JP2016505138A5 - - Google Patents
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- JP2016505138A5 JP2016505138A5 JP2015551784A JP2015551784A JP2016505138A5 JP 2016505138 A5 JP2016505138 A5 JP 2016505138A5 JP 2015551784 A JP2015551784 A JP 2015551784A JP 2015551784 A JP2015551784 A JP 2015551784A JP 2016505138 A5 JP2016505138 A5 JP 2016505138A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- target
- activatable antibody
- antibody
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 108091005804 Peptidases Proteins 0.000 claims 6
- 239000004365 Protease Substances 0.000 claims 6
- 239000012472 biological sample Substances 0.000 claims 6
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 3
- 125000006850 spacer group Chemical group 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 239000002872 contrast media Substances 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- JARGNLJYKBUKSJ-KGZKBUQUSA-N (2r)-2-amino-5-[[(2r)-1-(carboxymethylamino)-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid;hydrobromide Chemical compound Br.OC(=O)[C@H](N)CCC(=O)N[C@H](CO)C(=O)NCC(O)=O JARGNLJYKBUKSJ-KGZKBUQUSA-N 0.000 claims 1
- 108010075254 C-Peptide Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 claims 1
- 206010039509 Scab Diseases 0.000 claims 1
- -1 chromophore Substances 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 108010044804 gamma-glutamyl-seryl-glycine Proteins 0.000 claims 1
- 108700026078 glutathione trisulfide Proteins 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 230000000873 masking effect Effects 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361749212P | 2013-01-04 | 2013-01-04 | |
| US201361749220P | 2013-01-04 | 2013-01-04 | |
| US61/749,220 | 2013-01-04 | ||
| US61/749,212 | 2013-01-04 | ||
| US201361749486P | 2013-01-07 | 2013-01-07 | |
| US201361749529P | 2013-01-07 | 2013-01-07 | |
| US61/749,486 | 2013-01-07 | ||
| US61/749,529 | 2013-01-07 | ||
| US201361755810P | 2013-01-23 | 2013-01-23 | |
| US61/755,810 | 2013-01-23 | ||
| US201361763237P | 2013-02-11 | 2013-02-11 | |
| US61/763,237 | 2013-02-11 | ||
| US201361830940P | 2013-06-04 | 2013-06-04 | |
| US61/830,940 | 2013-06-04 | ||
| US201361897659P | 2013-10-30 | 2013-10-30 | |
| US61/897,659 | 2013-10-30 | ||
| PCT/US2014/010216 WO2014107599A2 (en) | 2013-01-04 | 2014-01-03 | Compositions and methods for detecting protease activity in biological systems |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019190445A Division JP7001652B2 (ja) | 2013-01-04 | 2019-10-17 | 生体系におけるプロテアーゼ活性を検出するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505138A JP2016505138A (ja) | 2016-02-18 |
| JP2016505138A5 true JP2016505138A5 (enExample) | 2017-02-09 |
| JP6605957B2 JP6605957B2 (ja) | 2019-11-13 |
Family
ID=51062553
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015551784A Active JP6605957B2 (ja) | 2013-01-04 | 2014-01-03 | 生体系におけるプロテアーゼ活性を検出するための組成物及び方法 |
| JP2019190445A Active JP7001652B2 (ja) | 2013-01-04 | 2019-10-17 | 生体系におけるプロテアーゼ活性を検出するための組成物及び方法 |
| JP2021209234A Active JP7223832B2 (ja) | 2013-01-04 | 2021-12-23 | 生体系におけるプロテアーゼ活性を検出するための組成物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019190445A Active JP7001652B2 (ja) | 2013-01-04 | 2019-10-17 | 生体系におけるプロテアーゼ活性を検出するための組成物及び方法 |
| JP2021209234A Active JP7223832B2 (ja) | 2013-01-04 | 2021-12-23 | 生体系におけるプロテアーゼ活性を検出するための組成物及び方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US10261083B2 (enExample) |
| EP (1) | EP2941643A4 (enExample) |
| JP (3) | JP6605957B2 (enExample) |
| CN (2) | CN112162094A (enExample) |
| AU (2) | AU2014204015A1 (enExample) |
| CA (1) | CA2896282C (enExample) |
| HK (1) | HK1210831A1 (enExample) |
| RU (1) | RU2015132436A (enExample) |
| WO (1) | WO2014107599A2 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2754072C (en) | 2009-03-02 | 2019-01-15 | Massachusetts Institute Of Technology | Methods and products for in vivo enzyme profiling |
| AU2012229103A1 (en) | 2011-03-15 | 2013-10-31 | Massachusetts Institute Of Technology | Multiplexed detection with isotope-coded reporters |
| GB201203442D0 (en) | 2012-02-28 | 2012-04-11 | Univ Birmingham | Immunotherapeutic molecules and uses |
| AU2013278075B2 (en) | 2012-06-22 | 2018-05-17 | Cytomx Therapeutics, Inc. | Anti-jagged 1/Jagged 2 cross-reactive antibodies, activatable anti-Jagged antibodies and methods of use thereof |
| WO2014107599A2 (en) | 2013-01-04 | 2014-07-10 | Cytomx Therapeutics, Inc. | Compositions and methods for detecting protease activity in biological systems |
| CN116063479A (zh) * | 2013-06-04 | 2023-05-05 | 西托姆克斯治疗公司 | 用于缀合可活化抗体的组合物和方法 |
| ES2828985T3 (es) | 2013-06-07 | 2021-05-28 | Massachusetts Inst Technology | Detección basada en la afinidad de biomarcadores sintéticos codificados por ligando |
| CA2918795A1 (en) * | 2013-07-25 | 2015-01-29 | Cytomx Therapeutics, Inc. | Multispecific antibodies, multispecific activatable antibodies and methods of using the same |
| KR102790260B1 (ko) | 2013-09-25 | 2025-04-01 | 싸이톰스 테라퓨틱스, 인크. | 매트릭스 메탈로프로테이나제 기질 및 다른 절단성 모이어티 및 이의 사용 방법 |
| US9540440B2 (en) | 2013-10-30 | 2017-01-10 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof |
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| US9562073B2 (en) | 2014-01-31 | 2017-02-07 | Cytomx Therapeutics, Inc. | Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof |
| CN107108738A (zh) | 2014-07-25 | 2017-08-29 | 西托姆克斯治疗公司 | 抗cd3抗体、可活化抗cd3抗体、多特异性抗cd3抗体、多特异性可活化抗cd3抗体及其使用方法 |
| WO2016028805A1 (en) * | 2014-08-18 | 2016-02-25 | Adrastia Biotech | Systems and methods of detecting solid tumor cancer |
| EP3244907B1 (en) | 2015-01-13 | 2020-02-19 | City of Hope | Ctla4-binding protein peptide-linker masks |
| MA41374A (fr) * | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
| CN108112254B (zh) | 2015-03-13 | 2022-01-28 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
| MX388350B (es) | 2015-05-04 | 2025-03-19 | Cytomx Therapeutics Inc | Anticuerpos anti-cd166, anticuerpos anti-cd166 activables, y metodos de uso de los mismos. |
| DK3303394T3 (da) | 2015-05-29 | 2020-07-06 | Agenus Inc | Anti-ctla-4-antistoffer og fremgangsmåder til anvendelse deraf |
| JP2018526972A (ja) | 2015-06-16 | 2018-09-20 | ジェネンテック， インコーポレイテッド | 抗ｃｄ３抗体及び使用方法 |
| JP2018518972A (ja) * | 2015-06-26 | 2018-07-19 | ユニバーシティ オブ サザン カリフォルニア | 腫瘍特異的活性化のためのマスキングキメラ抗原受容体ｔ細胞 |
| CN106519037B (zh) * | 2015-09-11 | 2019-07-23 | 科济生物医药（上海）有限公司 | 可活化的嵌合受体 |
| PL3377103T5 (pl) | 2015-11-19 | 2025-07-07 | Revitope Limited | Komplementacja funkcjonalnego fragmentu przeciwciała dla dwuskładnikowego układu do przekierowanego zabijania niepożądanych komórek |
| WO2017132552A1 (en) | 2016-01-27 | 2017-08-03 | Oncorus, Inc. | Oncolytic viral vectors and uses thereof |
| US10358496B2 (en) | 2016-03-01 | 2019-07-23 | Ralf Kleef | Low dose immune checkpoint blockade in metastatic cancer |
| EP3440013A4 (en) | 2016-04-08 | 2021-03-17 | Massachusetts Institute of Technology | METHODS FOR SPECIFICALLY PROFILING PROTEASE ACTIVITY AT LYMPHATIC GANGLIONS |
| CA3022928A1 (en) | 2016-05-05 | 2017-11-09 | Massachusetts Institute Of Technology | Methods and uses for remotely triggered protease activity measurements |
| WO2018106864A1 (en) | 2016-12-07 | 2018-06-14 | Agenus Inc. | Antibodies and methods of use thereof |
| PT3551660T (pt) | 2016-12-07 | 2023-11-30 | Ludwig Inst For Cancer Res Ltd | Anticorpos anti-ctla-4 e métodos de uso dos mesmos |
| JP2020500900A (ja) | 2016-12-09 | 2020-01-16 | シアトル ジェネティクス インコーポレーテッド | コイルドコイルでマスキングされた二価抗体 |
| US11519905B2 (en) | 2017-04-07 | 2022-12-06 | Massachusetts Institute Of Technology | Methods to spatially profile protease activity in tissue and sections |
| EP3630838A1 (en) | 2017-06-01 | 2020-04-08 | CytomX Therapeutics, Inc. | Activatable anti-pdl1 antibodies, and methods of use thereof |
| US11220544B2 (en) | 2017-07-14 | 2022-01-11 | Cytomx Therapeutics, Inc. | Anti-CD166 antibodies and uses thereof |
| MX2020000993A (es) | 2017-07-26 | 2020-07-22 | Oncorus Inc | Vectores virales oncolíticos y usos de estos. |
| AU2018347607B2 (en) | 2017-10-14 | 2025-08-21 | Cytomx Therapeutics, Inc. | Antibodies, activatable antibodies, bispecific antibodies, and bispecific activatable antibodies and methods of use thereof |
| MA51208A (fr) | 2017-12-01 | 2020-10-07 | Seattle Genetics Inc | Anticorps (masqués) contre cd47 et leurs utilisations pour le traîtement du cancer |
| MA51793A (fr) | 2018-02-08 | 2020-12-16 | Hoffmann La Roche | Molécules bispécifiques de liaison à l'antigène et procédés d'utilisation |
| WO2019173332A1 (en) | 2018-03-05 | 2019-09-12 | Massachusetts Institute Of Technology | Inhalable nanosensors with volatile reporters and uses thereof |
| CN112005304A (zh) | 2018-03-20 | 2020-11-27 | 西托姆克斯治疗公司 | 用于哺乳动物受试者中的可活化抗体种类的定量药理学建模的系统和方法 |
| MX2020012248A (es) | 2018-05-14 | 2021-04-28 | Werewolf Therapeutics Inc | Polipeptidos de citocina activables y metodos de uso de los mismos. |
| CA3100007A1 (en) | 2018-05-14 | 2019-11-21 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof |
| US20210322508A1 (en) * | 2018-08-13 | 2021-10-21 | Signablok, Inc. | Peptides and compositions for targeted treatment and imaging |
| WO2020055952A1 (en) * | 2018-09-11 | 2020-03-19 | Georgia Tech Research Corporation | Compositions and methods for immunotherapy profiling |
| WO2020068920A2 (en) | 2018-09-25 | 2020-04-02 | Massachusetts Institute Of Technology | Lung protease nanosensors and uses thereof |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN120248140A (zh) | 2018-12-06 | 2025-07-04 | 西托姆克斯治疗公司 | 基质金属蛋白酶可裂解的和丝氨酸或半胱氨酸蛋白酶可裂解的底物及其使用方法 |
| WO2020139926A2 (en) * | 2018-12-26 | 2020-07-02 | Akrevia Therapeutics Inc. | Anti-ctla4 antibodies and methods of use thereof |
| EP3911753A1 (en) | 2019-01-17 | 2021-11-24 | Massachusetts Institute of Technology | Sensors for detecting and imaging of cancer metastasis |
| KR20220023988A (ko) | 2019-05-14 | 2022-03-03 | 웨어울프 세라퓨틱스, 인크. | 분리 모이어티 및 이의 사용 방법 |
| BR112021022682A2 (pt) | 2019-05-14 | 2022-02-22 | Provention Bio Inc | Métodos e composições para prevenir diabetes do tipo 1 |
| US20220226514A1 (en) * | 2019-05-17 | 2022-07-21 | Cytomx Therapeutics, Inc. | Methods and compositions for determining the biodistribution of activatable anti-cd166 antibody conjugates |
| US20220233709A1 (en) | 2019-06-05 | 2022-07-28 | Seagen Inc. | Masked Antibody Formulations |
| WO2020247574A1 (en) | 2019-06-05 | 2020-12-10 | Seattle Genetics, Inc. | Methods of purifying masked antibodies |
| EP4058471A1 (en) | 2019-11-14 | 2022-09-21 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
| TWI897903B (zh) | 2019-12-13 | 2025-09-21 | 美商建南德克公司 | 抗ly6g6d抗體及其使用方法 |
| JP2023521384A (ja) | 2020-04-09 | 2023-05-24 | シートムエックス セラピューティクス，インコーポレイテッド | 活性化可能抗体を含む組成物 |
| US12006366B2 (en) | 2020-06-11 | 2024-06-11 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| CN111830254B (zh) * | 2020-07-29 | 2022-07-26 | 武汉生之源生物科技股份有限公司 | 一种基质金属蛋白酶-3测定试剂盒及其制备方法 |
| CN114859042B (zh) * | 2021-02-03 | 2023-11-03 | 广东菲鹏生物有限公司 | 一种鉴别结合突变型抗原的抗体的方法及试剂 |
| US20240352080A1 (en) | 2021-07-14 | 2024-10-24 | Seagen Inc. | Antibody Masking Domains |
| EP4377453A4 (en) * | 2021-07-26 | 2025-09-03 | Georgia Tech Res Inst | COMPOSITIONS AND METHODS FOR IN VIVO PROTEASE PROFILING BY DISPLAYING IMMUNE CELLS |
| WO2023034825A1 (en) * | 2021-08-30 | 2023-03-09 | Cytomx Therapeutics, Inc. | Method for determining protease activity in a biological sample |
| EP4405387A1 (en) | 2021-09-24 | 2024-07-31 | Seagen Inc. | Improved antibody masking domains |
| US20250172557A1 (en) * | 2022-03-01 | 2025-05-29 | The Board Of Regents Of The University Of Texas System | Methods for identifying lilrb ligands and blocking antibodies |
| US11958906B2 (en) | 2022-04-13 | 2024-04-16 | Genentech, Inc. | Pharmaceutical compositions of mosunetuzumab and methods of use |
| WO2025240659A2 (en) | 2024-05-14 | 2025-11-20 | Cytomx Therapeutics, Inc. | Activatable constructs, compositions and methods |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1286700A2 (en) | 2000-06-01 | 2003-03-05 | Universite Catholique De Louvain | Tumor activated prodrug compounds |
| AU9399501A (en) | 2000-10-09 | 2002-04-22 | Isis Innovation | Therapeutic antibodies |
| US7465790B2 (en) | 2000-10-09 | 2008-12-16 | Isis Innovation, Inc. | Therapeutic antibodies |
| US20040109855A1 (en) | 2002-07-23 | 2004-06-10 | Herman Waldmann | Therapeutic antibodies with reduced side effect |
| WO2004021861A2 (en) | 2002-09-03 | 2004-03-18 | Vit Lauermann | Targeted release |
| CA2620886C (en) | 2005-08-31 | 2017-03-14 | The Regents Of The University Of California | Cellular libraries of peptide sequences (clips) and methods of using the same |
| WO2007105027A1 (en) | 2006-03-10 | 2007-09-20 | Diatos | Anticancer drugs conjugated to antibody via an enzyme cleavable linker |
| EP2102244A2 (en) | 2006-12-19 | 2009-09-23 | Ablynx N.V. | Amino acid sequences directed against a metalloproteinase from the adam family and polypeptides comprising the same for the treatment of adam-related diseases and disorders |
| WO2009014726A1 (en) | 2007-07-26 | 2009-01-29 | The Regents Of The University Of California | Methods for enhancing bacterial cell display of proteins and peptides |
| EP3492488A1 (en) | 2007-08-22 | 2019-06-05 | The Regents of The University of California | Activatable binding polypeptides and methods of identification and use thereof |
| JP2012511033A (ja) * | 2008-12-08 | 2012-05-17 | テゴファーム コーポレーション | 多価化合物の可逆阻害用マスキングリガンド |
| US20110178279A1 (en) * | 2009-08-03 | 2011-07-21 | Williams John C | Development of masked therapeutic antibodies to limit off-target effects: application to anti-egfr antibodies |
| AU2010203353B2 (en) | 2009-01-12 | 2016-06-16 | Cytomx Therapeutics, Inc | Modified antibody compositions, methods of making and using thereof |
| WO2010129609A2 (en) | 2009-05-07 | 2010-11-11 | The Regents Of The University Of California | Antibodies and methods of use thereof |
| RU2713121C2 (ru) | 2012-04-27 | 2020-02-03 | Сайтомкс Терапьютикс, Инк. | Активируемые антитела, которые связываются с рецептором эпидермального фактора роста, и способы их применения |
| AU2013278075B2 (en) * | 2012-06-22 | 2018-05-17 | Cytomx Therapeutics, Inc. | Anti-jagged 1/Jagged 2 cross-reactive antibodies, activatable anti-Jagged antibodies and methods of use thereof |
| WO2014107599A2 (en) | 2013-01-04 | 2014-07-10 | Cytomx Therapeutics, Inc. | Compositions and methods for detecting protease activity in biological systems |
-
2014
- 2014-01-03 WO PCT/US2014/010216 patent/WO2014107599A2/en not_active Ceased
- 2014-01-03 CN CN202010717082.7A patent/CN112162094A/zh active Pending
- 2014-01-03 RU RU2015132436A patent/RU2015132436A/ru unknown
- 2014-01-03 HK HK15111420.0A patent/HK1210831A1/xx unknown
- 2014-01-03 JP JP2015551784A patent/JP6605957B2/ja active Active
- 2014-01-03 US US14/147,324 patent/US10261083B2/en active Active
- 2014-01-03 AU AU2014204015A patent/AU2014204015A1/en not_active Abandoned
- 2014-01-03 EP EP14735246.2A patent/EP2941643A4/en active Pending
- 2014-01-03 CN CN201480011969.7A patent/CN105008918A/zh active Pending
- 2014-01-03 CA CA2896282A patent/CA2896282C/en active Active
-
2018
- 2018-10-18 AU AU2018250437A patent/AU2018250437B2/en active Active
-
2019
- 2019-02-15 US US16/277,497 patent/US11035859B2/en active Active
- 2019-10-17 JP JP2019190445A patent/JP7001652B2/ja active Active
-
2021
- 2021-04-30 US US17/246,167 patent/US11867695B2/en active Active
- 2021-12-23 JP JP2021209234A patent/JP7223832B2/ja active Active
-
2023
- 2023-11-09 US US18/506,072 patent/US20240337658A1/en not_active Abandoned
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