JP2016519761A5 - - Google Patents
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- Publication number
- JP2016519761A5 JP2016519761A5 JP2016502967A JP2016502967A JP2016519761A5 JP 2016519761 A5 JP2016519761 A5 JP 2016519761A5 JP 2016502967 A JP2016502967 A JP 2016502967A JP 2016502967 A JP2016502967 A JP 2016502967A JP 2016519761 A5 JP2016519761 A5 JP 2016519761A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- sample
- protease
- inflammatory condition
- netosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 16
- 102000035195 Peptidases Human genes 0.000 claims 8
- 108091005804 Peptidases Proteins 0.000 claims 8
- 239000004365 Protease Substances 0.000 claims 7
- 235000019419 proteases Nutrition 0.000 claims 7
- 230000004968 inflammatory condition Effects 0.000 claims 4
- 230000000052 comparative effect Effects 0.000 claims 3
- LKDMKWNDBAVNQZ-UHFFFAOYSA-N 4-[[1-[[1-[2-[[1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)NC(C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(=O)NC=1C=CC(=CC=1)[N+]([O-])=O)CC1=CC=CC=C1 LKDMKWNDBAVNQZ-UHFFFAOYSA-N 0.000 claims 2
- 102000004173 Cathepsin G Human genes 0.000 claims 2
- 108090000617 Cathepsin G Proteins 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 2
- 108010028275 Leukocyte Elastase Proteins 0.000 claims 2
- 102000016799 Leukocyte elastase Human genes 0.000 claims 2
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 2
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 2
- 210000000440 neutrophil Anatomy 0.000 claims 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 2
- 206010003011 Appendicitis Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010051055 Deep vein thrombosis Diseases 0.000 claims 1
- 206010047249 Venous thrombosis Diseases 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 238000001962 electrophoresis Methods 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- 201000011461 pre-eclampsia Diseases 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 235000019833 protease Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000003127 radioimmunoassay Methods 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361799658P | 2013-03-15 | 2013-03-15 | |
| US61/799,658 | 2013-03-15 | ||
| PCT/US2014/029040 WO2014144572A2 (en) | 2013-03-15 | 2014-03-14 | Substrate profiling of proteases in neutrophil extracellular traps |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016519761A JP2016519761A (ja) | 2016-07-07 |
| JP2016519761A5 true JP2016519761A5 (enExample) | 2017-04-06 |
Family
ID=51538342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502967A Pending JP2016519761A (ja) | 2013-03-15 | 2014-03-14 | 好中球細胞外トラップにおけるプロテアーゼの基質プロファイリング |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9958459B2 (enExample) |
| EP (1) | EP2997352A4 (enExample) |
| JP (1) | JP2016519761A (enExample) |
| CN (1) | CN105339780A (enExample) |
| CA (1) | CA2906124A1 (enExample) |
| HK (1) | HK1214863A1 (enExample) |
| WO (1) | WO2014144572A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3607320A4 (en) | 2017-04-03 | 2021-04-21 | The Regents of the University of California | COMPOSITIONS AND METHODS OF DIAGNOSING Pancreatic Cancer |
| EP4182700A4 (en) * | 2020-07-20 | 2024-11-13 | Insmed Incorporated | METHODS FOR EXTRACTING NEUTROPHIL SERINE PROTEASES AND TREATMENT OF DIPETIDYL PEPTIDASE-1-MEDIATED DISEASES |
| CA3194956A1 (en) | 2020-09-11 | 2022-03-17 | Glympse Bio, Inc. | Ex vivo protease activity detection for disease detection/diagnostic, staging, monitoring and treatment |
| CN113238050A (zh) * | 2021-02-20 | 2021-08-10 | 吴炜 | 一种中性粒细胞胞外诱捕网的快速检测方法 |
| CN113310963B (zh) * | 2021-05-31 | 2023-12-01 | 四川大学华西医院 | 一种改进的中性粒细胞NETs免疫荧光检测方法 |
| CN115267172A (zh) * | 2022-07-29 | 2022-11-01 | 首都医科大学宣武医院 | 检测NSPs水平的物质在制备预测急性缺血性卒中患者预后产品中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2453528C (en) | 2001-08-01 | 2011-07-26 | Cellomics, Inc. | Novel fusion proteins and assays for molecular binding |
| US8569275B2 (en) * | 2002-08-28 | 2013-10-29 | Harbor Therapeutics, Inc. | Steroids having 7-oxgen and 17-heteroaryl substitution |
| JP4814788B2 (ja) | 2004-05-20 | 2011-11-16 | アステラス製薬株式会社 | 間質性膀胱炎の検査方法 |
| WO2006084210A2 (en) * | 2005-02-04 | 2006-08-10 | Regents Of The University Of California, San Diego | Hif modulating compounds and methods of use thereof |
| ATE479779T1 (de) | 2006-09-29 | 2010-09-15 | Leukocare Ag | Verfahren zum nachweis einer aktivierung des immunsystems oder des ausmasses von zelltod |
| WO2010022281A1 (en) | 2008-08-20 | 2010-02-25 | Greystone Pharmaceuticals, Inc. | Methods for using human neutrophil elastase as an indicator of active wound infection |
| US10577639B2 (en) | 2009-06-26 | 2020-03-03 | University Of Florida Research Foundation, Inc. | Rapid bed-side measurement of neutrophil elastase activity in biological fluids |
| EP2483244A1 (en) * | 2009-10-02 | 2012-08-08 | AstraZeneca AB | 2-pyridone compounds used as inhibitors of neutrophil elastase |
-
2014
- 2014-03-14 WO PCT/US2014/029040 patent/WO2014144572A2/en not_active Ceased
- 2014-03-14 JP JP2016502967A patent/JP2016519761A/ja active Pending
- 2014-03-14 US US14/771,322 patent/US9958459B2/en not_active Expired - Fee Related
- 2014-03-14 EP EP14762263.3A patent/EP2997352A4/en not_active Withdrawn
- 2014-03-14 CA CA2906124A patent/CA2906124A1/en not_active Abandoned
- 2014-03-14 HK HK16102826.8A patent/HK1214863A1/zh unknown
- 2014-03-14 CN CN201480015786.2A patent/CN105339780A/zh active Pending
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