JP2016510103A - 液体分注装置及びそれを制御する方法 - Google Patents
液体分注装置及びそれを制御する方法 Download PDFInfo
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B13/00—Pumps specially modified to deliver fixed or variable measured quantities
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/02—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to produce a jet, spray, or other discharge of particular shape or nature, e.g. in single drops, or having an outlet of particular shape
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B17/00—Pumps characterised by combination with, or adaptation to, specific driving engines or motors
- F04B17/03—Pumps characterised by combination with, or adaptation to, specific driving engines or motors driven by electric motors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/087—Multiple sequential chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
Abstract
Description
Claims (18)
- 入口ポート及び出口ポートを有するシリンダと、
前記シリンダ内のピストンであって、前記シリンダの長手方向の軸線に沿った線速度及び前記長手方向の軸線周りの回転速度を持つピストンと、を備えるポンプから、流体を分注する方法であって、
前記出口ポートにペンダント液滴を形成するように、前記出口ポートを通して第1の容量の前記流体を分注するステップと、
前記出口ポートを通して第2の容量の前記流体を分注するステップと、
全液滴を前記出口ポートから吐出するステップであって、前記全液滴の容量が前記第1の容量と前記第2の容量との合計であるステップと、を含む方法。 - 前記第1の容量が前記第2の容量より小さい請求項1に記載の方法。
- 前記第1の容量が前記第2の容量より大きい請求項1又は2に記載の方法。
- 前記分注するステップが、
第1の吐出段階の間に、前記線速度及び前記回転速度をそれぞれ第1の直線設定点及び第1の回転設定点にまで増大するように制御し、それにより前記第1の容量を有する前記ペンダント液滴を前記出口ポートに形成するステップと、
充満段階の間に、前記回転速度を、前記第1の回転設定点から、前記第1の回転設定点よりも大きい第2の回転設定点まで増大するように制御し、さらなる流体が前記入口ポートを通って前記シリンダ内に引き込まれるように前記線速度をゼロにまで減少させるステップと、
休止段階の間に、前記回転速度及び前記線速度のそれぞれをゼロにまで減少するように制御するステップと、
第2の吐出段階の間に、前記第2の容量が、前記出口ポートを通り抜けるように、前記回転速度を第3の回転設定点まで増大させ、前記線速度を第2の直線設定点まで増大させるステップと、を含む請求項1〜3のいずれか一項に記載の方法。 - 前記第1の回転設定点及び前記第3の回転設定点が等しい請求項1〜4のいずれか一項に記載の方法。
- 前記第1の容量が前記第2の容量より小さい請求項4に記載の方法。
- 前記第1の容量が前記第2の容量より大きい請求項4に記載の方法。
- 前記分注するステップが、
第1の吐出段階の間に、前記線速度及び前記回転速度を第1の直線設定点及び第1の回転設定点にまで増大するように制御し、前記第1の容量を有する前記ペンダント液滴を前記出口ポートに形成するステップと、
充満段階の間に、前記回転速度を、前記第1の回転設定点から、前記第1の回転設定点よりも大きい第2の回転設定点まで増大するように制御し、さらなる流体が前記シリンダ内に引き込まれるように前記線速度をゼロにまで減少させるステップと、
第2の吐出段階の間に、前記第2の容量が前記出口ポートを通り抜けるように、前記回転速度を第3の回転設定点まで増大させて前記線速度を第2の直線設定点まで増大させるステップと、を含む請求項1〜7のいずれか一項に記載の方法。 - 前記第1の回転設定点及び前記第3の回転設定点が等しい請求項8に記載の方法。
- 前記第1の容量が前記第2の容量より小さい請求項8に記載の方法。
- 前記第1の容量が前記第2の容量より大きい請求項8に記載の方法。
- 前記全液滴が、薬学的に又は化粧品として許容可能な薬剤を一つ以上含む請求項1〜11のいずれか一項に記載の方法。
- 前記全液滴が受け取り媒体上に分注される請求項12に記載の方法。
- 前記受け取り媒体が、薬学的に許容可能な錠剤又は受け取りバイアルである請求項13に記載の方法。
- 入口ポート及び出口ポートを有するシリンダと、
前記シリンダ内のピストンであって、前記シリンダの長手方向の軸線に沿った線速度及び前記長手方向の軸線周りの回転速度を持つピストンと、
多段階液滴吐出サイクルが記憶された制御装置であって、前記ピストンに動作可能に接続されている制御装置と、を備え、
前記制御装置が、2つの別個の段階において、前記出口ポートから前記液体の液滴を吐出するように、前記ピストンの前記線速度及び前記回転速度を制御する液体分注装置。 - 前記液滴が、第1の容量と第2の容量との合計である液滴容量を有し、前記制御装置が、前記2つの別個の段階のうちの第1の段階の間に前記第1の容量を吐出するとともに、前記2つの別個の段階のうちの第2の段階の間に第2の容量を吐出するように、前記ピストンを制御する請求項15に記載の液体分注装置。
- 前記制御装置と電気通信するリニアエンコーダをさらに備え、前記制御装置が、前記シリンダ内の前記ピストンのストローク長さを調整するように、リニアアクチュエータを制御し、それにより前記液滴容量を調整する請求項15又は16に記載の液体分注装置。
- 前記シリンダの前記入口ポートと流体連通している循環ループをさらに備え、前記流体が前記循環ループ内を連続的に循環される請求項15〜17のうちのいずれか一項に記載の液体分注装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201361790508P | 2013-03-15 | 2013-03-15 | |
US61/790,508 | 2013-03-15 | ||
PCT/IB2014/059828 WO2014141196A1 (en) | 2013-03-15 | 2014-03-14 | Liquid dispensing devices and methods of controlling the same |
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JP2016510103A true JP2016510103A (ja) | 2016-04-04 |
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JP2015562533A Ceased JP2016510103A (ja) | 2013-03-15 | 2014-03-14 | 液体分注装置及びそれを制御する方法 |
Country Status (11)
Country | Link |
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US (2) | US9416776B2 (ja) |
EP (1) | EP2971762A1 (ja) |
JP (1) | JP2016510103A (ja) |
KR (1) | KR20150128710A (ja) |
CN (1) | CN105008720B (ja) |
AU (1) | AU2014229242B2 (ja) |
BR (1) | BR112015020583A2 (ja) |
CA (1) | CA2905190A1 (ja) |
MX (1) | MX2015012356A (ja) |
RU (1) | RU2015144167A (ja) |
WO (1) | WO2014141196A1 (ja) |
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2014
- 2014-03-13 US US14/776,172 patent/US9416776B2/en active Active
- 2014-03-14 MX MX2015012356A patent/MX2015012356A/es unknown
- 2014-03-14 RU RU2015144167A patent/RU2015144167A/ru not_active Application Discontinuation
- 2014-03-14 KR KR1020157024825A patent/KR20150128710A/ko not_active Application Discontinuation
- 2014-03-14 AU AU2014229242A patent/AU2014229242B2/en not_active Ceased
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS59188539A (ja) * | 1983-03-21 | 1984-10-25 | マイルス・ラボラトリ−ズ・インコ−ポレ−テツド | 微小液滴分与機、その使い捨てポンプ要素及び既定微小液滴量を与える方法 |
JP2003262189A (ja) * | 2001-12-03 | 2003-09-19 | Ortho-Clinical Diagnostics Inc | 可変速度ポンプ駆動型計量システムのための流体計量配分アルゴリズム |
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US20160008813A1 (en) | 2016-01-14 |
KR20150128710A (ko) | 2015-11-18 |
MX2015012356A (es) | 2016-02-03 |
CA2905190A1 (en) | 2014-09-18 |
RU2015144167A3 (ja) | 2018-03-14 |
CN105008720A (zh) | 2015-10-28 |
US9416776B2 (en) | 2016-08-16 |
AU2014229242A1 (en) | 2015-08-06 |
CN105008720B (zh) | 2017-05-17 |
US20160032909A1 (en) | 2016-02-04 |
EP2971762A1 (en) | 2016-01-20 |
BR112015020583A2 (pt) | 2017-07-18 |
AU2014229242B2 (en) | 2016-07-14 |
RU2015144167A (ru) | 2017-04-21 |
WO2014141196A1 (en) | 2014-09-18 |
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