JP2016522257A5 - - Google Patents
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- Publication number
- JP2016522257A5 JP2016522257A5 JP2016521511A JP2016521511A JP2016522257A5 JP 2016522257 A5 JP2016522257 A5 JP 2016522257A5 JP 2016521511 A JP2016521511 A JP 2016521511A JP 2016521511 A JP2016521511 A JP 2016521511A JP 2016522257 A5 JP2016522257 A5 JP 2016522257A5
- Authority
- JP
- Japan
- Prior art keywords
- solution
- bromfenac
- weight
- buffer
- free acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000243 solution Substances 0.000 claims 16
- ZBPLOVFIXSTCRZ-UHFFFAOYSA-N bromfenac Chemical compound NC1=C(CC(O)=O)C=CC=C1C(=O)C1=CC=C(Br)C=C1 ZBPLOVFIXSTCRZ-UHFFFAOYSA-N 0.000 claims 9
- 229960003655 bromfenac Drugs 0.000 claims 9
- 239000002253 acid Substances 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000000872 buffer Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- 239000002738 chelating agent Substances 0.000 claims 3
- 239000007951 isotonicity adjuster Substances 0.000 claims 3
- 239000003002 pH adjusting agent Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000004721 Polyphenylene oxide Substances 0.000 claims 2
- 125000002877 alkyl aryl group Chemical group 0.000 claims 2
- 229960000686 benzalkonium chloride Drugs 0.000 claims 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- -1 fatty acid ester Chemical class 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 239000003186 pharmaceutical solution Substances 0.000 claims 2
- 229920000570 polyether Polymers 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 125000002672 4-bromobenzoyl group Chemical group BrC1=CC=C(C(=O)*)C=C1 0.000 claims 1
- JDSPXIPYMUGSIJ-UHFFFAOYSA-N 7-(4-bromobenzoyl)-1,3-dihydroindol-2-one Chemical compound C1=CC(Br)=CC=C1C(=O)C1=CC=CC2=C1NC(=O)C2 JDSPXIPYMUGSIJ-UHFFFAOYSA-N 0.000 claims 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims 1
- 206010015958 Eye pain Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 239000007979 citrate buffer Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000003204 osmotic effect Effects 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1816/DEL/2013 | 2013-06-19 | ||
| IN1816DE2013 | 2013-06-19 | ||
| PCT/US2014/042724 WO2014204952A1 (en) | 2013-06-19 | 2014-06-17 | Stable bromfenac solution |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016522257A JP2016522257A (ja) | 2016-07-28 |
| JP2016522257A5 true JP2016522257A5 (https=) | 2017-07-13 |
Family
ID=51136842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016521511A Pending JP2016522257A (ja) | 2013-06-19 | 2014-06-17 | 安定なブロムフェナク溶液 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20160143869A1 (https=) |
| EP (1) | EP3010485A1 (https=) |
| JP (1) | JP2016522257A (https=) |
| CA (1) | CA2911983A1 (https=) |
| EA (1) | EA201591910A1 (https=) |
| WO (1) | WO2014204952A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017002042A (ja) * | 2015-06-10 | 2017-01-05 | 参天製薬株式会社 | 点眼剤、及び点眼剤防腐効力維持方法 |
| JPWO2019117252A1 (ja) * | 2017-12-14 | 2020-12-17 | 参天製薬株式会社 | ２−アミノ−３−（４−ブロモベンゾイル）フェニル酢酸またはその塩を含有する点眼剤 |
| CN114224830A (zh) * | 2021-12-24 | 2022-03-25 | 辰欣药业股份有限公司 | 一种单剂量无抑菌剂的眼用制剂及其制备方法 |
| CN115887366A (zh) * | 2022-11-21 | 2023-04-04 | 山东诺明康药物研究院有限公司 | 一种溴芬酸钠离子敏感型原位凝胶滴眼液及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE400966B (sv) | 1975-08-13 | 1978-04-17 | Robins Co Inc A H | Forfarande for framstellning av 2-amino-3-(eller 5-)bensoyl-fenylettiksyror |
| CA1325382C (en) | 1988-01-27 | 1993-12-21 | Takahiro Ogawa | Locally administrable therapeutic composition for inflammatory disease |
| US5603929A (en) | 1994-11-16 | 1997-02-18 | Alcon Laboratories, Inc. | Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds |
| PT1586316E (pt) | 2003-01-21 | 2008-05-28 | Senju Pharma Co | Preparação líquida aquosa contendo ácido 2-amino-3-(4- bromobenzoil)fenilacético |
| ES2369089T3 (es) * | 2004-11-05 | 2011-11-25 | Senju Pharmaceutical Co., Ltd. | Gotas oftálmicas acuosas con migración intraocular acelerada. |
| US8778999B2 (en) * | 2009-03-05 | 2014-07-15 | Insite Vision Incorporated | Non-steroidal anti-inflammatory ophthalmic compositions |
| US20130023575A1 (en) * | 2011-07-22 | 2013-01-24 | Kamran Hosseini | Compositions and methods for the treatment of ocular surface allergies |
| HRP20241509T1 (hr) | 2011-10-12 | 2025-01-03 | Bausch & Lomb Incorporated | Pripravak za oči koji sadrži bromfenak s povećanom bioraspoloživošću |
| MX358604B (es) * | 2012-11-19 | 2018-08-28 | Bausch & Lomb | Composicion liquida acuosa que contiene acido 2-amino-3-(4-bromobenzoil) fenilacetico. |
-
2014
- 2014-06-17 CA CA2911983A patent/CA2911983A1/en not_active Abandoned
- 2014-06-17 EA EA201591910A patent/EA201591910A1/ru unknown
- 2014-06-17 JP JP2016521511A patent/JP2016522257A/ja active Pending
- 2014-06-17 EP EP14736572.0A patent/EP3010485A1/en not_active Withdrawn
- 2014-06-17 WO PCT/US2014/042724 patent/WO2014204952A1/en not_active Ceased
- 2014-06-17 US US14/898,268 patent/US20160143869A1/en not_active Abandoned
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