JP2016502406A5 - - Google Patents
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- Publication number
- JP2016502406A5 JP2016502406A5 JP2015543486A JP2015543486A JP2016502406A5 JP 2016502406 A5 JP2016502406 A5 JP 2016502406A5 JP 2015543486 A JP2015543486 A JP 2015543486A JP 2015543486 A JP2015543486 A JP 2015543486A JP 2016502406 A5 JP2016502406 A5 JP 2016502406A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- seq
- neurodegenerative disease
- neurodegenerative
- prediction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000004770 neurodegeneration Effects 0.000 claims 35
- 208000015122 neurodegenerative disease Diseases 0.000 claims 35
- 238000003745 diagnosis Methods 0.000 claims 19
- 238000000338 in vitro Methods 0.000 claims 15
- 238000000034 method Methods 0.000 claims 13
- 108020005196 Mitochondrial DNA Proteins 0.000 claims 9
- 208000024827 Alzheimer disease Diseases 0.000 claims 8
- 239000012472 biological sample Substances 0.000 claims 5
- 208000018737 Parkinson disease Diseases 0.000 claims 4
- 238000011304 droplet digital PCR Methods 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 238000003753 real-time PCR Methods 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 238000002105 Southern blotting Methods 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 210000004243 sweat Anatomy 0.000 claims 1
- 210000001138 tear Anatomy 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ESP201231807 | 2012-11-22 | ||
| ES201231807A ES2482866B1 (es) | 2012-11-22 | 2012-11-22 | Método de diagnóstico y/o pronóstico de enfermedades neurodegenerativas. |
| PCT/ES2013/070713 WO2014080054A1 (es) | 2012-11-22 | 2013-10-17 | Método de diagnóstico y/o pronóstico de enfermedades neurodegenerativas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016502406A JP2016502406A (ja) | 2016-01-28 |
| JP2016502406A5 true JP2016502406A5 (https=) | 2016-12-01 |
Family
ID=50775580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015543486A Pending JP2016502406A (ja) | 2012-11-22 | 2013-10-17 | 神経変性疾患の診断及び／又は予知の方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20150361495A1 (https=) |
| EP (1) | EP2924124A4 (https=) |
| JP (1) | JP2016502406A (https=) |
| ES (1) | ES2482866B1 (https=) |
| WO (1) | WO2014080054A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3181701A1 (en) * | 2015-12-17 | 2017-06-21 | Consejo Superior De Investigaciones Cientificas | Method for the sub-classification of patients suffering from parkinson disease |
| US20190119747A1 (en) * | 2016-03-28 | 2019-04-25 | Osaka University | Stress biomarker |
| JP6654326B2 (ja) * | 2016-03-28 | 2020-02-26 | 国立大学法人大阪大学 | 眼科疾患のバイオマーカー |
| FR3144164A1 (fr) | 2022-12-23 | 2024-06-28 | Neolys Diagnostics | Détermination du statut d’un individu vis-à-vis de la maladie d’Alzheimer |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5494794A (en) | 1992-10-20 | 1996-02-27 | Emory University | Detection of mitochondrial DNA mutations associated with Alzheimer's disease and Parkinson's disease |
| JPH1099085A (ja) * | 1996-05-16 | 1998-04-21 | Affymetrix Inc | ヒトミトコンドリアｄｎａの多形性 |
| US6218117B1 (en) * | 1998-06-15 | 2001-04-17 | Mitokor | Compositions and methods for identifying agents that quantitatively alter detectable extramitochondrial DNA:mitochondrial DNA ratios |
| US6441149B1 (en) * | 1998-06-15 | 2002-08-27 | Mitokor | Diagnostic method based on quantification of extramitochondrial DNA |
| JP2003521879A (ja) * | 1999-04-20 | 2003-07-22 | マイトコー | アルツハイマー病とともに分離するミトコンドリア遺伝子における一塩基多型 |
| DE60213406T2 (de) * | 2001-05-29 | 2007-03-08 | The University Of British Columbia, Vancouver | Pharmakologische anwendungen von mitochondriellen dna assays |
| US20040009518A1 (en) * | 2002-05-14 | 2004-01-15 | The Chinese University Of Hong Kong | Methods for evaluating a disease condition by nucleic acid detection and fractionation |
| US20090111093A1 (en) | 2004-03-29 | 2009-04-30 | The Regents Of The University Of California | Methods and compositions for pre-symptomatic or post-symptomatic diagnosis of alzheimer's disease and other neurodegenerative disorders |
| CN101248180B (zh) * | 2005-04-18 | 2013-09-25 | 米托米克斯公司 | 作为检测日光照射、前列腺癌和其它癌症的诊断工具的线粒体突变及重排 |
| US20100168051A1 (en) * | 2007-03-23 | 2010-07-01 | Afshan Malik | Altered Mitochondrial Activity in Diseases Resulting From Oxidative Stress |
| US9050275B2 (en) * | 2009-08-03 | 2015-06-09 | Theta Biomedical Consulting & Development Co., Inc. | Methods of screening for and treating autism spectrum disorders and compositions for same |
| JP2013511991A (ja) * | 2009-11-25 | 2013-04-11 | クアンタライフ， インコーポレイテッド | 遺伝子材料を検出する方法および組成物 |
| JP5831919B2 (ja) * | 2011-02-21 | 2015-12-09 | 国立大学法人北海道大学 | 神経変性疾患の検査方法 |
-
2012
- 2012-11-22 ES ES201231807A patent/ES2482866B1/es not_active Expired - Fee Related
-
2013
- 2013-10-17 JP JP2015543486A patent/JP2016502406A/ja active Pending
- 2013-10-17 US US14/443,607 patent/US20150361495A1/en not_active Abandoned
- 2013-10-17 WO PCT/ES2013/070713 patent/WO2014080054A1/es not_active Ceased
- 2013-10-17 EP EP13856389.5A patent/EP2924124A4/en not_active Withdrawn
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