JP2016506908A5 - - Google Patents
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- Publication number
- JP2016506908A5 JP2016506908A5 JP2015552819A JP2015552819A JP2016506908A5 JP 2016506908 A5 JP2016506908 A5 JP 2016506908A5 JP 2015552819 A JP2015552819 A JP 2015552819A JP 2015552819 A JP2015552819 A JP 2015552819A JP 2016506908 A5 JP2016506908 A5 JP 2016506908A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- individual
- composition according
- albumin
- nanoparticles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101710113436 GTPase KRas Proteins 0.000 claims description 20
- 230000035772 mutation Effects 0.000 claims description 15
- 102000009027 Albumins Human genes 0.000 claims description 12
- 108010088751 Albumins Proteins 0.000 claims description 12
- 239000002105 nanoparticle Substances 0.000 claims description 12
- 229940123237 Taxane Drugs 0.000 claims description 10
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims description 10
- 102200007373 rs17851045 Human genes 0.000 claims description 5
- 229930012538 Paclitaxel Natural products 0.000 claims description 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 4
- 239000002246 antineoplastic agent Substances 0.000 claims description 4
- 229940127089 cytotoxic agent Drugs 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 229960001592 paclitaxel Drugs 0.000 claims description 4
- 102200006657 rs104894228 Human genes 0.000 claims description 4
- 102200006532 rs112445441 Human genes 0.000 claims description 4
- 102200006520 rs121913240 Human genes 0.000 claims description 4
- 102200006531 rs121913529 Human genes 0.000 claims description 4
- 102200006537 rs121913529 Human genes 0.000 claims description 4
- 102200006539 rs121913529 Human genes 0.000 claims description 4
- 102200006538 rs121913530 Human genes 0.000 claims description 4
- 102200006540 rs121913530 Human genes 0.000 claims description 4
- 102200006541 rs121913530 Human genes 0.000 claims description 4
- 102220197834 rs121913535 Human genes 0.000 claims description 4
- 102200006648 rs28933406 Human genes 0.000 claims description 4
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 102220014333 rs112445441 Human genes 0.000 claims description 3
- 102200006533 rs121913535 Human genes 0.000 claims description 3
- 102220640055 Alpha-mannosidase 2_G12L_mutation Human genes 0.000 claims description 2
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 2
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 102220530637 Putative apolipoprotein(a)-like protein 2_G12F_mutation Human genes 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims description 2
- 229960005277 gemcitabine Drugs 0.000 claims description 2
- 102200006562 rs104894231 Human genes 0.000 claims description 2
- 102220197831 rs121913527 Human genes 0.000 claims description 2
- 102200006564 rs121917759 Human genes 0.000 claims description 2
- 102220334606 rs1348427922 Human genes 0.000 claims description 2
- 102220293980 rs143960528 Human genes 0.000 claims description 2
- 102200007376 rs770248150 Human genes 0.000 claims description 2
- 230000000869 mutational effect Effects 0.000 claims 1
- 102220197833 rs112445441 Human genes 0.000 claims 1
- 238000000034 method Methods 0.000 description 20
- 102200006525 rs121913240 Human genes 0.000 description 3
- 102220197780 rs121434596 Human genes 0.000 description 2
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361848793P | 2013-01-11 | 2013-01-11 | |
| US61/848,793 | 2013-01-11 | ||
| US201361752417P | 2013-01-14 | 2013-01-14 | |
| US61/752,417 | 2013-01-14 | ||
| US13/794,712 | 2013-03-11 | ||
| US13/794,712 US20140199405A1 (en) | 2013-01-11 | 2013-03-11 | Method for treating cancer based on mutation status of k-ras |
| PCT/US2014/011097 WO2014110408A1 (en) | 2013-01-11 | 2014-01-10 | Method for treating cancer based on mutation status of k-ras |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016506908A JP2016506908A (ja) | 2016-03-07 |
| JP2016506908A5 true JP2016506908A5 (Direct) | 2017-02-16 |
Family
ID=51165319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015552819A Pending JP2016506908A (ja) | 2013-01-11 | 2014-01-10 | Ｋ−ｒａｓの変異状態に基づくがんの処置方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20140199405A1 (Direct) |
| EP (1) | EP2943184A4 (Direct) |
| JP (1) | JP2016506908A (Direct) |
| KR (1) | KR20150103746A (Direct) |
| AU (1) | AU2014205254A1 (Direct) |
| BR (1) | BR112015016466A2 (Direct) |
| CA (1) | CA2897581A1 (Direct) |
| HK (1) | HK1217292A1 (Direct) |
| IL (1) | IL239740A0 (Direct) |
| MX (1) | MX2015008889A (Direct) |
| WO (1) | WO2014110408A1 (Direct) |
| ZA (1) | ZA201504878B (Direct) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1585548T1 (sl) | 2002-12-09 | 2018-11-30 | Abraxis Bioscience, Llc | Sestave in metode odmerjanja farmakoloških sredstev |
| US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| MX383644B (es) | 2005-02-18 | 2025-03-14 | Abraxis Bioscience Llc | Combinaciones y metodos de administracion de agentes terapeuticos y terapia de combinacion. |
| BRPI0615265A8 (pt) | 2005-08-31 | 2018-03-06 | Abraxis Bioscience Llc | composições compreendendo agentes farmacêuticos pouco hidrossoluíveis e agentes antimicrobianos |
| ES2548690T3 (es) | 2006-08-11 | 2015-10-20 | Johns Hopkins University | Secuencias consenso de codificación de cánceres colorrectales humanos |
| EP2117520B1 (en) | 2006-12-14 | 2018-08-29 | Abraxis BioScience, LLC | Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane |
| DK2155188T3 (da) * | 2007-06-01 | 2013-11-04 | Abraxis Bioscience Llc | Fremgangsmåder og sammensætninger til behandling af tilbagevendende kræft |
| EP3626233A1 (en) | 2009-04-15 | 2020-03-25 | Abraxis BioScience, LLC | Prion-free nanoparticle compositions and methods |
| ES2580135T3 (es) | 2010-03-26 | 2016-08-19 | Abraxis Bioscience, Llc | Métodos de tratamiento de carcinoma hepatocelular |
| KR20180050426A (ko) | 2010-03-29 | 2018-05-14 | 아브락시스 바이오사이언스, 엘엘씨 | 치료제의 약물 전달 및 유효성 향상 방법 |
| KR101894689B1 (ko) | 2010-03-29 | 2018-09-04 | 아브락시스 바이오사이언스, 엘엘씨 | 암의 치료 방법 |
| CA2801645A1 (en) | 2010-06-04 | 2011-12-08 | Abraxis Bioscience, Llc | Use of nanoparticules comprising a taxane and an albumin in the treatment of pancreatic cancer |
| CN103648521A (zh) | 2011-04-28 | 2014-03-19 | 阿布拉科斯生物科学有限公司 | 纳米颗粒组合物的血管内递送及其应用 |
| KR20140107417A (ko) | 2011-12-14 | 2014-09-04 | 아브락시스 바이오사이언스, 엘엘씨 | 입자의 동결건조 또는 동결을 위한 중합체 부형제의 용도 |
| US9149455B2 (en) | 2012-11-09 | 2015-10-06 | Abraxis Bioscience, Llc | Methods of treating melanoma |
| US9511046B2 (en) | 2013-01-11 | 2016-12-06 | Abraxis Bioscience, Llc | Methods of treating pancreatic cancer |
| WO2014159171A1 (en) | 2013-03-12 | 2014-10-02 | Abraxis Bioscience, Llc | Methods of treating lung cancer |
| SG11201507234UA (en) | 2013-03-14 | 2015-10-29 | Abraxis Bioscience Llc | Methods of treating bladder cancer |
| JP6781403B2 (ja) | 2013-12-09 | 2020-11-04 | タルゴバックス エーエスエー | ペプチド混合物 |
| EP3140320B1 (en) | 2014-05-06 | 2018-12-26 | Targovax Asa | Peptide vaccine comprising mutant ras peptide and chemotherapeutic agent |
| US10705070B1 (en) | 2015-03-05 | 2020-07-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug |
| US10527604B1 (en) | 2015-03-05 | 2020-01-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel |
| HUE070408T2 (hu) | 2015-06-29 | 2025-06-28 | Abraxis Bioscience Llc | Szirolimuszt és albumint tartalmazó nanorészecskék epitelioid sejtes tumorok kezelésében történõ alkalmazásra |
| EP3522887A4 (en) * | 2016-10-07 | 2020-06-10 | Abraxis BioScience, LLC | METHODS OF TREATING BILARIAN CANCER |
| EP3444272A1 (en) * | 2017-08-17 | 2019-02-20 | International-Drug-Development-Biotech | Treatment of ck8 positive cancers in relation with k-ras gene status |
| AU2019239953B2 (en) | 2018-03-20 | 2025-01-02 | Abraxis Bioscience, Llc | Methods of treating central nervous system disorders via administration of nanoparticles of an mtor inhibitor and an albumin |
| KR20220106758A (ko) | 2019-10-28 | 2022-07-29 | 아브락시스 바이오사이언스, 엘엘씨 | 알부민 및 라파마이신의 제약 조성물 |
| CN115867669A (zh) * | 2020-05-08 | 2023-03-28 | 凯帝夫肿瘤科技有限公司 | 监测kras突变的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX383644B (es) * | 2005-02-18 | 2025-03-14 | Abraxis Bioscience Llc | Combinaciones y metodos de administracion de agentes terapeuticos y terapia de combinacion. |
| US20090202989A1 (en) * | 2005-06-28 | 2009-08-13 | Hillan Kenneth J | Egfr and kras mutations |
| US8768629B2 (en) * | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
| DK2465950T3 (en) * | 2007-03-13 | 2017-10-09 | Amgen Inc | K-RAS MUTATIONS AND ANTI-EGFR ANTIBODY TREATMENT |
| WO2011116181A1 (en) * | 2010-03-17 | 2011-09-22 | Caris Life Sciences, Inc. | Theranostic and diagnostic methods using sparc and hsp90 |
| DK2470173T3 (en) * | 2009-08-25 | 2016-06-06 | Abraxis Bioscience Llc | Combination therapy of nanoparticle composition of the taxane and the hedgehog inhibitors |
| KR101894689B1 (ko) * | 2010-03-29 | 2018-09-04 | 아브락시스 바이오사이언스, 엘엘씨 | 암의 치료 방법 |
| US9469876B2 (en) * | 2010-04-06 | 2016-10-18 | Caris Life Sciences Switzerland Holdings Gmbh | Circulating biomarkers for metastatic prostate cancer |
| AU2011255438A1 (en) * | 2010-05-20 | 2013-01-10 | Synta Pharmaceuticals Corp. | Method of treating lung adenocarcinoma with Hsp90 inhibitory compounds |
| US20130004481A1 (en) * | 2011-01-12 | 2013-01-03 | Boehringer Ingelheim International Gmbh | Anticancer therapy |
| EP3444363B1 (en) * | 2011-06-03 | 2020-11-25 | Eisai R&D Management Co., Ltd. | Biomarkers for prediciting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
| WO2013134786A2 (en) * | 2012-03-09 | 2013-09-12 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Biomarker compositions and methods |
| AU2013201584A1 (en) * | 2012-03-12 | 2013-09-26 | Merrimack Pharmaceuticals, Inc. | Methods for treating pancreatic cancer using combination therapies comprising an anti-ErbB3 antibody |
-
2013
- 2013-03-11 US US13/794,712 patent/US20140199405A1/en not_active Abandoned
-
2014
- 2014-01-10 KR KR1020157021321A patent/KR20150103746A/ko not_active Withdrawn
- 2014-01-10 BR BR112015016466A patent/BR112015016466A2/pt not_active Application Discontinuation
- 2014-01-10 WO PCT/US2014/011097 patent/WO2014110408A1/en not_active Ceased
- 2014-01-10 HK HK16105270.2A patent/HK1217292A1/zh unknown
- 2014-01-10 MX MX2015008889A patent/MX2015008889A/es unknown
- 2014-01-10 EP EP14738060.4A patent/EP2943184A4/en not_active Withdrawn
- 2014-01-10 JP JP2015552819A patent/JP2016506908A/ja active Pending
- 2014-01-10 AU AU2014205254A patent/AU2014205254A1/en not_active Abandoned
- 2014-01-10 CA CA2897581A patent/CA2897581A1/en not_active Abandoned
-
2015
- 2015-07-01 IL IL239740A patent/IL239740A0/en unknown
- 2015-07-07 ZA ZA2015/04878A patent/ZA201504878B/en unknown
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