JP2016507248A5 - - Google Patents
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- Publication number
- JP2016507248A5 JP2016507248A5 JP2015558958A JP2015558958A JP2016507248A5 JP 2016507248 A5 JP2016507248 A5 JP 2016507248A5 JP 2015558958 A JP2015558958 A JP 2015558958A JP 2015558958 A JP2015558958 A JP 2015558958A JP 2016507248 A5 JP2016507248 A5 JP 2016507248A5
- Authority
- JP
- Japan
- Prior art keywords
- clonotype
- candidate
- database
- clonotypes
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 19
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 230000008521 reorganization Effects 0.000 claims 6
- 208000019420 lymphoid neoplasm Diseases 0.000 claims 4
- 230000008707 rearrangement Effects 0.000 claims 4
- 108700005091 Immunoglobulin Genes Proteins 0.000 claims 2
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 2
- 108020004511 Recombinant DNA Proteins 0.000 claims 2
- 208000007660 Residual Neoplasm Diseases 0.000 claims 2
- 108700042075 T-Cell Receptor Genes Proteins 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 102100032392 Circadian-associated transcriptional repressor Human genes 0.000 claims 1
- 101710130150 Circadian-associated transcriptional repressor Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361768269P | 2013-02-22 | 2013-02-22 | |
| US61/768,269 | 2013-02-22 | ||
| US13/834,794 US9528160B2 (en) | 2008-11-07 | 2013-03-15 | Rare clonotypes and uses thereof |
| US13/834,794 | 2013-03-15 | ||
| PCT/US2014/017416 WO2014130685A1 (en) | 2013-02-22 | 2014-02-20 | Rare clonotypes and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016507248A JP2016507248A (ja) | 2016-03-10 |
| JP2016507248A5 true JP2016507248A5 (enExample) | 2017-03-02 |
| JP6513035B2 JP6513035B2 (ja) | 2019-05-15 |
Family
ID=51391810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015558958A Active JP6513035B2 (ja) | 2013-02-22 | 2014-02-20 | 希少クロノタイプおよびその用途 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2959020B1 (enExample) |
| JP (1) | JP6513035B2 (enExample) |
| AU (1) | AU2014218910A1 (enExample) |
| CA (1) | CA2900240A1 (enExample) |
| ES (1) | ES2748204T3 (enExample) |
| WO (1) | WO2014130685A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
| EP3699296A1 (en) | 2008-11-07 | 2020-08-26 | Adaptive Biotechnologies Corporation | Methods of monitoring conditions by sequence analysis |
| US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| HUE029424T2 (en) | 2009-01-15 | 2017-02-28 | Adaptive Biotechnologies Corp | Adaptive immunity profiling and a method for producing monoclonal antibodies |
| RU2014144463A (ru) | 2009-06-25 | 2015-06-20 | Фред Хатчинсон Кансэр Рисёч Сентер | Способ измерения адаптивного иммунитета |
| US9043160B1 (en) | 2009-11-09 | 2015-05-26 | Sequenta, Inc. | Method of determining clonotypes and clonotype profiles |
| US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
| AU2012325791B2 (en) | 2011-10-21 | 2018-04-05 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| EP2788509B1 (en) | 2011-12-09 | 2018-07-11 | Adaptive Biotechnologies Corporation | Diagnosis of lymphoid malignancies and minimal residual disease detection |
| US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
| ES2662128T3 (es) | 2012-03-05 | 2018-04-05 | Adaptive Biotechnologies Corporation | Determinación de cadenas de receptor inmunitario emparejadas a partir de la frecuencia de subunidades coincidentes |
| PT2831276T (pt) | 2012-05-08 | 2016-07-26 | Adaptive Biotechnologies Corp | Composições e método para medição e calibração do viés de amplificação em reações pcr multiplex |
| ES2660027T3 (es) | 2012-10-01 | 2018-03-20 | Adaptive Biotechnologies Corporation | Evaluación de la inmunocompetencia por la diversidad de los receptores de inmunidad adaptativa y caracterización de la clonalidad |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| WO2015134787A2 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| EP3132059B1 (en) | 2014-04-17 | 2020-01-08 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| EP3715455A1 (en) | 2014-10-29 | 2020-09-30 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| US11066705B2 (en) | 2014-11-25 | 2021-07-20 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
| WO2016138122A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
| US11041202B2 (en) | 2015-04-01 | 2021-06-22 | Adaptive Biotechnologies Corporation | Method of identifying human compatible T cell receptors specific for an antigenic target |
| CN107849560B (zh) | 2015-04-27 | 2021-10-22 | 阿布维特罗有限责任公司 | 对治疗剂和疾病特异性抗原进行测序、确定、配对和验证的方法 |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| EP3676399B1 (en) | 2017-09-01 | 2022-05-11 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| EP3824103A1 (en) | 2018-07-18 | 2021-05-26 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
| BR112023019195A2 (pt) | 2021-03-24 | 2023-10-17 | Genentech Inc | Edição eficiente do gene tcr em linfócitos t |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990004648A1 (en) | 1988-10-20 | 1990-05-03 | Alexander Alan Morley | Method for diagnosis of monoclonality in leukaemia and lymphoma |
| US5837447A (en) | 1992-04-15 | 1998-11-17 | Blood Center Research Foundation, Inc., The | Monitoring an immune response by analysis of amplified immunoglobulin or T-cell-receptor nucleic acid |
| US6087096A (en) | 1995-11-13 | 2000-07-11 | Dau; Peter C. | Method of intrafamily fragment analysis of the T cell receptor α and β chain CDR3 regions |
| AU736742B2 (en) * | 1996-06-03 | 2001-08-02 | Governors Of The University Of Alberta, The | Methods for detection of rearranged DNA |
| CN1965089A (zh) | 2002-10-11 | 2007-05-16 | 鹿特丹伊拉兹马斯大学 | 用于基于pcr的克隆系研究的核酸扩增引物 |
| ATE421998T1 (de) | 2003-12-15 | 2009-02-15 | Pasteur Institut | Ermittlung des repertoires von b-lymphozyten populationen |
| WO2007087312A2 (en) | 2006-01-23 | 2007-08-02 | Population Genetics Technologies Ltd. | Molecular counting |
| US9528160B2 (en) * | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
| JP6158080B2 (ja) * | 2010-05-06 | 2017-07-05 | アダプティヴ バイオテクノロジーズ コーポレーション | クロノタイププロファイルを用いた健康状態および疾患状態のモニタリング |
-
2014
- 2014-02-20 CA CA2900240A patent/CA2900240A1/en not_active Abandoned
- 2014-02-20 EP EP14754622.0A patent/EP2959020B1/en active Active
- 2014-02-20 AU AU2014218910A patent/AU2014218910A1/en not_active Abandoned
- 2014-02-20 JP JP2015558958A patent/JP6513035B2/ja active Active
- 2014-02-20 WO PCT/US2014/017416 patent/WO2014130685A1/en not_active Ceased
- 2014-02-20 ES ES14754622T patent/ES2748204T3/es active Active
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