JP2016506736A5 - - Google Patents
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- Publication number
- JP2016506736A5 JP2016506736A5 JP2015556262A JP2015556262A JP2016506736A5 JP 2016506736 A5 JP2016506736 A5 JP 2016506736A5 JP 2015556262 A JP2015556262 A JP 2015556262A JP 2015556262 A JP2015556262 A JP 2015556262A JP 2016506736 A5 JP2016506736 A5 JP 2016506736A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- heregulin
- cells
- chga
- kinase inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cells Anatomy 0.000 claims 8
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 210000003890 endocrine cells Anatomy 0.000 claims 6
- 210000004039 endoderm cell Anatomy 0.000 claims 6
- 239000003590 rho kinase inhibitor Substances 0.000 claims 6
- 102000010792 Chromogranin A Human genes 0.000 claims 4
- 108010038447 Chromogranin A Proteins 0.000 claims 4
- 102000009071 ErbB Receptors Human genes 0.000 claims 4
- 108010073043 ErbB Receptors Proteins 0.000 claims 4
- NGOGFTYYXHNFQH-UHFFFAOYSA-N Fasudil Chemical compound C=1C=CC2=CN=CC=C2C=1S(=O)(=O)N1CCCNCC1 NGOGFTYYXHNFQH-UHFFFAOYSA-N 0.000 claims 4
- 102000004877 Insulin Human genes 0.000 claims 4
- 108090001061 Insulin Proteins 0.000 claims 4
- 210000002660 Insulin-Secreting Cells Anatomy 0.000 claims 4
- 210000002438 Upper Gastrointestinal Tract Anatomy 0.000 claims 4
- 229960002435 fasudil Drugs 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 230000003213 activating Effects 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 230000025458 RNA interference Effects 0.000 claims 2
- 108091005711 TGF-beta receptors Proteins 0.000 claims 2
- 230000003042 antagnostic Effects 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 230000000692 anti-sense Effects 0.000 claims 2
- 102000004965 antibodies Human genes 0.000 claims 2
- 108090001123 antibodies Proteins 0.000 claims 2
- 230000002860 competitive Effects 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000002987 rna-interference Effects 0.000 claims 2
- 239000011435 rock Substances 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
- 102100015783 NKX6-2 Human genes 0.000 claims 1
- 101710012719 NKX6-2 Proteins 0.000 claims 1
- 102000014413 Neuregulin Human genes 0.000 claims 1
- 108050003475 Neuregulin Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000000968 intestinal Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/761,078 | 2013-02-06 | ||
| US13/761,078 US9109245B2 (en) | 2009-04-22 | 2013-02-06 | Cell compositions derived from dedifferentiated reprogrammed cells |
| PCT/US2014/015156 WO2014124172A1 (en) | 2013-02-06 | 2014-02-06 | Cell compositions derived from dedifferentiated reprogrammed cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019078983A Division JP6721752B2 (ja) | 2013-02-06 | 2019-04-18 | 脱分化したリプログラミングされた細胞から導出された細胞組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016506736A JP2016506736A (ja) | 2016-03-07 |
| JP2016506736A5 true JP2016506736A5 (sl) | 2017-03-09 |
| JP6517702B2 JP6517702B2 (ja) | 2019-05-22 |
Family
ID=50239931
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556262A Active JP6517702B2 (ja) | 2013-02-06 | 2014-02-06 | 脱分化したリプログラミングされた細胞から導出された細胞組成物 |
| JP2019078983A Active JP6721752B2 (ja) | 2013-02-06 | 2019-04-18 | 脱分化したリプログラミングされた細胞から導出された細胞組成物 |
| JP2020104982A Active JP7250731B2 (ja) | 2013-02-06 | 2020-06-18 | 脱分化したリプログラミングされた細胞から導出された細胞組成物 |
| JP2022172222A Pending JP2023017838A (ja) | 2013-02-06 | 2022-10-27 | 脱分化したリプログラミングされた細胞から導出された細胞組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019078983A Active JP6721752B2 (ja) | 2013-02-06 | 2019-04-18 | 脱分化したリプログラミングされた細胞から導出された細胞組成物 |
| JP2020104982A Active JP7250731B2 (ja) | 2013-02-06 | 2020-06-18 | 脱分化したリプログラミングされた細胞から導出された細胞組成物 |
| JP2022172222A Pending JP2023017838A (ja) | 2013-02-06 | 2022-10-27 | 脱分化したリプログラミングされた細胞から導出された細胞組成物 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2954045A1 (sl) |
| JP (4) | JP6517702B2 (sl) |
| AU (4) | AU2014214879A1 (sl) |
| CA (2) | CA2898431C (sl) |
| HK (1) | HK1218139A1 (sl) |
| IL (4) | IL311689A (sl) |
| RU (2) | RU2754089C2 (sl) |
| WO (1) | WO2014124172A1 (sl) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9109245B2 (en) | 2009-04-22 | 2015-08-18 | Viacyte, Inc. | Cell compositions derived from dedifferentiated reprogrammed cells |
| CN106795487B (zh) | 2014-08-04 | 2021-11-19 | 武田药品工业株式会社 | 胰腺祖细胞的增殖方法 |
| MA45479A (fr) * | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
| CN109415680B (zh) * | 2016-05-18 | 2022-08-16 | 学校法人庆应义塾 | 类器官培养用细胞培养基、培养方法及类器官 |
| KR102448428B1 (ko) | 2017-01-27 | 2022-09-30 | 가부시키가이샤 가네카 | 내배엽계 세포 집단, 및 다능성 세포로부터 3배엽 중 어느 하나의 세포 집단을 제조하는 방법 |
| CA3066055A1 (en) | 2017-06-14 | 2018-12-20 | Semma Therapeutics, Inc. | Devices and methods for delivering therapeutics |
| JP7370600B2 (ja) * | 2018-08-03 | 2023-10-30 | オリヅルセラピューティクス株式会社 | 細胞製造法 |
| WO2020059892A1 (ja) * | 2018-09-19 | 2020-03-26 | 武田薬品工業株式会社 | インスリン産生細胞 |
| WO2020243666A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
| CN114173837A (zh) | 2019-05-31 | 2022-03-11 | W.L.戈尔及同仁股份有限公司 | 生物相容性膜复合材料 |
| WO2020243663A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
| CN114401752B (zh) | 2019-05-31 | 2023-04-04 | W.L.戈尔及同仁股份有限公司 | 具有受控氧扩散距离的细胞封装装置 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4794049B2 (ja) * | 1999-04-06 | 2011-10-12 | ジェネンテック， インコーポレイテッド | 糖尿病治療へのＥｒｂＢレセプターリガンドの使用 |
| US6759039B2 (en) * | 2000-06-30 | 2004-07-06 | Amcyte, Inc. | Culturing pancreatic stem cells having a specified, intermediate stage of development |
| JP2005503759A (ja) * | 2001-01-24 | 2005-02-10 | アメリカ合衆国 | 幹細胞の膵臓内分泌細胞への分化方法 |
| WO2007047509A2 (en) * | 2005-10-14 | 2007-04-26 | Regents Of The University Of Minnesota | Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype |
| WO2007143193A1 (en) * | 2006-06-02 | 2007-12-13 | University Of Georgia Research Foundation, Inc. | Pancreatic and liver endoderm cells and tissue by differentiation of definitive endoderm cells obtained from human embryonic stems |
| CN102282254B (zh) | 2008-11-14 | 2015-12-16 | 维赛特公司 | 源于人多能干细胞的胰腺细胞的包封 |
| DK2421957T3 (da) * | 2009-04-22 | 2021-01-25 | Viacyte Inc | Cellesammensætninger afledt af dedifferentierede omprogrammerede celler |
| US8685726B2 (en) * | 2009-04-27 | 2014-04-01 | Viacyte, Inc. | Small molecules supporting pluripotent cell growth and methods thereof |
-
2014
- 2014-02-06 IL IL311689A patent/IL311689A/en unknown
- 2014-02-06 CA CA2898431A patent/CA2898431C/en active Active
- 2014-02-06 AU AU2014214879A patent/AU2014214879A1/en not_active Abandoned
- 2014-02-06 JP JP2015556262A patent/JP6517702B2/ja active Active
- 2014-02-06 WO PCT/US2014/015156 patent/WO2014124172A1/en active Application Filing
- 2014-02-06 RU RU2018144412A patent/RU2754089C2/ru active
- 2014-02-06 IL IL290717A patent/IL290717B1/en unknown
- 2014-02-06 EP EP14708981.7A patent/EP2954045A1/en active Pending
- 2014-02-06 CA CA3212301A patent/CA3212301A1/en active Pending
- 2014-02-06 RU RU2015131279A patent/RU2675928C2/ru active
-
2015
- 2015-07-15 IL IL239953A patent/IL239953B/en active IP Right Grant
-
2016
- 2016-05-27 HK HK16106057.9A patent/HK1218139A1/zh unknown
-
2019
- 2019-02-26 AU AU2019201314A patent/AU2019201314B2/en active Active
- 2019-04-18 JP JP2019078983A patent/JP6721752B2/ja active Active
-
2020
- 2020-06-18 JP JP2020104982A patent/JP7250731B2/ja active Active
-
2021
- 2021-05-10 IL IL283088A patent/IL283088B/en unknown
-
2022
- 2022-01-07 AU AU2022200075A patent/AU2022200075C1/en active Active
- 2022-10-27 JP JP2022172222A patent/JP2023017838A/ja active Pending
-
2023
- 2023-04-26 AU AU2023202507A patent/AU2023202507A1/en active Pending
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