JP2016509050A5 - - Google Patents

Info

Publication number

JP2016509050A5

JP2016509050A5 JP2015558580A JP2015558580A JP2016509050A5 JP 2016509050 A5 JP2016509050 A5 JP 2016509050A5 JP 2015558580 A JP2015558580 A JP 2015558580A JP 2015558580 A JP2015558580 A JP 2015558580A JP 2016509050 A5 JP2016509050 A5 JP 2016509050A5

Authority

JP

Japan

Prior art keywords

compound

pretreatment

patient

day

days

Prior art date

2014-02-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 150000001875 compounds Chemical class 0.000 claims description 21
• 150000003839 salts Chemical class 0.000 claims description 13
• 238000000034 method Methods 0.000 claims description 10
• 238000011282 treatment Methods 0.000 claims description 7
• 208000009329 Graft vs Host Disease Diseases 0.000 claims description 6
• 208000024908 graft versus host disease Diseases 0.000 claims description 6
• 229960000390 fludarabine Drugs 0.000 claims description 5
• GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims description 5
• 238000002512 chemotherapy Methods 0.000 claims description 4
• 238000011134 hematopoietic stem cell transplantation Methods 0.000 claims description 4
• COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 claims description 3
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims description 3
• 229930105110 Cyclosporin A Natural products 0.000 claims description 3
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims description 3
• 108010036949 Cyclosporine Proteins 0.000 claims description 3
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims description 3
• 229960002092 busulfan Drugs 0.000 claims description 3
• 229960001265 ciclosporin Drugs 0.000 claims description 3
• 229960004397 cyclophosphamide Drugs 0.000 claims description 3
• 229960000485 methotrexate Drugs 0.000 claims description 3
• 239000002246 antineoplastic agent Substances 0.000 claims description 2
• 210000001185 bone marrow Anatomy 0.000 claims description 2
• 239000003795 chemical substances by application Substances 0.000 claims description 2
• 229940127089 cytotoxic agent Drugs 0.000 claims description 2
• 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 2
• 210000000987 immune system Anatomy 0.000 claims description 2
• 230000001400 myeloablative effect Effects 0.000 claims description 2
• 150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 2
• 239000003814 drug Substances 0.000 claims 9
• XXHKHLYABSAFDW-UHFFFAOYSA-N 5-amino-5-[2-chloro-4-(3-phenylmethoxyphenyl)sulfanylphenyl]pentane-1,3-diol Chemical compound C1=C(Cl)C(C(CC(O)CCO)N)=CC=C1SC1=CC=CC(OCC=2C=CC=CC=2)=C1 XXHKHLYABSAFDW-UHFFFAOYSA-N 0.000 claims 2
• 229940124597 therapeutic agent Drugs 0.000 claims 2
• JGCZBUBEWYTICT-UHFFFAOYSA-N 5-amino-5-[2-chloro-4-(3-phenylmethoxyphenyl)sulfanylphenyl]pentane-1,3-diol;hydrochloride Chemical group Cl.C1=C(Cl)C(C(CC(O)CCO)N)=CC=C1SC1=CC=CC(OCC=2C=CC=CC=2)=C1 JGCZBUBEWYTICT-UHFFFAOYSA-N 0.000 claims 1
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
• 238000011127 radiochemotherapy Methods 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 description 4
• 229910052736 halogen Inorganic materials 0.000 description 4
• 150000002367 halogens Chemical class 0.000 description 4
• 125000003545 alkoxy group Chemical group 0.000 description 3
• 229910052739 hydrogen Inorganic materials 0.000 description 2
• 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000004849 alkoxymethyl group Chemical group 0.000 description 1
• 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 description 1
• -1 benzyloxy, phenyl Chemical group 0.000 description 1
• 150000002431 hydrogen Chemical class 0.000 description 1
• 239000001257 hydrogen Substances 0.000 description 1
• 238000011321 prophylaxis Methods 0.000 description 1
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
• 125000004953 trihalomethyl group Chemical group 0.000 description 1