JP2016513647A5 - - Google Patents
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- Publication number
- JP2016513647A5 JP2016513647A5 JP2016502054A JP2016502054A JP2016513647A5 JP 2016513647 A5 JP2016513647 A5 JP 2016513647A5 JP 2016502054 A JP2016502054 A JP 2016502054A JP 2016502054 A JP2016502054 A JP 2016502054A JP 2016513647 A5 JP2016513647 A5 JP 2016513647A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- bimatoprost
- administered
- composition according
- reducing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 18
- AQOKCDNYWBIDND-FTOWTWDKSA-N bimatoprost Chemical compound CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-FTOWTWDKSA-N 0.000 claims 12
- 229960002470 bimatoprost Drugs 0.000 claims 12
- 102000016267 Leptin Human genes 0.000 claims 3
- 108010092277 Leptin Proteins 0.000 claims 3
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims 3
- 229940039781 leptin Drugs 0.000 claims 3
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 2
- 210000000229 preadipocyte Anatomy 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 208000031773 Insulin resistance syndrome Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 230000036528 appetite Effects 0.000 claims 1
- 235000019789 appetite Nutrition 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361793132P | 2013-03-15 | 2013-03-15 | |
| US61/793,132 | 2013-03-15 | ||
| PCT/US2014/026110 WO2014143629A1 (en) | 2013-03-15 | 2014-03-13 | Bimatoprost for enhancement of leptin production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016513647A JP2016513647A (ja) | 2016-05-16 |
| JP2016513647A5 true JP2016513647A5 (https=) | 2017-04-13 |
Family
ID=50442712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502054A Pending JP2016513647A (ja) | 2013-03-15 | 2014-03-13 | レプチン生産を増進するビマトプロスト |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20140275272A1 (https=) |
| EP (1) | EP2968361A1 (https=) |
| JP (1) | JP2016513647A (https=) |
| KR (1) | KR20150129735A (https=) |
| CN (1) | CN105338985A (https=) |
| AU (1) | AU2014228307A1 (https=) |
| BR (1) | BR112015021859A2 (https=) |
| CA (1) | CA2901529A1 (https=) |
| HK (1) | HK1220385A1 (https=) |
| RU (1) | RU2015134772A (https=) |
| WO (1) | WO2014143629A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016176640A1 (en) | 2015-04-30 | 2016-11-03 | Allergan, Inc. | Cosmetic method and therapeutic use for fat reduction |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| ATE141502T1 (de) | 1991-01-15 | 1996-09-15 | Alcon Lab Inc | Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US5688819A (en) | 1992-09-21 | 1997-11-18 | Allergan | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US7666912B2 (en) * | 2006-03-23 | 2010-02-23 | Massachusetts Eye And Ear Infirmary | Compositions and methods for reducing body fat |
| CA2749352A1 (en) * | 2009-02-20 | 2010-09-10 | Micro Labs Limited | Storage stable prostaglandin product |
| ES2687494T3 (es) * | 2011-01-19 | 2018-10-25 | Topokine Therapeutics, Inc. | Métodos y composiciones para reducir la grasa corporal |
-
2014
- 2014-03-13 HK HK16108521.3A patent/HK1220385A1/zh unknown
- 2014-03-13 US US14/209,099 patent/US20140275272A1/en not_active Abandoned
- 2014-03-13 AU AU2014228307A patent/AU2014228307A1/en not_active Abandoned
- 2014-03-13 KR KR1020157025059A patent/KR20150129735A/ko not_active Withdrawn
- 2014-03-13 WO PCT/US2014/026110 patent/WO2014143629A1/en not_active Ceased
- 2014-03-13 BR BR112015021859A patent/BR112015021859A2/pt active Search and Examination
- 2014-03-13 EP EP14716168.1A patent/EP2968361A1/en not_active Withdrawn
- 2014-03-13 RU RU2015134772A patent/RU2015134772A/ru not_active Application Discontinuation
- 2014-03-13 CA CA2901529A patent/CA2901529A1/en not_active Abandoned
- 2014-03-13 CN CN201480012846.5A patent/CN105338985A/zh active Pending
- 2014-03-13 JP JP2016502054A patent/JP2016513647A/ja active Pending
-
2015
- 2015-11-25 US US14/952,208 patent/US20160310505A1/en not_active Abandoned
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