JP2016521266A5 - - Google Patents
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- Publication number
- JP2016521266A5 JP2016521266A5 JP2016507617A JP2016507617A JP2016521266A5 JP 2016521266 A5 JP2016521266 A5 JP 2016521266A5 JP 2016507617 A JP2016507617 A JP 2016507617A JP 2016507617 A JP2016507617 A JP 2016507617A JP 2016521266 A5 JP2016521266 A5 JP 2016521266A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- ibrutinib
- lymphoma
- relapsed
- refractory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002177 L01XE27 - Ibrutinib Substances 0.000 claims 22
- XYFPWWZEPKGCCK-GOSISDBHSA-N ibrutinib Chemical compound C1=2C(N)=NC=NC=2N([C@H]2CN(CCC2)C(=O)C=C)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 XYFPWWZEPKGCCK-GOSISDBHSA-N 0.000 claims 22
- 229960001507 ibrutinib Drugs 0.000 claims 22
- 210000003719 b-lymphocyte Anatomy 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 230000002062 proliferating effect Effects 0.000 claims 9
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 8
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 8
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 8
- LQBVNQSMGBZMKD-UHFFFAOYSA-N venetoclax Chemical compound C=1C=C(Cl)C=CC=1C=1CC(C)(C)CCC=1CN(CC1)CCN1C(C=C1OC=2C=C3C=CNC3=NC=2)=CC=C1C(=O)NS(=O)(=O)C(C=C1[N+]([O-])=O)=CC=C1NCC1CCOCC1 LQBVNQSMGBZMKD-UHFFFAOYSA-N 0.000 claims 7
- 229960001183 venetoclax Drugs 0.000 claims 7
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 5
- 239000002775 capsule Substances 0.000 claims 4
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 3
- 239000002552 dosage form Substances 0.000 claims 2
- 201000003444 follicular lymphoma Diseases 0.000 claims 2
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims 2
- 208000021937 marginal zone lymphoma Diseases 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000036170 B-Cell Marginal Zone Lymphoma Diseases 0.000 claims 1
- 208000003950 B-cell lymphoma Diseases 0.000 claims 1
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
- 201000004085 CLL/SLL Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000023738 chronic lymphocytic leukemia/small lymphocytic lymphoma Diseases 0.000 claims 1
- 210000001280 germinal center Anatomy 0.000 claims 1
- 208000021173 high grade B-cell lymphoma Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361809810P | 2013-04-08 | 2013-04-08 | |
| US61/809,810 | 2013-04-08 | ||
| PCT/US2014/033378 WO2014168975A1 (en) | 2013-04-08 | 2014-04-08 | Ibrutinib combination therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019147994A Division JP6871978B2 (ja) | 2013-04-08 | 2019-08-09 | イブルチニブ併用療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016521266A JP2016521266A (ja) | 2016-07-21 |
| JP2016521266A5 true JP2016521266A5 (https=) | 2017-05-25 |
| JP6575952B2 JP6575952B2 (ja) | 2019-09-18 |
Family
ID=51689963
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016507617A Active JP6575952B2 (ja) | 2013-04-08 | 2014-04-08 | イブルチニブ併用療法 |
| JP2019147994A Active JP6871978B2 (ja) | 2013-04-08 | 2019-08-09 | イブルチニブ併用療法 |
| JP2021069171A Pending JP2021119150A (ja) | 2013-04-08 | 2021-04-15 | イブルチニブ併用療法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019147994A Active JP6871978B2 (ja) | 2013-04-08 | 2019-08-09 | イブルチニブ併用療法 |
| JP2021069171A Pending JP2021119150A (ja) | 2013-04-08 | 2021-04-15 | イブルチニブ併用療法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20160287592A1 (https=) |
| EP (1) | EP2983670A4 (https=) |
| JP (3) | JP6575952B2 (https=) |
| KR (1) | KR20150141971A (https=) |
| CN (2) | CN105263496A (https=) |
| AU (3) | AU2014251028A1 (https=) |
| BR (1) | BR112015025711A8 (https=) |
| CA (1) | CA2908375A1 (https=) |
| EA (1) | EA201591656A1 (https=) |
| HK (1) | HK1215374A1 (https=) |
| IL (2) | IL241710B (https=) |
| MX (2) | MX369503B (https=) |
| PH (2) | PH12015502337A1 (https=) |
| WO (1) | WO2014168975A1 (https=) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| JP2014520863A (ja) | 2011-07-13 | 2014-08-25 | ファーマサイクリックス，インク． | Ｂｒｕｔｏｎ型チロシンキナーゼの阻害剤 |
| EP2548877A1 (en) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
| EP3689878B1 (en) | 2011-07-19 | 2021-10-06 | Merck Sharp & Dohme B.V. | 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk-inhibitors |
| EP3812387A1 (en) | 2011-07-21 | 2021-04-28 | Sumitomo Dainippon Pharma Oncology, Inc. | Heterocyclic protein kinase inhibitors |
| KR20210033067A (ko) | 2012-06-04 | 2021-03-25 | 파마싸이클릭스 엘엘씨 | 브루톤 타이로신 키나아제 저해제의 결정 형태 |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| CN104704129A (zh) | 2012-07-24 | 2015-06-10 | 药品循环公司 | 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变 |
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| MX394360B (es) | 2013-03-14 | 2025-03-24 | Sumitomo Pharma Oncology Inc | Inhibidores de jak2 y alk2 y metodos para su uso. |
| CA2906157C (en) | 2013-03-15 | 2022-05-17 | G1 Therapeutics, Inc. | Highly active anti-neoplastic and anti-proliferative agents |
| ME03557B (me) | 2013-03-15 | 2020-07-20 | G1 Therapeutics Inc | Privremena zaštiтa normalnih ćelija током hemoterapije |
| JP6800750B2 (ja) * | 2013-08-02 | 2020-12-16 | ファーマサイクリックス エルエルシー | 固形腫瘍の処置方法 |
| US9415050B2 (en) | 2013-08-12 | 2016-08-16 | Pharmacyclics Llc | Methods for the treatment of HER2 amplified cancer |
| JP2016538270A (ja) * | 2013-10-25 | 2016-12-08 | ファーマサイクリックス エルエルシー | 移植片対宿主病を処置し予防する方法 |
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| US9885086B2 (en) | 2014-03-20 | 2018-02-06 | Pharmacyclics Llc | Phospholipase C gamma 2 and resistance associated mutations |
| WO2015146159A1 (en) | 2014-03-25 | 2015-10-01 | Ono Pharmaceutical Co., Ltd. | Prophylactic agent and/or therapeutic agent for diffuse large b-cell lymphoma |
| US9937171B2 (en) | 2014-04-11 | 2018-04-10 | Acerta Pharma B.V. | Methods of blocking the CXCR-4/SDF-1 signaling pathway with inhibitors of bruton's tyrosine kinase |
| WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| WO2015161288A1 (en) | 2014-04-17 | 2015-10-22 | G1 Therapeutics, Inc. | Tricyclic lactams for use as anti-neoplastic and anti-proliferative agents |
| CN105017256A (zh) | 2014-04-29 | 2015-11-04 | 浙江导明医药科技有限公司 | 多氟化合物作为布鲁顿酪氨酸激酶抑制剂 |
| US9949971B2 (en) | 2014-06-17 | 2018-04-24 | Acerta Pharma B.V. | Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor and/or a JAK-2 inhibitor |
| PL3179991T3 (pl) * | 2014-08-11 | 2022-02-14 | Acerta Pharma B.V. | Kombinacje terapeutyczne inhibitora btk i inhibitora bcl-2 |
| WO2016040848A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors |
| EP3191098A4 (en) | 2014-09-12 | 2018-04-25 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| TW201628622A (zh) * | 2014-11-17 | 2016-08-16 | 製藥公司 | Tlr抑制劑與布魯頓氏(bruton's)酪胺酸激酶抑制劑之組合 |
| WO2016090255A1 (en) * | 2014-12-05 | 2016-06-09 | Sriram Balasubramanian | Biological markers for predicting responsiveness to ibrutinib and r-chop combination therapy and methods of using the same |
| IL315294A (en) | 2015-03-03 | 2024-10-01 | Pharmacyclics Llc | Pharmaceutical formulations of bruton's tyrosine kinase inhibitor |
| US9717745B2 (en) | 2015-03-19 | 2017-08-01 | Zhejiang DTRM Biopharma Co. Ltd. | Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases |
| MA41827A (fr) * | 2015-03-27 | 2018-01-30 | Pharmacyclics Llc | Formes solvatées d'un inhibiteur de la tyrosine kinase de bruton |
| JP6823587B2 (ja) | 2015-04-13 | 2021-02-03 | 第一三共株式会社 | Ｍｄｍ２阻害剤とｂｔｋ阻害剤との併用治療法 |
| CN108135908A (zh) | 2015-04-20 | 2018-06-08 | Epizyme股份有限公司 | 用于治疗癌症的组合疗法 |
| HUE062258T2 (hu) | 2015-07-02 | 2023-10-28 | Acerta Pharma Bv | (S)-4-(8-amino-3-(1-(but-2-inoil)pirrolidin-2-il)imidazo[1,5-a]pirazin-1-il)-N-(piridin-2-il)benzamid szilárd alakjai és készítményei |
| EP3328380A4 (en) * | 2015-07-31 | 2019-07-24 | Pharmacyclics LLC | INHIBITOR COMBINATIONS OF BRUTON TYROSINE KINASE AND USES THEREOF |
| HK1255939A1 (zh) * | 2015-08-03 | 2019-09-06 | Gilead Sciences, Inc. | 用於治疗癌症之组合疗法 |
| HK1258762A1 (zh) * | 2015-10-02 | 2019-11-22 | Gilead Sciences, Inc. | Btk抑制剂gs-4059与选自jak、ask1、brd和/或mmp9抑制剂的抑制剂的组合，以治疗癌症、过敏性病症、自身免疫疾病或发炎性疾病 |
| WO2017087947A2 (en) * | 2015-11-19 | 2017-05-26 | Pharmacyclics Llc | Method of treatment of follicular lymphoma with a btk inhibitor |
| SG11201811237WA (en) | 2016-06-24 | 2019-01-30 | Infinity Pharmaceuticals Inc | Combination therapies |
| WO2018005865A1 (en) | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Synthesis of n-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines |
| AU2017295858A1 (en) | 2016-07-14 | 2019-01-24 | Mingsight Pharmaceuticals, Inc. | Treatment of cancer |
| CA3029851A1 (en) * | 2016-07-29 | 2018-02-01 | Oncternal Therapeutics, Inc. | Uses of indoline compounds such as tk216 for the treatment of cancer |
| WO2018021890A1 (ko) * | 2016-07-29 | 2018-02-01 | 이화여자대학교 산학협력단 | 크로메논 유도체 및 이를 포함하는 항암용 조성물 |
| KR20190092478A (ko) | 2016-12-05 | 2019-08-07 | 쥐원 쎄라퓨틱스, 인크. | 화학요법 레지멘 동안의 면역 반응의 보존 |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
| KR102635949B1 (ko) * | 2017-05-18 | 2024-02-14 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 종양 치료용 약물의 제조에 있어서의 ezh2 억제제 및 btk 억제제의 조합물의 용도 |
| US20200268761A1 (en) * | 2017-09-19 | 2020-08-27 | Cipla Limited | Compositions comprising ibrutinib and an alkaloid having enhanced bioavailability |
| TW201922256A (zh) | 2017-10-27 | 2019-06-16 | 中國大陸商浙江導明醫藥科技有限公司 | 治療淋巴樣惡性疾病之方法 |
| CN112165939A (zh) * | 2018-03-21 | 2021-01-01 | 梅制药公司 | 联合疗法 |
| KR20210003780A (ko) | 2018-04-05 | 2021-01-12 | 스미토모 다이니폰 파마 온콜로지, 인크. | Axl 키나제 억제제 및 그의 용도 |
| JP2021521170A (ja) | 2018-04-13 | 2021-08-26 | スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド | 骨髄増殖性新生物およびがんに関連する線維症の処置のためのｐｉｍキナーゼ阻害剤 |
| KR20210044736A (ko) | 2018-05-03 | 2021-04-23 | 주노 쎄러퓨티크스 인코퍼레이티드 | 키메라 항원 수용체(ｃａｒ) ｔ세포 요법과 키나제 억제제의 조합요법 |
| AU2019310590A1 (en) | 2018-07-26 | 2021-01-14 | Sumitomo Pharma Oncology, Inc. | Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same |
| CA3095699A1 (en) * | 2018-07-31 | 2020-02-06 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases |
| AU2019325685B2 (en) | 2018-08-24 | 2025-07-24 | Pharmacosmos Holding A/S | Improved synthesis of 1,4-diazaspiro(5.5)undecan-3-one |
| US20210222228A1 (en) * | 2018-08-26 | 2021-07-22 | Cardiff Oncology, Inc. | Plk1 target phosphorylation status and treatment of cancer with plk1 inhibitors |
| CA3111126A1 (en) * | 2018-08-31 | 2020-03-05 | Stichting Katholieke Universiteit | Synergistic combinations of amino acid depletion agent sensitizers (aadas) and amino acid depletion agents (aada), and therapeutic methods of use thereof |
| EP3849559A4 (en) * | 2018-09-12 | 2022-06-01 | Denovo Biopharma LLC | COMBINATION OF ENZASTAURIN AND INHIBITORS OF BTK AND USES THEREOF |
| WO2020113216A1 (en) * | 2018-11-30 | 2020-06-04 | Aptose Biosciences Inc. | Combination therapy with 2,3-dihydro-isoindole-1-one compounds and methods for treating patients with various mutations |
| EP3886992A1 (en) * | 2018-11-30 | 2021-10-06 | Janssen Biotech, Inc. | Methods of treating follicular lymphoma |
| KR20260008165A (ko) | 2019-02-12 | 2026-01-15 | 스미토모 파마 아메리카, 인크. | 헤테로시클릭 단백질 키나제 억제제를 포함하는 제제 |
| PH12021551936A1 (en) * | 2019-02-15 | 2022-05-23 | Janssen Biotech Inc | Combination therapy for treatment of b-cell malignancies |
| US20220144950A1 (en) * | 2019-03-13 | 2022-05-12 | The Brigham And Women's Hospital, Inc. | Targeting regulatory b cells and their regulators for cancer immunotherapy |
| US20230100235A1 (en) * | 2020-02-05 | 2023-03-30 | Carna Biosciences, Inc. | Anticancer agent composition |
| US10988479B1 (en) | 2020-06-15 | 2021-04-27 | G1 Therapeutics, Inc. | Morphic forms of trilaciclib and methods of manufacture thereof |
| GB202009764D0 (en) * | 2020-06-26 | 2020-08-12 | Cambridge Entpr Ltd | Therapeutic treatment using protein kinase c (pkc) inhibitors and cytotoxic agents |
| US20230010803A1 (en) * | 2021-06-30 | 2023-01-12 | Janssen Pharmaceutica Nv | Treatments for diffuse large b-cell lymphoma |
| WO2023285677A1 (en) * | 2021-07-16 | 2023-01-19 | Spexis Ag | Pharmaceutical combinations for treating cancer |
| WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
| CN115554301A (zh) * | 2022-10-24 | 2023-01-03 | 徐诺药业(南京)有限公司 | Hdac抑制剂和伊布替尼在制备预防或者治疗套细胞淋巴瘤的药物中的用途 |
| CN120302975A (zh) | 2022-10-31 | 2025-07-11 | 住友制药美国公司 | 治疗骨髓增生性肿瘤的pim1抑制剂 |
| WO2025249980A1 (ko) * | 2024-05-31 | 2025-12-04 | (주)노보메디슨 | 림프종의 예방 또는 치료를 위한 포셀티닙의 병용투여 요법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008001156A1 (en) * | 2006-06-26 | 2008-01-03 | Centre Regional De Lutte Contre Le Cancer - Centre Francois Baclesse | CANCER THERAPY USING BcI-XL-SPECIFIC siNA |
| DK2526933T3 (en) * | 2006-09-22 | 2015-05-18 | Pharmacyclics Inc | Inhibitors of Bruton's tyrosine kinase |
| CA2679347A1 (en) * | 2007-03-02 | 2008-09-12 | Mdrna Inc. | Nucleic acid compounds for inhibiting bcl2 gene expression and uses thereof |
| JP5832721B2 (ja) * | 2007-03-14 | 2015-12-16 | バイオンシル・エス．アール．エル．Ｂｉｏｎｓｉｌ Ｓ．Ｒ．Ｌ． | 上皮腫瘍細胞における薬剤耐性のモジュレータ化合物 |
| ES2367760T3 (es) * | 2008-03-27 | 2011-11-08 | Janssen Pharmaceutica, N.V. | Derivados de quinazolinona como inhibidores de la polimerización de la tubulina. |
| WO2010138588A2 (en) * | 2009-05-26 | 2010-12-02 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| CA3007787C (en) * | 2010-06-03 | 2020-03-10 | Pharmacyclics Llc | The use of inhibitors of bruton's tyrosine kinase (btk) |
| HK1212240A1 (en) * | 2012-09-07 | 2016-06-10 | 吉宁特有限公司 | Combination therapy of a type ii anti-cd20 antibody with a selective bcl-2 inhibitor |
-
2014
- 2014-04-08 EP EP14782886.7A patent/EP2983670A4/en not_active Withdrawn
- 2014-04-08 JP JP2016507617A patent/JP6575952B2/ja active Active
- 2014-04-08 CN CN201480025176.0A patent/CN105263496A/zh active Pending
- 2014-04-08 CA CA2908375A patent/CA2908375A1/en not_active Abandoned
- 2014-04-08 CN CN201911007617.5A patent/CN111317821A/zh active Pending
- 2014-04-08 MX MX2015013970A patent/MX369503B/es active IP Right Grant
- 2014-04-08 KR KR1020157029969A patent/KR20150141971A/ko not_active Ceased
- 2014-04-08 WO PCT/US2014/033378 patent/WO2014168975A1/en not_active Ceased
- 2014-04-08 AU AU2014251028A patent/AU2014251028A1/en not_active Abandoned
- 2014-04-08 EA EA201591656A patent/EA201591656A1/ru unknown
- 2014-04-08 HK HK16103284.1A patent/HK1215374A1/zh unknown
- 2014-04-08 BR BR112015025711A patent/BR112015025711A8/pt not_active Application Discontinuation
- 2014-04-08 US US14/778,536 patent/US20160287592A1/en not_active Abandoned
-
2015
- 2015-09-20 IL IL241710A patent/IL241710B/en active IP Right Grant
- 2015-10-02 MX MX2019013429A patent/MX2019013429A/es unknown
- 2015-10-08 PH PH12015502337A patent/PH12015502337A1/en unknown
-
2018
- 2018-11-14 IL IL263026A patent/IL263026A/en unknown
-
2019
- 2019-05-07 AU AU2019203205A patent/AU2019203205A1/en not_active Abandoned
- 2019-08-01 US US16/529,467 patent/US20200368235A1/en not_active Abandoned
- 2019-08-09 JP JP2019147994A patent/JP6871978B2/ja active Active
-
2020
- 2020-12-01 PH PH12020552065A patent/PH12020552065A1/en unknown
-
2021
- 2021-01-07 AU AU2021200066A patent/AU2021200066A1/en not_active Abandoned
- 2021-04-15 JP JP2021069171A patent/JP2021119150A/ja active Pending
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