ES2482866B1 - Método de diagnóstico y/o pronóstico de enfermedades neurodegenerativas. - Google Patents

Método de diagnóstico y/o pronóstico de enfermedades neurodegenerativas. Download PDF

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Publication number
ES2482866B1
ES2482866B1 ES201231807A ES201231807A ES2482866B1 ES 2482866 B1 ES2482866 B1 ES 2482866B1 ES 201231807 A ES201231807 A ES 201231807A ES 201231807 A ES201231807 A ES 201231807A ES 2482866 B1 ES2482866 B1 ES 2482866B1
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ES
Spain
Prior art keywords
seq
mitochondrial dna
adn
mitocondrial
csf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES201231807A
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English (en)
Spanish (es)
Other versions
ES2482866A1 (es
Inventor
Ramon Trullas Oliva
Joana FIGUEIRÓ SILVA
Petar MIHAYLOVICH PODLESNIY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centro De Investigacion Biomedica En Red De Enferm
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas CIBERNED
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Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC, Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas CIBERNED filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES201231807A priority Critical patent/ES2482866B1/es
Priority to PCT/ES2013/070713 priority patent/WO2014080054A1/es
Priority to EP13856389.5A priority patent/EP2924124A4/en
Priority to JP2015543486A priority patent/JP2016502406A/ja
Priority to US14/443,607 priority patent/US20150361495A1/en
Publication of ES2482866A1 publication Critical patent/ES2482866A1/es
Application granted granted Critical
Publication of ES2482866B1 publication Critical patent/ES2482866B1/es
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ES201231807A 2012-11-22 2012-11-22 Método de diagnóstico y/o pronóstico de enfermedades neurodegenerativas. Expired - Fee Related ES2482866B1 (es)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ES201231807A ES2482866B1 (es) 2012-11-22 2012-11-22 Método de diagnóstico y/o pronóstico de enfermedades neurodegenerativas.
PCT/ES2013/070713 WO2014080054A1 (es) 2012-11-22 2013-10-17 Método de diagnóstico y/o pronóstico de enfermedades neurodegenerativas
EP13856389.5A EP2924124A4 (en) 2012-11-22 2013-10-17 METHOD FOR DIAGNOSIS AND / OR FORECASTING NEURODEEGENERATIVE DISEASES
JP2015543486A JP2016502406A (ja) 2012-11-22 2013-10-17 神経変性疾患の診断及び／又は予知の方法
US14/443,607 US20150361495A1 (en) 2012-11-22 2013-10-17 Method for the diagnosis and/or prognosis of neurodegenerative diseases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201231807A ES2482866B1 (es) 2012-11-22 2012-11-22 Método de diagnóstico y/o pronóstico de enfermedades neurodegenerativas.

Publications (2)

Publication Number Publication Date
ES2482866A1 ES2482866A1 (es) 2014-08-04
ES2482866B1 true ES2482866B1 (es) 2015-05-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
ES201231807A Expired - Fee Related ES2482866B1 (es) 2012-11-22 2012-11-22 Método de diagnóstico y/o pronóstico de enfermedades neurodegenerativas.

Country Status (5)

Country Link
US (1) US20150361495A1 (https=)
EP (1) EP2924124A4 (https=)
JP (1) JP2016502406A (https=)
ES (1) ES2482866B1 (https=)
WO (1) WO2014080054A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3181701A1 (en) * 2015-12-17 2017-06-21 Consejo Superior De Investigaciones Cientificas Method for the sub-classification of patients suffering from parkinson disease
US20190119747A1 (en) * 2016-03-28 2019-04-25 Osaka University Stress biomarker
JP6654326B2 (ja) * 2016-03-28 2020-02-26 国立大学法人大阪大学 眼科疾患のバイオマーカー
FR3144164A1 (fr) 2022-12-23 2024-06-28 Neolys Diagnostics Détermination du statut d’un individu vis-à-vis de la maladie d’Alzheimer

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494794A (en) 1992-10-20 1996-02-27 Emory University Detection of mitochondrial DNA mutations associated with Alzheimer's disease and Parkinson's disease
JPH1099085A (ja) * 1996-05-16 1998-04-21 Affymetrix Inc ヒトミトコンドリアｄｎａの多形性
US6218117B1 (en) * 1998-06-15 2001-04-17 Mitokor Compositions and methods for identifying agents that quantitatively alter detectable extramitochondrial DNA:mitochondrial DNA ratios
US6441149B1 (en) * 1998-06-15 2002-08-27 Mitokor Diagnostic method based on quantification of extramitochondrial DNA
JP2003521879A (ja) * 1999-04-20 2003-07-22 マイトコー アルツハイマー病とともに分離するミトコンドリア遺伝子における一塩基多型
DE60213406T2 (de) * 2001-05-29 2007-03-08 The University Of British Columbia, Vancouver Pharmakologische anwendungen von mitochondriellen dna assays
US20040009518A1 (en) * 2002-05-14 2004-01-15 The Chinese University Of Hong Kong Methods for evaluating a disease condition by nucleic acid detection and fractionation
US20090111093A1 (en) 2004-03-29 2009-04-30 The Regents Of The University Of California Methods and compositions for pre-symptomatic or post-symptomatic diagnosis of alzheimer's disease and other neurodegenerative disorders
CN101248180B (zh) * 2005-04-18 2013-09-25 米托米克斯公司 作为检测日光照射、前列腺癌和其它癌症的诊断工具的线粒体突变及重排
US20100168051A1 (en) * 2007-03-23 2010-07-01 Afshan Malik Altered Mitochondrial Activity in Diseases Resulting From Oxidative Stress
US9050275B2 (en) * 2009-08-03 2015-06-09 Theta Biomedical Consulting & Development Co., Inc. Methods of screening for and treating autism spectrum disorders and compositions for same
JP2013511991A (ja) * 2009-11-25 2013-04-11 クアンタライフ， インコーポレイテッド 遺伝子材料を検出する方法および組成物
JP5831919B2 (ja) * 2011-02-21 2015-12-09 国立大学法人北海道大学 神経変性疾患の検査方法

Also Published As

Publication number Publication date
JP2016502406A (ja) 2016-01-28
EP2924124A1 (en) 2015-09-30
US20150361495A1 (en) 2015-12-17
WO2014080054A1 (es) 2014-05-30
ES2482866A1 (es) 2014-08-04
EP2924124A4 (en) 2016-08-31

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