JP2016517405A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016517405A5 JP2016517405A5 JP2015562539A JP2015562539A JP2016517405A5 JP 2016517405 A5 JP2016517405 A5 JP 2016517405A5 JP 2015562539 A JP2015562539 A JP 2015562539A JP 2015562539 A JP2015562539 A JP 2015562539A JP 2016517405 A5 JP2016517405 A5 JP 2016517405A5
- Authority
- JP
- Japan
- Prior art keywords
- idpsc
- stem cells
- isolated population
- disease
- idpscs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 96
- 239000000203 mixture Substances 0.000 claims description 50
- 210000004027 cell Anatomy 0.000 claims description 34
- 239000003550 marker Substances 0.000 claims description 31
- 210000005258 dental pulp stem cell Anatomy 0.000 claims description 20
- 210000001178 neural stem cell Anatomy 0.000 claims description 20
- 102000034615 Glial cell line-derived neurotrophic factor Human genes 0.000 claims description 16
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 claims description 16
- 102000004230 Neurotrophin 3 Human genes 0.000 claims description 16
- 108090000742 Neurotrophin 3 Proteins 0.000 claims description 16
- 238000003306 harvesting Methods 0.000 claims description 16
- 229940032018 neurotrophin 3 Drugs 0.000 claims description 16
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims description 13
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims description 13
- 208000016192 Demyelinating disease Diseases 0.000 claims description 12
- 238000012258 culturing Methods 0.000 claims description 12
- 102100022595 Broad substrate specificity ATP-binding cassette transporter ABCG2 Human genes 0.000 claims description 10
- 101710176164 Broad substrate specificity ATP-binding cassette transporter ABCG2 Proteins 0.000 claims description 10
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 claims description 10
- 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 claims description 10
- 102100035721 Syndecan-1 Human genes 0.000 claims description 10
- 108090000058 Syndecan-1 Proteins 0.000 claims description 10
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims description 10
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims description 10
- 102100023995 Beta-nerve growth factor Human genes 0.000 claims description 9
- 101710129634 Beta-nerve growth factor Proteins 0.000 claims description 9
- 108010025020 Nerve Growth Factor Proteins 0.000 claims description 9
- 102000007072 Nerve Growth Factors Human genes 0.000 claims description 9
- 230000004770 neurodegeneration Effects 0.000 claims description 9
- 210000000130 stem cell Anatomy 0.000 claims description 8
- 101100257359 Caenorhabditis elegans sox-2 gene Proteins 0.000 claims description 7
- 108010067306 Fibronectins Proteins 0.000 claims description 7
- 101100310657 Mus musculus Sox1 gene Proteins 0.000 claims description 7
- 101100257363 Mus musculus Sox2 gene Proteins 0.000 claims description 7
- 101150086694 SLC22A3 gene Proteins 0.000 claims description 7
- 210000004209 hair Anatomy 0.000 claims description 7
- 210000005036 nerve Anatomy 0.000 claims description 7
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 7
- 239000003900 neurotrophic factor Substances 0.000 claims description 7
- 210000003994 retinal ganglion cell Anatomy 0.000 claims description 7
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 6
- 102100026802 72 kDa type IV collagenase Human genes 0.000 claims description 5
- 101710151806 72 kDa type IV collagenase Proteins 0.000 claims description 5
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims description 5
- 102000012422 Collagen Type I Human genes 0.000 claims description 5
- 108010022452 Collagen Type I Proteins 0.000 claims description 5
- 102000006354 HLA-DR Antigens Human genes 0.000 claims description 5
- 108010058597 HLA-DR Antigens Proteins 0.000 claims description 5
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 claims description 5
- 101001008874 Homo sapiens Mast/stem cell growth factor receptor Kit Proteins 0.000 claims description 5
- 101000692109 Homo sapiens Syndecan-2 Proteins 0.000 claims description 5
- 101000692107 Homo sapiens Syndecan-3 Proteins 0.000 claims description 5
- 101000740519 Homo sapiens Syndecan-4 Proteins 0.000 claims description 5
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims description 5
- 102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 claims description 5
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims description 5
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 claims description 5
- 206010072170 Skin wound Diseases 0.000 claims description 5
- 102100026087 Syndecan-2 Human genes 0.000 claims description 5
- 102100026084 Syndecan-3 Human genes 0.000 claims description 5
- 102100037220 Syndecan-4 Human genes 0.000 claims description 5
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims description 5
- 208000019622 heart disease Diseases 0.000 claims description 5
- 230000001464 adherent effect Effects 0.000 claims description 4
- 239000002537 cosmetic Substances 0.000 claims description 4
- 230000034994 death Effects 0.000 claims description 4
- 230000006862 enzymatic digestion Effects 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000021595 spermatogenesis Effects 0.000 claims description 4
- 201000004384 Alopecia Diseases 0.000 claims description 3
- 201000011240 Frontotemporal dementia Diseases 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 208000001647 Renal Insufficiency Diseases 0.000 claims description 3
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims description 3
- 239000003242 anti bacterial agent Substances 0.000 claims description 3
- 229940088710 antibiotic agent Drugs 0.000 claims description 3
- 201000011510 cancer Diseases 0.000 claims description 3
- 230000006378 damage Effects 0.000 claims description 3
- 230000003676 hair loss Effects 0.000 claims description 3
- 201000006370 kidney failure Diseases 0.000 claims description 3
- 210000002569 neuron Anatomy 0.000 claims description 3
- 229930002330 retinoic acid Natural products 0.000 claims description 3
- 208000020431 spinal cord injury Diseases 0.000 claims description 3
- 239000008174 sterile solution Substances 0.000 claims description 3
- 229960001727 tretinoin Drugs 0.000 claims description 3
- 208000024827 Alzheimer disease Diseases 0.000 claims description 2
- 208000030939 Chronic inflammatory demyelinating polyneuropathy Diseases 0.000 claims description 2
- 208000027932 Collagen disease Diseases 0.000 claims description 2
- 206010010957 Copper deficiency Diseases 0.000 claims description 2
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims description 2
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims description 2
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims description 2
- 206010016717 Fistula Diseases 0.000 claims description 2
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims description 2
- 208000023105 Huntington disease Diseases 0.000 claims description 2
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims description 2
- 206010029260 Neuroblastoma Diseases 0.000 claims description 2
- 208000029067 Neuromyelitis optica spectrum disease Diseases 0.000 claims description 2
- 208000018737 Parkinson disease Diseases 0.000 claims description 2
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims description 2
- 208000024571 Pick disease Diseases 0.000 claims description 2
- 208000024777 Prion disease Diseases 0.000 claims description 2
- 201000000582 Retinoblastoma Diseases 0.000 claims description 2
- 206010040943 Skin Ulcer Diseases 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 claims description 2
- 208000036815 beta tubulin Diseases 0.000 claims description 2
- 201000005795 chronic inflammatory demyelinating polyneuritis Diseases 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 210000003981 ectoderm Anatomy 0.000 claims description 2
- 210000001900 endoderm Anatomy 0.000 claims description 2
- 230000003890 fistula Effects 0.000 claims description 2
- 230000002757 inflammatory effect Effects 0.000 claims description 2
- 208000014674 injury Diseases 0.000 claims description 2
- 208000028867 ischemia Diseases 0.000 claims description 2
- 208000036546 leukodystrophy Diseases 0.000 claims description 2
- 210000003716 mesoderm Anatomy 0.000 claims description 2
- 201000006417 multiple sclerosis Diseases 0.000 claims description 2
- 230000023105 myelination Effects 0.000 claims description 2
- 208000010125 myocardial infarction Diseases 0.000 claims description 2
- 210000000933 neural crest Anatomy 0.000 claims description 2
- 208000008795 neuromyelitis optica Diseases 0.000 claims description 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 2
- 206010036807 progressive multifocal leukoencephalopathy Diseases 0.000 claims description 2
- 231100000019 skin ulcer Toxicity 0.000 claims description 2
- 210000000278 spinal cord Anatomy 0.000 claims description 2
- 208000009174 transverse myelitis Diseases 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 102000016359 Fibronectins Human genes 0.000 claims 3
- 210000004556 brain Anatomy 0.000 claims 3
- 210000004748 cultured cell Anatomy 0.000 claims 3
- 201000010235 heart cancer Diseases 0.000 claims 2
- 208000024348 heart neoplasm Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 102000006386 Myelin Proteins Human genes 0.000 claims 1
- 108010083674 Myelin Proteins Proteins 0.000 claims 1
- 208000003435 Optic Neuritis Diseases 0.000 claims 1
- 208000010641 Tooth disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000003128 head Anatomy 0.000 claims 1
- 210000005012 myelin Anatomy 0.000 claims 1
- 208000002670 vitamin B12 deficiency Diseases 0.000 claims 1
- 210000003074 dental pulp Anatomy 0.000 description 32
- 239000002609 medium Substances 0.000 description 11
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 description 10
- 206010021143 Hypoxia Diseases 0.000 description 8
- 108090000099 Neurotrophin-4 Proteins 0.000 description 8
- 102100033857 Neurotrophin-4 Human genes 0.000 description 8
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 6
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 6
- 102000008730 Nestin Human genes 0.000 description 6
- 108010088225 Nestin Proteins 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
- 210000002744 extracellular matrix Anatomy 0.000 description 6
- 230000001146 hypoxic effect Effects 0.000 description 6
- 210000005055 nestin Anatomy 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- 210000003491 skin Anatomy 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 4
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 4
- 102100037362 Fibronectin Human genes 0.000 description 4
- 102000015098 Tumor Suppressor Protein p53 Human genes 0.000 description 4
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 4
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 4
- 230000001537 neural effect Effects 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 102100022749 Aminopeptidase N Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 3
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 description 3
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 description 3
- 101710202239 Tubulin beta-3 chain Proteins 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 230000002207 retinal effect Effects 0.000 description 3
- 102100022464 5'-nucleotidase Human genes 0.000 description 2
- 102100032912 CD44 antigen Human genes 0.000 description 2
- 108091016585 CD44 antigen Proteins 0.000 description 2
- 102100037241 Endoglin Human genes 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 208000003098 Ganglion Cysts Diseases 0.000 description 2
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 2
- 102000008055 Heparan Sulfate Proteoglycans Human genes 0.000 description 2
- 229920002971 Heparan sulfate Polymers 0.000 description 2
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 description 2
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 2
- 101000881679 Homo sapiens Endoglin Proteins 0.000 description 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 2
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 description 2
- 101000608935 Homo sapiens Leukosialin Proteins 0.000 description 2
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 2
- 101000687905 Homo sapiens Transcription factor SOX-2 Proteins 0.000 description 2
- 102100025304 Integrin beta-1 Human genes 0.000 description 2
- 102100026879 Interleukin-2 receptor subunit beta Human genes 0.000 description 2
- 229930182816 L-glutamine Natural products 0.000 description 2
- 108010085895 Laminin Proteins 0.000 description 2
- 102000007547 Laminin Human genes 0.000 description 2
- 102100039564 Leukosialin Human genes 0.000 description 2
- -1 NT4 Proteins 0.000 description 2
- 102100037369 Nidogen-1 Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 108010039918 Polylysine Proteins 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
- 108090000054 Syndecan-2 Proteins 0.000 description 2
- 208000005400 Synovial Cyst Diseases 0.000 description 2
- 102100024270 Transcription factor SOX-2 Human genes 0.000 description 2
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 description 2
- 102000013127 Vimentin Human genes 0.000 description 2
- 108010065472 Vimentin Proteins 0.000 description 2
- 108010031318 Vitronectin Proteins 0.000 description 2
- 102100035140 Vitronectin Human genes 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 239000007640 basal medium Substances 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 230000007850 degeneration Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 230000007954 hypoxia Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 108010082117 matrigel Proteins 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 210000003757 neuroblast Anatomy 0.000 description 2
- 108010008217 nidogen Proteins 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 210000003668 pericyte Anatomy 0.000 description 2
- 210000001428 peripheral nervous system Anatomy 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 210000001778 pluripotent stem cell Anatomy 0.000 description 2
- 229920000656 polylysine Polymers 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 210000004357 third molar Anatomy 0.000 description 2
- 210000005048 vimentin Anatomy 0.000 description 2
- WOVKYSAHUYNSMH-RRKCRQDMSA-N 5-bromodeoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-RRKCRQDMSA-N 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 208000010693 Charcot-Marie-Tooth Disease Diseases 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical group OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 125000003338 L-glutaminyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C(=O)N([H])[H] 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 210000001130 astrocyte Anatomy 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000004413 cardiac myocyte Anatomy 0.000 description 1
- 238000002659 cell therapy Methods 0.000 description 1
- 208000015114 central nervous system disease Diseases 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 210000003061 neural cell Anatomy 0.000 description 1
- 210000004498 neuroglial cell Anatomy 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 230000004031 neuronal differentiation Effects 0.000 description 1
- 210000004248 oligodendroglia Anatomy 0.000 description 1
- 231100000590 oncogenic Toxicity 0.000 description 1
- 230000002246 oncogenic effect Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000037393 skin firmness Effects 0.000 description 1
- 210000000603 stem cell niche Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000007998 vessel formation Effects 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019037436A JP6920363B2 (ja) | 2013-03-15 | 2019-03-01 | 多機能未成熟歯髄幹細胞および療法適用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361800245P | 2013-03-15 | 2013-03-15 | |
| US201361791594P | 2013-03-15 | 2013-03-15 | |
| US61/791,594 | 2013-03-15 | ||
| US61/800,245 | 2013-03-15 | ||
| PCT/IB2014/059850 WO2014141210A2 (en) | 2013-03-15 | 2014-03-15 | Multifunctional immature dental pulp stem cells and therapeutic applications |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019037436A Division JP6920363B2 (ja) | 2013-03-15 | 2019-03-01 | 多機能未成熟歯髄幹細胞および療法適用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016517405A JP2016517405A (ja) | 2016-06-16 |
| JP2016517405A5 true JP2016517405A5 (OSRAM) | 2017-04-20 |
| JP6491606B2 JP6491606B2 (ja) | 2019-03-27 |
Family
ID=51538238
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015562539A Active JP6491606B2 (ja) | 2013-03-15 | 2014-03-15 | 多機能未成熟歯髄幹細胞および療法適用 |
| JP2019037436A Active JP6920363B2 (ja) | 2013-03-15 | 2019-03-01 | 多機能未成熟歯髄幹細胞および療法適用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019037436A Active JP6920363B2 (ja) | 2013-03-15 | 2019-03-01 | 多機能未成熟歯髄幹細胞および療法適用 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9790468B2 (OSRAM) |
| EP (2) | EP2970880B1 (OSRAM) |
| JP (2) | JP6491606B2 (OSRAM) |
| BR (1) | BR102014006335B8 (OSRAM) |
| CA (1) | CA2904804A1 (OSRAM) |
| IL (2) | IL280850B2 (OSRAM) |
| WO (1) | WO2014141210A2 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11278574B2 (en) | 2013-03-15 | 2022-03-22 | Avita International Ltd. | Use of stem cells expressing mesenchymal and neuronal markers and compositions thereof to treat neurological disease |
| US11207352B2 (en) | 2013-03-15 | 2021-12-28 | Avita International Ltd. | Compositions comprising stem cells expressing mesenchymal and neuronal markers and uses thereof to treat neurological disease |
| US11306290B2 (en) | 2013-03-15 | 2022-04-19 | Avita International Ltd. | Stem cells expressing mesenchymal and neuronal markers, compositions thereof, and methods of preparation thereof |
| RU2714236C2 (ru) * | 2014-08-14 | 2020-02-13 | Авита Интернэшнл Лтд. | Композиции стволовых клеток и способы получения стволовых клеток для применения в терапии |
| EP3426267B1 (en) * | 2016-03-09 | 2023-01-11 | Avita International Ltd. | Uses of dental pulp stem cells expressing mesenchymal and neuronal markers and compositions thereof to treat neurological disease |
| GB201703058D0 (en) * | 2017-02-24 | 2017-04-12 | Ucl Business Plc | Biomarkers |
| US20190167724A1 (en) * | 2017-12-04 | 2019-06-06 | Caire Medical-Biotechnology International Co. | Neuroprotective composition, preparation process thereof and medical uses thereof |
| US20210236557A1 (en) * | 2018-04-30 | 2021-08-05 | Avita Internatonal Ltd. | Immature dental pulp stem cells and methods of use to treat bone marrow failure |
| US20210244773A1 (en) * | 2018-05-02 | 2021-08-12 | Leslie Morse | Dental pulp stem cells and uses thereof |
| US20220211764A1 (en) * | 2019-05-14 | 2022-07-07 | University Of Tsukuba | Neural cell population, neural cell-containing preparation, and method for producing said population and preparation |
| KR20210029569A (ko) * | 2019-09-06 | 2021-03-16 | 경상국립대학교산학협력단 | 치아 주변조직 유래 다분화능 줄기세포를 포함하는 비만 또는 비알코올성 지방간의 예방 또는 치료용 약학적 조성물 |
| WO2023227972A1 (en) | 2022-05-24 | 2023-11-30 | Iceta - Instituto De Ciências, Tecnologias E Agroambiente Da Universidade Do Porto | Process for preparation and cryopreservation of dental pulp from definitive teeth and products thereof based on isolated mesenchymal stem cells |
| WO2024166074A1 (en) * | 2023-02-10 | 2024-08-15 | Avita International Ltd. | Method of producing and preparation of exosomes (nestaexo) derived from human immature dental pulp stem cells for therapeutic applications |
| CN119868281B (zh) * | 2025-03-28 | 2025-06-24 | 新北辰(湖北)生物科技集团有限公司 | 一种含有牙髓干细胞的修复注射制剂及其制备方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650148A (en) | 1988-12-15 | 1997-07-22 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system |
| US5082670A (en) | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
| US5612211A (en) | 1990-06-08 | 1997-03-18 | New York University | Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors |
| US5693482A (en) | 1992-07-27 | 1997-12-02 | California Institute Of Technology | Neural chest stem cell assay |
| US7927587B2 (en) | 1999-08-05 | 2011-04-19 | Regents Of The University Of Minnesota | MAPC administration for the treatment of lysosomal storage disorders |
| GB0003930D0 (en) | 2000-02-18 | 2000-04-12 | King S College London | Cell |
| WO2001076507A2 (en) | 2000-04-11 | 2001-10-18 | The University Of Miami | Use of oxygen carriers to improve grafted cell survival in neural transplantation |
| AU7707801A (en) | 2000-07-21 | 2002-02-05 | Us Health | Adult human dental pulp stem cells in vitro and in vivo |
| US6899915B2 (en) | 2000-11-29 | 2005-05-31 | President And Fellows Of Harvard College | Methods and compositions for culturing a biological tooth |
| AUPR540301A0 (en) * | 2001-06-01 | 2001-06-28 | Walter And Eliza Hall Institute Of Medical Research, The | A method of purification of cells |
| CA2474141A1 (en) | 2002-01-14 | 2003-07-24 | The Board Of Trustees Of The University Of Illinois | Novel mammalian multipotent stem cells and compositions, methods of preparation and methods of administration thereof |
| AU2003206844B2 (en) | 2002-02-06 | 2010-04-08 | Tissuedent Gmbh & Co. Kg | Pluripotent embryonic-like stem cells derived from teeth and uses thereof |
| EP1572099A4 (en) * | 2002-10-04 | 2007-01-03 | Univ California | SCREENING AND THERAPEUTIC METHODS RELATED TO THE NEUROGENESIS |
| US7597885B2 (en) | 2004-03-26 | 2009-10-06 | Aderans Research Institute, Inc. | Tissue engineered biomimetic hair follicle graft |
| ATE431846T1 (de) * | 2005-03-23 | 2009-06-15 | Stiftung Caesar | Neurale stammzellen |
| AU2006292203A1 (en) | 2005-09-21 | 2007-03-29 | Dask Technologies, Llc | Methods and compositions for organ and tissue functionality |
| EP1987135A2 (en) | 2006-01-27 | 2008-11-05 | Auxocell Laboratories, Inc. | Methods and compositions relating to stem cell transplantation |
| WO2008080200A1 (en) | 2006-12-29 | 2008-07-10 | Irina Kerkis | Process for obtaining stem cells |
| US20110002895A1 (en) | 2007-12-05 | 2011-01-06 | Minoru Ueda | Composition for autotransplantation or allotransplantation using dental pulp stem cell, and use of the composition |
| US20120219531A1 (en) | 2008-03-17 | 2012-08-30 | Agency For Science, Technology And Research | Microcarriers for Stem Cell Culture |
| ITRM20080342A1 (it) * | 2008-06-26 | 2009-12-27 | Univ Degli Studi Udine | Cellule di polpa dentale midollo-simili, metodi per isolamento ed uso. |
| CN101848994A (zh) | 2008-07-30 | 2010-09-29 | 国立大学法人京都大学 | 有效建立诱导的多能干细胞的方法 |
| SG193847A1 (en) * | 2008-09-04 | 2013-10-30 | Abt Holding Co | Use of stem cells to prevent neuronal dieback |
| US7847353B2 (en) * | 2008-12-05 | 2010-12-07 | Bae Systems Information And Electronic Systems Integration Inc. | Multi-thickness semiconductor with fully depleted devices and photonic integration |
| US20100297094A1 (en) | 2009-01-30 | 2010-11-25 | Harlan John M | Therapy or prevention of diseases with cells or cell supernatant |
| ES2360434B1 (es) * | 2009-07-21 | 2012-04-12 | Universitat Internacional De Catalunya | Celulas madre pluripotenciales obtenidas a partir de la pulpa dental. |
| EP2339611B1 (en) | 2009-12-23 | 2015-11-11 | ISMECA Semiconductor Holding SA | Wafer handler comprising a vision system |
| CA2802896C (en) | 2010-07-01 | 2021-05-11 | Regenerative Research Foundation | Methods for culturing undifferentiated cells using sustained release compositions |
| US20120009601A1 (en) | 2010-07-08 | 2012-01-12 | The General Hospital Corporation | Methods and compositions for reprogramming cells |
| WO2012020687A1 (en) | 2010-08-13 | 2012-02-16 | Kyoto University | Method of inducing differentiation from pluripotent stem cells to germ cells |
| BR102013021202B1 (pt) | 2013-08-20 | 2022-09-06 | Ccb - Centro De Criogenia Brasil Ltda | Processo de produção de células tronco multipotentes e progenitores |
-
2014
- 2014-03-14 US US14/214,016 patent/US9790468B2/en active Active
- 2014-03-15 EP EP14765285.3A patent/EP2970880B1/en active Active
- 2014-03-15 IL IL280850A patent/IL280850B2/en unknown
- 2014-03-15 EP EP22171061.9A patent/EP4095233A1/en not_active Withdrawn
- 2014-03-15 CA CA2904804A patent/CA2904804A1/en active Pending
- 2014-03-15 WO PCT/IB2014/059850 patent/WO2014141210A2/en not_active Ceased
- 2014-03-15 JP JP2015562539A patent/JP6491606B2/ja active Active
- 2014-03-17 BR BR102014006335A patent/BR102014006335B8/pt active IP Right Grant
-
2015
- 2015-09-10 IL IL241470A patent/IL241470B/en active IP Right Grant
-
2017
- 2017-09-07 US US15/698,546 patent/US20180187158A1/en not_active Abandoned
-
2019
- 2019-03-01 JP JP2019037436A patent/JP6920363B2/ja active Active
-
2020
- 2020-03-27 US US16/833,151 patent/US20200339954A1/en not_active Abandoned
-
2022
- 2022-09-26 US US17/935,574 patent/US12480095B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016517405A5 (OSRAM) | ||
| Patel et al. | Multipotent menstrual blood stromal stem cells: isolation, characterization, and differentiation | |
| EP2495311B1 (en) | Method for producing mesenchymal stem cells from human pluripotent stem cells, and mesenchymal stem cells produced by same | |
| Liu et al. | Concise reviews: characteristics and potential applications of human dental tissue-derived mesenchymal stem cells | |
| US20150118748A1 (en) | High-concentration stem cell production method | |
| Kadam et al. | Islet neogenesis from the constitutively nestin expressing human umbilical cord matrix derived mesenchymal stem cells | |
| Yam et al. | Dental stem cells: a future asset of ocular cell therapy | |
| CN104204190B (zh) | 人类多能性类胚胎干细胞先驱细胞 | |
| WO2010069204A1 (zh) | 亚全能干细胞、其制备方法及其用途 | |
| EP3513797B1 (en) | Method of treating the effects of stroke | |
| AU2018289935A1 (en) | Treatment agent for epidermolysis bullosa | |
| US9446073B2 (en) | Non-lineage committed precursor cells from the dental papillary tissue of teeth | |
| Huang et al. | Critical reviews in oral biology & medicine: mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine | |
| Feter et al. | Dental mesenchymal stem cell: Its role in tooth development, types, surface antigens and differentiation potential | |
| KR101793722B1 (ko) | 성상세포의 생산방법 | |
| US20090162326A1 (en) | Method for isolating stem cells and stem cells derived from a pad-like tissue of teeth | |
| WO2008080200A1 (en) | Process for obtaining stem cells | |
| Park et al. | Neural progenitors generated from the mesenchymal stem cells of first-trimester human placenta matured in the hypoxic-ischemic rat brain and mediated restoration of locomotor activity | |
| Tangjit et al. | Optimal xeno-free culture condition for clinical grade stem cells from human exfoliated deciduous teeth | |
| KR20140016841A (ko) | 태아연골조직유래 줄기세포원 및 이를 포함하는 세포치료제 | |
| KR102275454B1 (ko) | 전능성 줄기세포로부터 중간엽 줄기세포를 분화시키는 방법 | |
| Vasyliev et al. | In vitro properties of neural crest-derived multipotent stem cells from a bulge region of whisker follicle | |
| Yu | Human amniotic fluid-derived and amniotic membrane-derived stem cells | |
| Fracaro et al. | Dental pulp-derived stem cells: a promising source for regenerative medicine | |
| Guan et al. | Ischemia, immunosuppression, and SSEA‐1‐negative cells all contribute to tumors resulting from mouse embryonic stem cell‐derived neural progenitor transplantation |