JP2016518439A5 - - Google Patents
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- Publication number
- JP2016518439A5 JP2016518439A5 JP2016513431A JP2016513431A JP2016518439A5 JP 2016518439 A5 JP2016518439 A5 JP 2016518439A5 JP 2016513431 A JP2016513431 A JP 2016513431A JP 2016513431 A JP2016513431 A JP 2016513431A JP 2016518439 A5 JP2016518439 A5 JP 2016518439A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- layer
- composition according
- hydrocortisone
- contact
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 25
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 14
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 12
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 12
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 12
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 12
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 10
- 229960000890 hydrocortisone Drugs 0.000 claims 7
- 238000007789 sealing Methods 0.000 claims 7
- 239000001856 Ethyl cellulose Substances 0.000 claims 5
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 5
- 235000019325 ethyl cellulose Nutrition 0.000 claims 5
- 229920001249 ethyl cellulose Polymers 0.000 claims 5
- 235000019359 magnesium stearate Nutrition 0.000 claims 5
- 230000000873 masking effect Effects 0.000 claims 5
- 229920000642 polymer Polymers 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000011230 binding agent Substances 0.000 claims 3
- 206010001367 Adrenal insufficiency Diseases 0.000 claims 2
- 208000005676 Adrenogenital syndrome Diseases 0.000 claims 2
- 208000008448 Congenital adrenal hyperplasia Diseases 0.000 claims 2
- 208000017515 adrenocortical insufficiency Diseases 0.000 claims 2
- 239000010419 fine particle Substances 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000009747 swallowing Effects 0.000 claims 2
- 206010020571 Hyperaldosteronism Diseases 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- 230000001919 adrenal effect Effects 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 208000015124 ovarian disease Diseases 0.000 claims 1
- 201000004535 ovarian dysfunction Diseases 0.000 claims 1
- 231100000543 ovarian dysfunction Toxicity 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1308933.9 | 2013-05-17 | ||
| GBGB1308933.9A GB201308933D0 (en) | 2013-05-17 | 2013-05-17 | Paediatric composition |
| PCT/GB2014/051442 WO2014184525A1 (en) | 2013-05-17 | 2014-05-12 | Composition comprising hydrocortisone |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016518439A JP2016518439A (ja) | 2016-06-23 |
| JP2016518439A5 true JP2016518439A5 (enExample) | 2017-06-08 |
| JP6371379B2 JP6371379B2 (ja) | 2018-08-08 |
Family
ID=48746932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513431A Active JP6371379B2 (ja) | 2013-05-17 | 2014-05-12 | ヒドロコルチゾンを含有する組成物 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US9649280B2 (enExample) |
| EP (1) | EP2978414B1 (enExample) |
| JP (1) | JP6371379B2 (enExample) |
| KR (1) | KR102219919B1 (enExample) |
| CN (1) | CN105120848B (enExample) |
| AU (1) | AU2014267041B2 (enExample) |
| BR (1) | BR112015028025B1 (enExample) |
| CA (1) | CA2909060C (enExample) |
| CY (1) | CY1123284T1 (enExample) |
| DK (1) | DK2978414T3 (enExample) |
| ES (1) | ES2813382T3 (enExample) |
| GB (2) | GB201308933D0 (enExample) |
| HR (1) | HRP20201315T1 (enExample) |
| HU (1) | HUE050917T2 (enExample) |
| IL (1) | IL242275B (enExample) |
| LT (1) | LT2978414T (enExample) |
| MX (1) | MX379168B (enExample) |
| PL (1) | PL2978414T3 (enExample) |
| PT (1) | PT2978414T (enExample) |
| RS (1) | RS60734B1 (enExample) |
| RU (1) | RU2664678C2 (enExample) |
| SI (1) | SI2978414T1 (enExample) |
| SM (1) | SMT202000473T1 (enExample) |
| WO (1) | WO2014184525A1 (enExample) |
| ZA (1) | ZA201507210B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201119985D0 (en) | 2011-11-19 | 2012-01-04 | Diurnal Ltd | Treatment of adrenal insufficiency |
| GB201308933D0 (en) | 2013-05-17 | 2013-07-03 | Diurnal Ltd | Paediatric composition |
| US20190180872A1 (en) * | 2017-12-12 | 2019-06-13 | International Business Machines Corporation | Second Opinion Decision Support Using Patient Electronic Medical Records |
| WO2025144994A1 (en) * | 2023-12-29 | 2025-07-03 | Regents Of The University Of Minnesota | Compositions and methods for intranasal delivery of hydrocortisone |
| WO2025240605A1 (en) | 2024-05-15 | 2025-11-20 | Neurocrine Biosciences, Inc. | Combination treatment |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2062634T3 (es) | 1990-08-30 | 1994-12-16 | Senju Pharma Co | Composicion con liberacion controlada del farmaco. |
| DK0876142T3 (da) | 1996-01-16 | 2001-11-19 | Advanced Polymer Systems Inc | Topisk tilførsel af lægemidler til den nedre mavetarmkanal |
| KR20040016202A (ko) * | 2002-08-16 | 2004-02-21 | 주식회사 제이알팜 | 쓴맛이 차폐된 히드로코르티손 경구용 약제 조성물 및 그제조방법 |
| JP2007533697A (ja) | 2004-04-22 | 2007-11-22 | デュオコート エービー | グルココルチコイド救急治療用の医薬組成物 |
| SE0401031D0 (sv) | 2004-04-22 | 2004-04-22 | Duocort Ab | A new glucocorticoid replacement therapy |
| RU2382637C2 (ru) * | 2004-04-30 | 2010-02-27 | Астеллас Фарма Инк. | Фармацевтическая композиция для перорального введения в форме частиц с рассчитанным временем высвобождения и быстро распадающиеся таблетки, содержащие указанную композицию |
| RU2385156C2 (ru) * | 2004-05-31 | 2010-03-27 | Лабораториос Альмираль С.А. | Комбинации, содержащие антимускариновые средства и кортикостероиды |
| US20070281007A1 (en) * | 2004-08-27 | 2007-12-06 | Jacob Jules S | Mucoadhesive Oral Formulations of High Permeability, High Solubility Drugs |
| RU2290940C2 (ru) * | 2004-10-18 | 2007-01-10 | Государственное образовательное учреждение высшего профессионального образования "Нижегородская Государственная Медицинская академия" МЗ РФ (ГОУ ВПО НижГМА) | Средство для коррекции острой почечной недостаточности при токсическом гепаторенальном синдроме, индуцированном четыреххлористым углеродом, и способ коррекции острой почечной недостаточности при токсическом гепаторенальном синдроме, индуцированном четыреххлористым углеродом |
| WO2007053197A2 (en) * | 2005-06-03 | 2007-05-10 | Elan Pharma International, Limited | Nanoparticulate acetaminophen formulations |
| WO2008126076A2 (en) * | 2007-04-11 | 2008-10-23 | Perrigo Israel Pharmaceuticals Ltd. | Low-dose mometasone formulations |
| GB0817120D0 (en) | 2008-09-19 | 2008-10-29 | Diurnal Ltd | Treatment of adrenal insufficiency |
| NZ595428A (en) | 2009-04-07 | 2013-04-26 | Duocourt Pharma Ab | Improved glucocorticoid therapy |
| KR20150043548A (ko) * | 2009-10-01 | 2015-04-22 | 앱탈리스 파마테크, 인코포레이티드 | 경구 투여용 코르티코스테로이드 조성물 |
| SG10201407965XA (en) * | 2009-12-02 | 2015-02-27 | Aptalis Pharma Ltd | Fexofenadine microcapsules and compositions containing them |
| BR112012029466A2 (pt) | 2010-05-20 | 2017-03-01 | Duocort Phama Ab | "composição de glicocorticoide, método melhorado para tratar a deficiência de glicocorticoide, e, método para dar origem a uma dosagem individualizada de glicocorticoides" |
| GB201119985D0 (en) * | 2011-11-19 | 2012-01-04 | Diurnal Ltd | Treatment of adrenal insufficiency |
| GB201308933D0 (en) | 2013-05-17 | 2013-07-03 | Diurnal Ltd | Paediatric composition |
-
2013
- 2013-05-17 GB GBGB1308933.9A patent/GB201308933D0/en not_active Ceased
-
2014
- 2014-05-12 MX MX2015015759A patent/MX379168B/es unknown
- 2014-05-12 DK DK14727028.4T patent/DK2978414T3/da active
- 2014-05-12 LT LTEP14727028.4T patent/LT2978414T/lt unknown
- 2014-05-12 US US14/888,648 patent/US9649280B2/en active Active
- 2014-05-12 AU AU2014267041A patent/AU2014267041B2/en active Active
- 2014-05-12 CA CA2909060A patent/CA2909060C/en active Active
- 2014-05-12 JP JP2016513431A patent/JP6371379B2/ja active Active
- 2014-05-12 PT PT147270284T patent/PT2978414T/pt unknown
- 2014-05-12 RS RS20201002A patent/RS60734B1/sr unknown
- 2014-05-12 WO PCT/GB2014/051442 patent/WO2014184525A1/en not_active Ceased
- 2014-05-12 EP EP14727028.4A patent/EP2978414B1/en active Active
- 2014-05-12 SM SM20200473T patent/SMT202000473T1/it unknown
- 2014-05-12 SI SI201431640T patent/SI2978414T1/sl unknown
- 2014-05-12 HR HRP20201315TT patent/HRP20201315T1/hr unknown
- 2014-05-12 CN CN201480021880.9A patent/CN105120848B/zh active Active
- 2014-05-12 HU HUE14727028A patent/HUE050917T2/hu unknown
- 2014-05-12 GB GB1516973.3A patent/GB2527233B/en active Active
- 2014-05-12 KR KR1020157035705A patent/KR102219919B1/ko active Active
- 2014-05-12 PL PL14727028T patent/PL2978414T3/pl unknown
- 2014-05-12 ES ES14727028T patent/ES2813382T3/es active Active
- 2014-05-12 RU RU2015150303A patent/RU2664678C2/ru active
- 2014-05-12 BR BR112015028025-0A patent/BR112015028025B1/pt active IP Right Grant
-
2015
- 2015-09-29 ZA ZA2015/07210A patent/ZA201507210B/en unknown
- 2015-10-26 IL IL242275A patent/IL242275B/en active IP Right Grant
-
2020
- 2020-08-27 CY CY20201100803T patent/CY1123284T1/el unknown
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