JP2016515619A5 - - Google Patents
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- JP2016515619A5 JP2016515619A5 JP2016506341A JP2016506341A JP2016515619A5 JP 2016515619 A5 JP2016515619 A5 JP 2016515619A5 JP 2016506341 A JP2016506341 A JP 2016506341A JP 2016506341 A JP2016506341 A JP 2016506341A JP 2016515619 A5 JP2016515619 A5 JP 2016515619A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- cancer
- regimen designed
- target drug
- chemotherapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 Puremetorekise de Chemical compound 0.000 claims description 7
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| PCT/US2014/032253 WO2014165412A2 (en) | 2013-04-01 | 2014-03-28 | Methods and compositions for treating cancers having acquired resistance to chemotherapeutic and targeted drugs using carboxyamidotriazole orotate |
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| WO2016015095A1 (en) * | 2014-07-31 | 2016-02-04 | The University Of Western Australia | A method for the identification of immunotherapy-drug combinations using a network approach |
| KR102456433B1 (ko) | 2016-03-02 | 2022-10-19 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 에리불린-기반 항체-약물 콘주게이트 및 사용 방법 |
| WO2018134254A1 (en) | 2017-01-17 | 2018-07-26 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| CN107890467A (zh) * | 2017-11-24 | 2018-04-10 | 中国医学科学院基础医学研究所 | 干扰能量代谢的药物在胰腺癌复发中的应用 |
| US20220168276A1 (en) * | 2020-08-05 | 2022-06-02 | Tactical Therapeotics Inc. | Mehods and Compositions for Treating SARS-CoV-2 Infection using Carboxyamidotriazole Orotate |
| WO2024208247A1 (zh) * | 2023-04-04 | 2024-10-10 | 广东银珠医药科技有限公司 | 羧胺三唑在制备治疗肿瘤骨转移的药物中的用途 |
| WO2024235217A1 (zh) * | 2023-05-15 | 2024-11-21 | 广东银珠医药科技有限公司 | 一种抗肺癌联合用药物及其应用 |
| CN119971050A (zh) * | 2023-11-10 | 2025-05-13 | 广东银珠医药科技有限公司 | 羧胺三唑与化疗药的组合物及联用治疗实体瘤的用途 |
| WO2025214445A1 (zh) * | 2024-04-12 | 2025-10-16 | 广东银珠医药科技有限公司 | 一种三氮唑类化合物及其用途 |
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| IL122782A (en) * | 1995-07-21 | 2003-03-12 | Gruppe Constantia | Triazole salts and pharmaceutical compositions containing the same and methods for evaluating the susceptibility of a cancer to growth inhibition utilizing the same |
| US5728707A (en) | 1995-07-21 | 1998-03-17 | Constantia Gruppe | Treatment and prevention of primary and metastatic neoplasms with salts of aminoimidazole carboxamide |
| US8034823B2 (en) * | 2005-02-22 | 2011-10-11 | Savvipharm Inc | Method of increasing drug oral bioavailability and compositions of less toxic orotate salts |
| US7750018B2 (en) * | 2006-12-06 | 2010-07-06 | Tactical Therapeutics, Inc | Use of carboxiamidotriazole (CAI) orotate in macular degeneration |
| EP2193135A1 (en) * | 2007-08-13 | 2010-06-09 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| CN101669941B (zh) * | 2008-09-09 | 2012-11-07 | 中国医学科学院基础医学研究所 | 一种联合用药治疗恶性肿瘤的方法以及抗恶性肿瘤的药物 |
| US8877785B2 (en) * | 2009-09-04 | 2014-11-04 | Tactical Therapeutics Inc | Methods and compositions for enhancing sensitivity of cytotoxic drugs with timely combinatorial therapy with carboxyamidotriazole orotate |
| US8377973B2 (en) * | 2009-09-04 | 2013-02-19 | Tactical Therapeutics Inc | Compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazole orotate formulations |
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