JP2016222577A - External preparation composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an external preparation composition excellent in dispersibility of a granular gel in a stationary state without being affected by fluctuations of pH in an external liquid or the addition of a salt, wherein, when being applied, the external preparation composition exhibits a fresh and refreshing feel of use and good coatability.SOLUTION: A composition comprises external liquid of (A) fermented cellulose and flowable gel which contains (B) granular gel containing one or more kinds selected from the group consisting of carrageenan, gellan gum, agar, curdlan, low methoxyl pectin, gelatin, alginic acid and alginate.SELECTED DRAWING: None

Description

  The present invention relates to an external preparation composition containing a granular gel.

  As an external preparation composition containing a granular gel (for example, a cosmetic containing a granular gel), Patent Document 1 discloses an external liquid containing at least one selected from a carboxyvinyl polymer and an alkyl-modified carboxyvinyl polymer. Discloses an external preparation composition containing gel particles which solidify water with agar and contain at least one selected from a carboxyvinyl polymer and an alkyl-modified carboxyvinyl polymer. Patent Documents 2 and 3 disclose cosmetics containing capsules formed from pectin and / or alginate and a polyvalent metal salt in a carboxyvinyl polymer solution.

JP 2013-75878 A JP 2010-202596 A JP 2010-202595 A

All the techniques disclosed in Patent Documents 1 to 3 use a carboxyvinyl polymer in the external liquid. This carboxyvinyl polymer has the advantage that it can impart a fresh feel to the cosmetic, but it is difficult to say that it is sufficient from the viewpoint of the dispersibility of the granular gel. Further, since the carboxyvinyl polymer is easily affected by pH, the external liquid mainly composed of carboxyvinyl polymer has a problem that the viscosity is likely to fluctuate with pH fluctuation and the dispersion stability of the granular gel cannot be maintained. Moreover, the addition of salts to an external preparation composition containing a carboxyvinyl polymer causes a significant decrease in viscosity, formation of aggregates, and the like, and has a problem that the formulation of the external preparation composition is limited.
Patent Documents 2 and 3 disclose that an aqueous solution of xanthan gum can be used as an external solution. However, an external preparation composition obtained using xanthan gum feels sticky and slimy, and has a refreshed feeling of use. Can't get.

  In view of the prior art as described above, the present invention aims to provide an external preparation composition excellent in the dispersibility of the granular gel, and in particular, the granular gel also against pH fluctuation of the external liquid and addition of salts. An object of the present invention is to provide an external preparation composition that can maintain the dispersion stability of the composition. Another object of the present invention is to provide a granular gel-containing external preparation composition that has a fresh and refreshing feeling when applied to the skin, hair, oral cavity, and the like, and good applicability. To do.

  As a result of intensive studies to solve the above-described problems, the present inventors have (B) carrageenan, gellan gum, agar, curdlan, (A) in an external liquid containing fermented cellulose or fluid gel. Obtaining the knowledge that the above problem can be solved by including a granular gel containing at least one selected from the group consisting of low methoxyl pectin, gelatin, alginic acid, and alginate, the present invention has been completed. It was.

This invention relates to the external preparation composition which has the following aspects;
Item 1. (A) In the external liquid containing fermented cellulose or fluid gel,
(B) A granular gel containing at least one selected from the group consisting of carrageenan, gellan gum, agar, curdlan, rhomethoxyl pectin, gelatin, alginic acid and alginates is included.
External preparation composition.
Item 2. Item 2. The external preparation composition according to Item 1, wherein the external preparation composition is an external preparation composition for skin, hair, intraoral mucosa, or intranasal mucosa.
Item 3.
(A) In the outer liquid containing fermented cellulose or fluid gel,
(B) characterized by containing a granular gel containing at least one selected from the group consisting of carrageenan, gellan gum, agar, curdlan, rhomethoxyl pectin, gelatin, alginic acid and alginates.
A method for producing an external preparation composition.

  ADVANTAGE OF THE INVENTION By this invention, the external preparation composition which is hard to receive the physical property change of external liquid by addition of pH fluctuation | variation and salt, and is excellent in the dispersibility of the granular gel in a stationary state can be provided. In addition, according to the present invention, while the dispersibility of the granular gel is excellent, the granular gel easily disintegrates when applied to the skin, hair, oral cavity, and the like, and a fresh, refreshing feeling of use and good An external preparation composition showing applicability can be provided.

The external preparation composition of the present invention is characterized in that an external liquid containing (A) fermented cellulose or fluid gel is used as the external liquid.
(Fermented cellulose)
The fermented cellulose used in the present invention is cellulose produced by cellulose-producing bacteria (for example, bacteria belonging to the genus Acetobacter, Pseudomonas, Agrobacterium, etc.). Fermented cellulose has a very fine fiber diameter compared to the fiber diameter of general cellulose fibers derived from plants. On the other hand, the fiber length is long, which is greatly different from crystalline cellulose obtained by obtaining only pure crystalline regions.

  In the present invention, it is preferable to use a fermented cellulose composite compounded with another polymer substance as the fermented cellulose. The complex is substantially composed of fermented cellulose and another polymer substance, and is preferably a complex in a state where another polymer substance is attached to the surface of the fermented cellulose fiber. In this way, when the fermented cellulose composite is added to the external liquid by adhering other polymer substances to the surface of the fermented cellulose fiber, the fermented cellulose fiber is easily loosened, so that the granular gel in a stationary state It is possible to provide an external preparation composition that is more excellent in the dispersibility of the composition, the feeling of use when applied to the skin, hair, oral cavity, and the like and the applicability.

  The method for combining fermented cellulose is not particularly limited. For example, a method of obtaining a fermented cellulose complex by mixing a liquid containing fermented cellulose with a solution of another polymer substance, and then alcohol precipitation using isopropyl alcohol or the like, spray drying, etc., gel of fermented cellulose Is immersed in a solution of another polymer substance, or a method disclosed in Japanese Patent Application Laid-Open No. 09-121787, specifically, in the culture of fermented cellulose-producing microorganisms, The fermented cellulose can be combined using a method of adding bismuth. If desired, the fermented cellulose composite can be dried to obtain a dry powder.

  The other polymer substance used for such complexing is not particularly limited as long as it is a polysaccharide that dissolves in the external liquid. For example, galactomannan (eg guar gum, locust bean gum, tara gum, etc.), xanthan gum, carboxymethylcellulose, sodium carboxymethylcellulose, carboxymethylcellulose calcium, tamarind seed gum, pectin, tragacanth gum, caraya gum, carrageenan, agar, alginic acid, alginates, gellan gum , Curdlan, pullulan, psyllium seed gum, glucomannan, chitin, chitosan, starch, dextrin and the like. A preferred polymer substance is at least one selected from the group consisting of carboxymethylcellulose, sodium carboxymethylcellulose, carboxymethylcellulose calcium, xanthan gum and guar gum.

The dried powder of the fermented cellulose composite is commercially available. For example, “Sun Artist [registered trademark] H-PN” and “Sun Artist [registered trademark] H manufactured by San-Ei Gen FFI Co., Ltd.” -PG "and the like.
In the above formulation, “Sun Artist® H-PN” is a fermented cellulose composite formulation of fermented cellulose, sodium carboxymethylcellulose and xanthan gum, and “Sun Artist® H-PG” is fermented cellulose, It is a fermented cellulose complex preparation of sodium carboxymethylcellulose and guar gum.

  The fermented cellulose content in the external liquid is not particularly limited, but preferably the fermented cellulose content is 0.001-1% by mass, more preferably 0.005-0.8% by mass, and still more preferably 0.01. It is -0.6 mass%. By setting the fermentable cellulose content in the external liquid within the above range, an external preparation composition that is extremely excellent in dispersibility of the granular gel in a stationary state can be provided. Moreover, the external preparation composition of this invention has the refreshing feeling of use and favorable applicability | paintability that the collapsible granular gel and external liquid couple | bond together at the time of application | coating. In addition, in this invention, fermented cellulose single-piece | unit content means the content of fermented cellulose itself, and when using a fermented cellulose composite as fermented cellulose, it calculates except the content of the polymeric substance etc. which were used for the composite.

(solvent)
The solvent used in the external liquid in the present invention is not particularly limited, and for example, one or more selected from the group consisting of water, lower alcohols and polyhydric alcohols can be used. The carbon number of the lower alcohol is 7 or less, more preferably 6 or less, still more preferably 5 or less, and still more preferably 3 or less.
Examples of the lower alcohol having 7 or less carbon atoms include ethanol and propanol. Examples of the polyhydric alcohol include glycerin, diglycerin, glycol (for example, ethylene glycol, diethylene glycol, diethylene glycol monoalkyl ether, triethylene glycol). Propylene glycol, dipropylene glycol, 1,3-butylene glycol, hexylene glycol, etc.). In addition, as for the external liquid used by this invention, it is preferable that 50 mass% or more of a solvent is water, and it is more preferable that 70 mass% or more of a solvent is water.
Moreover, the said solvent can be used in common as a solvent of the external liquid containing a fluid gel, and a granular gel.

The external liquid containing fermented cellulose can be prepared by adding fermented cellulose to a solvent. In addition, it is preferable to homogenize the external liquid containing fermented cellulose from a viewpoint of making a cellulose fiber loosen easily. The homogenization treatment can be performed according to a conventional method using, for example, a high-pressure homogenizer, a colloid mill, a nanomizer, a homomixer, or a homodisper. Although the conditions for the homogenization treatment are not particularly limited, for example, a preferable pressure condition (pressure) when using a high-pressure homogenizer, a nanomizer, or the like is 1 MPa or more, more preferably 5 MPa or more, and further preferably 10 MPa or more. The upper limit of the pressure is not particularly limited, and examples thereof include 300 MPa.
Moreover, the preferable rotation conditions (rotation speed) when using a homomixer, a homodisper, etc. are 3000 rpm or more, More preferably, it is 6000 rpm or more. The upper limit of the rotational speed is not particularly limited, but is 12000 rpm, for example.

(Fluidity gel)
In the present invention, the fluid gel is an aggregate of fine gels. Since it is an aggregate of fine gels, it has fluidity as if it were liquid in appearance. Flowable gels are also known as “microgels” and can be prepared according to conventional methods.
The production method of the fluid gel used in the present invention is not particularly limited. For example, (i) the solvent containing the gelling agent is heated to a temperature higher than the dissolution temperature of the gelling agent, and the solution is applied with external force such as stirring. It can be prepared by a method of cooling to the gel point or below, or (ii) by preparing a gel containing a gelling agent and then applying an external force such as stirring to make the gel fine (crushed). .

The type of gelling agent used for the flowable gel is not particularly limited. For example, agar, deacylated gellan gum, kappa carrageenan, curdlan, rhomethoxyl pectin, gelatin, alginic acid and alginates (for example, sodium alginate, potassium alginate) Or one or more selected from the group consisting of calcium alginate and the like).
Although the content of the gelling agent in the external liquid is not particularly limited, the preferable content is 0.001 to 15% by mass, more preferably 0.01 to 10% by mass, still more preferably 0.05 to 8% by mass. Even more preferably, it is 0.1 to 5 mass.

(Gel formation accelerator)
Among the above gelling agents, when one or more selected from the group consisting of deacylated gellan gum, kappa carrageenan, rhomethoxyl pectin, alginic acid and alginate is used, gel formation occurs when preparing a fluid gel It is preferable to use a salt or an acid in combination as an accelerator. The type of the salt is not particularly limited, and is a monovalent salt (for example, sodium salt, potassium salt, etc.), divalent salt (for example, calcium salt, magnesium salt, copper salt, etc.), or trivalent salt (for example, An aluminum salt).

  For example, as the gelling agent, preferred salts when using at least one selected from the group consisting of deacylated gellan gum, rhomethoxyl pectin, alginic acid and alginates are divalent or higher polyvalent metal salts, and more preferable. Salts are calcium salts. The type of calcium salt is not particularly limited. For example, calcium lactate, calcium chloride, calcium carbonate, calcium citrate, calcium acetate, calcium phosphate, calcium pyrophosphate, calcium sulfate, calcium silicate, calcium oxide, calcium hydroxide, calcined calcium, Examples include calcium ascorbate, calcium gluconate, and calcium glutamate. Preferred calcium salts are calcium lactate and / or calcium chloride.

  Further, preferred salts when using kappa-type carrageenan as a gelling agent are potassium salt and / or calcium salt. The type of potassium salt is not particularly limited, but for example, potassium chloride, potassium pyrophosphate, potassium polyphosphate, potassium metaphosphate, potassium phosphate, potassium lactate, potassium carbonate, potassium gluconate, potassium sulfate, potassium hydroxide, sorbic acid Examples thereof include potassium and potassium glutamate. Preferred potassium salts include at least one selected from the group consisting of potassium chloride, potassium pyrophosphate, potassium polyphosphate, potassium metaphosphate and potassium phosphate. The kind in particular of calcium salt is not restrict | limited, The above-mentioned calcium salt can be used.

Similarly, the type of acid is not particularly limited, and acids that can be used in the external preparation composition can be widely used. For example, an organic acid or an inorganic acid.
The content of the gel formation accelerator in the external liquid containing the flowable gel is not particularly limited. For example, when salts are used as the gel formation accelerator, salt conversion (for example, sodium, potassium, calcium, magnesium, copper or The aluminum content is 0.001 to 10% by mass, more preferably 0.005 to 5% by mass, and still more preferably 0.01 to 3% by mass.

  In the present invention, by using a flowable gel as an external liquid, it is possible to provide an external preparation composition that is extremely excellent in the dispersibility of a granular gel in a stationary state, as in the case of using fermented cellulose as an external liquid. it can. Moreover, at the time of application | coating, a granular gel collapse | disintegrates easily and this and external liquid combine, and it can provide the external preparation composition which has a fresh, refreshing feeling of use, and favorable applicability | paintability.

(B) Granular gel The granular gel used in the present invention can stably maintain the shape of the granular gel in the external liquid when the external preparation composition is allowed to stand, and is applied to the skin, hair, oral cavity, and the like. In some cases, it is desirable for the shape to collapse easily.
From this point of view, in the present invention, as the granular gel, the group consisting of (B) carrageenan, gellan gum, agar, curdlan, rhomethoxyl pectin, gelatin, alginic acid and alginates (for example, sodium alginate, potassium alginate, calcium alginate, etc.) A granular gel containing one or more selected from the above is used. The granular gel prepared using these can stably maintain the shape of the granular gel in the external liquid, and when applied to the skin, hair, or oral cavity, the shape of the granular gel is easily disintegrated. Furthermore, when the gel disintegrates, these granular gels, combined with the external liquid containing (A) fermented cellulose or flowable gel, realize a fresh and refreshing feeling of use and good applicability. be able to. In the present invention, it is particularly preferable to contain (B) carrageenan and / or gellan gum as the granular gel.

Carrageenan is a natural polymer extracted and purified from the red alga seaweed. The main chain of carrageenan is composed of galactose, and is roughly classified into kappa-type carrageenan, iota-type carrageenan and lambda-type carrageenan depending on the difference in the position and number of the sulfate group bonded thereto and the presence or absence of an anhydro structure. The type of carrageenan used in the present invention is not particularly limited, but a preferred carrageenan is a kappa carrageenan.
Gellan gum is a polysaccharide produced by Sphingomonas elodea . Gellan gum is a linear heteropolysaccharide composed of four sugar repeating units, glucose, glucuronic acid, glucose and rhamnose. At the time when gellan gum is produced by the fermentation method, acetyl group and glyceryl group are present in the glucose having 1-3 bonded main chain. A product obtained by collecting and commercializing this is native gellan gum, and a product obtained by removing an acyl group (acetyl group and glyceryl group) from this native gellan gum is deacylated gellan gum. The type of gellan gum used in the present invention is not particularly limited, but a preferred gellan gum is a deacylated gellan gum.

  The content of the component (B) in the granular gel is not particularly limited, but from the viewpoints of disintegration of the granular gel at the time of coating, and the feeling of use and coating properties of the external preparation composition containing the granular gel, (B) The preferable content of the components is 0.05 to 20% by mass, more preferably 0.1 to 10% by mass, and still more preferably 0.2 to 5% by mass.

The granular gel used in the present invention preferably contains (b) a thickener having no gelling ability in addition to the component (B). (B) By using a thickener that does not have gelling ability, an external preparation composition in which the granular gel is not easily disintegrated by vibration during transportation can be provided. In addition, while having excellent shape retention of the granular gel in the external liquid, the granular gel easily disintegrates at the time of application, and has an advantage that it can be easily applied uniformly to the skin, hair, oral cavity, and the like.
The type of the thickener (b) having no gelling ability used in the present invention is not particularly limited. For example, high methoxyl (HM) pectin, tamarind seed gum, iota carrageenan, lambda carrageenan, xanthan gum, succinoglycan, guar gum, tara gum, locust bean gum, gati gum, gum arabic, caraya gum, psyllium seed gum, quince seed gum, Pullulan, rhamsan gum, macrohomopsis gum, hyaluronic acid, polyacrylic acid, polyethylene glycol, polyacrylamide, polyalkylacrylamide, polyalkylacrylamide copolymer, carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, carboxymethylcellulose, methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose , Hydroxypropyl cellulose, fermented cellulose, fine Cellulose), starch, gum (e.g., laponite, bentonite, smectite, etc.) and the like. From the viewpoint of improving the shape retention and disintegration property of the granular gel and the coating property of the external preparation composition, (b) high methoxyl pectin, guar gum, iota-type carrageenan, tamarind as a thickener having no gelling ability It is preferable to use one or more selected from the group consisting of seed gum and fermented cellulose.

  The content of the component (b) in the granular gel is not particularly limited, but a preferable content is 0.01 to 10% by mass, more preferably 0.05 to 5% by mass, still more preferably 0.1 to 2% by mass. %.

  In the present invention, the term “granular” means that the size is smaller than that of the container containing the external preparation composition, and the shape is not particularly limited. Examples include a drop shape, a spherical shape, an oval shape, a rectangular parallelepiped shape, a rectangular parallelepiped shape, a flower shape, or a star shape. The size of the granular gel is not particularly limited, but a preferable size is 0.1 μm to 20 mm in the major axis (longest side), more preferably 1 μm to 10 mm in the major axis.

When aesthetics are required for the external preparation composition, or when the active ingredient is encapsulated in the granular gel, the major axis of the granular gel is preferably set to 0.5 mm or more. However, in general, granular gels having a major axis of 0.5 mm or more are difficult to stably disperse in the external liquid, so that the appearance aesthetics are impaired and the active ingredients are uniformly applied. Have problems such as being unable to.
Therefore, the external preparation composition of the present invention has an advantage that the granular gel can be uniformly dispersed in the external liquid even if it is a granular gel having a major axis as large as 0.5 mm or more.

The granular gel used by this invention can be manufactured in accordance with a conventional method except containing a component (B) and a component (b) as needed.
For example, when one or more selected from the group consisting of carrageenan, gellan gum, agar, and gelatin is used as component (B), a solution containing component (B) is prepared, and the solution is used as a cooling medium (for example, The granular gel of the present invention can be prepared by dripping or spraying onto a silicone oil or the like. Moreover, the gel is formed by forming the gel by filling the solution into a granular container and cooling it, or cooling the solution to the gelation temperature of the component (B) or less, and then processing the gel into particles. By doing so, the granular gel of the present invention can be prepared.
Since curdlan has a property of gelling (coagulating) by heating, when curdlan is used as component (B), a dispersion in which a solvent and curdlan are mixed is prepared and the dispersion is heated to a heating medium For example, the granular gel of the present invention can be prepared by dripping or spraying onto silicone oil or the like. In addition, a method of heating the dispersion liquid in a granular container, or forming the gel by heating the dispersion liquid to a temperature equal to or higher than the gelling temperature of the curdlan, and then processing the gel into particles Thus, the granular gel of the present invention can be prepared.
Moreover, when using a kappa-type carrageenan and / or a deacyl-type gellan gum as a component (B), it is preferable to use together the above-mentioned gel formation promoter. For example, it is desirable to add a gel formation accelerator to the solution before dropping or spraying the solution on a cooling medium, or before cooling the solution to the gelation temperature of the component (B) or lower. .
For the type and content of the gel formation accelerator, the above-mentioned column (Gel formation accelerator) can be referred to.

  Moreover, when using 1 or more types selected from the group which consists of a low methoxyl pectin, alginic acid, and alginate as a component (B), the solution of a component (B) is prepared and the gel formation acceleration | stimulation is carried out. A method of dripping or spraying on a solution containing an agent (for example, a solution containing a polyvalent metal salt having a valence of 2 or more), or a gel formation accelerator is added to the solution to form a gel, and then the gel is By processing into a granular form, the granular gel of the present invention can be prepared.

The granular gel of this invention can contain the various raw materials used for an external preparation composition as needed. For example, other ingredients blended in pharmaceuticals, quasi drugs, cosmetics (cosmetics), such as drugs, active ingredients, oils, surfactants, moisturizers, thickeners, preservatives, astringents, whitening An agent, a pH adjuster, water, alcohols, an ultraviolet absorber, an ultraviolet scattering agent, a brightener, a pigment, a fragrance, an insoluble solid, and the like can be appropriately blended as necessary.
Moreover, it is possible to mix | blend an oil-soluble component and a water-insoluble component with the granular gel of this invention. Conventionally, in order to mix | blend an oil-soluble component uniformly in an external preparation composition, it is necessary to emulsify an external preparation composition itself, and as a result, there exists a problem that an external preparation composition becomes cloudy. However, according to the external preparation composition of the present invention, the non-emulsifying external preparation composition in which the oil-soluble component is uniformly blended by dispersing the granular gel encapsulating the oil-soluble component in the external liquid. Can be provided. Thereby, transparency of an external preparation composition can be improved.

  The granular gel used in the present invention has a property that the gel easily disintegrates during coating. Furthermore, it is possible to provide an external preparation composition that does not cause so-called “scum” when the granular gel is disintegrated, and has a fresh and refreshing feeling of use and good coating properties in combination with the external liquid described later. it can.

External preparation composition The external preparation composition targeted by the present invention refers to a composition used by applying to the outer skin (skin), hair, oral mucosa or intranasal mucosa, and the purpose of use is not particularly limited. Can be used for various purposes. For example, it can be used for pharmaceuticals, quasi drugs or cosmetics (cosmetics), and a particularly preferred application is cosmetics. The type of the composition is not particularly limited, and the external preparation composition of the present invention includes, for example, an external preparation, a spray, an ointment, a cream, a mouthwash, a mouth moistening agent, a toothpaste, a mouth freshener, Antiperspirant, hair dye, facial cleanser, cleansing, lotion, milky lotion, serum, pack, sunscreen, makeup base, foundation, lipstick, lip balm, eye makeup, body soap, body cream, massage cream, hand cream, It can be used as a shampoo, conditioner, hair care agent, hair styling agent, perfume, scrub agent and the like.
The pH of the external preparation composition of the present invention is not particularly limited and can be used in a wide range of pH (for example, pH 2 to 12), and has an advantage that the dispersibility of the granular gel is excellent at any pH. Thereby, the external preparation composition of this invention can be used for a wide use.

  Hereinafter, the present invention will be described in more detail with reference to examples. However, these examples do not limit the present invention. In the examples, “parts” and “%” mean “parts by mass” and “mass%”, respectively, and “*” in the text indicates that manufactured by San-Ei Gen FFI Co., Ltd. "*" Signifies that it is a registered trademark of San-Eigen FFI Corporation.

Experimental Example 1 Preparation of external preparation composition (for skin: cosmetic) ( preparation of external liquid)
According to the formulation in Table 1, (A) an external solution was prepared.
(External liquid 1-2, 5-8)
Fermented cellulose, carboxyvinyl polymer or xanthan gum was added to water and stirred for 10 minutes at room temperature to prepare a solution. Next, external liquids 1, 5 and 7 were prepared by adding and mixing a humectant (PCA glyceres-25 isostearate, glycerin) and an antiseptic (methylparaben). External solutions 2, 6 and 8 were adjusted to pH 7 with sodium hydroxide, then moisturizer (PCA isostearic acid glyceres-25, glycerin, sodium pyrrolidonecarboxylate) and preservative (methylparaben). Were added and mixed to prepare an external solution.

(Outside liquid 3)
Deacylated gellan gum was added to water and heated at 90 ° C. with stirring for 10 minutes, and then a calcium chloride solution was added to prepare a deacylated gellan gum solution.
Separately, a humectant (PCA isostearic acid glyceres-25, glycerin) and a preservative (methylparaben) heated at 50 ° C. with stirring were prepared, and this and the solution were mixed and filled into a container. While the outer wall of the container was cooled to below the gel point with cold water, homodisper treatment was performed for 3 minutes under a stirring condition of 5000 rpm to prepare an external liquid containing a fluid gel (external liquid having a fluid gel as a skeleton).
(Outside liquid 4)
Deacylated gellan gum was added to water and heated at 90 ° C. with stirring for 10 minutes, and then a calcium chloride solution was added to prepare a deacylated gellan gum solution.
Separately, a humectant (PCA isostearic acid glyceres-25, glycerin) and an antiseptic (methylparaben) heated at 50 ° C. for 5 minutes with stirring were prepared, and this was mixed with the solution and sodium pyrrolidonecarboxylate. Then, an external solution to which sodium hydroxide was added was prepared. The outer liquid is filled in the container, and the outer wall of the container is cooled to below the gel point with cold water and homodispered for 3 minutes under a stirring condition of 5000 rpm. External solution) was prepared.

Note 1) After adding the fermented cellulose preparation to water, it was added as a fermented cellulose solution that was homogenized (high pressure 10 MPa, second pressure 5 MPa) with a high-pressure homogenizer. The numbers in the table indicate the fermented cellulose content in the external liquid.
The fermented cellulose preparation is a preparation containing 100% by mass of fermented cellulose, xanthan gum and a fermented cellulose complex of sodium carboxymethylcellulose, and the preparation “Sun Artist * H-PN *” containing 50% by mass of fermented cellulose alone. used.

(Preparation of granular gel)
A granular gel was prepared according to the formulation in Table 2.
(Phase I)
Kappa-type carrageenan and deacylated gellan gum, high methoxyl pectin, guar gum, or iota-type carrageenan were added to water, followed by heating at 90 ° C. for 10 minutes with stirring, followed by addition of calcium chloride.
(Phase II)
1,3-butylene glycol, titanium oxide, pearl pigment, lecithin, and methyl paraoxybenzoate were added to water and heated to 50 ° C.
(Preparation of granular gel)
The phases I and II were mixed and cooled to 50 ° C., and then the mixture was dropped into cooled silicone oil to prepare a granular gel. The granular gel was recovered and washed with water. The major axis of the obtained granular gel was 2 to 6 mm.

(Preparation of external preparation composition)
According to the formulation of Table 3, 10 parts by mass of granular gel was added to 90 parts by mass of external liquid to prepare an external preparation composition (cosmetics) containing the granular gel. About the prepared external preparation composition, the dispersibility of a granular gel and the usability | use_condition and applicability | paintability of an external preparation composition were evaluated. The results are shown in Table 3.
(Dispersibility of granular gel)
The prepared external preparation composition was allowed to stand at room temperature for 1 day, and the dispersibility of the granular gel was visually evaluated.
(Feeling of use)
1 g of the prepared external preparation composition was spread on the back of the hand, and the feeling of use (feel) was evaluated.
(Applicability)
1 g of the prepared external preparation composition was spread on the back of the hand, and the ease of spreading and the ease of staying on the application part (hardness to fall off) were evaluated.

All of the cosmetics (Examples 1-1 to 1-9) in which a granular gel containing kappa-type carrageenan or deacyl-type gellan gum is added to the outer solution containing fermented cellulose or flowable gel are used as the outer solution. The granular gel was uniformly dispersed therein. Further, it was shown that the granular gel was uniformly dispersed regardless of the presence or absence of salts (sodium pyrrolidonecarboxylate) in the external liquid and the pH, and the dispersion stability of the granular gel was extremely excellent. In addition, when the cosmetics of Examples 1-1 to 1-9 were applied to the back of the hand, the granular gel was easily disintegrated, and this combined with the external liquid combined with a fresh, refreshing feeling of use and good applicability. Had. In addition, no “cass” was formed when the granular gel collapsed.
On the other hand, in the cosmetic (Comparative Examples 1-1 and 1-2) in which the granular gel was added to the external liquid containing the carboxyvinyl polymer, the granular gel was all precipitated at the bottom of the container after one day of preparation. Further, when the cosmetic was applied to the back of the hand, the makeup easily dropped from the back of the hand.
Similarly, in the cosmetic (Comparative Examples 1-3 and 1-4) in which the granular gel was added to the external liquid containing xanthan gum, the granular gel was all precipitated at the bottom of the container after 1 day of preparation. In addition, it was very slimy and had a sticky feel.

Moreover, about the cosmetics containing the granular gel of Examples 1-1 to 1-9, when the shape retention of the granular gel was confirmed according to the following method, the cosmetic containing the granular gels 1 and 2 was 25% (4 The granular gel was broken, but the cosmetic containing the granular gels 3 to 6 did not disintegrate even after the shape retention test (the broken granular gel was less than 10% (2 or less). )Met).
(Shape retention test)
In a 100 mL container, 50 mL of external liquid and 20 granular gels were placed, and shaken in a shaker (“Double Shaker NR-30” manufactured by Taitec Co., Ltd.) at 100 rpm for 10 minutes. The number of granular gels retaining the shape after shaking was confirmed.

(Use for dispenser containers)
When the cosmetic material containing granular gel of Examples 1-1 to 1-9 was filled in a dispenser container (gas-free, non-mesh type) and the cosmetic material containing granular gel was extruded, the granular gel easily disintegrated, The cosmetic solution was discharged by integrating the external liquid and the disintegrated granular gel. When the cosmetic was applied to the back of the hand, it was easy to spread and did not easily sag from the back of the hand, showing good applicability. In addition, the feeling of use was refreshing and refreshing.

Claims (3)

(A) In the external liquid containing fermented cellulose or fluid gel,
(B) A granular gel containing at least one selected from the group consisting of carrageenan, gellan gum, agar, curdlan, rhomethoxyl pectin, gelatin, alginic acid and alginates is included.
External preparation composition.   The external preparation composition according to claim 1, wherein the external preparation composition is an external preparation composition for skin, hair, intraoral mucosa, or intranasal mucosa. (A) In the outer liquid containing fermented cellulose or fluid gel,
(B) characterized by containing a granular gel containing at least one selected from the group consisting of carrageenan, gellan gum, agar, curdlan, rhomethoxyl pectin, gelatin, alginic acid and alginates.
A method for producing an external preparation composition.