JP2016510657A - 医療デバイスの表面上のトポグラフィ的特徴およびパターン、ならびにその作製方法 - Google Patents
医療デバイスの表面上のトポグラフィ的特徴およびパターン、ならびにその作製方法 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2/36—Femoral heads ; Femoral endoprostheses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
- A61F2002/0081—Special surfaces of prostheses, e.g. for improving ingrowth directly machined on the prosthetic surface, e.g. holes, grooves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
- A61F2002/30028—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/3011—Cross-sections or two-dimensional shapes
- A61F2002/30138—Convex polygonal shapes
- A61F2002/30143—Convex polygonal shapes hexagonal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/3011—Cross-sections or two-dimensional shapes
- A61F2002/30138—Convex polygonal shapes
- A61F2002/30156—Convex polygonal shapes triangular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30795—Blind bores, e.g. of circular cross-section
- A61F2002/30805—Recesses of comparatively large area with respect to their low depth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/3082—Grooves
- A61F2002/30827—Plurality of grooves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/3082—Grooves
- A61F2002/30827—Plurality of grooves
- A61F2002/3083—Plurality of grooves inclined obliquely with respect to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2002/30925—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth etched
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
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- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
Description
パターン自体が、好ましい細胞応答を促進する任意の不連続形状であってもよい。その形状は、適切な細胞応答を生じさせるために必要な任意のサイズ、数、高さ、または深さのものであってもよい。例示的パターンの図を図7〜8に示す。図7Aは、トポグラフィ的特徴の6角形の不連続パターン700を示す。図7Bは、トポグラフィ的特徴の3角形の不連続パターン800を示す。図8は、たとえば8角形の溝特徴802が正方形の溝特徴8040と置き換わって交互になったものなどの内部整合形状パターン800を示す。
Claims (14)
- 少なくとも1つの表面を有する医療デバイスであって、前記少なくとも1つの表面の中または上に、トポグラフィ的特徴の少なくとも第1の不連続パターンが配される、デバイス。
- 前記医療デバイスは、血管内ステント、ステントグラフト、グラフト、心臓弁、静脈弁、フィルター、閉塞デバイス、カテーテル、シース、骨インプラント、歯科インプラント、植込み型避妊具、植込み型抗腫瘍ペレットまたはロッド、シャントおよびパッチ、ペースメーカー、針、一時的固定ロッド、任意のタイプの医療デバイスに対する医療用ワイヤまたは医療用チューブ、およびその他の植込み型医療デバイスを含む群より選択される、請求項1に記載のデバイス。
- 前記トポグラフィ的特徴の第1の不連続パターンは、トポグラフィ的特徴の幾何学的パターンを含む、請求項1に記載のデバイス。
- 前記幾何学的パターンは、3角形、正方形、6角形、矩形、偏菱形、ダイヤモンド形、円形、楕円形、5角形、または8角形を含む、請求項3に記載のデバイス。
- 前記トポグラフィ的特徴の第1の不連続パターンは、細胞移動を向上することによって治癒を促進する、請求項1に記載のデバイス。
- 前記トポグラフィ的特徴の第1の不連続パターンは、細胞増殖を抑制する、請求項1に記載のデバイス。
- 前記トポグラフィ的特徴の第1の不連続パターンは、骨芽細胞形成を高めるために細胞を留める、請求項1に記載のデバイス。
- 前記デバイスの前記少なくとも1つの表面の中または上に、トポグラフィ的特徴の少なくとも第2の不連続パターンをさらに含む、請求項1に記載のデバイス。
- 前記トポグラフィ的特徴の少なくとも第1および第2の不連続パターンの各々は、異なる細胞応答を達成する、請求項8に記載のデバイス。
- 前記トポグラフィ的特徴の第2の不連続パターンは、内皮細胞移動を向上することによって治癒を促進する、請求項8に記載のデバイス。
- 前記トポグラフィ的特徴の第2の不連続パターンは、細胞増殖を抑制する、請求項8に記載のデバイス。
- 前記トポグラフィ的特徴の第2の不連続パターンは、骨芽細胞形成を高めるために細胞を留める、請求項8に記載のデバイス。
- 医療デバイスを製造する方法であって、
a.内表面および外表面を有する医療デバイスを形成するステップと、
b.前記医療デバイスの前記内表面および外表面の少なくとも一方に、トポグラフィ的特徴の少なくとも1つの不連続パターンを形成するステップと
を含む、方法。 - トポグラフィ的特徴の少なくとも1つの不連続パターンを形成する前記ステップは、フォトリソグラフィ、機械的転写、電気化学的機械加工、放電機械加工、およびレーザーエッチングからなる群のうちの少なくとも1つをさらに含む、請求項13に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/801,173 | 2013-03-13 | ||
US13/801,173 US11045297B2 (en) | 2012-10-18 | 2013-03-13 | Topographical features and patterns on a surface of a medical device and methods of making the same |
PCT/US2014/018079 WO2014158550A1 (en) | 2013-03-13 | 2014-02-24 | Topographical features and patterns on a surface of a medical device and methods of making the same |
Publications (2)
Publication Number | Publication Date |
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JP2016510657A true JP2016510657A (ja) | 2016-04-11 |
JP6941441B2 JP6941441B2 (ja) | 2021-09-29 |
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JP2016500367A Active JP6941441B2 (ja) | 2013-03-13 | 2014-02-24 | 医療デバイスの表面上のトポグラフィ的特徴およびパターン、ならびにその作製方法 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP2967823A4 (ja) |
JP (1) | JP6941441B2 (ja) |
AU (2) | AU2014242126A1 (ja) |
CA (1) | CA2905251C (ja) |
WO (1) | WO2014158550A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2020072515A1 (en) * | 2018-10-01 | 2020-04-09 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Bioscaffold for in vivo use |
CN112472381B (zh) * | 2019-09-12 | 2023-06-16 | 先健科技(深圳)有限公司 | 支架 |
CN112472380B (zh) * | 2019-09-12 | 2023-05-02 | 先健科技(深圳)有限公司 | 覆膜支架 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010039454A1 (en) * | 1993-11-02 | 2001-11-08 | John Ricci | Orthopedic implants having ordered microgeometric surface patterns |
JP2007526032A (ja) * | 2004-03-04 | 2007-09-13 | バイオロック インターナショナル, インコーポレイテッド | 微小幾何学的パターンのある面を有する外科用ステント |
JP2010516432A (ja) * | 2007-01-30 | 2010-05-20 | メドトロニック ヴァスキュラー インコーポレイテッド | 凹凸のある医療機器 |
US20120290074A1 (en) * | 2011-05-09 | 2012-11-15 | Palmaz Scientific, Inc. | Implantable medical device having enhanced endothelial migration features and methods of making the same |
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Publication number | Priority date | Publication date | Assignee | Title |
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US20030216803A1 (en) * | 2003-05-28 | 2003-11-20 | Ledergerber Walter J. | Textured and drug eluting stent-grafts |
US9016221B2 (en) * | 2004-02-17 | 2015-04-28 | University Of Florida Research Foundation, Inc. | Surface topographies for non-toxic bioadhesion control |
US20080110881A1 (en) * | 2006-11-15 | 2008-05-15 | Schulz Gerald B | Ez lift |
US20090093879A1 (en) * | 2007-10-04 | 2009-04-09 | Debra Wawro | Micro- and nano-patterned surface features to reduce implant fouling and regulate wound healing |
WO2009123624A1 (en) * | 2008-04-01 | 2009-10-08 | Hewlett-Packard Development Company, L.P. | Method and system for coating an article |
US20120232649A1 (en) * | 2008-11-20 | 2012-09-13 | Insight Innovations, Llc | Intraocular Lens Cell Migration Inhibition System |
WO2011140120A1 (en) * | 2010-05-05 | 2011-11-10 | Walker Jeffrey P | Medical devices, methods of producing medical devices, and projection photolithography apparatus for producing medical devices |
US8329021B2 (en) * | 2010-10-28 | 2012-12-11 | Palmaz Scientific, Inc. | Method for mass transfer of micro-patterns onto medical devices |
-
2014
- 2014-02-24 AU AU2014242126A patent/AU2014242126A1/en not_active Abandoned
- 2014-02-24 CA CA2905251A patent/CA2905251C/en active Active
- 2014-02-24 WO PCT/US2014/018079 patent/WO2014158550A1/en active Application Filing
- 2014-02-24 JP JP2016500367A patent/JP6941441B2/ja active Active
- 2014-02-24 EP EP14772710.1A patent/EP2967823A4/en active Pending
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2018
- 2018-08-23 AU AU2018220082A patent/AU2018220082A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010039454A1 (en) * | 1993-11-02 | 2001-11-08 | John Ricci | Orthopedic implants having ordered microgeometric surface patterns |
JP2007526032A (ja) * | 2004-03-04 | 2007-09-13 | バイオロック インターナショナル, インコーポレイテッド | 微小幾何学的パターンのある面を有する外科用ステント |
JP2010516432A (ja) * | 2007-01-30 | 2010-05-20 | メドトロニック ヴァスキュラー インコーポレイテッド | 凹凸のある医療機器 |
US20120290074A1 (en) * | 2011-05-09 | 2012-11-15 | Palmaz Scientific, Inc. | Implantable medical device having enhanced endothelial migration features and methods of making the same |
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JP6941441B2 (ja) | 2021-09-29 |
CA2905251A1 (en) | 2014-10-02 |
EP2967823A1 (en) | 2016-01-20 |
EP2967823A4 (en) | 2016-11-16 |
AU2014242126A1 (en) | 2015-11-05 |
CA2905251C (en) | 2023-03-28 |
WO2014158550A1 (en) | 2014-10-02 |
AU2018220082A1 (en) | 2018-09-13 |
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