USOS |
| KR20240095481A (ko) | 2016-03-17 | 2024-06-25 | 세다르스-신나이 메디칼 센터 | Rnaset2를 통한 염증성 장 질환의 진단 방법 |
-
2014
- 2014-05-16 ES ES18201967T patent/ES2894963T3/es active Active
- 2014-05-16 JP JP2016514143A patent/JP6482533B2/ja active Active
- 2014-05-16 KR KR1020157034355A patent/KR102295125B1/ko active Active
- 2014-05-16 WO PCT/US2014/038468 patent/WO2014186750A2/en not_active Ceased
- 2014-05-16 EP EP21193676.0A patent/EP3988673A3/en active Pending
- 2014-05-16 US US14/890,712 patent/US20160090629A1/en not_active Abandoned
- 2014-05-16 EP EP14797214.5A patent/EP2997165A4/en not_active Withdrawn
- 2014-05-16 EP EP18201967.9A patent/EP3498867B1/en active Active
- 2014-05-16 KR KR1020237020524A patent/KR20230093538A/ko not_active Ceased
- 2014-05-16 CN CN201480038133.6A patent/CN105358713B/zh active Active
- 2014-05-16 KR KR1020257028341A patent/KR20250130857A/ko active Pending
- 2014-05-16 KR KR1020217026836A patent/KR20210107176A/ko not_active Ceased
-
2018
- 2018-04-05 US US15/946,632 patent/US20180230543A1/en not_active Abandoned
- 2018-06-29 JP JP2018124311A patent/JP2018148931A/ja not_active Withdrawn
-
2020
- 2020-06-03 JP JP2020096798A patent/JP2020127437A/ja not_active Withdrawn
-
2021
- 2021-08-02 US US17/392,098 patent/US12281359B2/en active Active
-
2022
- 2022-06-09 JP JP2022093628A patent/JP2022111329A/ja not_active Withdrawn
-
2024
- 2024-12-06 JP JP2024213907A patent/JP2025023316A/ja active Pending
-
2025
- 2025-03-19 US US19/084,586 patent/US20250243548A1/en active Pending
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