JP2016510327A - ｐ５３再活性化のためのオリゴオキソピペラジン - Google Patents

ｐ５３再活性化のためのオリゴオキソピペラジン Download PDF

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Publication number
JP2016510327A
JP2016510327A JP2015553892A JP2015553892A JP2016510327A JP 2016510327 A JP2016510327 A JP 2016510327A JP 2015553892 A JP2015553892 A JP 2015553892A JP 2015553892 A JP2015553892 A JP 2015553892A JP 2016510327 A JP2016510327 A JP 2016510327A
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alkyl
arylalkyl
heteroaryl
cycloalkyl
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JP2015553892A
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Japanese (ja)
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JP2016510327A5 (enExample
Inventor
パラムジット エス． アローラ
パラムジット エス． アローラ
キンティン パン
キンティン パン
アナ マップ
アナ マップ
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New York University NYU
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New York University NYU
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Publication of JP2016510327A publication Critical patent/JP2016510327A/ja
Publication of JP2016510327A5 publication Critical patent/JP2016510327A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015553892A 2013-01-19 2014-01-21 ｐ５３再活性化のためのオリゴオキソピペラジン Pending JP2016510327A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361754575P 2013-01-19 2013-01-19
US61/754,575 2013-01-19
PCT/US2014/012337 WO2014113794A2 (en) 2013-01-19 2014-01-21 Oligooxopiperazines for p53 reactivation

Publications (2)

Publication Number Publication Date
JP2016510327A true JP2016510327A (ja) 2016-04-07
JP2016510327A5 JP2016510327A5 (enExample) 2017-02-23

Family

ID=51207874

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015553892A Pending JP2016510327A (ja) 2013-01-19 2014-01-21 ｐ５３再活性化のためのオリゴオキソピペラジン

Country Status (7)

Country Link
US (1) US9695153B2 (enExample)
EP (1) EP2945631A4 (enExample)
JP (1) JP2016510327A (enExample)
CN (1) CN105246481A (enExample)
AU (1) AU2014207311A1 (enExample)
CA (1) CA2898329A1 (enExample)
WO (1) WO2014113794A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015264201A1 (en) * 2014-05-21 2017-01-12 New York University Oxopiperazine helix mimetics for control of hypoxia-inducible gene expression
KR102456433B1 (ko) 2016-03-02 2022-10-19 에자이 알앤드디 매니지먼트 가부시키가이샤 에리불린-기반 항체-약물 콘주게이트 및 사용 방법
WO2018134254A1 (en) 2017-01-17 2018-07-26 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
WO2019118973A1 (en) 2017-12-15 2019-06-20 Inthera Bioscience AG 1 -(piperidinocarbonylmethyl)-2-oxopiperazine derivatives for treating cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012021144A1 (en) * 2010-08-12 2012-02-16 New York University Oligooxopiperazines and methods of making and using them
JP2015508779A (ja) * 2012-02-16 2015-03-23 ニューヨーク・ユニバーシティ 低酸素状態で誘導可能な遺伝子発現の、オリゴオキソピペラジン非ペプチド性へリックス模倣体による制御

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3542230A1 (de) 1985-11-29 1987-06-04 Bayer Ag Verfahren zur herstellung von oligomeren und telechelen mit carboxy-piperazin-einheiten und neue oligomere und telechele des poly(carboxypiperazins)
GB9022790D0 (en) 1990-10-19 1990-12-05 Wyeth John & Brother Ltd Piperazine derivatives
SK79797A3 (en) 1994-12-23 1997-11-05 Thomae Gmbh Dr K Piperazine derivatives, medicaments containing the same, their use and process for preparing the same
FR2803594B1 (fr) 2000-01-11 2002-07-19 Centre Nat Rech Scient Oligomeres de mimes contraints non peptidiques de dipeptides ou de tripeptides, et leurs utilisations
KR100464261B1 (ko) 2002-01-24 2005-01-03 주식회사 파나진 Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
US6841675B1 (en) 2002-06-13 2005-01-11 The Regents Of The University Of California Piperazine-based nucleic acid analogs
KR100962301B1 (ko) 2006-11-03 2010-06-11 재단법인서울대학교산학협력재단 자궁경부암을 위한 치료용 조성물
US20090197895A1 (en) 2008-01-31 2009-08-06 The Scripps Research Institute Oxazole-pyrrole-piperazine alpha-helix mimetic
JP2012503013A (ja) * 2008-09-18 2012-02-02 ニューヨーク ユニバーシティ ＨＩＦ−１αと水素結合代替ヘリックスを有するｐ３００／ＣＢＰの間の相互作用の阻害

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012021144A1 (en) * 2010-08-12 2012-02-16 New York University Oligooxopiperazines and methods of making and using them
JP2015508779A (ja) * 2012-02-16 2015-03-23 ニューヨーク・ユニバーシティ 低酸素状態で誘導可能な遺伝子発現の、オリゴオキソピペラジン非ペプチド性へリックス模倣体による制御

Also Published As

Publication number Publication date
EP2945631A4 (en) 2016-06-29
US9695153B2 (en) 2017-07-04
WO2014113794A3 (en) 2014-09-12
CN105246481A (zh) 2016-01-13
AU2014207311A1 (en) 2015-08-20
EP2945631A2 (en) 2015-11-25
CA2898329A1 (en) 2014-07-24
WO2014113794A2 (en) 2014-07-24
US20140205655A1 (en) 2014-07-24

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