JP2016517409A5 - - Google Patents
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- Publication number
- JP2016517409A5 JP2016517409A5 JP2016500472A JP2016500472A JP2016517409A5 JP 2016517409 A5 JP2016517409 A5 JP 2016517409A5 JP 2016500472 A JP2016500472 A JP 2016500472A JP 2016500472 A JP2016500472 A JP 2016500472A JP 2016517409 A5 JP2016517409 A5 JP 2016517409A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- hydrogen
- linear
- hydroxymethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C[C@]1(C(*)CC(*)C(*)C1)C(CC1)C(*)C2C1(*)C(*)(*)C(*)C2 Chemical compound C[C@]1(C(*)CC(*)C(*)C1)C(CC1)C(*)C2C1(*)C(*)(*)C(*)C2 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361786020P | 2013-03-14 | 2013-03-14 | |
| US61/786,020 | 2013-03-14 | ||
| PCT/US2014/019126 WO2014158654A1 (en) | 2013-03-14 | 2014-02-27 | Ship1 modulators and methods related thereto |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016517409A JP2016517409A (ja) | 2016-06-16 |
| JP2016517409A5 true JP2016517409A5 (OSRAM) | 2017-02-09 |
| JP6407951B2 JP6407951B2 (ja) | 2018-10-17 |
Family
ID=50288307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500472A Expired - Fee Related JP6407951B2 (ja) | 2013-03-14 | 2014-02-27 | Ｓｈｉｐ１モジュレーターおよびそれに関連する組成物および方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9765085B2 (OSRAM) |
| EP (1) | EP2970122B1 (OSRAM) |
| JP (1) | JP6407951B2 (OSRAM) |
| KR (3) | KR20220110337A (OSRAM) |
| CN (2) | CN108892637A (OSRAM) |
| AU (1) | AU2014242041B2 (OSRAM) |
| BR (1) | BR112015023009A2 (OSRAM) |
| CA (1) | CA2902768A1 (OSRAM) |
| ES (1) | ES2740779T3 (OSRAM) |
| IL (1) | IL240968A0 (OSRAM) |
| MX (1) | MX2015012111A (OSRAM) |
| RU (1) | RU2679805C2 (OSRAM) |
| WO (1) | WO2014158654A1 (OSRAM) |
| ZA (1) | ZA201506674B (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9540353B2 (en) | 2013-01-09 | 2017-01-10 | Aquinox Pharmaceuticals (Canada) Inc. | SHIP1 modulators and methods related thereto |
| RU2015143675A (ru) | 2013-03-14 | 2017-04-27 | Экуинокс Фармасьютикалз (Кэнэда) Инк. | Ship1 модуляторы и относящиеся к ним способы |
| KR20220110337A (ko) | 2013-03-14 | 2022-08-05 | 에퀴녹스 파머수티칼스 (캐나다) 인코포레이티드 | Ship1 조절제 및 그와 관련된 방법 |
| US9944590B2 (en) | 2015-06-26 | 2018-04-17 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol |
| US10053415B2 (en) | 2016-01-20 | 2018-08-21 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
| WO2017149052A1 (en) * | 2016-03-02 | 2017-09-08 | Patheon Austria Gmbh Co. & Kg | Process and intermediates for the production of 17(20)-ene b-seco steroids |
| WO2018126040A1 (en) | 2016-12-28 | 2018-07-05 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of (1s,3s,4r)-4-((3as,4r,5s,7as)-4- (aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3- (hydroxymethyl)-4-methylcyclohexanol |
| CN112533905A (zh) * | 2018-04-06 | 2021-03-19 | 塔罗制药公司 | 可用于治疗疼痛和炎症的茚衍生物 |
| CN112654632A (zh) | 2018-04-06 | 2021-04-13 | 塔罗制药公司 | 可用于治疗疼痛和炎症的十六氢-1H-环戊二烯并[a]菲衍生物 |
| IL277904B2 (en) | 2018-04-06 | 2024-05-01 | Aquinox Pharmaceuticals Canada Inc | History of indan for use in the treatment of pain and inflammation |
| CN112940062B (zh) * | 2021-02-23 | 2022-09-06 | 浙江神洲药业有限公司 | 一种16-去氢黄体酮的制备方法 |
| CN117024374A (zh) * | 2023-08-08 | 2023-11-10 | 安庆百谊生物科技有限公司 | 一种3-甲基-1，2，4-噻二唑-5-碳酰肼或其盐的合成方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1084718B (de) | 1958-07-08 | 1960-07-07 | Bayer Ag | Verfahren zur Herstellung von Secosteroiden |
| SE345995B (OSRAM) | 1969-01-31 | 1972-06-19 | Bristol Myers Co | |
| US3682983A (en) | 1969-11-12 | 1972-08-08 | Klaus Prezewowsky | Preparation of {66 {11 {11 -17 ethinyl steroids |
| US3962275A (en) | 1972-06-05 | 1976-06-08 | Hoffmann-La Roche Inc. | 7-oxa steroids |
| US3869467A (en) | 1972-06-05 | 1975-03-04 | Hoffmann La Roche | 17-{62 -Hydroxy-17-{60 -methyl-5-{60 -androstano{9 3,2-c{9 or{8 2,3-d{9 isoxazoles |
| JPH01290624A (ja) | 1988-05-16 | 1989-11-22 | Shiono Chem Kk | ５，６―セコ―ステロール誘導体血清脂質低下剤 |
| WO1993013124A1 (en) | 1991-12-20 | 1993-07-08 | Glaxo Inc. | Inhibitors of 5-alpha-testosterone reductase |
| JPH05221901A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール誘導体 |
| JPH05221924A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール化合物 |
| US5464866A (en) | 1992-08-17 | 1995-11-07 | Alcon Laboratories, Inc. | Substituted hydrindanes for the treatment of angiogenesis-dependent diseases |
| AP459A (en) | 1992-12-18 | 1996-02-14 | Glaxo Wellcome Inc | Substituted 6-azaandrostenones. |
| DK0707566T3 (da) | 1993-07-09 | 2000-09-04 | Theramex | Hidtil ukendte strukturelle analoger til vitamin D |
| US5541322A (en) | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
| US6046185A (en) | 1996-07-11 | 2000-04-04 | Inflazyme Pharmaceuticals Ltd. | 6,7-oxygenated steroids and uses related thereto |
| EP1118654A4 (en) | 1999-04-16 | 2007-03-07 | Nippon Mitsubishi Oil Corp | TRACTION DRIVE FLUIDS |
| DK1278763T3 (da) | 2000-04-28 | 2007-06-11 | Inflazyme Pharm Ltd | 3-Nitrogen-6,7-dioxygensteroider og anvendelser relateret dertil |
| JP2004534042A (ja) | 2001-05-22 | 2004-11-11 | インフラジム ファーマシューティカルズ リミテッド | ステロイド−５−エン化合物のステロイド−５−エン−７−オン化合物へのアリル酸化、続くヒドロホウ素化および酸化による、６，７−ジヒドロキシステロイドの生成のための方法およびこの方法の中間体 |
| WO2004035601A1 (en) | 2002-10-17 | 2004-04-29 | The University Of British Columbia | Ship 1 modulators |
| CA2463136A1 (en) | 2001-10-17 | 2003-04-24 | Raymond Andersen | Ship 1 modulators |
| ES2359916T3 (es) * | 2003-04-15 | 2011-05-30 | Aquinox Pharmaceuticals Inc. | Derivados de indeno como agentes farmacéuticos. |
| WO2007147251A1 (en) | 2006-06-21 | 2007-12-27 | The University Of British Columbia | Ship 1 modulator compounds |
| WO2008038965A1 (en) * | 2006-09-26 | 2008-04-03 | Kyungpook National University Industry-Academic Cooperation Foundation | 7alpha-aminosteroid derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for anticancer or antibiotics containing the same as an active ingredient |
| US8101605B2 (en) | 2009-12-04 | 2012-01-24 | Aquinox Pharmaceuticals Inc. | SHIP1 modulators and methods related thereto |
| EP2605767B1 (en) | 2010-08-20 | 2016-07-27 | The University Of British Columbia | Ship1 modulators and related methods |
| AU2011343970A1 (en) * | 2010-12-13 | 2013-07-04 | Rutgers University | Methods of producing and using brassinosteroids to promote growth, repair and maintenance of skeletal muscle and skin |
| KR20220110337A (ko) | 2013-03-14 | 2022-08-05 | 에퀴녹스 파머수티칼스 (캐나다) 인코포레이티드 | Ship1 조절제 및 그와 관련된 방법 |
| RU2015143675A (ru) | 2013-03-14 | 2017-04-27 | Экуинокс Фармасьютикалз (Кэнэда) Инк. | Ship1 модуляторы и относящиеся к ним способы |
| US9944590B2 (en) | 2015-06-26 | 2018-04-17 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol |
| US10053415B2 (en) | 2016-01-20 | 2018-08-21 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
| WO2018058144A1 (en) | 2016-09-26 | 2018-03-29 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1 activator for treating prostatis |
-
2014
- 2014-02-27 KR KR1020227025934A patent/KR20220110337A/ko not_active Abandoned
- 2014-02-27 MX MX2015012111A patent/MX2015012111A/es unknown
- 2014-02-27 ES ES14710727T patent/ES2740779T3/es active Active
- 2014-02-27 AU AU2014242041A patent/AU2014242041B2/en not_active Ceased
- 2014-02-27 WO PCT/US2014/019126 patent/WO2014158654A1/en not_active Ceased
- 2014-02-27 US US14/772,731 patent/US9765085B2/en not_active Expired - Fee Related
- 2014-02-27 CN CN201810634778.6A patent/CN108892637A/zh active Pending
- 2014-02-27 EP EP14710727.0A patent/EP2970122B1/en active Active
- 2014-02-27 RU RU2015143676A patent/RU2679805C2/ru active
- 2014-02-27 CA CA2902768A patent/CA2902768A1/en not_active Abandoned
- 2014-02-27 KR KR1020217030879A patent/KR102427491B1/ko active Active
- 2014-02-27 BR BR112015023009A patent/BR112015023009A2/pt not_active Application Discontinuation
- 2014-02-27 JP JP2016500472A patent/JP6407951B2/ja not_active Expired - Fee Related
- 2014-02-27 KR KR1020157028154A patent/KR102308319B1/ko not_active Expired - Fee Related
- 2014-02-27 CN CN201480024563.2A patent/CN105164108B/zh not_active Expired - Fee Related
-
2015
- 2015-08-31 IL IL240968A patent/IL240968A0/en unknown
- 2015-09-09 ZA ZA2015/06674A patent/ZA201506674B/en unknown
-
2017
- 2017-08-14 US US15/676,726 patent/US10174046B2/en active Active
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