JP2016512555A5 - - Google Patents
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- Publication number
- JP2016512555A5 JP2016512555A5 JP2016501805A JP2016501805A JP2016512555A5 JP 2016512555 A5 JP2016512555 A5 JP 2016512555A5 JP 2016501805 A JP2016501805 A JP 2016501805A JP 2016501805 A JP2016501805 A JP 2016501805A JP 2016512555 A5 JP2016512555 A5 JP 2016512555A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- aki
- stem cells
- placental stem
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 10
- 206010038436 Renal failure acute Diseases 0.000 claims 10
- 230000003169 placental Effects 0.000 claims 8
- 210000000130 stem cell Anatomy 0.000 claims 7
- 230000003247 decreasing Effects 0.000 claims 4
- 229940109239 Creatinine Drugs 0.000 claims 3
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 3
- 206010016807 Fluid retention Diseases 0.000 claims 2
- 206010003119 Arrhythmia Diseases 0.000 claims 1
- 210000004369 Blood Anatomy 0.000 claims 1
- 206010006326 Breath odour Diseases 0.000 claims 1
- 102100016492 CD34 Human genes 0.000 claims 1
- 108060001251 CD34 Proteins 0.000 claims 1
- 208000006017 Cardiac Tamponade Diseases 0.000 claims 1
- 206010007521 Cardiac arrhythmias Diseases 0.000 claims 1
- 230000037250 Clearance Effects 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 206010013781 Dry mouth Diseases 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 208000001780 Epistaxis Diseases 0.000 claims 1
- 230000036826 Excretion Effects 0.000 claims 1
- 210000003414 Extremities Anatomy 0.000 claims 1
- 206010016256 Fatigue Diseases 0.000 claims 1
- 208000002513 Flank Pain Diseases 0.000 claims 1
- 206010018836 Haematochezia Diseases 0.000 claims 1
- 206010019233 Headache Diseases 0.000 claims 1
- 208000002287 Hemorrhoids Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 210000003734 Kidney Anatomy 0.000 claims 1
- 210000004072 Lung Anatomy 0.000 claims 1
- 108090000028 MMP12 Proteins 0.000 claims 1
- 102000003729 Neprilysin Human genes 0.000 claims 1
- 206010029446 Nocturia Diseases 0.000 claims 1
- 206010030124 Oedema peripheral Diseases 0.000 claims 1
- 208000005333 Pulmonary Edema Diseases 0.000 claims 1
- 206010037423 Pulmonary oedema Diseases 0.000 claims 1
- 206010072226 Renal vascular thrombosis Diseases 0.000 claims 1
- 206010039911 Seizure Diseases 0.000 claims 1
- 210000002966 Serum Anatomy 0.000 claims 1
- 102100008333 THY1 Human genes 0.000 claims 1
- 101700026084 THY1 Proteins 0.000 claims 1
- 206010044565 Tremor Diseases 0.000 claims 1
- 210000003932 Urinary Bladder Anatomy 0.000 claims 1
- 210000002700 Urine Anatomy 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 claims 1
- 230000004596 appetite loss Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004027 cells Anatomy 0.000 claims 1
- 230000035512 clearance Effects 0.000 claims 1
- 230000001809 detectable Effects 0.000 claims 1
- 230000029142 excretion Effects 0.000 claims 1
- 230000024924 glomerular filtration Effects 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 235000021266 loss of appetite Nutrition 0.000 claims 1
- 235000019656 metallic taste Nutrition 0.000 claims 1
- 230000027939 micturition Effects 0.000 claims 1
- 230000002441 reversible Effects 0.000 claims 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
Claims (9)
- 急性腎損傷(AKI)を有する対象のAKIを治療するための医薬組成物であって、治療有効量の胎盤幹細胞を含み、ここで、該治療有効量が、該対象における、AKIの1以上の症状もしくは合併症の検出可能な改善、又はAKIの1以上の症状もしくは合併症の進行の低下をもたらすのに十分な量である、前記医薬組成物。
- 急性腎損傷(AKI)を有する対象のAKIと関連する1以上の症状又は合併症を予防するための医薬組成物であって、治療有効量の胎盤幹細胞を含み、ここで、該治療有効量が、該対象におけるAKIの1以上の症状又は合併症の発症を予防するのに十分な量である、前記医薬組成物。
- 前記胎盤幹細胞が、CD10+、CD34-、CD105+、CD200+胎盤幹細胞である、請求項1又は2記載の医薬組成物。
- 前記胎盤幹細胞がOCT-4を発現する、請求項3項記載の医薬組成物。
- 前記胎盤幹細胞がさらに、CD45-及びCD90+である、請求項3又は4記載の医薬組成物。
- 前記胎盤幹細胞がさらに、CD80-及びCD86-である、請求項3〜5のいずれか一項記載の医薬組成物。
- 前記AKIと関連する症状が、疲労、血便、口臭、口の中の金属味、痣、手の震え、高血圧、鼻血、吃逆、発作、息切れ、排尿パターンの変化(例えば、定期的に排尿する能力の喪失、もしくは夜間の頻尿)、食欲不振、頭痛、吐き気及び嘔吐、不整脈、脇腹の疼痛(例えば、腎血管の血栓症もしくは腎臓の炎症が原因で起こる)、口渇、触知可能な膀胱、四肢の体液貯留(末梢浮腫)及び肺の体液貯留(肺水腫)、並びに/又は心タンポナーデである、請求項1〜6のいずれか一項記載の医薬組成物。
- 前記対象における糸球体濾過量の増加、血清クレアチニンレベルの減少、尿クレアチニンレベルの減少、クレアチニンクリアランスの増加、血中尿素窒素(BUN)のレベルの減少、及び/又はナトリウム排泄分画の減少をもたらす、請求項1〜7のいずれか一項記載の医薬組成物。
- 前記胎盤幹細胞が、全身、静脈内、動脈内、又は局所に投与される、請求項1〜8のいずれか一項記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361785252P | 2013-03-14 | 2013-03-14 | |
| US61/785,252 | 2013-03-14 | ||
| PCT/US2014/025266 WO2014159826A1 (en) | 2013-03-14 | 2014-03-13 | Use of placental stem cells in treatment of acute kidney injury |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018206365A Division JP2019055955A (ja) | 2013-03-14 | 2018-11-01 | 急性腎損傷の治療における胎盤幹細胞の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016512555A JP2016512555A (ja) | 2016-04-28 |
| JP2016512555A5 true JP2016512555A5 (ja) | 2017-04-13 |
Family
ID=51625261
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501805A Pending JP2016512555A (ja) | 2013-03-14 | 2014-03-13 | 急性腎損傷の治療における胎盤幹細胞の使用 |
| JP2018206365A Pending JP2019055955A (ja) | 2013-03-14 | 2018-11-01 | 急性腎損傷の治療における胎盤幹細胞の使用 |
| JP2020180987A Withdrawn JP2021038229A (ja) | 2013-03-14 | 2020-10-29 | 急性腎損傷の治療における胎盤幹細胞の使用 |
| JP2022176132A Pending JP2023022018A (ja) | 2013-03-14 | 2022-11-02 | 急性腎損傷の治療における胎盤幹細胞の使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018206365A Pending JP2019055955A (ja) | 2013-03-14 | 2018-11-01 | 急性腎損傷の治療における胎盤幹細胞の使用 |
| JP2020180987A Withdrawn JP2021038229A (ja) | 2013-03-14 | 2020-10-29 | 急性腎損傷の治療における胎盤幹細胞の使用 |
| JP2022176132A Pending JP2023022018A (ja) | 2013-03-14 | 2022-11-02 | 急性腎損傷の治療における胎盤幹細胞の使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20160030488A1 (ja) |
| EP (1) | EP2968420B1 (ja) |
| JP (4) | JP2016512555A (ja) |
| DK (1) | DK2968420T3 (ja) |
| ES (1) | ES2703784T3 (ja) |
| HK (1) | HK1220135A1 (ja) |
| PL (1) | PL2968420T3 (ja) |
| PT (1) | PT2968420T (ja) |
| WO (1) | WO2014159826A1 (ja) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3046078A1 (en) * | 2016-12-05 | 2018-06-14 | Celularity Inc. | Treatment of lymphedema and related conditions using placental adherent cells |
| US10456419B2 (en) | 2017-02-27 | 2019-10-29 | Payman Sadeghi | Method for treating migraine headaches |
| US10932711B2 (en) | 2017-02-27 | 2021-03-02 | Payman Sadeghi | Method and system for neurohydrodissection |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7311905B2 (en) * | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| WO2003068937A2 (en) * | 2002-02-13 | 2003-08-21 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta and uses and methods of treatment using said cells |
| US7910755B2 (en) * | 2004-09-29 | 2011-03-22 | Harbor Biosciences, Inc. | Stem cell expansion and uses |
| WO2007079183A2 (en) * | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Placental stem cell populations |
| RS52921B (en) * | 2007-02-12 | 2014-02-28 | Anthrogenesis Corporation | TREATMENT OF INFLAMMATORY DISEASES USING PLACENTAL CELL CELLS |
| CA2701435C (en) * | 2007-10-05 | 2017-06-20 | Ethicon, Inc. | Repair and regeneration of renal tissue using human umbilical cord tissue-derived cells |
| WO2009114826A2 (en) * | 2008-03-13 | 2009-09-17 | Angiodynamics, Inc. | Treatment systems and methods for renal-related diseases |
| EP3088512B1 (en) * | 2010-04-07 | 2019-12-11 | Celularity, Inc. | Use of placental stem cells for treating heart and circulatory diseases by promoting angiogenesis |
| MX2012011543A (es) * | 2010-04-08 | 2013-05-06 | Anthrogenesis Corp | Tratamiento de sarcoidosis empleando celulas madre placentarias. |
| EP2731440A4 (en) * | 2011-07-15 | 2015-04-29 | Anthrogenesis Corp | RADIATION LESSON TREATMENT USING ADHESENT CELLS DERIVED FROM AMNIOS |
-
2014
- 2014-03-13 PT PT14775592T patent/PT2968420T/pt unknown
- 2014-03-13 US US14/774,262 patent/US20160030488A1/en not_active Abandoned
- 2014-03-13 DK DK14775592.0T patent/DK2968420T3/da active
- 2014-03-13 ES ES14775592T patent/ES2703784T3/es active Active
- 2014-03-13 WO PCT/US2014/025266 patent/WO2014159826A1/en active Application Filing
- 2014-03-13 JP JP2016501805A patent/JP2016512555A/ja active Pending
- 2014-03-13 PL PL14775592T patent/PL2968420T3/pl unknown
- 2014-03-13 EP EP14775592.0A patent/EP2968420B1/en active Active
-
2016
- 2016-07-14 HK HK16108271.5A patent/HK1220135A1/zh unknown
-
2018
- 2018-11-01 JP JP2018206365A patent/JP2019055955A/ja active Pending
-
2019
- 2019-08-14 US US16/541,091 patent/US11696930B2/en active Active
-
2020
- 2020-10-29 JP JP2020180987A patent/JP2021038229A/ja not_active Withdrawn
-
2022
- 2022-11-02 JP JP2022176132A patent/JP2023022018A/ja active Pending
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