JP2016505138A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016505138A5 JP2016505138A5 JP2015551784A JP2015551784A JP2016505138A5 JP 2016505138 A5 JP2016505138 A5 JP 2016505138A5 JP 2015551784 A JP2015551784 A JP 2015551784A JP 2015551784 A JP2015551784 A JP 2015551784A JP 2016505138 A5 JP2016505138 A5 JP 2016505138A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- target
- activatable antibody
- antibody
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361749220P | 2013-01-04 | 2013-01-04 | |
| US201361749212P | 2013-01-04 | 2013-01-04 | |
| US61/749,212 | 2013-01-04 | ||
| US61/749,220 | 2013-01-04 | ||
| US201361749529P | 2013-01-07 | 2013-01-07 | |
| US201361749486P | 2013-01-07 | 2013-01-07 | |
| US61/749,529 | 2013-01-07 | ||
| US61/749,486 | 2013-01-07 | ||
| US201361755810P | 2013-01-23 | 2013-01-23 | |
| US61/755,810 | 2013-01-23 | ||
| US201361763237P | 2013-02-11 | 2013-02-11 | |
| US61/763,237 | 2013-02-11 | ||
| US201361830940P | 2013-06-04 | 2013-06-04 | |
| US61/830,940 | 2013-06-04 | ||
| US201361897659P | 2013-10-30 | 2013-10-30 | |
| US61/897,659 | 2013-10-30 | ||
| PCT/US2014/010216 WO2014107599A2 (en) | 2013-01-04 | 2014-01-03 | Compositions and methods for detecting protease activity in biological systems |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019190445A Division JP7001652B2 (ja) | 2013-01-04 | 2019-10-17 | 生体系におけるプロテアーゼ活性を検出するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505138A JP2016505138A (ja) | 2016-02-18 |
| JP2016505138A5 true JP2016505138A5 (enExample) | 2017-02-09 |
| JP6605957B2 JP6605957B2 (ja) | 2019-11-13 |
Family
ID=51062553
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015551784A Active JP6605957B2 (ja) | 2013-01-04 | 2014-01-03 | 生体系におけるプロテアーゼ活性を検出するための組成物及び方法 |
| JP2019190445A Active JP7001652B2 (ja) | 2013-01-04 | 2019-10-17 | 生体系におけるプロテアーゼ活性を検出するための組成物及び方法 |
| JP2021209234A Active JP7223832B2 (ja) | 2013-01-04 | 2021-12-23 | 生体系におけるプロテアーゼ活性を検出するための組成物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019190445A Active JP7001652B2 (ja) | 2013-01-04 | 2019-10-17 | 生体系におけるプロテアーゼ活性を検出するための組成物及び方法 |
| JP2021209234A Active JP7223832B2 (ja) | 2013-01-04 | 2021-12-23 | 生体系におけるプロテアーゼ活性を検出するための組成物及び方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US10261083B2 (enExample) |
| EP (1) | EP2941643A4 (enExample) |
| JP (3) | JP6605957B2 (enExample) |
| CN (2) | CN112162094A (enExample) |
| AU (2) | AU2014204015A1 (enExample) |
| CA (1) | CA2896282C (enExample) |
| HK (1) | HK1210831A1 (enExample) |
| RU (1) | RU2015132436A (enExample) |
| WO (1) | WO2014107599A2 (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2403964B1 (en) | 2009-03-02 | 2021-09-08 | Massachusetts Institute of Technology | Methods and products for in vivo enzyme profiling |
| ES2881535T3 (es) | 2011-03-15 | 2021-11-29 | Massachusetts Inst Technology | Detección multiplexada con indicadores codificados con isótopos |
| GB201203442D0 (en) | 2012-02-28 | 2012-04-11 | Univ Birmingham | Immunotherapeutic molecules and uses |
| SG11201408554QA (en) | 2012-06-22 | 2015-02-27 | Cytomx Therapeutics Inc | Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof |
| CA2896282C (en) | 2013-01-04 | 2021-07-20 | Cytomx Therapeutics, Inc. | Compositions and methods for detecting protease activity in biological systems |
| BR112015030514A2 (pt) * | 2013-06-04 | 2017-08-29 | Cytomx Therapeutics Inc | Composições e métodos para conjugação de anticorpos ativáveis |
| WO2014197840A1 (en) | 2013-06-07 | 2014-12-11 | Massachusetts Institute Of Technology | Affinity-based detection of ligand-encoded synthetic biomarkers |
| JP6693872B2 (ja) * | 2013-07-25 | 2020-05-13 | シトムクス セラピューティクス，インコーポレイティド | 多重特異性抗体、多重特異性活性化可能抗体、及びそれらの使用方法 |
| KR102488220B1 (ko) | 2013-09-25 | 2023-01-12 | 싸이톰스 테라퓨틱스, 인크. | 매트릭스 메탈로프로테이나제 기질 및 다른 절단성 모이어티 및 이의 사용 방법 |
| US9540440B2 (en) | 2013-10-30 | 2017-01-10 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof |
| WO2015089283A1 (en) | 2013-12-11 | 2015-06-18 | Cytomx Therapeutics, Inc. | Antibodies that bind activatable antibodies and methods of use thereof |
| KR102466591B1 (ko) | 2014-01-31 | 2022-11-14 | 싸이톰스 테라퓨틱스, 인크. | 마트립타제 및 ｕ-플라스미노겐 활성화인자 기질 및 다른 절단성 모이어티 및 이의 사용 방법 |
| WO2016014974A2 (en) | 2014-07-25 | 2016-01-28 | Cytomx Therapeutics, Inc. | Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same |
| WO2016028805A1 (en) * | 2014-08-18 | 2016-02-25 | Adrastia Biotech | Systems and methods of detecting solid tumor cancer |
| EP3733696A1 (en) * | 2015-01-13 | 2020-11-04 | City of Hope | Ctla4-binding protein peptide-linker masks |
| MA41374A (fr) * | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
| CN108112254B (zh) | 2015-03-13 | 2022-01-28 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
| SG10202110908WA (en) | 2015-05-04 | 2021-11-29 | Cytomx Therapeutics Inc | Anti-cd166 antibodies, activatable anti-cd166 antibodies, and methods of use thereof |
| CA2986765A1 (en) | 2015-05-29 | 2016-12-08 | Agenus Inc. | Anti-ctla-4 antibodies and methods of use thereof |
| WO2016204966A1 (en) | 2015-06-16 | 2016-12-22 | Genentech, Inc. | Anti-cd3 antibodies and methods of use |
| CN107709356A (zh) * | 2015-06-26 | 2018-02-16 | 南加利福尼亚大学 | 用于肿瘤特异性活化的掩蔽嵌合抗原受体t细胞 |
| CN106519037B (zh) * | 2015-09-11 | 2019-07-23 | 科济生物医药（上海）有限公司 | 可活化的嵌合受体 |
| EP3903818A1 (en) | 2015-11-19 | 2021-11-03 | Revitope Limited | Functional antibody fragment complementation for a two-components system for redirected killing of unwanted cells |
| ES2919953T3 (es) | 2016-01-27 | 2022-07-29 | Oncorus Inc | Vectores víricos oncolíticos y usos de los mismos |
| EP3213768A1 (en) | 2016-03-01 | 2017-09-06 | LODOCO CLINICAL Kft | Combination of low dose immune checkpoint blockade with high dose il-2 for treating metastatic cancer |
| EP3440013A4 (en) | 2016-04-08 | 2021-03-17 | Massachusetts Institute of Technology | METHOD FOR SPECIFIC PROFILING OF PROTEASE ACTIVITY ON LYMPH NODES |
| CA3022928A1 (en) | 2016-05-05 | 2017-11-09 | Massachusetts Institute Of Technology | Methods and uses for remotely triggered protease activity measurements |
| CN118634323A (zh) | 2016-12-07 | 2024-09-13 | 艾吉纳斯公司 | 抗体和其使用方法 |
| FI3551660T3 (fi) | 2016-12-07 | 2023-12-11 | Agenus Inc | Anti-ctla-4-vasta-aineita ja niiden käyttömenetelmiä |
| KR20190089034A (ko) | 2016-12-09 | 2019-07-29 | 시애틀 지네틱스, 인크. | 코일드 코일에 의해 차폐된 이가 항체 |
| AU2018248327B2 (en) | 2017-04-07 | 2024-10-10 | Massachusetts Institute Of Technology | Methods to spatially profile protease activity in tissue and sections |
| BR112019025188A2 (pt) | 2017-06-01 | 2020-06-23 | Cytomx Therapeutics, Inc. | Anticorpos anti-pdl1 ativáveis e métodos de uso dos mesmos |
| SG11202000105QA (en) | 2017-07-14 | 2020-02-27 | Cytomx Therapeutics Inc | Anti-cd166 antibodies and uses thereof |
| RU2771110C2 (ru) | 2017-07-26 | 2022-04-26 | Онкорус, Инк. | Онколитические вирусные векторы и их применение |
| US11472889B2 (en) | 2017-10-14 | 2022-10-18 | Cytomx Therapeutics, Inc. | Antibodies, activatable antibodies, bispecific antibodies, and bispecific activatable antibodies and methods of use thereof |
| TWI831759B (zh) | 2017-12-01 | 2024-02-11 | 美商思進公司 | Cd47抗體及其用於治療癌症之用途 |
| AR115360A1 (es) | 2018-02-08 | 2021-01-13 | Genentech Inc | Moléculas de unión al antígeno y métodos de uso |
| US11054428B2 (en) | 2018-03-05 | 2021-07-06 | Massachusetts Institute Of Technology | Inhalable nanosensors with volatile reporters and uses thereof |
| JP2021518603A (ja) | 2018-03-20 | 2021-08-02 | シートムエックス セラピューティクス，インコーポレイテッド | 哺乳動物対象における活性化可能抗体種の定量薬理学モデリングのためのシステムおよび方法 |
| WO2019222294A1 (en) | 2018-05-14 | 2019-11-21 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
| US20210130430A1 (en) | 2018-05-14 | 2021-05-06 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
| CN113840832A (zh) | 2018-05-14 | 2021-12-24 | 狼人治疗公司 | 可活化白介素-2多肽及其使用方法 |
| US20210322508A1 (en) * | 2018-08-13 | 2021-10-21 | Signablok, Inc. | Peptides and compositions for targeted treatment and imaging |
| JP2022500400A (ja) * | 2018-09-11 | 2022-01-04 | ジョージア テック リサーチ コーポレイション | 免疫療法プロファイリングのための組成物および方法 |
| WO2020068920A2 (en) | 2018-09-25 | 2020-04-02 | Massachusetts Institute Of Technology | Lung protease nanosensors and uses thereof |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| SG11202105476XA (en) | 2018-12-06 | 2021-06-29 | Cytomx Therapeutics Inc | Matrix metalloprotease-cleavable and serine or cysteine protease-cleavable substrates and methods of use thereof |
| EP3902833A2 (en) * | 2018-12-26 | 2021-11-03 | City of Hope | Activatable masked anti-ctla4 binding proteins |
| WO2020150560A1 (en) | 2019-01-17 | 2020-07-23 | Massachusetts Institute Of Technology | Sensors for detecting and imaging of cancer metastasis |
| BR112021022682A2 (pt) | 2019-05-14 | 2022-02-22 | Provention Bio Inc | Métodos e composições para prevenir diabetes do tipo 1 |
| KR20220023988A (ko) | 2019-05-14 | 2022-03-03 | 웨어울프 세라퓨틱스, 인크. | 분리 모이어티 및 이의 사용 방법 |
| WO2020236679A1 (en) * | 2019-05-17 | 2020-11-26 | Cytomx Therapeutics, Inc. | Methods and compositions for determining the biodistribution of activatable anti-cd166 antibody conjugates |
| WO2020247572A1 (en) | 2019-06-05 | 2020-12-10 | Seattle Genetics, Inc. | Masked antibody formulations |
| WO2020247574A1 (en) | 2019-06-05 | 2020-12-10 | Seattle Genetics, Inc. | Methods of purifying masked antibodies |
| BR112022009110A2 (pt) | 2019-11-14 | 2022-07-26 | Werewolf Therapeutics Inc | Polipeptídeos de citocina ativáveis e métodos de uso destes |
| BR112022011357A2 (pt) | 2019-12-13 | 2022-08-23 | Genentech Inc | Anticorpos isolado, um ou mais ácidos nucleicos isolados, um ou mais vetores, uma ou mais células hospedeiras, composição, kit, uso do anticorpo, métodos para produzir o anticorpo e método para tratar ou retardar a progressão de um câncer ly6g6d positivo |
| CA3174665A1 (en) | 2020-04-09 | 2021-10-14 | Cytomx Therapeutics, Inc. | Compositions containing activatable antibodies |
| US12006366B2 (en) | 2020-06-11 | 2024-06-11 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| CN111830254B (zh) * | 2020-07-29 | 2022-07-26 | 武汉生之源生物科技股份有限公司 | 一种基质金属蛋白酶-3测定试剂盒及其制备方法 |
| CN116973566A (zh) * | 2021-02-03 | 2023-10-31 | 广东菲鹏生物有限公司 | 一种鉴别结合突变型抗原的抗体的方法及试剂 |
| WO2022251253A1 (en) | 2021-05-24 | 2022-12-01 | Provention Bio, Inc. | Methods for treating type 1 diabetes |
| WO2023288236A1 (en) | 2021-07-14 | 2023-01-19 | Seagen Inc. | Antibody masking domains |
| US20250116658A1 (en) * | 2021-07-26 | 2025-04-10 | Georgia Tech Research Corporation | Compositions and methods for in vivo protease profiling by immune cell display |
| US20240384323A1 (en) * | 2021-08-30 | 2024-11-21 | Cytomx Therapeutics, Inc. | Method for determining protease activity in a biological sample |
| WO2023049825A1 (en) | 2021-09-24 | 2023-03-30 | Seagen Inc. | Improved antibody masking domains |
| US20250172557A1 (en) * | 2022-03-01 | 2025-05-29 | The Board Of Regents Of The University Of Texas System | Methods for identifying lilrb ligands and blocking antibodies |
| EP4508086A1 (en) | 2022-04-13 | 2025-02-19 | Genentech, Inc. | Pharmaceutical compositions of mosunetuzumab and methods of use |
| WO2025240659A2 (en) | 2024-05-14 | 2025-11-20 | Cytomx Therapeutics, Inc. | Activatable constructs, compositions and methods |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1286700A2 (en) | 2000-06-01 | 2003-03-05 | Universite Catholique De Louvain | Tumor activated prodrug compounds |
| US7465790B2 (en) | 2000-10-09 | 2008-12-16 | Isis Innovation, Inc. | Therapeutic antibodies |
| JP4334866B2 (ja) | 2000-10-09 | 2009-09-30 | アイシス イノヴェイション リミテッド | 治療用抗体 |
| US20040109855A1 (en) | 2002-07-23 | 2004-06-10 | Herman Waldmann | Therapeutic antibodies with reduced side effect |
| US8809504B2 (en) | 2002-09-03 | 2014-08-19 | Vit Lauermann | Inhibitor which is deactivatable by a reagent produced by a target cell |
| EP2535346B1 (en) | 2005-08-31 | 2017-08-02 | The Regents of The University of California | Cellular libraries of peptide sequences (CLiPS) and methods of using the same |
| CA2645347A1 (en) | 2006-03-10 | 2007-09-20 | Diatos | Anticancer drugs conjugated to antibody via an enzyme cleavable linker |
| AU2007336243B2 (en) | 2006-12-19 | 2012-07-26 | Ablynx N.V. | Amino acid sequences directed against a metalloproteinase from the ADAM family and polypeptides comprising the same for the treatment of ADAM-related diseases and disorders |
| WO2009014726A1 (en) | 2007-07-26 | 2009-01-29 | The Regents Of The University Of California | Methods for enhancing bacterial cell display of proteins and peptides |
| US20090304719A1 (en) * | 2007-08-22 | 2009-12-10 | Patrick Daugherty | Activatable binding polypeptides and methods of identification and use thereof |
| US20100189727A1 (en) | 2008-12-08 | 2010-07-29 | Tegopharm Corporation | Masking Ligands For Reversible Inhibition Of Multivalent Compounds |
| US20110178279A1 (en) * | 2009-08-03 | 2011-07-21 | Williams John C | Development of masked therapeutic antibodies to limit off-target effects: application to anti-egfr antibodies |
| WO2010081173A2 (en) | 2009-01-12 | 2010-07-15 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
| EP2427479B1 (en) | 2009-05-07 | 2018-11-21 | The Regents of The University of California | Antibodies and methods of use thereof |
| CN110078827A (zh) | 2012-04-27 | 2019-08-02 | 西托姆克斯治疗公司 | 结合表皮生长因子受体的可活化的抗体其使用方法 |
| SG11201408554QA (en) | 2012-06-22 | 2015-02-27 | Cytomx Therapeutics Inc | Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof |
| CA2896282C (en) | 2013-01-04 | 2021-07-20 | Cytomx Therapeutics, Inc. | Compositions and methods for detecting protease activity in biological systems |
-
2014
- 2014-01-03 CA CA2896282A patent/CA2896282C/en active Active
- 2014-01-03 HK HK15111420.0A patent/HK1210831A1/xx unknown
- 2014-01-03 CN CN202010717082.7A patent/CN112162094A/zh active Pending
- 2014-01-03 US US14/147,324 patent/US10261083B2/en active Active
- 2014-01-03 AU AU2014204015A patent/AU2014204015A1/en not_active Abandoned
- 2014-01-03 WO PCT/US2014/010216 patent/WO2014107599A2/en not_active Ceased
- 2014-01-03 EP EP14735246.2A patent/EP2941643A4/en active Pending
- 2014-01-03 RU RU2015132436A patent/RU2015132436A/ru unknown
- 2014-01-03 JP JP2015551784A patent/JP6605957B2/ja active Active
- 2014-01-03 CN CN201480011969.7A patent/CN105008918A/zh active Pending
-
2018
- 2018-10-18 AU AU2018250437A patent/AU2018250437B2/en active Active
-
2019
- 2019-02-15 US US16/277,497 patent/US11035859B2/en active Active
- 2019-10-17 JP JP2019190445A patent/JP7001652B2/ja active Active
-
2021
- 2021-04-30 US US17/246,167 patent/US11867695B2/en active Active
- 2021-12-23 JP JP2021209234A patent/JP7223832B2/ja active Active
-
2023
- 2023-11-09 US US18/506,072 patent/US20240337658A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2015132436A (ru) | Способы обнаружения активности протеазы в биологических системах и композиции для их осуществления | |
| Guerrero et al. | Mechanistic peptidomics: factors that dictate specificity in the formation of endogenous peptides in human milk | |
| US9772328B2 (en) | Bimolecular protease-based biosensor | |
| CN106796222B (zh) | 针对tsh受体的自身抗体的检测 | |
| Hoshijima et al. | Roles of heterotypic CCN2/CTGF–CCN3/NOV and homotypic CCN2–CCN2 interactions in expression of the differentiated phenotype of chondrocytes | |
| KR20150095691A (ko) | 단일 분자 검출을 이용한 분자 분석물질의 디지털 분석 | |
| RU2011108943A (ru) | Профилактика, лечение и диагностика инфекции, вызванной бактериями p.gingivalis | |
| JP2017533181A5 (enExample) | ||
| Lin et al. | Development of a highly thermostable immunoassay based on a nanobody-alkaline phosphatase fusion protein for carcinoembryonic antigen detection | |
| Wang et al. | A fluorogenic peptide probe developed by in vitro selection using tRNA carrying a fluorogenic amino acid | |
| CN101842707A (zh) | 用于对选自bnp和bnp原的不稳定抗原定量的免疫测定法 | |
| SE0000675D0 (sv) | Monoclonal antibodies | |
| CN106568940A (zh) | 一种体外定量测定vWF‑CP酶活性的底物、方法及试剂盒 | |
| Leung et al. | Osteopontin fragments with intact thrombin-sensitive site circulate in cervical cancer patients | |
| JP6624755B2 (ja) | プロテインタグ、タグ化タンパク質及びタンパク質精製方法 | |
| DE60219645D1 (de) | Antikörper gegen metastin und dessen verwendung zur diagnose von schwangerschaft | |
| Mukherjee et al. | One-pot synthesis of heterodimeric agonists that activate the canonical Wnt signaling pathway | |
| WO2005103713A3 (en) | Methods, compositions and compound assays for inhibiting amyloid-beta protein production | |
| FR3001805A1 (fr) | Procede de detection d'un cancer colorectal | |
| JP2017037014A5 (enExample) | ||
| RU2005115973A (ru) | Растворимые субстраты на основе notch для гамма-секретазы, а также способы и композиции для их применения | |
| CN108431032B (zh) | 纤维蛋白原捕捉剂检测ciz1 b变体的用途 | |
| US10502741B2 (en) | Means and methods for detecting activated MALT1 | |
| Jägerbrink et al. | Proinsulin C-peptide interaction with protein tyrosine phosphatase 1B demonstrated with a labeling reaction | |
| CN112462074B (zh) | 一种cd277三种亚型蛋白的鉴定方法及检测试剂盒 |