JP2016509067A5 - - Google Patents
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- JP2016509067A5 JP2016509067A5 JP2015559259A JP2015559259A JP2016509067A5 JP 2016509067 A5 JP2016509067 A5 JP 2016509067A5 JP 2015559259 A JP2015559259 A JP 2015559259A JP 2015559259 A JP2015559259 A JP 2015559259A JP 2016509067 A5 JP2016509067 A5 JP 2016509067A5
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- JP
- Japan
- Prior art keywords
- npc
- pharmaceutical composition
- therapeutic agent
- composition
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 36
- 239000003814 drug Substances 0.000 claims 27
- 229940124597 therapeutic agent Drugs 0.000 claims 27
- 239000000203 mixture Substances 0.000 claims 21
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 claims 16
- JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 claims 12
- 241000124008 Mammalia Species 0.000 claims 6
- 239000010409 thin film Substances 0.000 claims 5
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 claims 4
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 claims 4
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims 4
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 4
- 208000025157 Oral disease Diseases 0.000 claims 4
- 229920002125 Sokalan® Polymers 0.000 claims 4
- 230000002378 acidificating effect Effects 0.000 claims 4
- KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 claims 4
- 229940117893 apigenin Drugs 0.000 claims 4
- XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 claims 4
- 235000008714 apigenin Nutrition 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 229960003260 chlorhexidine Drugs 0.000 claims 4
- 229940043259 farnesol Drugs 0.000 claims 4
- 229930002886 farnesol Natural products 0.000 claims 4
- 229940091249 fluoride supplement Drugs 0.000 claims 4
- 208000030194 mouth disease Diseases 0.000 claims 4
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 claims 4
- 241000283690 Bos taurus Species 0.000 claims 3
- 241000282472 Canis lupus familiaris Species 0.000 claims 3
- 241000283086 Equidae Species 0.000 claims 3
- 241000282326 Felis catus Species 0.000 claims 3
- 241000282412 Homo Species 0.000 claims 3
- 241001494479 Pecora Species 0.000 claims 3
- 241000288906 Primates Species 0.000 claims 3
- 241000282887 Suidae Species 0.000 claims 3
- 208000002925 dental caries Diseases 0.000 claims 3
- 208000007565 gingivitis Diseases 0.000 claims 3
- 201000001245 periodontitis Diseases 0.000 claims 3
- 230000001960 triggered effect Effects 0.000 claims 3
- 208000006819 Denture Stomatitis Diseases 0.000 claims 2
- 208000007027 Oral Candidiasis Diseases 0.000 claims 2
- 238000009825 accumulation Methods 0.000 claims 2
- 230000032770 biofilm formation Effects 0.000 claims 2
- 208000002064 Dental Plaque Diseases 0.000 claims 1
- 206010064687 Device related infection Diseases 0.000 claims 1
- 206010033078 Otitis media Diseases 0.000 claims 1
- 239000012620 biological material Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000010408 film Substances 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000022760 infectious otitis media Diseases 0.000 claims 1
- 238000002789 length control Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000007937 lozenge Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 208000019206 urinary tract infection Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361768929P | 2013-02-25 | 2013-02-25 | |
| US61/768,929 | 2013-02-25 | ||
| PCT/US2014/018211 WO2014130994A1 (en) | 2013-02-25 | 2014-02-25 | Nanoparticles for controlled release of anti-biofilm agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016509067A JP2016509067A (ja) | 2016-03-24 |
| JP2016509067A5 true JP2016509067A5 (cg-RX-API-DMAC7.html) | 2017-03-30 |
| JP6309980B2 JP6309980B2 (ja) | 2018-04-11 |
Family
ID=51391907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015559259A Expired - Fee Related JP6309980B2 (ja) | 2013-02-25 | 2014-02-25 | 抗バイオフィルム剤を制御放出するためのナノ粒子及びその使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9566247B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2958557B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6309980B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN105142620B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014218569B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2902157A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014130994A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0811530B1 (pt) | 2007-05-14 | 2019-01-02 | Research Foundation Of State Univ Of New York | composição compreendendo indutor(es) de resposta fisiológica à dispersão ácido decanóico, superfície, solução, método ex vivo de tratamento ou inibição da formação de um biofilme sobre uma superfície |
| JP6721603B2 (ja) * | 2015-03-04 | 2020-07-15 | ダウ グローバル テクノロジーズ エルエルシー | 固体混合物からの難水溶性物質の効果的な可溶化のための賦形剤としてのコポリマー |
| CN113876600B (zh) * | 2015-10-21 | 2024-05-17 | 密歇根大学董事会 | 用纳米粒检测和治疗龋和微腔 |
| US11207378B2 (en) | 2016-04-04 | 2021-12-28 | University Of Virginia Patent Foundation | Compositions for inhibiting formation of and/or disrupting bacterial biofilms and methods of use therefor |
| WO2018026764A1 (en) * | 2016-08-01 | 2018-02-08 | University Of Rochester | Nanoparticles for controlled release of anti-biofilm agents and methods of use |
| CN106370636B (zh) * | 2016-08-31 | 2019-02-26 | 中国科学院新疆生态与地理研究所 | 一种检测生物膜表面吸附纳米颗粒的方法 |
| CN110621286A (zh) * | 2017-02-23 | 2019-12-27 | 阿里拉健康波士顿有限责任公司 | 生态友好型破坏生物膜的抗微生物制剂、其开发及用途 |
| EP3589937A4 (en) * | 2017-03-03 | 2020-10-21 | The Procter and Gamble Company | ION QUANTIFICATION PROCESSES IN DENTAL BIOFILM |
| EP3612570A4 (en) * | 2017-04-17 | 2021-01-13 | The University of Chicago | POLYMERIC MATERIALS FOR THE ADMINISTRATION OF SHORT-CHAIN FATTY ACIDS TO THE INTESTINE FOR HUMAN HEALTH AND DISEASE TREATMENT APPLICATIONS |
| CA3060720A1 (en) | 2017-05-16 | 2018-11-22 | Johnson & Johnson Consumer Inc. | Coated particles and their uses |
| DE102017130893A1 (de) * | 2017-12-21 | 2019-06-27 | Paul Hartmann Ag | pH regulierende Wundauflage |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| WO2020051352A1 (en) | 2018-09-06 | 2020-03-12 | Greenmark Biomedical Inc. | Dental imaging and/or curing system |
| CN109091453A (zh) * | 2018-09-18 | 2018-12-28 | 成都爱睿康美医疗科技有限责任公司 | 葡萄糖响应性的可注射纳米凝胶及其制备方法和应用 |
| CA3117446A1 (en) * | 2018-10-22 | 2020-04-30 | Takeda Pharmaceutical Company Limited | Nanoparticle encapsulation to target g protein-coupled receptors in endosomes |
| CN109827814A (zh) * | 2019-03-11 | 2019-05-31 | 南京大学 | 一种新型大气颗粒物琼脂采样膜制备及免溶剂提取细胞暴露方法 |
| EP3946489A4 (en) * | 2019-03-26 | 2022-12-07 | Temple University - Of The Commonwealth System of Higher Education | INTELLIGENT COMPOSITE WITH ANTIBIOFILM, MINERALIZATION AND ANTI-INFECTIVE THERAPEUTIC ACTION |
| US12195755B2 (en) | 2019-05-20 | 2025-01-14 | Brown University | Placental lipid bilayer for cell-free molecular interaction studies |
| DE102019122569A1 (de) | 2019-08-22 | 2021-02-25 | Mühlbauer Technology Gmbh | Flavonoidderivat |
| US20210179884A1 (en) | 2019-12-17 | 2021-06-17 | Columbia Insurance Company | Redox chased suspension bead additives for paints and stains |
| JP2023553010A (ja) | 2020-12-03 | 2023-12-20 | バテル・メモリアル・インスティテュート | 非ウイルス性送達のためのポリマーナノ粒子およびｄｎａナノ構造組成物ならびに方法 |
| JP2024516108A (ja) | 2021-04-07 | 2024-04-12 | バテル・メモリアル・インスティテュート | 非ウイルス性担体を同定および使用するための迅速な設計、構築、試験、および学習技術 |
| WO2023091676A1 (en) * | 2021-11-19 | 2023-05-25 | The Regents Of The University Of Michigan | Biofilm-targeting nanoparticles to increase the anticaries effect of fluoride |
| KR20250033234A (ko) | 2022-07-11 | 2025-03-07 | 벤자민무어앤드캄파니 | 비이온성 수지, 및 얼룩 차단 건축용 조성물용 비이온성 수지 및 양이온성 첨가제의 혼합물 |
| CN115671264B (zh) * | 2023-01-04 | 2023-03-07 | 云南伦扬科技有限公司 | 一种用于靶向光催化变形链球菌生物膜的级联纳米酶 |
| WO2024226999A1 (en) * | 2023-04-28 | 2024-10-31 | Brown University | Methods of making and using nanoparticles for treatment of microbial biofilms |
| CN116570734B (zh) * | 2023-07-13 | 2023-10-13 | 四川大学华西医院 | 一种具有靶向功能的核壳壳结构药物胶束及其制备方法 |
| WO2025072751A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| WO2025122954A1 (en) | 2023-12-08 | 2025-06-12 | Battelle Memorial Institute | Use of dna origami nanostructures for molecular information based data storage systems |
| CN118955827B (zh) * | 2024-07-31 | 2025-09-12 | 安徽农业大学 | 一种纳米载体及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5116602A (en) * | 1989-09-27 | 1992-05-26 | Colgate-Palmolive Company | Antiplaque oral compositions |
| EP1534340B1 (en) | 2002-09-06 | 2011-11-16 | Cerulean Pharma Inc. | Cyclodextrin-based polymers for delivering the therapeutic agents covalently bound thereto |
| WO2005030174A1 (en) | 2003-09-23 | 2005-04-07 | Massachusetts Institute Of Technology | Ph-triggered microparticles |
| WO2006122127A1 (en) * | 2005-05-10 | 2006-11-16 | Naomi Balaban | Compositions for administering rnaiii-inhibiting peptides |
| US8119162B2 (en) * | 2005-11-10 | 2012-02-21 | Colgate-Palmolive Company | Particles that disrupt or impede bacterial adhesion, related compositions and methods |
| WO2007070801A2 (en) * | 2005-12-12 | 2007-06-21 | Allaccem, Inc. | Methods and systems for preparing antimicrobial films and coatings |
| US20100021391A1 (en) * | 2006-07-14 | 2010-01-28 | Montana State University | Novel nanoparticles for biofilm targeting |
| US8188068B2 (en) * | 2007-08-10 | 2012-05-29 | Allaccem, Inc. | Bridged polycyclic compound based compositions for coating oral surfaces in pets |
| CA2724014C (en) | 2008-05-13 | 2016-09-13 | University Of Washington | Micellic assemblies |
| BRPI0915885A2 (pt) * | 2008-07-09 | 2015-11-03 | Univ Nebraska | micelas funcionais para a liberação direcionada de substâncias químicas em tecido duro |
| US8697375B2 (en) * | 2008-09-02 | 2014-04-15 | University Of Maryland, Baltimore | In vivo biofilm infection diagnosis and treatment |
| WO2012103257A2 (en) * | 2011-01-25 | 2012-08-02 | The Regents Of The University Of California | Transcutaneous multimodal delivery systems |
-
2014
- 2014-02-25 CN CN201480023441.1A patent/CN105142620B/zh not_active Expired - Fee Related
- 2014-02-25 EP EP14754022.3A patent/EP2958557B1/en active Active
- 2014-02-25 AU AU2014218569A patent/AU2014218569B2/en not_active Ceased
- 2014-02-25 US US14/768,945 patent/US9566247B2/en active Active
- 2014-02-25 CA CA2902157A patent/CA2902157A1/en not_active Abandoned
- 2014-02-25 JP JP2015559259A patent/JP6309980B2/ja not_active Expired - Fee Related
- 2014-02-25 WO PCT/US2014/018211 patent/WO2014130994A1/en not_active Ceased
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