JP2016183139A - Chewable formulations - Google Patents
Chewable formulations Download PDFInfo
- Publication number
- JP2016183139A JP2016183139A JP2015065455A JP2015065455A JP2016183139A JP 2016183139 A JP2016183139 A JP 2016183139A JP 2015065455 A JP2015065455 A JP 2015065455A JP 2015065455 A JP2015065455 A JP 2015065455A JP 2016183139 A JP2016183139 A JP 2016183139A
- Authority
- JP
- Japan
- Prior art keywords
- dietary fiber
- weight
- chewable
- combination
- chewable agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Abstract
Description
本発明は、食物繊維を含むチュアブル剤に関する。より詳細には、本発明は、所定量以上の食物繊維を含みながらも、歯に対する付着が有意に抑制されてなるチュアブル剤に関する。また本発明は、所定量以上の食物繊維を含みながらも、歯に対する付着が有意に抑制され、且つ食物繊維特有の不快な味も軽減し、総合的に服用感が改善されたチュアブル剤に関する。 The present invention relates to a chewable preparation containing dietary fiber. More specifically, the present invention relates to a chewable agent in which adhesion to teeth is significantly suppressed while containing a predetermined amount or more of dietary fiber. In addition, the present invention relates to a chewable agent that contains a predetermined amount or more of dietary fiber, has significantly suppressed adhesion to teeth, reduces unpleasant taste peculiar to dietary fiber, and has an overall improved feeling of taking.
食物繊維には多くの腸疾患や代謝性疾患に対して、予防効果があることが認められている。例えば、便の量を増加させ、また腸内のビフィズス菌や乳酸菌の割合を増やすことによって便秘を改善し、腸内における発癌物質の生成を抑える効果；体内でコレステロールから作られる胆汁酸の体外（便中）への排泄を促進し、血中コレステロール値を下げる効果；及び食後の血糖値の急激な上昇を抑える効果等の他、欧米では食物繊維を一日あたり２４ｇ以上摂取すると、心筋梗塞による死亡率の低下が観察されるという研究報告もある（非特許文献１）。このように、いわゆる生活習慣病の予防等の観点から、近年、食物繊維の摂取が重要視されており、厚生労働省では「日本人の食事摂取基準」（2010年版）として、１日あたりの食物繊維の摂取目標値として、１８歳以上では男性１９ｇ以上、女性１７ｇ以上を推奨している。 Dietary fiber has been shown to have a preventive effect on many bowel and metabolic diseases. For example, by increasing the amount of stool and increasing the proportion of bifidobacteria and lactic acid bacteria in the intestine, it improves constipation and suppresses the production of carcinogens in the intestine; In addition to the effect of promoting excretion (in the stool) and lowering blood cholesterol level; and the effect of suppressing a rapid increase in blood glucose level after meals, etc., in the United States and Europe, intake of 24 g or more of dietary fiber per day is caused by myocardial infarction There is also a research report that a decrease in mortality is observed (Non-patent Document 1). In this way, in view of the prevention of so-called lifestyle-related diseases, in recent years, the intake of dietary fiber has been regarded as important, and the Ministry of Health, Labor and Welfare has set the “food intake standard for Japanese people” (2010 edition) as food per day. As the fiber intake target value, males over 19g and females over 17g are recommended for ages 18 and over.
しかしながら、食生活の欧米化やライフスタイルの変化に伴い、上記量の食物繊維を、毎日の食事から摂取することは容易でない。 However, it is not easy to take the above-mentioned amount of dietary fiber from a daily meal with the westernization of eating habits and lifestyle changes.
このため、食物繊維を多く含むことを謳った食品が種々提案されている。例えば、所定量以上の食物繊維を含むことで「おなかの調子を整える」または「糖の吸収をおだやかにする」といった表示を付した特定保健用食品（非特許文献２）、食物繊維を含む粉末または顆粒状の製剤を用時に水や飲料に溶解して服用するタイプのものや、食物繊維を含む錠剤を水や飲料とともに服用するタイプの食品が知られている。 For this reason, various foods intended to contain a large amount of dietary fiber have been proposed. For example, specific health foods (Non-Patent Document 2) with a label such as “to adjust tummy” or “smooth sugar absorption” by containing dietary fiber above a predetermined amount, powder containing dietary fiber Alternatively, there are known a type in which a granular preparation is dissolved in water or a beverage at the time of use and a type of food in which a tablet containing dietary fiber is taken with water or a beverage.
従来から提案並びに販売されている前述の食物繊維含有食品は、食事では十分に摂取できない量の食物繊維を摂取するうえで便利な食品であるものの、時間や場所を選ばず、何時でも何処でも服用できるものではない。また、持ち運びが比較的容易な製剤タイプのものであっても、それを服用するためには水や飲料が必要であるという多少の不便さがある。そこで、何時でも何処でも簡単に所定量の食物繊維が摂取できる食物繊維含有食品が求められる。 The above-mentioned dietary fiber-containing foods that have been proposed and sold in the past are convenient foods for ingesting an amount of dietary fiber that cannot be adequately consumed with meals, but can be taken anytime, anywhere, regardless of time or place. It is not possible. Moreover, even if it is a formulation type that is relatively easy to carry, there is some inconvenience that water and beverages are required to take it. Accordingly, there is a need for a dietary fiber-containing food that can easily take a predetermined amount of dietary fiber anytime and anywhere.
一方、何時でも何処でも簡単に摂取できる製剤としては、口腔内で咀嚼して服用するタイプの製剤である「チュアブル剤」がある。しかし、本発明者が、検討したところ、服用錠数低減のために一錠あたりの食物繊維含有量を多くすると、歯に対して付着しやすくなり、また食物繊維特有の不快な味が発現して、服用感が著しく低下することが判明した。 On the other hand, as a preparation that can be easily taken at any time and anywhere, there is a “chewable agent” which is a type of preparation chewed in the oral cavity. However, as a result of studies by the present inventor, if the dietary fiber content per tablet is increased to reduce the number of tablets taken, it tends to adhere to the teeth, and an unpleasant taste peculiar to dietary fiber appears. It has been found that the feeling of taking is significantly reduced.
そこで、本発明は、所定量の食物繊維を含みながらも、歯に対する付着が有意に抑制されてなるチュアブル剤を提供することを目的とする。特に本発明は、所定量以上の食物繊維を含みながらも、歯に対する付着が有意に抑制され、且つ食物繊維特有の不快な味も軽減し、総合的に服用感が改善されたチュアブル剤を提供することを目的とする。 Then, an object of this invention is to provide the chewable agent by which adhesion with respect to a tooth | gear is suppressed significantly, including a predetermined amount of dietary fiber. In particular, the present invention provides a chewable agent that contains a predetermined amount or more of dietary fiber, has significantly suppressed adhesion to teeth, and has reduced the unpleasant taste peculiar to dietary fiber. The purpose is to do.
本発明者は、上記課題を解決すべく鋭意検討を重ねていたところ、製剤全量に対し１５重量％以上の食物繊維を含有するチュアブル剤において、（Ａ）食物繊維として水溶性と不溶性の２種類を組み合わせて用い、また他成分として、（Ｂ）天然系甘味料及び合成系甘味料、並びに（Ｃ）酸味料を配合することで、上記課題を解決することができることを見出した。特に、食物繊維特有の不快な味の軽減効果（風味改善効果）は、上記処方において（Ｃ）酸味料として少なくも２種類の酸味料の組み合わせを用いることで、より一層向上すること、また歯に対する付着抑制効果は、（Ｄ）滑沢剤を用いることで向上し、少なくとも２種類の滑沢剤を組み合わせて用いることで、より一層向上することを見出した。 The present inventor has made extensive studies to solve the above-mentioned problems. As a result, (A) two types of water-soluble and insoluble as dietary fiber in a chewable preparation containing 15% by weight or more of dietary fiber based on the total amount of the preparation. It was found that the above-mentioned problems can be solved by combining (B) natural sweetener and synthetic sweetener and (C) acidulant as other components. In particular, the unpleasant taste-reducing effect (flavor improving effect) peculiar to dietary fiber can be further improved by using a combination of at least two types of acidulants as the acidulant (C) in the above-mentioned formulation. It has been found that the adhesion-suppressing effect with respect to (D) is improved by using a lubricant, and is further improved by using at least two kinds of lubricants in combination.
本発明はかかる知見に基づいて、さらに検討を重ねて完成したものであり、下記の実施形態を有する。 The present invention has been completed through further studies based on such findings, and has the following embodiments.
（Ｉ）チュアブル剤
（Ｉ−１）製剤１００重量％中、食物繊維を少なくとも１５重量％の割合で含有するチュアブル剤であって、
（Ａ）上記食物繊維が水溶性食物繊維及び不溶性食物繊維であり、さらに
（Ｂ）天然系甘味料及び合成系甘味料、及び
（Ｃ）酸味料
を含有することを特徴とする、チュアブル剤。
（Ｉ−２）上記（Ｃ）成分が少なくも２種類の酸味料の組み合わせである、
（Ｉ−１）に記載するチュアブル剤。
（Ｉ−３）さらに（Ｄ）滑沢剤を含有する、（Ｉ−１）または（Ｉ−２）に記載するチュアブル剤。
（Ｉ−４）上記（Ｄ）成分が少なくとも２種類の滑沢剤の組み合わせである、（Ｉ−３）に記載するチュアブル剤。
（Ｉ−５）上記（Ｄ）成分としてステアリン酸塩を含む、（Ｉ−３）または（Ｉ−４）に記載するチュアブル剤。
（Ｉ−６）上記（Ｄ）成分としてステアリン酸塩と脂肪酸エステルを含有する、（Ｉ−４）に記載するチュアブル剤。
（Ｉ−７）ステアリン酸塩１００重量部に対する脂肪酸エステルの割合が５０〜５００重量部である、（Ｉ−６）に記載するチュアブル剤。
（Ｉ−８）（Ａ）成分１重量部に対して、（Ｂ）成分を０．３〜３．５重量部の割合で含有する（Ｉ−１）〜（Ｉ−７）のいずれかに記載するチュアブル剤。
（Ｉ−９）（Ａ）成分１重量部に対して、（Ｃ）成分を０．０１〜０．３重量部の割合で含有する（Ｉ−１）〜（Ｉ−８）のいずれかに記載するチュアブル剤。
(I) Chewable agent (I-1) A chewable agent containing dietary fiber in a proportion of at least 15% by weight in 100% by weight of the preparation,
(A) The chewable agent, wherein the dietary fiber is a water-soluble dietary fiber and an insoluble dietary fiber, and further comprises (B) a natural sweetener and a synthetic sweetener, and (C) an acidulant.
(I-2) The above component (C) is a combination of at least two types of acidulants.
The chewable agent described in (I-1).
(I-3) The chewable agent according to (I-1) or (I-2), further comprising (D) a lubricant.
(I-4) The chewable agent described in (I-3), wherein the component (D) is a combination of at least two types of lubricants.
(I-5) The chewable agent according to (I-3) or (I-4), which contains stearate as the component (D).
(I-6) The chewable agent according to (I-4), which contains stearate and a fatty acid ester as the component (D).
(I-7) The chewable agent described in (I-6), wherein the ratio of the fatty acid ester to 100 parts by weight of stearate is 50 to 500 parts by weight.
(I-8) Any one of (I-1) to (I-7) containing 0.3 to 3.5 parts by weight of component (B) with respect to 1 part by weight of component (A) Chewable agent to be described.
(I-9) In any one of (I-1) to (I-8), the component (C) is contained in an amount of 0.01 to 0.3 parts by weight relative to 1 part by weight of the component (A). Chewable agent to be described.
（II）チュアブル剤の歯に対する付着抑制方法
（II−１）製剤１００重量％中、食物繊維を少なくとも１５重量％の割合で含有するチュアブル剤の歯に対する付着抑制方法であって、
（Ａ）上記食物繊維として水溶性食物繊維維及び不溶性食物繊維を用い、さらに
上記チュアブル剤に、（Ｂ）天然系甘味料及び合成系甘味料、並びに（Ｃ）酸味料を配合することを特徴とする、上記方法。
（II−２）チュアブル剤に、さらに（Ｄ）滑沢剤を配合する、（II−１）記載の歯付着抑制方法。
（II−３）上記（Ｄ）成分が少なくも２種類の滑沢剤の組み合わせである、（II−２）に記載する歯付着抑制方法。
（II−４）上記（Ｄ）成分としてステアリン酸塩を用いる、（II−２）または（II−３）に記載する歯付着抑制方法。
（II−５）上記（Ｄ）成分としてステアリン酸塩と脂肪酸エステルを含有する、（II−３）に記載する歯付着抑制方法。
（II−６）上記（Ｃ）成分として少なくも２種類の酸味料の組み合わせを用いる、（II−１）乃至（II−５）のいずれかに記載する歯付着抑制方法。
（II−７）（Ａ）成分１重量部に対して、（Ｂ）成分を０．３〜３．５重量部の割合で配合する（II−１）乃至（II−６）のいずれかに記載する歯付着抑制方法。
（II−８）（Ａ）成分１重量部に対して、（Ｃ）成分を０．０１〜０．３重量部の割合で配合する（II−１）乃至（II−７）のいずれかに記載する歯付着抑制方法。
(II) Method for suppressing adhesion of chewable agent to teeth (II-1) A method for suppressing adhesion of chewable agent to teeth containing dietary fiber in a proportion of at least 15% by weight in 100% by weight of the preparation,
(A) A water-soluble dietary fiber and an insoluble dietary fiber are used as the dietary fiber, and (B) a natural sweetener and a synthetic sweetener, and (C) an acidulant are added to the chewable agent. And the above method.
(II-2) The method for inhibiting tooth adhesion according to (II-1), further comprising (D) a lubricant in the chewable agent.
(II-3) The method for suppressing tooth adhesion described in (II-2), wherein the component (D) is a combination of at least two lubricants.
(II-4) The method for suppressing tooth adhesion described in (II-2) or (II-3), wherein stearate is used as the component (D).
(II-5) The method for suppressing tooth adhesion described in (II-3), which contains stearate and a fatty acid ester as the component (D).
(II-6) The method for suppressing tooth adhesion according to any one of (II-1) to (II-5), wherein a combination of at least two types of acidulants is used as the component (C).
(II-7) The component (B) is blended at a ratio of 0.3 to 3.5 parts by weight with respect to 1 part by weight of the component (A). (II-1) to (II-6) The tooth adhesion suppression method to describe.
(II-8) In any one of (II-1) to (II-7), the component (C) is blended at a ratio of 0.01 to 0.3 parts by weight with respect to 1 part by weight of the component (A). The tooth adhesion suppression method to describe.
本発明によれば、製剤全量に対し１５重量％以上の食物繊維を含有するチュアブル剤において、（Ａ）食物繊維として水溶性食物繊維と不溶性食物繊維の２種類を組み合わせて用い、また他成分として（Ｂ）天然系甘味料及び合成系甘味料、並びに（Ｃ）酸味料を併用することで、上記（Ａ）〜（Ｃ）の少なくとも一つの条件を満たさないチュアブル剤と比較して、口腔内で咀嚼した際の歯に対する付着が抑制され、また食物繊維特有の不快な味が低減して製剤の風味が改善するという効果を得ることができる。特に、後者の効果（食物繊維特有の不快な味の軽減効果（風味改善効果））は、（Ｃ）酸味料として少なくも２種類の酸味料の組み合わせを用いることで一層向上させることができる。また歯に対する付着抑制効果は、さらに（Ｄ）滑沢剤を用いることで向上させることができ、２種類以上の滑沢剤を組み合わせて用いることで一層向上させることができる。 According to the present invention, in the chewable preparation containing 15% by weight or more of dietary fiber based on the total amount of the preparation, (A) two kinds of water-soluble dietary fiber and insoluble dietary fiber are used in combination as dietary fiber, and as other components (B) By using a natural sweetener and a synthetic sweetener, and (C) an acidulant in combination, a chewable agent that does not satisfy at least one of the above conditions (A) to (C) is used in the oral cavity. Adhesion to the teeth when chewing with can be suppressed, and an unpleasant taste peculiar to dietary fiber can be reduced to improve the flavor of the preparation. In particular, the latter effect (reduction effect of unpleasant taste peculiar to dietary fiber (flavor improvement effect)) can be further improved by using a combination of at least two kinds of acidulants as (C) acidulants. Moreover, the adhesion inhibitory effect with respect to a tooth | gear can further be improved by using (D) lubricant, and can further be improved by using combining 2 or more types of lubricants.
（Ｉ）チュアブル剤
本発明は、製剤１００重量％中、食物繊維を少なくとも１５重量％の割合で含有するチュアブル剤であって、
（Ａ）上記食物繊維が水溶性食物繊維及び不溶性食物繊維であり、さらに
（Ｂ）天然系甘味料及び合成系甘味料、及び
（Ｃ）酸味料
を含有することを特徴とする。
(I) Chewable agent The present invention is a chewable agent containing at least 15% by weight of dietary fiber in 100% by weight of the preparation,
(A) The dietary fiber is a water-soluble dietary fiber and an insoluble dietary fiber, and further contains (B) a natural sweetener and a synthetic sweetener, and (C) an acidulant.
チュアブル剤（咀嚼剤）は、服用する際に、そのまま飲み込まないで、口腔内でよくかみ砕いてから嚥下する服用形態の製剤である。このため、服用に際して必ずしも水を必要としない。 A chewable agent (chewing agent) is a preparation in a dosage form that is not swallowed as it is, but is swallowed after being well chewed in the oral cavity. For this reason, water is not necessarily required for taking.
本発明が対象とするチュアブル剤は、当該服用形態を有するものであればよく、その剤型は、錠剤（タブレット）状（裸錠）、丸剤状、およびチューインガム状（板状、粒状）の形態から任意に選択して用いることができる。その大きさも特に制限されないものの、口腔内でかみ砕いて嚥下することから一定以上の大きさを有することが好ましい。例えば、円型、楕円型または角型の錠剤形態を有する製剤の場合、直径または１辺の長さが１０〜２０ｍｍの範囲にあるような製剤を好適に例示することができる。 The chewable agent targeted by the present invention is not limited as long as it has the dosage form, and its dosage form is in the form of tablets (tablets), pills, and chewing gums (plates, granules). Any form can be selected and used. Although the size is not particularly limited, it is preferable to have a certain size or more because it is chewed in the oral cavity and swallowed. For example, in the case of a preparation having a circular, elliptical or square tablet form, a preparation having a diameter or a side length in the range of 10 to 20 mm can be preferably exemplified.
以下、本発明のチュアブル剤に含まれる各成分について説明する。 Hereinafter, each component contained in the chewable agent of the present invention will be described.
（Ａ）食物繊維
食物繊維は、大きくわけて水溶性食物繊維(SDF:soluble dietary fiber)と不溶性食物繊維(IDF:insoluble dietary fiber)に分類される。本発明は、これらの水溶性食物繊維と不溶性食物繊維を組み合わせて用いることを一つの特徴とする。
(A) Dietary fiber Dietary fiber is roughly classified into water-soluble dietary fiber (SDF) and insoluble dietary fiber (IDF). One feature of the present invention is that these water-soluble dietary fibers and insoluble dietary fibers are used in combination.
水溶性食物繊維としては、制限はされないが、例えば、難消化性デキストリン、ポリデキストロース、及びカルボキシメチルセルロースナトリウム（以上、化学修飾多糖類）、寒天、アガロース、アルギン酸ナトリウム（低分子化アルギン酸ナトリウムを含む）、イヌリン、カラギーナン、水溶性大豆多糖類、サイリウム、フコイダン、及びラミナラン、アラビアガム、ペクチン（低分子化ペプチンを含む）、グァーガム、グァー豆酵素分解物（グアーガム分解物）、ローカストビーンガム、プルラン、カードラン、キサンタンガム、ジェランガム、低分子化ヘミセルロース、及びグルコマンナン等を挙げることができる。これらの水溶性食物繊維は、１種単独で下記に説明する不溶性食物繊維と併用してもよいし、また２種以上を任意に選択して、下記に説明する不溶性食物繊維と併用してもよい。好ましくは難消化性デキストリンなどの化学修飾多糖類である。 Although it does not restrict | limit as water-soluble dietary fiber, For example, indigestible dextrin, polydextrose, and sodium carboxymethylcellulose (above, chemically modified polysaccharide), agar, agarose, sodium alginate (including low molecular weight sodium alginate) , Inulin, carrageenan, water-soluble soybean polysaccharide, psyllium, fucoidan, and laminaran, gum arabic, pectin (including low molecular weight peptin), guar gum, guar bean enzyme degradation product (guar gum degradation product), locust bean gum, pullulan, Examples thereof include curdlan, xanthan gum, gellan gum, low molecular weight hemicellulose, and glucomannan. These water-soluble dietary fibers may be used alone or in combination with the insoluble dietary fiber described below, or two or more types may be arbitrarily selected and used in combination with the insoluble dietary fiber described below. Good. Preferably, it is a chemically modified polysaccharide such as indigestible dextrin.
不溶性食物繊維としては、制限はされないが、例えば、セルロース類、ペクチン質（不溶性）、リグニン、キチン、及びキトサン等を挙げることができる。ここでセルロース類には、セルロース、ヘミセルロース、α−セルロース、結晶セルロース、及び微結晶性セルロースが含まれる。これらの不溶性食物繊維は、１種単独で上記で説明する水溶性食物繊維と併用してもよいし、また２種以上を任意に選択して、上記で説明する水溶性食物繊維と併用してもよい。好ましくはセルロース類であり、より好ましくはセルロースである。 Examples of insoluble dietary fiber include, but are not limited to, celluloses, pectin (insoluble), lignin, chitin, and chitosan. Here, the cellulose includes cellulose, hemicellulose, α-cellulose, crystalline cellulose, and microcrystalline cellulose. These insoluble dietary fibers may be used alone or in combination with the water-soluble dietary fiber described above, or two or more types may be arbitrarily selected and used in combination with the water-soluble dietary fiber described above. Also good. Preferred are celluloses, and more preferred is cellulose.
水溶性食物繊維と不溶性食物繊維の好ましい組み合わせ態様は、制限されないものの、水溶性食物繊維からなる群から選択される少なくとも１つとセルロース類からなる群から選択される少なくとも１つとの組み合わせ；難消化性デキストリン、及びポリデキストロースから選ばれる少なくとも１種と、セルロース、ヘミセルロース、及び結晶セルロースから選ばれる少なくとも１種との組み合わせを挙げることができる。好ましくは後述する実験例に示す難消化性デキストリンとセルロースとの組み合わせである。 Although the preferable combination aspect of a water-soluble dietary fiber and an insoluble dietary fiber is not restrict | limited, The combination of at least 1 selected from the group which consists of water-soluble dietary fiber, and at least 1 selected from the group which consists of celluloses; A combination of at least one selected from dextrin and polydextrose and at least one selected from cellulose, hemicellulose, and crystalline cellulose can be given. Preferably, it is a combination of indigestible dextrin and cellulose shown in the experimental examples described later.
水溶性食物繊維と不溶性食物繊維の配合割合は、制限されないものの、水溶性食物繊維１００重量部に対する不溶性食物繊維の割合として、好ましくは１０〜１００重量部の範囲を挙げることができる。より好ましくは１０〜８０重量部であり、特に好ましくは１４〜５０重量部である。 Although the mixing ratio of the water-soluble dietary fiber and the insoluble dietary fiber is not limited, the ratio of the insoluble dietary fiber to 100 parts by weight of the water-soluble dietary fiber is preferably in the range of 10 to 100 parts by weight. More preferably, it is 10-80 weight part, Especially preferably, it is 14-50 weight part.
チュアブル剤中に含まれる水溶性食物繊維と不溶性食物繊維の総量としては、製剤全量１００重量％中、通常１５重量％以上を挙げることができる。好ましくは１５〜６０重量％、より好ましくは２０〜６０重量％である。この範囲で食物繊維を配合することで、チュアブル剤の摂取総量を抑制することにより服用時の負担を軽減しながら、有効量の食物繊維を手軽に摂取できるという効果を得ることができる。 The total amount of the water-soluble dietary fiber and the insoluble dietary fiber contained in the chewable agent can be usually 15% by weight or more in 100% by weight of the total preparation. Preferably it is 15-60 weight%, More preferably, it is 20-60 weight%. By blending dietary fiber in this range, it is possible to obtain an effect that an effective amount of dietary fiber can be easily consumed while reducing the burden at the time of taking by suppressing the total intake of chewable agents.
（Ｂ）甘味料
甘味料は、大きくわけて糖質系甘味料と非糖質系甘味料に分類され、また非糖質系甘味料はさらに天然甘味料と合成甘味料（人工甘味料）に分類される。本発明が対象とする天然系甘味料は、植物等の天然の資源からそれに含まれる甘味成分を抽出し、必要に応じて精製したもの、並びに当該植物に含まれる甘味成分を原料として、水素添加（還元）又は加水分解などの加工処理を施して生成される甘味料である。かかる天然系甘味料には、前述する糖質系甘味料、及び非糖質系甘味料のうち天然甘味料が含まれる。一方、本発明が対象とする合成系甘味料は、植物などの天然に存在しない甘味成分であって、化学合成によって人工的に製造される甘味料である。当該合成系甘味料には、前述する非糖質系甘味料のうち合成甘味料（人工甘味料）が含まれる。
(B) Sweetener sweeteners are roughly classified into saccharide-based sweeteners and non-saccharide-type sweeteners. Non-saccharide-type sweeteners are further classified into natural sweeteners and synthetic sweeteners (artificial sweeteners). being classified. Natural sweeteners targeted by the present invention are extracted from a natural ingredient such as a plant and purified as necessary, and hydrogenated using the sweet ingredient contained in the plant as a raw material. A sweetener produced by processing such as (reduction) or hydrolysis. Such natural sweeteners include natural sweeteners among the above-mentioned saccharide sweeteners and non-saccharide sweeteners. On the other hand, the synthetic sweetener targeted by the present invention is a sweetener that does not exist naturally, such as plants, and is artificially produced by chemical synthesis. The synthetic sweeteners include synthetic sweeteners (artificial sweeteners) among the non-sugar sweeteners described above.
本発明は、これらの天然系甘味料と合成系甘味料を組み合わせて用いることを一つの特徴とする。 One feature of the present invention is that these natural sweeteners and synthetic sweeteners are used in combination.
天然系甘味料としては、上記定義に該当するものであれば制限されないものの、例えば、砂糖；ブドウ糖、麦芽糖、果糖、水飴、異性化糖、及びイソマルトオリゴ糖等の澱粉由来の糖；フラクロオリゴ糖、ガラクトオリゴ糖、キシロオリゴ糖、乳果オリゴ糖、大豆オリゴ糖、ラフィノース、トレハロース、及び乳糖等の糖類；ソルビトール、マンニトール、マルチトール、還元水飴、還元パラチノース、キシリトール、及びエリスリトール等の糖アルコール；ステビア、甘草（グリチルリチン）、羅漢果、ソーマチン、モネリン、及びクルクリン等の天然甘味料を挙げることができる。これらの天然系甘味料は、１種単独で下記に説明する合成系甘味料と併用してもよいし、また２種以上を任意に選択して、下記に説明する合成系甘味料と併用してもよい。好ましくは糖アルコール、糖類であり、より好ましくは糖アルコールである。 The natural sweetener is not limited as long as it falls within the above definition. For example, sugar; sugar derived from starch such as glucose, maltose, fructose, starch syrup, isomerized sugar, and isomaltoligosaccharide; Sugars such as galactooligosaccharide, xylo-oligosaccharide, dairy oligosaccharide, soybean oligosaccharide, raffinose, trehalose, and lactose; sugar alcohols such as sorbitol, mannitol, maltitol, reduced starch syrup, reduced palatinose, xylitol, and erythritol; stevia, licorice And natural sweeteners such as (glycyrrhizin), Rahan fruit, thaumatin, monelin, and curculin. These natural sweeteners may be used alone or in combination with the synthetic sweetener described below, or two or more of them may be arbitrarily selected and used in combination with the synthetic sweetener described below. May be. Preferred are sugar alcohols and saccharides, and more preferred are sugar alcohols.
合成系甘味料としても、上記定義に該当するものであれば制限されない。例えば、サッカリン、サッカリンナトリウム、アスパルテーム、アセスルファムカリウム、スクラロース、ネオテーム、ズルチン、及びサイクラミン酸等を挙げることができる。これらの合成系甘味料は、１種単独で上記に説明する天然系甘味料と併用してもよいし、また２種以上を任意に選択して、上記に説明する天然系甘味料と併用してもよい。好ましくはアスパルテーム、アセスルファムカリウム、ネオテーム、サッカリン、サッカリンナトリウムであり、より好ましくはアスパルテーム、アセスルファムカリウム、ネオテームである。 The synthetic sweetener is not limited as long as it falls within the above definition. For example, saccharin, saccharin sodium, aspartame, acesulfame potassium, sucralose, neotame, dulcin, cyclamic acid and the like can be mentioned. These synthetic sweeteners may be used alone or in combination with the natural sweetener described above, or two or more may be arbitrarily selected and used in combination with the natural sweetener described above. May be. Aspartame, acesulfame potassium, neotame, saccharin, and saccharin sodium are preferred, and aspartame, acesulfame potassium, and neotame are more preferred.
天然系甘味料と合成系甘味料の好ましい組み合わせ態様は、制限されないものの、糖アルコールからなる群から選択される少なくとも１つの天然系甘味料と合成系甘味料からなる群から選択される少なくとも１つの組み合わせを挙げることができる。より好ましくは糖アルコール（天然系甘味料）とアスパルテーム、アセスルファムカリウム、ネオテーム、サッカリン、及びサッカリンナトリウムよりなる群から選択されるいずれか少なくとも一つの合成系甘味料との組み合わせを挙げることができる。好ましくは後述する実験例に示す糖アルコール（天然系甘味料）とアスパルテーム、アセスルファムカリウム、及びネオテームよりなる群から選択される少なくとも１つの合成系甘味料との組み合わせである。 A preferred combination aspect of the natural sweetener and the synthetic sweetener is not limited, but at least one selected from the group consisting of at least one natural sweetener and synthetic sweetener selected from the group consisting of sugar alcohols. Combinations can be mentioned. More preferred examples include a combination of a sugar alcohol (natural sweetener) and at least one synthetic sweetener selected from the group consisting of aspartame, acesulfame potassium, neotame, saccharin, and saccharin sodium. Preferably, it is a combination of a sugar alcohol (natural sweetener) and at least one synthetic sweetener selected from the group consisting of aspartame, acesulfame potassium, and neotame as shown in the experimental examples described later.
天然系甘味料と合成系甘味料の配合割合は、制限されないものの、天然系甘味料１００重量部に対する合成系甘味料の割合として、好ましくは０．１５〜１．５重量部の範囲を挙げることができる。より好ましくは０．１５〜１重量部であり、特に好ましくは０．３〜０．６５重量部である。 Although the blending ratio of the natural sweetener and the synthetic sweetener is not limited, the ratio of the synthetic sweetener to 100 parts by weight of the natural sweetener is preferably 0.15 to 1.5 parts by weight. Can do. More preferably, it is 0.15-1 weight part, Most preferably, it is 0.3-0.65 weight part.
チュアブル剤中に含まれる天然系甘味料と合成系甘味料の総量としては、製剤全量１００重量％中、通常２０〜５１重量％を挙げることができる。好ましくは２０〜３５重量％、より好ましくは２４〜３５重量％である。この範囲で甘味料を配合することで、製剤中に一定量以上の食物繊維を含有しながらも、不快な味を軽減して服用しやすいという本発明の効果をより一層高めることができる。 The total amount of the natural sweetener and the synthetic sweetener contained in the chewable agent can usually include 20 to 51% by weight in 100% by weight of the total preparation. Preferably it is 20 to 35 weight%, More preferably, it is 24 to 35 weight%. By blending the sweetener in this range, the effect of the present invention that it is easy to take while reducing an unpleasant taste can be further enhanced while containing a certain amount or more of dietary fiber in the preparation.
またチュアブル剤中に含まれる食物繊維の総量１重量部に対する、天然系甘味料及び合成系甘味料の総量としては、制限されないものの、好ましくは０．３〜３．５重量部の範囲を挙げることができる。より好ましくは０．３３〜３．３５重量部である。この範囲で甘味料を配合することで、製剤中に一定量以上の食物繊維を含有しながらも、不快な味を軽減して服用しやすいという本発明の効果を一層高めることができる。 The total amount of natural sweeteners and synthetic sweeteners relative to 1 part by weight of the total amount of dietary fiber contained in the chewable agent is not limited, but preferably 0.3 to 3.5 parts by weight. Can do. More preferably, it is 0.33 to 3.35 parts by weight. By blending a sweetener within this range, the effect of the present invention that it is easy to take while reducing an unpleasant taste can be further enhanced while containing a certain amount or more of dietary fiber in the preparation.
（Ｃ）酸味料
酸味料は、食品において酸味を与える調味料として、あるいは食品の酸化を防止したり、水素イオンの度合（水素イオン指数: pH）を調整するために使用される食品添加剤である。
(C) Acidulant Acidulant is a food additive used as a seasoning to give acidity in foods, to prevent oxidation of foods, or to adjust the degree of hydrogen ions (hydrogen ion index: pH). is there.
本発明においても、食品添加剤として使用される酸味料を広く用いることができる。かかる酸味料としては、酢酸、クエン酸、リンゴ酸、乳酸、コハク酸、酒石酸、グルコン酸、及びリン酸、またはこれらの塩を挙げることができる。好ましくはクエン酸、クエン酸ナトリウム、リンゴ酸、酒石酸、コハク酸であり、より好ましくはクエン酸、クエン酸ナトリウム及びリンゴ酸である。 Also in this invention, the sour agent used as a food additive can be widely used. Such acidulants can include acetic acid, citric acid, malic acid, lactic acid, succinic acid, tartaric acid, gluconic acid, and phosphoric acid, or salts thereof. Citric acid, sodium citrate, malic acid, tartaric acid, and succinic acid are preferable, and citric acid, sodium citrate, and malic acid are more preferable.
これらは１種単独で使用してもよいし、２種以上を任意に選択して使用することもできる。異なる酸味料を２種以上組み合わせて使用することが好ましく、かかる併用によって、後述する試験例で示すように、特に製剤中に配合した食物繊維特有の味をより一層低減し、良好な味を有するチュアブル剤を調製することができる。酸味料の好ましい組み合わせ態様は、制限されないものの、クエン酸とリンゴ酸との組み合わせ、クエン酸ナトリウムとリンゴ酸との組み合わせ、酒石酸とリンゴ酸との組み合わせ、コハク酸とリンゴ酸との組み合わせを例示することができる。酸味料を２種以上併用する場合の各酸味料の配合割合は、制限されないものの、例えば２種を併用する場合、一方の酸味料の量１００重量部に対して２５〜４００重量部の範囲を例示することができる。 These may be used individually by 1 type, and can also select and use 2 or more types arbitrarily. It is preferable to use a combination of two or more different acidulants, and as a result of such combination, the taste specific to dietary fiber blended in the formulation is further reduced, and the taste is good, as shown in the test examples described later. Chewable agents can be prepared. Although the preferable combination aspect of a sour agent is not restrict | limited, The combination of a citric acid and malic acid, the combination of sodium citrate and malic acid, the combination of tartaric acid and malic acid, the combination of succinic acid and malic acid is illustrated be able to. The blending ratio of each acidulant when two or more acidulants are used in combination is not limited. For example, when two kinds are used in combination, the range of 25 to 400 parts by weight with respect to 100 parts by weight of one acidulant is used. It can be illustrated.
チュアブル剤中に含まれる酸味料の総量としては、製剤全量１００重量％中、通常０．５〜５重量％を挙げることができる。好ましくは０．８〜４重量％、より好ましくは１〜４重量％である。この範囲で酸味料を配合することで、製剤中に一定量以上の食物繊維を含有しながらも、不快な味を軽減して服用しやすいという本発明の効果をより一層高めることができる。 As the total amount of acidulant contained in the chewable agent, 0.5 to 5% by weight can be usually mentioned in 100% by weight of the total preparation. Preferably it is 0.8 to 4 weight%, More preferably, it is 1 to 4 weight%. By blending an acidulant in this range, the effect of the present invention that it is easy to take while reducing an unpleasant taste can be further enhanced while containing a certain amount or more of dietary fiber in the preparation.
またチュアブル剤中に含まれる食物繊維の総量１重量部に対する、酸味料の総量としては、制限されないものの、好ましくは０．０１〜０．３重量部の範囲を挙げることができる。より好ましくは０．０１〜０．２７重量部である。この範囲で酸味料を配合することで、製剤中に一定量以上の食物繊維を含有しながらも、不快な味を軽減して服用しやすいという本発明の効果をより一層高めることができる。 Further, the total amount of the acidulant with respect to 1 part by weight of the total amount of dietary fiber contained in the chewable agent is not limited, but preferably 0.01 to 0.3 parts by weight. More preferably, it is 0.01-0.27 weight part. By blending an acidulant in this range, the effect of the present invention that it is easy to take while reducing an unpleasant taste can be further enhanced while containing a certain amount or more of dietary fiber in the preparation.
（Ｄ）滑沢剤
本発明のチュアブル剤は、上記（Ａ）〜（Ｃ）成分に加えて、さらに滑沢剤を含有していてもよい。滑沢剤は、錠剤を製造する際に、粉体や顆粒の流動性をよくし圧縮形成を容易にするために加える添加剤である。
(D) Lubricant The chewable agent of the present invention may further contain a lubricant in addition to the components (A) to (C). Lubricants are additives that are added to improve the fluidity of powders and granules and facilitate compression formation when manufacturing tablets.
本発明において、滑沢剤は、錠剤の製造に使用される一般的な滑沢剤を広く用いることができる。具体的には、ステアリン酸マグネシウム及びステアリン酸カルシウムなどのステアリン酸塩、ショ糖脂肪酸エステル及びグリセリン脂肪酸エステル等の脂肪酸エステル類、タルク、水素添加植物油、硬化ナタネ油、及び粉末油脂などを挙げることができる。好ましくはステアリン酸塩、脂肪酸エステル類およびタルクであり、より好ましくはステアリン酸塩および脂肪酸エステル類である。 In the present invention, as the lubricant, a general lubricant used for producing tablets can be widely used. Specific examples include stearates such as magnesium stearate and calcium stearate, fatty acid esters such as sucrose fatty acid ester and glycerin fatty acid ester, talc, hydrogenated vegetable oil, hydrogenated rapeseed oil, and powdered oil and fat. . Preferred are stearates, fatty acid esters and talc, and more preferred are stearates and fatty acid esters.
これらは１種単独で使用してもよいし、２種以上を任意に選択して使用することもできる。異なる滑沢剤を２種以上組み合わせて使用することが好ましく、かかる併用によって、後述する試験例で示すように、特に製剤中に配合した食物繊維の歯に対する付着性が有意に抑制され、味の改善（食物繊維特有の風味の低減）とともに、良好な服用感を有するチュアブル剤を調製することができる。滑沢剤の好ましい組み合わせ態様は、制限されないものの、ステアリン酸塩と脂肪酸エステル類との組み合わせ、ステアリン酸塩とショ糖脂肪酸エステルとの組み合わせを例示することができる。滑沢剤を２種以上併用する場合の各滑沢剤の配合割合は、制限されないものの、例えば２種を併用する場合、一方の滑沢剤（例えばステアリン酸塩）の量１００重量部に対して５０〜５００重量部の範囲を例示することができる。 These may be used individually by 1 type, and can also select and use 2 or more types arbitrarily. It is preferable to use a combination of two or more different lubricants, and as a result of such combined use, as shown in the test examples to be described later, especially the adhesion of dietary fiber formulated in the preparation to the teeth is significantly suppressed, A chewable agent having a good feeling of taking can be prepared together with improvement (reduction of flavor peculiar to dietary fiber). Although the preferable combination aspect of a lubricant agent is not restrict | limited, The combination of a stearate and fatty acid ester and the combination of a stearate and a sucrose fatty acid ester can be illustrated. The blending ratio of each lubricant when two or more lubricants are used in combination is not limited. For example, when two lubricants are used together, the amount of one lubricant (for example, stearate) is 100 parts by weight. The range of 50 to 500 parts by weight can be exemplified.
チュアブル剤中に含まれる滑沢剤の総量としては、製剤全量１００重量％中、通常０．５〜１０重量％を挙げることができる、好ましくは１〜８重量、より好ましくは２〜６重量％である。この範囲で滑沢剤を配合することで、製剤中に一定量以上の食物繊維を含有しながらも、服用時の歯への付着や不快な味を軽減して服用しやすいという本発明の効果をより高めることができる。 The total amount of the lubricant contained in the chewable agent can be generally 0.5 to 10% by weight, preferably 1 to 8% by weight, more preferably 2 to 6% by weight, based on 100% by weight of the total preparation. It is. By blending a lubricant in this range, the effect of the present invention is easy to take while reducing the adhesion to the teeth and unpleasant taste when taking, while containing a certain amount of dietary fiber in the preparation Can be further enhanced.
またチュアブル剤中に含まれる食物繊維の総量１重量部に対する滑沢剤の総量としては、制限されないものの、好ましくは０．００８〜０．４重量部の範囲を挙げることができる。より好ましくは０．０３〜０．４重量部である。この範囲で滑沢剤を配合することで、製剤中に一定量以上の食物繊維を含有しながらも、服用時の歯への付着や不快な味を軽減して服用しやすいという本発明の効果をより一層高めることができる。 Further, the total amount of the lubricant with respect to 1 part by weight of the total amount of dietary fiber contained in the chewable agent is not limited, but a range of 0.008 to 0.4 parts by weight can be preferably mentioned. More preferably, it is 0.03-0.4 weight part. By blending a lubricant in this range, the effect of the present invention is easy to take while reducing the adhesion to the teeth and unpleasant taste when taking, while containing a certain amount of dietary fiber in the preparation Can be further increased.
（Ｅ）その他の成分
本発明のチュアブル剤は、必要に応じて、本発明の効果を損なわない範囲で、他の成分を配合することができる。他の成分としては、チュアブル剤を製造するために当業界で通常使用される製剤成分を挙げることができ、例えば賦形剤、結合剤、崩壊剤、増粘剤、香料、着色剤、抗酸化剤、保存剤などを挙げることができる。これらは製剤の形態や摂取者の嗜好などに応じて、適宜選択することができる。
(E) Other components The chewable agent of this invention can mix | blend another component in the range which does not impair the effect of this invention as needed. Other ingredients can include pharmaceutical ingredients commonly used in the industry to produce chewables, such as excipients, binders, disintegrants, thickeners, fragrances, colorants, antioxidants Agents, preservatives and the like. These can be appropriately selected according to the form of the preparation, the taste of the user, and the like.
また本発明のチュアブル剤には、必要に応じて、本発明の効果を損なわない範囲で、食物繊維以外の生理活性成分や薬理活性成分を配合することもできる。かかる成分としてば、ビタミン類、アミノ酸やその重合物（ペプチド、蛋白質）、ポリフェノール、植物エキス、ローヤルゼリー、タンパク質、カルニチン、乳酸菌、エラスチン、及びセラミドなどを例示することができる。 In addition, the chewable agent of the present invention can be blended with physiologically active ingredients and pharmacologically active ingredients other than dietary fiber as needed, as long as the effects of the present invention are not impaired. Examples of such components include vitamins, amino acids and their polymers (peptides, proteins), polyphenols, plant extracts, royal jelly, proteins, carnitine, lactic acid bacteria, elastin, and ceramide.
（Ｆ）チュアブル剤の製造、及び用法など
本発明のチュアブル剤は、上記成分を配合して、定法に従ってチュアブル剤の形態に成形することによって製造される。
(F) Manufacture of chewable agent and usage, etc. The chewable agent of the present invention is produced by blending the above components and molding it into a chewable agent form according to a conventional method.
本発明のチュアブル剤の服用量は、服用する人の年齢、体重、性別、摂取の目的などによって適宜選択することができ、特に制限されるものではないが、成人の場合、通常、食物繊維の量が１日あたり２．５〜５ｇ、好ましくは３．５〜５ｇとなるような量で、１日に１回または複数分けて服用することができる。特に制限されないが、例えば本発明のチュアブル剤が１製剤あたり（錠剤の場合、１錠あたり）５０重量％の食物繊維を含む１０００ｍｇ重量の錠剤である場合、これを１日に１０錠服用すると１日あたり５ｇの食物繊維を摂取することができる。 The dose of the chewable agent of the present invention can be appropriately selected depending on the age, weight, sex, purpose of intake, etc. of the person taking it, and is not particularly limited. The amount is 2.5 to 5 g per day, preferably 3.5 to 5 g, and can be taken once a day or divided into a plurality. Although not particularly limited, for example, when the chewable agent of the present invention is a tablet having a weight of 1000 mg containing 50% by weight of dietary fiber per formulation (in the case of a tablet), taking 10 tablets a day will result in 1 5 g of dietary fiber can be ingested per day.
本発明のチュアブル剤は、日常の食事では不足がちな食物繊維を、何時でも何処でも手軽に服用・摂取することのできるサプリメント（補助食品）として用いることができる。斯くして食物繊維を毎日所定量摂取することによって、おなかの調子を整え快便をもらたすことができ、また血中コレステロール値や血糖値の低下により生活習慣病を予防することが可能になる。 The chewable preparation of the present invention can be used as a supplement (supplementary food) that can be easily taken and taken anytime and anywhere in dietary fiber that tends to be insufficient in a daily diet. Thus, by taking a predetermined amount of dietary fiber every day, the stomach can be conditioned and comfortable, and lifestyle-related diseases can be prevented by lowering blood cholesterol levels and blood sugar levels. Become.
（II）チュアブル剤の歯に対する付着抑制方法
本発明は、また製剤１００重量％中、食物繊維を少なくとも１５重量％の割合で含有するチュアブル剤について、歯に対する付着を抑制する方法を提供する。
(II) Method for suppressing adhesion of chewable agent to teeth The present invention also provides a method for suppressing adhesion to teeth for chewable agents containing dietary fiber in a proportion of at least 15% by weight in 100% by weight of the preparation.
当該方法は、（Ａ）上記食物繊維として水溶性食物繊維及び不溶性食物繊維を用い、さらに上記チュアブル剤の調製に際して、その成分として、（Ｂ）天然系甘味料及び合成系甘味料、並びに（Ｃ）酸味料を配合することによって実施することができる。 In this method, (A) water-soluble dietary fiber and insoluble dietary fiber are used as the dietary fiber, and (B) natural sweetener and synthetic sweetener, and (C ) It can be carried out by blending a sour agent.
ここで使用される（Ａ）水溶性食物繊維及び不溶性食物繊維の種類、その配合比及び量、（Ｂ）天然系甘味料及び合成系甘味料の種類、その配合比及び量、（Ｃ）酸味料の種類及び量については、上記（Ｉ）で説明した通りであり、ここでも上記記載が援用される。 (A) Types of water-soluble dietary fiber and insoluble dietary fiber used here, blending ratio and amount thereof, (B) Types of natural sweetener and synthetic sweetener, blending ratio and amount thereof, (C) Acidity About the kind and quantity of a charge, it is as having demonstrated in said (I), The said description is used here also.
上記のチュアブル剤における歯への付着は、上記チュアブル剤にさらに（Ｄ）滑沢剤を配合することによって抑制することができる。好ましくは２種以上の滑沢剤を併用することで歯への付着を有意に抑制することができる。ここで使用される（Ｄ）滑沢剤の種類、その配合比及び量についても、上記（Ｉ）で説明した通りであり、ここでも上記記載が援用される。 Adhesion to the teeth in the chewable agent can be suppressed by further blending (D) a lubricant with the chewable agent. Preferably, adhesion to teeth can be significantly suppressed by using two or more kinds of lubricants in combination. The kind of (D) lubricant used here, the blending ratio, and the amount thereof are also as described in the above (I), and the above description is also used here.
以下、試験例及び処方例により、本発明の構成及び効果をより詳細に説明する。但し、本発明はかかる試験例及び処方例によって何ら制限されるものではない。 Hereinafter, the configuration and effects of the present invention will be described in more detail with reference to test examples and formulation examples. However, the present invention is not limited by such test examples and formulation examples.
試験例１ チュアブル剤の調製、及びその評価
（１）チュアブル剤の調製
表１に記載する各成分を混合及び篩過し、慣用方法に従って打錠して錠剤形態を有する各種のチュアブル剤（実施例１〜１２、比較例１〜４）を調製した。なお、チュアブル剤は、１錠あたり１０００ｍｇの直径１５ｍｍの錠剤として調製した。
Test Example 1 Preparation of chewable agent and its evaluation
(1) Preparation of chewable agents Each component described in Table 1 is mixed and sieved, and various chewable agents (Examples 1 to 12, Comparative Examples 1 to 4) having a tablet form by tableting according to a conventional method. Prepared. The chewable preparation was prepared as a tablet having a diameter of 15 mm and 1000 mg per tablet.
（２）評価試験
（２−１）試験方法
味に関して訓練した専門家（パネラー）５名に、各チュアブル剤（実施例１〜１２、比較例１〜４）を１錠ずつ、口内で咀嚼して服用してもらい、歯に対する付着と味について、下記の基準に従って評価をしてもらった。なお、各パネラーには、各チュアブル剤を口に含む前に、必ず少なくとも１回、水で口内を漱いでもらい、口腔内を常に一定の状態にして試験をしてもらった。
(2) Evaluation test
(2-1) Test method 5 experts (panelists) trained on taste taste each chewable agent (Examples 1 to 12, Comparative Examples 1 to 4), one by one, chewed in mouth and taken In addition, the adhesion and taste to teeth were evaluated according to the following criteria. In addition, before each chewable agent was included in the mouth, each panelist was asked to rub the mouth with water at least once, and the oral cavity was always kept in a constant state for testing.
各パネラーの評価点を総計して（味については後述する３点の各評価点を総計する）、後述する判定基準に従って、総合評価を行った。 The evaluation points of each paneler were summed up (total evaluation points of 3 points to be described later for taste), and overall evaluation was performed according to the determination criteria to be described later.
［評価基準］
（ａ）歯への付着
「全く気にならない」を得点５、「とても気になる」を得点１として５段階で評価した。
（ｂ）味
味は口腔内で咀嚼開始時（トップ味）、咀嚼中（ミドル味）、及び咀嚼終了時の後残り（ラスト味）の３点について、それぞれ下記の基準に従って評価する。
５：良い、４：やや良い、３：どちらでもない、２：やや悪い、１：悪い。
[Evaluation criteria]
(A) Adhesion to teeth Scored 5 as "I don't care at all", and scored as 1 as "I am very worried".
(B) Taste Taste is evaluated according to the following criteria for the three points of chewing start (top taste), during chewing (middle taste), and the remaining after chewing (last taste) in the oral cavity.
5: Good, 4: Somewhat good, 3: None, 2: Somewhat bad, 1: Bad.
［総合判定］
（ａ）歯への付着抑制効果
◎：評価点の総計が２０以上２５以下
○：評価点の総計が１５以上２０未満
△：評価点の総計が１０以上１５未満
×：評価点の総計が５以上１０未満
（ｂ）味（食物繊維特有の風味マスキング効果）
◎：評価点の総計が６０以上７５以下
○：評価点の総計が４５以上６０未満
△：評価点の総計が３０以上４５未満
×：評価点の総計が３０未満。
（ｃ）服用感（歯への付着及び味の点から評価した総合的な服用感）
◎：（ａ）及び（ｂ）の両方が◎である場合
○：（ａ）及び（ｂ）の両方が◎ではないが、いずれもが○以上である場合
△：（ａ）及び（ｂ）の両方が△以上で、且つ少なくとも一方が△である場合
×：（ａ）及び（ｂ）のいずれか少なくとも一方が×である場合。
[Comprehensive judgment]
(A) Effect of suppressing adhesion to teeth ◎: Total score of 20 to 25 ○: Total score of 15 to less than 20 Δ: Total score of 10 to less than 15 ×: Total score of 5 Less than 10 (b) taste (flavor masking effect peculiar to dietary fiber)
A: The total evaluation score is 60 or more and 75 or less. O: The total evaluation score is 45 or more and less than 60. Δ: The total evaluation score is 30 or more and less than 45. x: The total evaluation score is less than 30.
(C) Feeling of taking (total feeling taken from the viewpoint of adhesion to the teeth and taste)
◎: When both (a) and (b) are ◎: Both (a) and (b) are not ◎, but both are ◯ or more Δ: (a) and (b) In the case where both are Δ or more and at least one is Δ ×: When at least one of (a) and (b) is ×.
（２−２）試験結果
結果を表１に併せて示す。
(2-2) The results of the test are also shown in Table 1.
この結果からわかるように、食物繊維を１種類しか配合しない場合（比較例１及び２）、天然系甘味料と合成系甘味料を併用し、且つ酸味料を配合すると（比較例２）、食物繊維特有の味はやや改善するが（×→△）、歯に対する付着抑制効果は認められず（×→×）、服用感の総合評価は悪かった（×）。一方、食物繊維を２種類組み合わせて用いると（比較例３及び４）、食物繊維を１種類しか配合しない場合（比較例１）と比べて、歯に対する付着はやや改善するものの（×→△）、甘味料を１種しか配合しない場合（比較例３）や２種併用しても酸味料を配合しない場合（比較例４）は、食物繊維特有の味は改善せず（×→×）、服用感の総合評価は悪かった（×）。 As can be seen from this result, when only one type of dietary fiber is blended (Comparative Examples 1 and 2), a natural sweetener and a synthetic sweetener are used in combination, and an acidulant is blended (Comparative Example 2). Although the taste peculiar to the fibers was slightly improved (× → Δ), the effect of suppressing adhesion to teeth was not observed (× → ×), and the overall evaluation of the feeling of taking was poor (×). On the other hand, when two types of dietary fiber are used in combination (Comparative Examples 3 and 4), adhesion to teeth is slightly improved compared to the case where only one type of dietary fiber is blended (Comparative Example 1) (× → Δ). In the case where only one kind of sweetener is blended (Comparative Example 3) or in the case where two kinds of sweeteners are not blended (Comparative Example 4), the taste specific to dietary fiber is not improved (× → ×), The overall evaluation of the feeling of administration was poor (×).
これに対して、比較例２と実施例１との対比からわかるように、天然系甘味料と合成系甘味料を併用し、酸味料を配合し、且つ食物繊維として水溶性食物繊維と不溶性食物繊維を併用すると、食物繊維特有の不快な味が低減し味の改善が認められるとともに、歯に対する付着性も抑制されることが認められた（実施例１及び２）。 On the other hand, as can be seen from the comparison between Comparative Example 2 and Example 1, a natural sweetener and a synthetic sweetener are used in combination, an acidulant is added, and water-soluble dietary fiber and insoluble food are used as dietary fiber. When the fiber was used in combination, the unpleasant taste peculiar to dietary fiber was reduced, the taste was improved, and the adhesion to the teeth was also suppressed (Examples 1 and 2).
また、チュアブル剤の味は、さらに酸味料を２種以上併用することでより一層改善し良好になることが確認された（実施例３）。さらに、チュアブル剤の歯に対する付着性は、さらに滑沢剤を２種以上併用することでより一層改善し良好になることが確認された（実施例４〜１２）。 In addition, it was confirmed that the taste of the chewable agent was further improved and improved by using two or more acidulants in combination (Example 3). Furthermore, it was confirmed that the adhesion of the chewable agent to the teeth was further improved and improved by using two or more lubricants in combination (Examples 4 to 12).
実施例１３〜２９
表２に本発明のチュアブル剤（実施例１３〜２９）の処方を記載する。これらについても同様に、チュアブル剤の歯に対する付着性を抑制し、味も良好であり、服用感に優れるものであった。
Examples 13-29
Table 2 describes the formulation of the chewable agent of the present invention (Examples 13 to 29). Similarly, the adhesion of the chewable agent to the teeth was suppressed, the taste was good, and the feeling of taking was excellent.
Claims (7)
（Ａ）上記食物繊維が水溶性食物繊維及び不溶性食物繊維であり、さらに
（Ｂ）天然系甘味料及び合成系甘味料、及び
（Ｃ）酸味料
を含有することを特徴とする、チュアブル剤。 A chewable preparation containing at least 15% by weight of dietary fiber in 100% by weight of the preparation,
(A) The chewable agent, wherein the dietary fiber is a water-soluble dietary fiber and an insoluble dietary fiber, and further comprises (B) a natural sweetener and a synthetic sweetener, and (C) an acidulant.
請求項１に記載するチュアブル剤。 The (C) component is a combination of at least two types of acidulants,
The chewable agent according to claim 1.
（Ａ）上記食物繊維として水溶性食物繊維及び不溶性食物繊維を用い、さらに
上記チュアブル剤に、（Ｂ）天然系甘味料及び合成系甘味料、並びに（Ｃ）酸味料を配合することを特徴とする、上記方法。 A method for suppressing adhesion of a chewable agent containing at least 15% by weight of dietary fiber in 100% by weight of a preparation, to a tooth,
(A) A water-soluble dietary fiber and an insoluble dietary fiber are used as the dietary fiber, and the chewable agent is further blended with (B) a natural sweetener and a synthetic sweetener, and (C) an acidulant. The above method.
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| JP2001086956A (en) * | 1999-09-24 | 2001-04-03 | Morishita Jintan Kk | Granules containing edible fibers, and method for producing the same |
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