CA2894220A1 - Dot1l inhibitors for use in the treatment of leukemia - Google Patents
Dot1l inhibitors for use in the treatment of leukemia Download PDFInfo
- Publication number
- CA2894220A1 CA2894220A1 CA2894220A CA2894220A CA2894220A1 CA 2894220 A1 CA2894220 A1 CA 2894220A1 CA 2894220 A CA2894220 A CA 2894220A CA 2894220 A CA2894220 A CA 2894220A CA 2894220 A1 CA2894220 A1 CA 2894220A1
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- cancer
- amino
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- methyl
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Molecular Biology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201261745294P | 2012-12-21 | 2012-12-21 | |
| US61/745,294 | 2012-12-21 | ||
| PCT/US2013/077082 WO2014100662A1 (en) | 2012-12-21 | 2013-12-20 | Dot1 l inhibitors for use in the treatment of leukemia |
Publications (1)
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| CA2894220A1 true CA2894220A1 (en) | 2014-06-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2894220A Abandoned CA2894220A1 (en) | 2012-12-21 | 2013-12-20 | Dot1l inhibitors for use in the treatment of leukemia |
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| Country | Link |
|---|---|
| US (2) | US20150342979A1 (enExample) |
| EP (1) | EP2934550A1 (enExample) |
| JP (2) | JP2016510316A (enExample) |
| AU (1) | AU2013361076B2 (enExample) |
| CA (1) | CA2894220A1 (enExample) |
| WO (1) | WO2014100662A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20150284422A1 (en) | 2012-08-10 | 2015-10-08 | Epizyme, Inc. | Inhibitors of protein methyltransferase dot1l and methods of use thereof |
| WO2014039839A1 (en) | 2012-09-06 | 2014-03-13 | Epizyme, Inc. | Method of treating leukemia |
| US9446064B2 (en) | 2013-03-14 | 2016-09-20 | Epizyme, Inc. | Combination therapy for treating cancer |
| EP2968387A4 (en) | 2013-03-15 | 2017-04-05 | Epizyme, Inc. | Methods of synthesizing substituted purine compounds |
| WO2016011402A1 (en) * | 2014-07-18 | 2016-01-21 | The Regents Of The University Of Colorado, A Body Corporate | Dot1l inhibition in patients with mn1-high aml |
| US20170335402A1 (en) * | 2014-08-08 | 2017-11-23 | Baylor College Of Medicine | Dot1l inhibitors and uses thereof |
| WO2016029127A1 (en) * | 2014-08-22 | 2016-02-25 | The Regents Of The University Of Colorado, A Body Corporate | Dot1l inhibitors and uses thereof |
| EP3193879A4 (en) * | 2014-09-17 | 2018-05-16 | Epizyme, Inc. | Injectable formulations for treating cancer |
| EP3200826B1 (en) * | 2014-09-30 | 2021-04-21 | Vecht-lifshitz, Susan Eve | Pharmaceutical compositions for treating ebola virus disease |
| GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
| WO2017132398A1 (en) | 2016-01-26 | 2017-08-03 | Memorial Sloan-Kettering Cancer Center | Targeting chromatin regulators inhibits leukemogenic gene expression in npm1 mutant leukemia |
| US11944627B2 (en) | 2017-03-24 | 2024-04-02 | Kura Oncology, Inc. | Methods for treating hematological malignancies and Ewing's sarcoma |
| GB201901817D0 (en) | 2019-02-11 | 2019-04-03 | Phoremost Ltd | Methods |
| CN110092804A (zh) * | 2019-03-29 | 2019-08-06 | 广州盈升生物科技有限公司 | 一种含双环基团的嘌呤化合物及其制备方法 |
| TW202508595A (zh) | 2023-05-04 | 2025-03-01 | 美商銳新醫藥公司 | 用於ras相關疾病或病症之組合療法 |
| WO2025034702A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 for use in the treatment of ras protein-related disease or disorder |
| WO2025080946A2 (en) | 2023-10-12 | 2025-04-17 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
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| WO2008041767A1 (en) * | 2006-10-05 | 2008-04-10 | Banyu Pharmaceutical Co., Ltd. | Gene/protein marker for prediction or diagnosis of pharmacological efficacy of aurora a inhibitor |
| CA2598893C (en) * | 2006-10-11 | 2012-04-10 | Astellas Pharma Inc. | Eml4-alk fusion gene |
| JP2010046057A (ja) * | 2008-07-22 | 2010-03-04 | Akita Univ | 癌細胞の治療感受性増強剤、癌細胞の治療感受性の判定方法、および癌細胞の治療感受性判定キット |
| BR112013013659B8 (pt) * | 2010-12-03 | 2024-02-27 | Epizyme Inc | Compostos moduladores de enzimas epigenéticas, composição farmacêutica compreendendo ditos compostos e usos da dita composição farmacêutica para tratar câncer, câncer hematológico ou leucemia |
| WO2014039839A1 (en) * | 2012-09-06 | 2014-03-13 | Epizyme, Inc. | Method of treating leukemia |
| US9446064B2 (en) * | 2013-03-14 | 2016-09-20 | Epizyme, Inc. | Combination therapy for treating cancer |
| WO2015073706A1 (en) * | 2013-11-13 | 2015-05-21 | Epizyme, Inc. | Methods for treating cancer |
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2013
- 2013-12-20 CA CA2894220A patent/CA2894220A1/en not_active Abandoned
- 2013-12-20 AU AU2013361076A patent/AU2013361076B2/en not_active Ceased
- 2013-12-20 WO PCT/US2013/077082 patent/WO2014100662A1/en not_active Ceased
- 2013-12-20 JP JP2015549801A patent/JP2016510316A/ja active Pending
- 2013-12-20 US US14/654,125 patent/US20150342979A1/en not_active Abandoned
- 2013-12-20 EP EP13821345.9A patent/EP2934550A1/en not_active Withdrawn
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2018
- 2018-10-11 JP JP2018192426A patent/JP2019031525A/ja active Pending
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2019
- 2019-09-19 US US16/575,957 patent/US20200113923A1/en not_active Abandoned
Also Published As
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| AU2013361076B2 (en) | 2018-08-30 |
| JP2019031525A (ja) | 2019-02-28 |
| WO2014100662A1 (en) | 2014-06-26 |
| JP2016510316A (ja) | 2016-04-07 |
| US20200113923A1 (en) | 2020-04-16 |
| US20150342979A1 (en) | 2015-12-03 |
| EP2934550A1 (en) | 2015-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20181212 |
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| FZDE | Discontinued |
Effective date: 20210831 |