JP2016500681A - 膜破壊性の応答性ナノスケールヒドロゲルによる低分子干渉ｒｎａ及びマイクロｒｎａの送達 - Google Patents

膜破壊性の応答性ナノスケールヒドロゲルによる低分子干渉ｒｎａ及びマイクロｒｎａの送達 Download PDF

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JP2016500681A
JP2016500681A JP2015536990A JP2015536990A JP2016500681A JP 2016500681 A JP2016500681 A JP 2016500681A JP 2015536990 A JP2015536990 A JP 2015536990A JP 2015536990 A JP2015536990 A JP 2015536990A JP 2016500681 A JP2016500681 A JP 2016500681A
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hydrogel
composition
sirna
cells
nanogel
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JP2016500681A5 (enExample
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ニコラス ペッパス
ニコラス ペッパス
ウィリアム リヒティ
ウィリアム リヒティ
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University of Texas System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015536990A 2012-10-14 2013-10-14 膜破壊性の応答性ナノスケールヒドロゲルによる低分子干渉ｒｎａ及びマイクロｒｎａの送達 Ceased JP2016500681A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261713610P 2012-10-14 2012-10-14
US61/713,610 2012-10-14
PCT/US2013/064887 WO2014059430A1 (en) 2012-10-14 2013-10-14 Delivery of small interfering rna and micro rna through membrane-disruptive, responsive nanoscalle hydrogels

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JP2016500681A true JP2016500681A (ja) 2016-01-14
JP2016500681A5 JP2016500681A5 (enExample) 2016-12-22

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JP2015536990A Ceased JP2016500681A (ja) 2012-10-14 2013-10-14 膜破壊性の応答性ナノスケールヒドロゲルによる低分子干渉ｒｎａ及びマイクロｒｎａの送達

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US (1) US20150216814A1 (enExample)
EP (1) EP2906242A1 (enExample)
JP (1) JP2016500681A (enExample)
CA (1) CA2888135A1 (enExample)
IL (1) IL238245A0 (enExample)
WO (1) WO2014059430A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016073706A1 (en) * 2014-11-06 2016-05-12 Board Of Regents, The University Of Texas System Delivery of small interfering rna and micro rna through nanogels containing hydrophobic pseudo-peptides
CA3002786C (en) * 2015-10-30 2021-09-07 Bonac Corporation Composition stably containing single-stranded nucleic acid molecule that suppresses expression of tgf-.beta.1 gene

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163092A (en) * 1975-02-11 1979-07-31 Plastomedical Sciences, Inc. Cationic hydrogels based on hydroxyalkyl acrylates and methacrylates
JPH10110006A (ja) * 1996-10-08 1998-04-28 Arakawa Chem Ind Co Ltd カチオン性微粒子ゲルおよびその製造方法
JP2006512425A (ja) * 2002-09-13 2006-04-13 ノベオン アイピー ホールディングス コーポレイション 多目的カチオン性ポリマーおよび会合性ポリマー、ならびにそれらを含む組成物およびそれらの調製方法
JP2011522050A (ja) * 2008-06-03 2011-07-28 ノバルティス アーゲー バルサルタンのパルス放出
WO2012001012A2 (en) * 2010-06-28 2012-01-05 Centrum Für Angewandte Nanotechnologie (Can) Gmbh A micellular combination comprising a nanoparticle and a plurality of surfmer ligands

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163092A (en) * 1975-02-11 1979-07-31 Plastomedical Sciences, Inc. Cationic hydrogels based on hydroxyalkyl acrylates and methacrylates
JPH10110006A (ja) * 1996-10-08 1998-04-28 Arakawa Chem Ind Co Ltd カチオン性微粒子ゲルおよびその製造方法
JP2006512425A (ja) * 2002-09-13 2006-04-13 ノベオン アイピー ホールディングス コーポレイション 多目的カチオン性ポリマーおよび会合性ポリマー、ならびにそれらを含む組成物およびそれらの調製方法
JP2011522050A (ja) * 2008-06-03 2011-07-28 ノバルティス アーゲー バルサルタンのパルス放出
WO2012001012A2 (en) * 2010-06-28 2012-01-05 Centrum Für Angewandte Nanotechnologie (Can) Gmbh A micellular combination comprising a nanoparticle and a plurality of surfmer ligands

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHRISTODOULAKIS,K.E ETAL: "Amphoteric Core-shell Microgels:Contraphilic Two-Compartment Colloidal Particles", LANGMUIR, vol. 26, no. 2, JPN6017034429, 2010, pages 639 - 647, ISSN: 0003638440 *

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US20150216814A1 (en) 2015-08-06
WO2014059430A1 (en) 2014-04-17
EP2906242A1 (en) 2015-08-19
IL238245A0 (en) 2015-06-30
CA2888135A1 (en) 2014-04-17

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