JP2016503070A5 - - Google Patents
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- JP2016503070A5 JP2016503070A5 JP2015551668A JP2015551668A JP2016503070A5 JP 2016503070 A5 JP2016503070 A5 JP 2016503070A5 JP 2015551668 A JP2015551668 A JP 2015551668A JP 2015551668 A JP2015551668 A JP 2015551668A JP 2016503070 A5 JP2016503070 A5 JP 2016503070A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- beta
- composition according
- beta cells
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 230000014101 glucose homeostasis Effects 0.000 claims 5
- 208000024891 symptom Diseases 0.000 claims 5
- 208000027418 Wounds and injury Diseases 0.000 claims 4
- 230000006378 damage Effects 0.000 claims 4
- 208000014674 injury Diseases 0.000 claims 4
- 230000006057 immunotolerant effect Effects 0.000 claims 3
- 229940126409 proton pump inhibitor Drugs 0.000 claims 3
- 230000001172 regenerating effect Effects 0.000 claims 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical group CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 2
- 108010036949 Cyclosporine Proteins 0.000 claims 2
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 2
- 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 claims 2
- 208000001280 Prediabetic State Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 108700025316 aldesleukin Proteins 0.000 claims 2
- 229960001265 ciclosporin Drugs 0.000 claims 2
- 229930182912 cyclosporin Natural products 0.000 claims 2
- 230000001771 impaired effect Effects 0.000 claims 2
- 201000009104 prediabetes syndrome Diseases 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 229940087463 proleukin Drugs 0.000 claims 2
- 239000000612 proton pump inhibitor Substances 0.000 claims 2
- 210000003289 regulatory T cell Anatomy 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- HMLGSIZOMSVISS-ONJSNURVSA-N (7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2,2-dimethylpropanoyloxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound N([C@@H]1C(N2C(=C(C=C)CSC21)C(O)=O)=O)C(=O)\C(=N/OCOC(=O)C(C)(C)C)C1=CSC(N)=N1 HMLGSIZOMSVISS-ONJSNURVSA-N 0.000 claims 1
- 101710081722 Antitrypsin Proteins 0.000 claims 1
- 108010008165 Etanercept Proteins 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 102000006395 Globulins Human genes 0.000 claims 1
- 102000008214 Glutamate decarboxylase Human genes 0.000 claims 1
- 108091022930 Glutamate decarboxylase Proteins 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 229940119178 Interleukin 1 receptor antagonist Drugs 0.000 claims 1
- 108700021006 Interleukin-1 receptor antagonist Proteins 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- 229930003316 Vitamin D Natural products 0.000 claims 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 1
- 229960002459 alefacept Drugs 0.000 claims 1
- 229960004238 anakinra Drugs 0.000 claims 1
- 230000001494 anti-thymocyte effect Effects 0.000 claims 1
- 230000001475 anti-trypsic effect Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000005784 autoimmunity Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 229960000403 etanercept Drugs 0.000 claims 1
- 230000004153 glucose metabolism Effects 0.000 claims 1
- 210000002767 hepatic artery Anatomy 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- 239000003407 interleukin 1 receptor blocking agent Substances 0.000 claims 1
- 238000001361 intraarterial administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 210000004153 islets of langerhan Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 claims 1
- 229960004866 mycophenolate mofetil Drugs 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000004923 pancreatic tissue Anatomy 0.000 claims 1
- 239000000816 peptidomimetic Substances 0.000 claims 1
- 210000003240 portal vein Anatomy 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- 229960004641 rituximab Drugs 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229960001967 tacrolimus Drugs 0.000 claims 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
- 239000002753 trypsin inhibitor Substances 0.000 claims 1
- 229960002109 tuberculosis vaccine Drugs 0.000 claims 1
- 210000003606 umbilical vein Anatomy 0.000 claims 1
- 235000019166 vitamin D Nutrition 0.000 claims 1
- 239000011710 vitamin D Substances 0.000 claims 1
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 1
- 229940046008 vitamin d Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361749197P | 2013-01-04 | 2013-01-04 | |
| US61/749,197 | 2013-01-04 | ||
| PCT/US2013/061972 WO2014052625A1 (en) | 2012-09-27 | 2013-09-26 | Insulin independence among patients with diabetes utilizing a ppi in combination with an immune tolerance agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016503070A JP2016503070A (ja) | 2016-02-01 |
| JP2016503070A5 true JP2016503070A5 (https=) | 2016-11-10 |
Family
ID=54250581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015551668A Pending JP2016503070A (ja) | 2013-01-04 | 2013-09-26 | 免疫寛容剤と併用してｐｐｉを利用する糖尿病を有する患者の間でのインスリン非依存性 |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP2941250A4 (https=) |
| JP (1) | JP2016503070A (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8732150B2 (en) | 2010-09-23 | 2014-05-20 | Salesforce.Com, Inc. | Methods and apparatus for suppressing network feed activities using an information feed in an on-demand database service environment |
| US20140280329A1 (en) | 2013-03-15 | 2014-09-18 | Salesforce.Com, Inc. | Systems and methods for cross-referencing feed items |
| US9665261B2 (en) | 2013-10-28 | 2017-05-30 | Salesforce.Com, Inc. | Providing a user interface for customizing state transitions of panes in a bounding window |
| US10198484B2 (en) | 2015-09-10 | 2019-02-05 | Salesforce.Com, Inc. | Displaying reduced and detailed visual representations of calendar items based on mouse cursor movement |
| JP2019077615A (ja) * | 2016-03-09 | 2019-05-23 | 公立大学法人和歌山県立医科大学 | 非アルコール性脂肪性肝疾患／非アルコール性脂肪性肝炎の治療剤 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1883417A2 (en) * | 2005-05-25 | 2008-02-06 | Curedm Inc. | Peptides, derivatives and analogs thereof, and methods of using same |
-
2013
- 2013-09-26 EP EP13840277.1A patent/EP2941250A4/en not_active Withdrawn
- 2013-09-26 JP JP2015551668A patent/JP2016503070A/ja active Pending
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