JP2016520611A5 - - Google Patents
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- Publication number
- JP2016520611A5 JP2016520611A5 JP2016516476A JP2016516476A JP2016520611A5 JP 2016520611 A5 JP2016520611 A5 JP 2016520611A5 JP 2016516476 A JP2016516476 A JP 2016516476A JP 2016516476 A JP2016516476 A JP 2016516476A JP 2016520611 A5 JP2016520611 A5 JP 2016520611A5
- Authority
- JP
- Japan
- Prior art keywords
- activity
- mpo
- subjected
- colon
- colon tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000003896 Myeloperoxidases Human genes 0.000 description 4
- 108090000235 Myeloperoxidases Proteins 0.000 description 4
- 210000001072 colon Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- AFYNADDZULBEJA-UHFFFAOYSA-N bicinchoninic acid Chemical compound C1=CC=CC2=NC(C=3C=C(C4=CC=CC=C4N=3)C(=O)O)=CC(C(O)=O)=C21 AFYNADDZULBEJA-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361829764P | 2013-05-31 | 2013-05-31 | |
| US61/829,764 | 2013-05-31 | ||
| PCT/NZ2014/000102 WO2014193248A1 (en) | 2013-05-31 | 2014-05-30 | Beta-casein a2 and prevention of inflammation of the bowel |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019106371A Division JP7224242B2 (ja) | 2013-05-31 | 2019-06-06 | ベータカゼインａ２および腸の炎症の予防 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520611A JP2016520611A (ja) | 2016-07-14 |
| JP2016520611A5 true JP2016520611A5 (https=) | 2021-02-12 |
| JP6867158B2 JP6867158B2 (ja) | 2021-04-28 |
Family
ID=51989162
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016516476A Active JP6867158B2 (ja) | 2013-05-31 | 2014-05-30 | ベータカゼインａ２および腸の炎症の予防 |
| JP2019106371A Active JP7224242B2 (ja) | 2013-05-31 | 2019-06-06 | ベータカゼインａ２および腸の炎症の予防 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019106371A Active JP7224242B2 (ja) | 2013-05-31 | 2019-06-06 | ベータカゼインａ２および腸の炎症の予防 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20160113997A1 (https=) |
| EP (2) | EP3542813A1 (https=) |
| JP (2) | JP6867158B2 (https=) |
| KR (2) | KR102282972B1 (https=) |
| CN (2) | CN105407971B (https=) |
| AU (2) | AU2014271423B2 (https=) |
| BR (1) | BR112015029987A8 (https=) |
| CA (1) | CA2913890C (https=) |
| CL (1) | CL2015003507A1 (https=) |
| DK (1) | DK3003485T3 (https=) |
| ES (1) | ES2742306T3 (https=) |
| IL (2) | IL242833B (https=) |
| MX (2) | MX391963B (https=) |
| MY (1) | MY179497A (https=) |
| PH (2) | PH12015502674B1 (https=) |
| RU (1) | RU2669553C2 (https=) |
| SG (2) | SG10201709509RA (https=) |
| WO (1) | WO2014193248A1 (https=) |
| ZA (1) | ZA201508983B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3542813A1 (en) * | 2013-05-31 | 2019-09-25 | The A2 Milk Company Limited | Beta-casein a2 and prevention of inflammation of the bowel |
| MX368912B (es) * | 2013-07-12 | 2019-10-21 | A2 Milk Co Ltd | Beta-caseína a2 y reducción y prevención de síntomas de intolerancia a la lactosa. |
| GB2519101A (en) * | 2013-10-09 | 2015-04-15 | Nicoventures Holdings Ltd | Electronic vapour provision system |
| US20170086481A1 (en) * | 2014-06-03 | 2017-03-30 | Abbott Laboratories | Nutritional compositions comprising a lipophilic active ingredient |
| JP7137745B2 (ja) * | 2015-05-22 | 2022-09-15 | ズィ・エイツー・ミルク・カンパニー・リミテッド | ベータカゼインａ２および抗酸化能 |
| WO2017003300A1 (en) * | 2015-06-29 | 2017-01-05 | The A2 Milk Company Limited | A2 beta-casein and viscosity of milk products |
| WO2017171563A1 (en) | 2016-03-30 | 2017-10-05 | The A2 Milk Company Limited | Beta-caseins and cognitive function |
| JP6873234B2 (ja) * | 2016-09-30 | 2021-05-19 | ズィ・エイツー・ミルク・カンパニー・リミテッド | ベータカゼイン類および腸微生物叢 |
| CN109563049B (zh) * | 2016-10-14 | 2022-11-29 | 豪夫迈·罗氏有限公司 | 作为eaat3抑制剂的咪唑化合物 |
| NL2019906B1 (en) * | 2017-11-14 | 2019-05-20 | Ausnutria Hyproca B V | Composition comprising a2 b-casein and a vegetable fat mixture |
| CN112205476A (zh) * | 2019-07-11 | 2021-01-12 | 北京三元食品股份有限公司 | β-酪蛋白A2、其组合物在促进双歧杆菌属增殖中的应用 |
| WO2021003741A1 (zh) * | 2019-07-11 | 2021-01-14 | 北京三元食品股份有限公司 | β-酪蛋白A2、其组合物在促进双歧杆菌属增殖中的应用 |
| CN115708530B (zh) * | 2022-11-15 | 2024-08-09 | 北大荒完达山乳业股份有限公司 | 一种促进消化舒适性并稳定血糖的孕产妇配方奶粉及其制备方法 |
| CN117322467A (zh) * | 2023-10-11 | 2024-01-02 | 东北农业大学 | A2β-酪蛋白在制备功能性食品中的应用 |
| WO2026003044A1 (en) * | 2024-06-25 | 2026-01-02 | Ntd Labs, S.L. | Casein hydrolysate for treating crohn's disease |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2204245C (en) | 1994-11-04 | 2008-07-22 | Robert Bartlett Elliott | Method of selecting non-diabetogenic milk or milk products and milk or milk products so selected |
| NZ306584A (en) * | 1995-05-16 | 2000-02-28 | Corran Norman Stuart Mclachlan | Milk or dairy products derived from animals and which are free of beta casein |
| AU4266100A (en) * | 1995-05-16 | 2000-10-12 | Corran Norman Stuart Mclachlan | Food product and process |
| WO1996036239A1 (en) | 1995-05-16 | 1996-11-21 | Corran Norman Stuart Mclachlan | Food product and process |
| US6570060B2 (en) | 1995-05-16 | 2003-05-27 | Mclachlan Corran Norman Stuart | Milk lacking β-casein A1 |
| AU771754B2 (en) * | 1999-06-29 | 2004-04-01 | New Zealand Milk Institute Limited, The | Prophylactic dietary supplement based on milk |
| NZ516712A (en) * | 1999-06-29 | 2003-10-31 | New Zealand Milk Inst Ltd | Prophylactic dietary supplement based on milk |
| AU9037401A (en) | 2000-09-08 | 2002-03-22 | New Zealand Dairy Board | Milk containing beta-casein with proline at position 67 does not aggravate neurological disorders |
| CA2444470A1 (en) * | 2001-04-10 | 2002-10-24 | Societe Des Produits Nestle S.A. | Method and composition for prophylaxis of diabetes |
| US20060280802A1 (en) | 2002-10-04 | 2006-12-14 | Campbell Julie H | Therapeutic uses of beta-casein a2 and dietary supplement containing beta-casein a2 |
| US7481127B2 (en) | 2004-09-27 | 2009-01-27 | Lester William T | Continuously variable transmission using oscillating torque and one-way drives |
| WO2008041219A1 (en) * | 2006-10-06 | 2008-04-10 | Kerry Group Services International Limited | A milk protein composition and use thereof |
| US8871276B2 (en) * | 2008-02-11 | 2014-10-28 | Technion Research And Development Foundation Ltd. | Beta-casein assemblies for mucosal delivery of therapeutic bioactive agents |
| TWI516269B (zh) * | 2009-08-14 | 2016-01-11 | 禾伸堂生技股份有限公司 | 使用於炎症性腸疾病（ｉｂｄ）治療和預防之透明質酸混合物 |
| EP3542813A1 (en) * | 2013-05-31 | 2019-09-25 | The A2 Milk Company Limited | Beta-casein a2 and prevention of inflammation of the bowel |
| MX368912B (es) * | 2013-07-12 | 2019-10-21 | A2 Milk Co Ltd | Beta-caseína a2 y reducción y prevención de síntomas de intolerancia a la lactosa. |
-
2014
- 2014-05-30 EP EP19169044.5A patent/EP3542813A1/en not_active Withdrawn
- 2014-05-30 EP EP14804528.9A patent/EP3003485B1/en not_active Revoked
- 2014-05-30 US US14/894,711 patent/US20160113997A1/en not_active Abandoned
- 2014-05-30 MX MX2019010594A patent/MX391963B/es unknown
- 2014-05-30 SG SG10201709509RA patent/SG10201709509RA/en unknown
- 2014-05-30 WO PCT/NZ2014/000102 patent/WO2014193248A1/en not_active Ceased
- 2014-05-30 AU AU2014271423A patent/AU2014271423B2/en active Active
- 2014-05-30 KR KR1020157036746A patent/KR102282972B1/ko active Active
- 2014-05-30 SG SG11201509769QA patent/SG11201509769QA/en unknown
- 2014-05-30 BR BR112015029987A patent/BR112015029987A8/pt not_active Application Discontinuation
- 2014-05-30 JP JP2016516476A patent/JP6867158B2/ja active Active
- 2014-05-30 DK DK14804528.9T patent/DK3003485T3/da active
- 2014-05-30 CN CN201480042721.7A patent/CN105407971B/zh active Active
- 2014-05-30 KR KR1020217023199A patent/KR102402455B1/ko active Active
- 2014-05-30 CN CN202011164629.1A patent/CN112316116A/zh active Pending
- 2014-05-30 RU RU2015153113A patent/RU2669553C2/ru active
- 2014-05-30 ES ES14804528T patent/ES2742306T3/es active Active
- 2014-05-30 MY MYPI2015704353A patent/MY179497A/en unknown
- 2014-05-30 CA CA2913890A patent/CA2913890C/en active Active
- 2014-05-30 MX MX2015016493A patent/MX367794B/es active IP Right Grant
-
2015
- 2015-11-27 PH PH12015502674A patent/PH12015502674B1/en unknown
- 2015-11-29 IL IL242833A patent/IL242833B/en active IP Right Grant
- 2015-11-30 CL CL2015003507A patent/CL2015003507A1/es unknown
- 2015-12-09 ZA ZA2015/08983A patent/ZA201508983B/en unknown
-
2018
- 2018-10-11 IL IL262302A patent/IL262302B/en active IP Right Grant
- 2018-12-06 AU AU2018274937A patent/AU2018274937B2/en active Active
-
2019
- 2019-06-06 JP JP2019106371A patent/JP7224242B2/ja active Active
- 2019-06-13 PH PH12019550096A patent/PH12019550096A1/en unknown
-
2020
- 2020-02-07 US US16/784,911 patent/US11911439B2/en active Active
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