JP2016512547A5 - - Google Patents
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- Publication number
- JP2016512547A5 JP2016512547A5 JP2016501680A JP2016501680A JP2016512547A5 JP 2016512547 A5 JP2016512547 A5 JP 2016512547A5 JP 2016501680 A JP2016501680 A JP 2016501680A JP 2016501680 A JP2016501680 A JP 2016501680A JP 2016512547 A5 JP2016512547 A5 JP 2016512547A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- alkoxy
- alkyl
- composition according
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 125000003545 alkoxy group Chemical group 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 8
- -1 amino, hydroxyl Chemical group 0.000 claims 7
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 5
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- 206010016654 Fibrosis Diseases 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000004761 fibrosis Effects 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 206010028594 Myocardial fibrosis Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 230000002500 effect on skin Effects 0.000 claims 1
- 230000003176 fibrotic effect Effects 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 239000007972 injectable composition Substances 0.000 claims 1
- 239000000644 isotonic solution Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 238000007634 remodeling Methods 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361782185P | 2013-03-14 | 2013-03-14 | |
| US61/782,185 | 2013-03-14 | ||
| PCT/US2014/024922 WO2014159733A1 (en) | 2013-03-14 | 2014-03-12 | Compounds for treatment of fibrosis diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016512547A JP2016512547A (ja) | 2016-04-28 |
| JP2016512547A5 true JP2016512547A5 (OSRAM) | 2017-04-20 |
Family
ID=51625237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501680A Pending JP2016512547A (ja) | 2013-03-14 | 2014-03-12 | 線維症疾患の治療のための化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9744169B2 (OSRAM) |
| EP (1) | EP2968321A4 (OSRAM) |
| JP (1) | JP2016512547A (OSRAM) |
| KR (1) | KR20150129729A (OSRAM) |
| CN (1) | CN105120867A (OSRAM) |
| AU (1) | AU2014244506A1 (OSRAM) |
| CA (1) | CA2905841A1 (OSRAM) |
| WO (1) | WO2014159733A1 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104379583B (zh) * | 2012-06-15 | 2016-06-08 | 广州源生医药科技有限公司 | 作为wnt信号传导抑制剂的化合物、组合物及其应用 |
| WO2014159733A1 (en) | 2013-03-14 | 2014-10-02 | Curegenix, Inc. | Compounds for treatment of fibrosis diseases |
| CN105348298B (zh) * | 2014-07-04 | 2019-03-19 | 沈阳中化农药化工研发有限公司 | 取代芳基吡啶类化合物及其用途 |
| JP6853819B2 (ja) * | 2015-10-08 | 2021-03-31 | スーチョウ ユンシュアン イーヤオ カジ ヨウシェン ゴンス | Ｗｎｔシグナル伝達経路阻害剤およびその治療用途 |
| WO2017062688A1 (en) * | 2015-10-08 | 2017-04-13 | Suzhou Yunxuan Yiyao Keji Youxian Gongsi | Wnt signaling pathway inhibitors and therapeutic applications thereof |
| CA3065318A1 (en) * | 2017-06-02 | 2018-12-06 | Iterion Therapeutics, Inc. | Methods for treatment of fibrotic diseases |
| CN107441045B (zh) | 2017-07-21 | 2018-10-19 | 广州源生医药科技有限公司 | 用于递送Wnt信号通路抑制剂的脂质体制剂及其制备方法 |
| KR102717600B1 (ko) | 2017-10-06 | 2024-10-15 | 포르마 세라퓨틱스 인크. | 유비퀴틴 특이적 펩티다제 30의 억제 |
| CN107823208A (zh) * | 2017-10-25 | 2018-03-23 | 南京多宝生物科技有限公司 | 吗啉类化合物在制备治疗和预防肾纤维化药物中的应用 |
| CN112513036B (zh) | 2018-05-17 | 2024-05-24 | 福马治疗有限公司 | 用作泛素特异性肽酶30抑制剂的稠合双环化合物 |
| JP7551507B2 (ja) * | 2018-06-01 | 2024-09-17 | イテリオン・セラピューティクス・インコーポレイテッド | テガビビントおよび関連化合物の製剤 |
| ES2945834T3 (es) | 2018-10-05 | 2023-07-07 | Forma Therapeutics Inc | Pirrolinas fusionadas que actúan como inhibidores de la proteasa 30 específica de ubiquitina (USP30) |
| CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| CN110448675A (zh) * | 2019-09-20 | 2019-11-15 | 苏州大学 | 一种放射性皮肤损伤防治药物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999011622A1 (en) * | 1997-09-03 | 1999-03-11 | Guilford Pharmaceuticals Inc. | Amino-substituted compounds, methods, and compositions for inhibiting parp activity |
| AU2006227776A1 (en) | 2005-03-18 | 2006-09-28 | Institute For Chemical Genomics | Alpha-helix mimetics and methods relating to the treatment of fibrosis |
| US20130274215A1 (en) * | 2010-04-08 | 2013-10-17 | Fate Therapeutics, Inc. | Pharmaceutical compositions to treat fibrosis |
| CN102558173B (zh) * | 2010-12-31 | 2015-05-20 | 广州源生医药科技有限公司 | 抑制wnt信号传导的化合物、组合物及其应用 |
| CN104379583B (zh) | 2012-06-15 | 2016-06-08 | 广州源生医药科技有限公司 | 作为wnt信号传导抑制剂的化合物、组合物及其应用 |
| WO2014159733A1 (en) | 2013-03-14 | 2014-10-02 | Curegenix, Inc. | Compounds for treatment of fibrosis diseases |
-
2014
- 2014-03-12 WO PCT/US2014/024922 patent/WO2014159733A1/en not_active Ceased
- 2014-03-12 EP EP14775320.6A patent/EP2968321A4/en not_active Withdrawn
- 2014-03-12 US US14/772,334 patent/US9744169B2/en active Active
- 2014-03-12 JP JP2016501680A patent/JP2016512547A/ja active Pending
- 2014-03-12 CN CN201480013812.8A patent/CN105120867A/zh active Pending
- 2014-03-12 CA CA2905841A patent/CA2905841A1/en active Pending
- 2014-03-12 AU AU2014244506A patent/AU2014244506A1/en not_active Abandoned
- 2014-03-12 KR KR1020157024835A patent/KR20150129729A/ko not_active Withdrawn
-
2017
- 2017-07-14 US US15/650,494 patent/US10285988B2/en active Active
-
2019
- 2019-03-19 US US16/357,898 patent/US20190209558A1/en not_active Abandoned