JP2016510316A5 - - Google Patents
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- JP2016510316A5 JP2016510316A5 JP2015549801A JP2015549801A JP2016510316A5 JP 2016510316 A5 JP2016510316 A5 JP 2016510316A5 JP 2015549801 A JP2015549801 A JP 2015549801A JP 2015549801 A JP2015549801 A JP 2015549801A JP 2016510316 A5 JP2016510316 A5 JP 2016510316A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound
- subject
- tables
- mll
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 150000001875 compounds Chemical class 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 208000032839 leukemia Diseases 0.000 claims 6
- 102000004632 fms-Like Tyrosine Kinase 3 Human genes 0.000 claims 5
- 108010003374 fms-Like Tyrosine Kinase 3 Proteins 0.000 claims 5
- 102100039489 Histone-lysine N-methyltransferase, H3 lysine-79 specific Human genes 0.000 claims 4
- 102100021090 Homeobox protein Hox-A9 Human genes 0.000 claims 4
- 101000963360 Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-79 specific Proteins 0.000 claims 4
- 101150029107 MEIS1 gene Proteins 0.000 claims 4
- 108700041619 Myeloid Ecotropic Viral Integration Site 1 Proteins 0.000 claims 4
- 102000047831 Myeloid Ecotropic Viral Integration Site 1 Human genes 0.000 claims 4
- 108010027263 homeobox protein HOXA9 Proteins 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- 230000005856 abnormality Effects 0.000 claims 3
- 210000000349 chromosome Anatomy 0.000 claims 3
- 230000002068 genetic effect Effects 0.000 claims 3
- 230000004927 fusion Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000008707 rearrangement Effects 0.000 claims 2
- SFHYNDMGZXWXBU-LIMNOBDPSA-N 6-amino-2-[[(e)-(3-formylphenyl)methylideneamino]carbamoylamino]-1,3-dioxobenzo[de]isoquinoline-5,8-disulfonic acid Chemical compound O=C1C(C2=3)=CC(S(O)(=O)=O)=CC=3C(N)=C(S(O)(=O)=O)C=C2C(=O)N1NC(=O)N\N=C\C1=CC=CC(C=O)=C1 SFHYNDMGZXWXBU-LIMNOBDPSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000004976 peripheral blood cell Anatomy 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000005945 translocation Effects 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261745294P | 2012-12-21 | 2012-12-21 | |
| US61/745,294 | 2012-12-21 | ||
| PCT/US2013/077082 WO2014100662A1 (en) | 2012-12-21 | 2013-12-20 | Dot1 l inhibitors for use in the treatment of leukemia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018192426A Division JP2019031525A (ja) | 2012-12-21 | 2018-10-11 | 白血病の治療に使用するためのｄｏｔ１ｌ阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016510316A JP2016510316A (ja) | 2016-04-07 |
| JP2016510316A5 true JP2016510316A5 (enExample) | 2017-02-02 |
Family
ID=49956460
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015549801A Pending JP2016510316A (ja) | 2012-12-21 | 2013-12-20 | 白血病の治療に使用するためのｄｏｔ１ｌ阻害剤 |
| JP2018192426A Pending JP2019031525A (ja) | 2012-12-21 | 2018-10-11 | 白血病の治療に使用するためのｄｏｔ１ｌ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018192426A Pending JP2019031525A (ja) | 2012-12-21 | 2018-10-11 | 白血病の治療に使用するためのｄｏｔ１ｌ阻害剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20150342979A1 (enExample) |
| EP (1) | EP2934550A1 (enExample) |
| JP (2) | JP2016510316A (enExample) |
| AU (1) | AU2013361076B2 (enExample) |
| CA (1) | CA2894220A1 (enExample) |
| WO (1) | WO2014100662A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150284422A1 (en) | 2012-08-10 | 2015-10-08 | Epizyme, Inc. | Inhibitors of protein methyltransferase dot1l and methods of use thereof |
| WO2014039839A1 (en) | 2012-09-06 | 2014-03-13 | Epizyme, Inc. | Method of treating leukemia |
| US9446064B2 (en) | 2013-03-14 | 2016-09-20 | Epizyme, Inc. | Combination therapy for treating cancer |
| EP2968387A4 (en) | 2013-03-15 | 2017-04-05 | Epizyme, Inc. | Methods of synthesizing substituted purine compounds |
| WO2016011402A1 (en) * | 2014-07-18 | 2016-01-21 | The Regents Of The University Of Colorado, A Body Corporate | Dot1l inhibition in patients with mn1-high aml |
| US20170335402A1 (en) * | 2014-08-08 | 2017-11-23 | Baylor College Of Medicine | Dot1l inhibitors and uses thereof |
| WO2016029127A1 (en) * | 2014-08-22 | 2016-02-25 | The Regents Of The University Of Colorado, A Body Corporate | Dot1l inhibitors and uses thereof |
| EP3193879A4 (en) * | 2014-09-17 | 2018-05-16 | Epizyme, Inc. | Injectable formulations for treating cancer |
| EP3200826B1 (en) * | 2014-09-30 | 2021-04-21 | Vecht-lifshitz, Susan Eve | Pharmaceutical compositions for treating ebola virus disease |
| GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
| WO2017132398A1 (en) | 2016-01-26 | 2017-08-03 | Memorial Sloan-Kettering Cancer Center | Targeting chromatin regulators inhibits leukemogenic gene expression in npm1 mutant leukemia |
| US11944627B2 (en) | 2017-03-24 | 2024-04-02 | Kura Oncology, Inc. | Methods for treating hematological malignancies and Ewing's sarcoma |
| GB201901817D0 (en) | 2019-02-11 | 2019-04-03 | Phoremost Ltd | Methods |
| CN110092804A (zh) * | 2019-03-29 | 2019-08-06 | 广州盈升生物科技有限公司 | 一种含双环基团的嘌呤化合物及其制备方法 |
| TW202508595A (zh) | 2023-05-04 | 2025-03-01 | 美商銳新醫藥公司 | 用於ｒａｓ相關疾病或病症之組合療法 |
| WO2025034702A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 for use in the treatment of ras protein-related disease or disorder |
| WO2025080946A2 (en) | 2023-10-12 | 2025-04-17 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008041767A1 (en) * | 2006-10-05 | 2008-04-10 | Banyu Pharmaceutical Co., Ltd. | Gene/protein marker for prediction or diagnosis of pharmacological efficacy of aurora a inhibitor |
| CA2598893C (en) * | 2006-10-11 | 2012-04-10 | Astellas Pharma Inc. | Eml4-alk fusion gene |
| JP2010046057A (ja) * | 2008-07-22 | 2010-03-04 | Akita Univ | 癌細胞の治療感受性増強剤、癌細胞の治療感受性の判定方法、および癌細胞の治療感受性判定キット |
| BR112013013659B8 (pt) * | 2010-12-03 | 2024-02-27 | Epizyme Inc | Compostos moduladores de enzimas epigenéticas, composição farmacêutica compreendendo ditos compostos e usos da dita composição farmacêutica para tratar câncer, câncer hematológico ou leucemia |
| WO2014039839A1 (en) * | 2012-09-06 | 2014-03-13 | Epizyme, Inc. | Method of treating leukemia |
| US9446064B2 (en) * | 2013-03-14 | 2016-09-20 | Epizyme, Inc. | Combination therapy for treating cancer |
| WO2015073706A1 (en) * | 2013-11-13 | 2015-05-21 | Epizyme, Inc. | Methods for treating cancer |
-
2013
- 2013-12-20 CA CA2894220A patent/CA2894220A1/en not_active Abandoned
- 2013-12-20 AU AU2013361076A patent/AU2013361076B2/en not_active Ceased
- 2013-12-20 WO PCT/US2013/077082 patent/WO2014100662A1/en not_active Ceased
- 2013-12-20 JP JP2015549801A patent/JP2016510316A/ja active Pending
- 2013-12-20 US US14/654,125 patent/US20150342979A1/en not_active Abandoned
- 2013-12-20 EP EP13821345.9A patent/EP2934550A1/en not_active Withdrawn
-
2018
- 2018-10-11 JP JP2018192426A patent/JP2019031525A/ja active Pending
-
2019
- 2019-09-19 US US16/575,957 patent/US20200113923A1/en not_active Abandoned
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