JP2016520603A5 - - Google Patents
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- JP2016520603A5 JP2016520603A5 JP2016516143A JP2016516143A JP2016520603A5 JP 2016520603 A5 JP2016520603 A5 JP 2016520603A5 JP 2016516143 A JP2016516143 A JP 2016516143A JP 2016516143 A JP2016516143 A JP 2016516143A JP 2016520603 A5 JP2016520603 A5 JP 2016520603A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- rutin
- composition according
- curcumin
- reducing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims 24
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims 8
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 claims 5
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 claims 5
- 235000016709 nutrition Nutrition 0.000 claims 5
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 claims 5
- 235000005493 rutin Nutrition 0.000 claims 5
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 claims 5
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 claims 5
- 229960004555 rutoside Drugs 0.000 claims 5
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- 235000012754 curcumin Nutrition 0.000 claims 4
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- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims 4
- 244000099147 Ananas comosus Species 0.000 claims 3
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims 2
- JUUBCHWRXWPFFH-UHFFFAOYSA-N Hydroxytyrosol Chemical compound OCCC1=CC=C(O)C(O)=C1 JUUBCHWRXWPFFH-UHFFFAOYSA-N 0.000 claims 2
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- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims 2
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- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims 2
- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 claims 1
- JKQXZKUSFCKOGQ-JLGXGRJMSA-N (3R,3'R)-beta,beta-carotene-3,3'-diol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-JLGXGRJMSA-N 0.000 claims 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims 1
- RFWGABANNQMHMZ-UHFFFAOYSA-N 8-acetoxy-7-acetyl-6,7,7a,8-tetrahydro-5H-benzo[g][1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]quinoline Natural products CC=C1C(CC(=O)OCCC=2C=C(O)C(O)=CC=2)C(C(=O)OC)=COC1OC1OC(CO)C(O)C(O)C1O RFWGABANNQMHMZ-UHFFFAOYSA-N 0.000 claims 1
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- HKVGJQVJNQRJPO-UHFFFAOYSA-N Demethyloleuropein Natural products O1C=C(C(O)=O)C(CC(=O)OCCC=2C=C(O)C(O)=CC=2)C(=CC)C1OC1OC(CO)C(O)C(O)C1O HKVGJQVJNQRJPO-UHFFFAOYSA-N 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 108010024636 Glutathione Proteins 0.000 claims 1
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 1
- 241000254191 Harpagophytum procumbens Species 0.000 claims 1
- QUQPHWDTPGMPEX-UHFFFAOYSA-N Hesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-UHFFFAOYSA-N 0.000 claims 1
- 244000241838 Lycium barbarum Species 0.000 claims 1
- 235000015459 Lycium barbarum Nutrition 0.000 claims 1
- 235000015468 Lycium chinense Nutrition 0.000 claims 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims 1
- 235000004429 Matricaria chamomilla var recutita Nutrition 0.000 claims 1
- RFWGABANNQMHMZ-HYYSZPHDSA-N Oleuropein Chemical compound O([C@@H]1OC=C([C@H](C1=CC)CC(=O)OCCC=1C=C(O)C(O)=CC=1)C(=O)OC)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RFWGABANNQMHMZ-HYYSZPHDSA-N 0.000 claims 1
- 244000082490 Proboscidea louisianica Species 0.000 claims 1
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- 235000019096 Proboscidea parviflora Nutrition 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 240000007323 Rhaphidophora montana Species 0.000 claims 1
- 244000178231 Rosmarinus officinalis Species 0.000 claims 1
- 241000124033 Salix Species 0.000 claims 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 1
- 235000006468 Thea sinensis Nutrition 0.000 claims 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims 1
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- JKQXZKUSFCKOGQ-LQFQNGICSA-N Z-zeaxanthin Natural products C([C@H](O)CC=1C)C(C)(C)C=1C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-LQFQNGICSA-N 0.000 claims 1
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- ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 claims 1
- 235000011576 oleuropein Nutrition 0.000 claims 1
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- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13169653.6 | 2013-05-29 | ||
| EP13169653 | 2013-05-29 | ||
| PCT/EP2014/061022 WO2014191448A1 (en) | 2013-05-29 | 2014-05-28 | Compositions for use in cartilage breakdown |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016520603A JP2016520603A (ja) | 2016-07-14 |
| JP2016520603A5 true JP2016520603A5 (enExample) | 2017-07-06 |
Family
ID=48485058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016516143A Pending JP2016520603A (ja) | 2013-05-29 | 2014-05-28 | 軟骨破壊における使用のための組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20160101125A1 (enExample) |
| EP (1) | EP3003338A1 (enExample) |
| JP (1) | JP2016520603A (enExample) |
| CN (1) | CN105246499A (enExample) |
| AU (1) | AU2014273186A1 (enExample) |
| BR (1) | BR112015029354A2 (enExample) |
| CA (1) | CA2913621A1 (enExample) |
| WO (1) | WO2014191448A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015029611B1 (pt) * | 2013-05-29 | 2023-01-17 | Société Des Produits Nestlé S.A | Uso de uma composição compreendendo oleuropeína |
| JP2021502327A (ja) * | 2017-11-08 | 2021-01-28 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | オレウロペインの生物変換 |
| EP3706759B1 (en) * | 2017-11-08 | 2023-11-15 | Société des Produits Nestlé S.A. | Homovanillyl alcohol (hva), hva isomer, methods of making compositions comprising such compounds, and methods using such compounds |
| CA3078317A1 (en) * | 2017-11-08 | 2019-05-16 | Societe Des Produits Nestle S.A. | Bioconversion of oleuropein |
| ES2955922T3 (es) * | 2017-11-08 | 2023-12-11 | Nestle Sa | Procedimiento para seleccionar un probiótico |
| CN108686119A (zh) * | 2018-06-27 | 2018-10-23 | 陶燃 | 一种治疗痛风的药物组合物及其应用 |
| WO2021024801A1 (ja) * | 2019-08-02 | 2021-02-11 | サントリーホールディングス株式会社 | 軟骨再生促進用組成物 |
| CN115023150B (zh) * | 2019-12-17 | 2024-04-26 | 三得利控股株式会社 | 硫酸软骨素合成促进用组合物 |
| WO2021170806A1 (en) * | 2020-02-28 | 2021-09-02 | Biosearch, S.A. | Uses and compositions based on polyphenols for improving the oral bioavailability of hydroxytyrosol |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0725761A (ja) * | 1993-07-09 | 1995-01-27 | Kureha Chem Ind Co Ltd | 軟骨保護剤 |
| EP1127572A3 (en) * | 2000-02-25 | 2003-05-02 | Basf Aktiengesellschaft | Use of flavones for treating cycloxygenase-2 mediated diseases |
| US20040219240A1 (en) * | 2001-06-20 | 2004-11-04 | Babish John G. | Anti-inflammatory pharmaceutical compositions for reducing inflammation and the treatment or prevention of gastric toxicity |
| JP4592249B2 (ja) * | 2001-11-30 | 2010-12-01 | 江崎グリコ株式会社 | リウマチの症状改善用飲食品および医薬 |
| US6887497B2 (en) * | 2002-12-19 | 2005-05-03 | Vitacost.Com, Inc. | Composition for the treatment and prevention of osteoarthritis, rheumatoid arthritis and improved joint function |
| BRPI0621321A2 (pt) * | 2006-02-10 | 2011-12-06 | Mannatech Inc | formulações de suplemento dietético de multivitamìnico e multimineral natural para melhor absorção e utilização biológica |
| EP2040696B1 (en) * | 2006-07-14 | 2017-01-25 | DSM IP Assets B.V. | Compositions and use thereof for the treatment, co-treatment or prevention of inflammatory disorders |
| CA2623733A1 (en) * | 2007-03-02 | 2008-09-02 | Sam Ziff | Supplements for pain management |
| US7871609B2 (en) * | 2007-03-02 | 2011-01-18 | Sam Ziff | Supplements for pain management |
| CA2679847A1 (en) * | 2007-03-19 | 2008-09-25 | Metaproteomics, Llc. | Methods and compositions for promoting bone and joint health |
| ES2548867T3 (es) * | 2009-03-20 | 2015-10-21 | Bioxtract S.A. | Composición farmacéutica que presenta propiedades antiinflamatorias y antihistamínicas |
| EP2580967A1 (en) * | 2011-10-11 | 2013-04-17 | Nestec S.A. | Accelerating muscle recovery after immobilization-induced muscle atrophy |
| BR112015029611B1 (pt) * | 2013-05-29 | 2023-01-17 | Société Des Produits Nestlé S.A | Uso de uma composição compreendendo oleuropeína |
-
2014
- 2014-05-28 EP EP14726982.3A patent/EP3003338A1/en not_active Withdrawn
- 2014-05-28 CN CN201480030533.2A patent/CN105246499A/zh active Pending
- 2014-05-28 BR BR112015029354A patent/BR112015029354A2/pt not_active Application Discontinuation
- 2014-05-28 WO PCT/EP2014/061022 patent/WO2014191448A1/en not_active Ceased
- 2014-05-28 JP JP2016516143A patent/JP2016520603A/ja active Pending
- 2014-05-28 AU AU2014273186A patent/AU2014273186A1/en not_active Abandoned
- 2014-05-28 CA CA2913621A patent/CA2913621A1/en not_active Abandoned
- 2014-05-28 US US14/894,085 patent/US20160101125A1/en not_active Abandoned
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