JP2016523561A5 - - Google Patents
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- Publication number
- JP2016523561A5 JP2016523561A5 JP2016525449A JP2016525449A JP2016523561A5 JP 2016523561 A5 JP2016523561 A5 JP 2016523561A5 JP 2016525449 A JP2016525449 A JP 2016525449A JP 2016525449 A JP2016525449 A JP 2016525449A JP 2016523561 A5 JP2016523561 A5 JP 2016523561A5
- Authority
- JP
- Japan
- Prior art keywords
- vertebrate
- mrap2
- cell according
- modification
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 19
- 238000012986 modification Methods 0.000 claims 18
- 230000004048 modification Effects 0.000 claims 18
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 16
- 238000000034 method Methods 0.000 claims 12
- 230000037430 deletion Effects 0.000 claims 8
- 238000012217 deletion Methods 0.000 claims 8
- 241001465754 Metazoa Species 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 5
- 241000282898 Sus scrofa Species 0.000 claims 4
- 101100024157 Mus musculus Mrap2 gene Proteins 0.000 claims 3
- 101710163270 Nuclease Proteins 0.000 claims 3
- 108010091086 Recombinases Proteins 0.000 claims 3
- 102000018120 Recombinases Human genes 0.000 claims 3
- 241000894007 species Species 0.000 claims 3
- 241000283690 Bos taurus Species 0.000 claims 2
- 241000283707 Capra Species 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 2
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 2
- 241001494479 Pecora Species 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 210000004102 animal cell Anatomy 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 108091033409 CRISPR Proteins 0.000 claims 1
- 238000010354 CRISPR gene editing Methods 0.000 claims 1
- 108010051219 Cre recombinase Proteins 0.000 claims 1
- 238000010459 TALEN Methods 0.000 claims 1
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 claims 1
- 210000005013 brain tissue Anatomy 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000003307 slaughter Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361844666P | 2013-07-10 | 2013-07-10 | |
| US61/844,666 | 2013-07-10 | ||
| PCT/US2014/045934 WO2015006437A1 (en) | 2013-07-10 | 2014-07-09 | Mrap2 knockouts |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016523561A JP2016523561A (ja) | 2016-08-12 |
| JP2016523561A5 true JP2016523561A5 (https=) | 2017-08-10 |
| JP6443811B2 JP6443811B2 (ja) | 2018-12-26 |
Family
ID=52280563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016525449A Active JP6443811B2 (ja) | 2013-07-10 | 2014-07-09 | Ｍｒａｐ２ノックアウト |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20160143256A1 (https=) |
| EP (1) | EP3019005B1 (https=) |
| JP (1) | JP6443811B2 (https=) |
| KR (1) | KR102297747B1 (https=) |
| CN (1) | CN105555132B (https=) |
| AU (1) | AU2014287250A1 (https=) |
| CA (1) | CA2917961A1 (https=) |
| WO (1) | WO2015006437A1 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| US10900034B2 (en) | 2014-12-03 | 2021-01-26 | Agilent Technologies, Inc. | Guide RNA with chemical modifications |
| EP3280803B1 (en) | 2015-04-06 | 2021-05-26 | The Board of Trustees of the Leland Stanford Junior University | Chemically modified guide rnas for crispr/cas-mediated gene regulation |
| JP7109784B2 (ja) | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝子編集のための進化したＣａｓ９蛋白質 |
| CN108601822B (zh) * | 2016-03-28 | 2022-07-22 | 东丽株式会社 | 免疫诱导剂 |
| BR112018069318A2 (pt) * | 2016-03-28 | 2019-01-22 | Toray Industries | composição farmacêutica para tratamento e/ou prevenção de um câncer, anticorpo ou fragmento do mesmo, combinação farmacêutica para tratamento e/ou prevenção de um câncer e método para tratar e/ou prevenir um câncer |
| KR101863653B1 (ko) * | 2016-06-02 | 2018-06-05 | 전남대학교 산학협력단 | 락토페린 발현용 넉-인 벡터 및 이를 이용한 넉인 방법 |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| KR102547316B1 (ko) | 2016-08-03 | 2023-06-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| EP3526320A1 (en) | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| JP2020510038A (ja) | 2017-03-09 | 2020-04-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | がんワクチン |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3797160A1 (en) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| JP7657726B2 (ja) | 2019-03-19 | 2025-04-07 | ザ ブロード インスティテュート，インコーポレーテッド | 編集ヌクレオチド配列を編集するための方法および組成物 |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
| CN115232812B (zh) * | 2021-07-12 | 2025-10-24 | 南京启真基因工程有限公司 | 一种构建mrap2基因突变的重症早发性肥胖症模型猪核移植供体细胞的方法 |
| JP2024534945A (ja) | 2021-09-10 | 2024-09-26 | アジレント・テクノロジーズ・インク | 化学修飾を有するプライム編集のためのガイドｒｎａ |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
| US6060642A (en) * | 1997-08-15 | 2000-05-09 | The Regents Of The University Of California | Serotonin 5-HT6 receptor knockout mouse |
| WO2001091548A2 (en) * | 2000-06-01 | 2001-12-06 | Pharmacia & Upjohn Company | Mice heterozygous for wfs1 gene as mouse models for depression |
| WO2005108415A2 (en) * | 2004-04-30 | 2005-11-17 | Biogen Idec Ma Inc. | Membrane associated molecules |
| CA2891996A1 (en) | 2005-10-18 | 2007-04-26 | Duke University | Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity |
| US20100120627A1 (en) * | 2006-08-02 | 2010-05-13 | Abdelmajid Belouchi | Genemap of the human genes associated with psoriasis |
| AU2012312260B2 (en) * | 2011-09-21 | 2017-08-31 | Sangamo Therapeutics, Inc. | Methods and compositions for regulation of transgene expression |
-
2014
- 2014-07-09 EP EP14822448.8A patent/EP3019005B1/en active Active
- 2014-07-09 CA CA2917961A patent/CA2917961A1/en not_active Abandoned
- 2014-07-09 US US14/903,621 patent/US20160143256A1/en not_active Abandoned
- 2014-07-09 WO PCT/US2014/045934 patent/WO2015006437A1/en not_active Ceased
- 2014-07-09 JP JP2016525449A patent/JP6443811B2/ja active Active
- 2014-07-09 AU AU2014287250A patent/AU2014287250A1/en not_active Abandoned
- 2014-07-09 KR KR1020167003290A patent/KR102297747B1/ko active Active
- 2014-07-09 CN CN201480049908.XA patent/CN105555132B/zh active Active
-
2018
- 2018-12-06 US US16/211,672 patent/US20190313614A1/en not_active Abandoned
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