JP2016169202A - Medicine for intestinal disorders - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide pulverized powder of foliage of barley that can be used daily and has the effect of calming intestinal disorders.SOLUTION: A medicine for intestinal disorders according to the present invention contains at least one pulverized powder selected from the group consisting of specific varieties of barley as an active ingredient.SELECTED DRAWING: None

Description

The present invention relates to an intestinal regulating agent.

In recent years, an increasing number of people are suffering from constipation due to changes in eating habits, bias in the contents of meals, stress, and the like. Constipation is caused by a long stay of stool in the intestine. Severe constipation may increase the number of harmful bacteria in the intestine and increase the absorption of harmful substances, which may cause colon cancer. Therefore, development of a substance having an effect of improving constipation and a composition having an intestinal regulating action obtained by blending the substance are underway.

For example, the present applicant has proposed a bowel movement improving agent containing a young wheat powder containing 30% by mass or more of a water-insoluble component as an active ingredient (Patent Document 1). However, Patent Document 2 merely describes that barley young leaf powder has a bowel movement improving action, and it was necessary to search for barley varieties to obtain better effects.

On the other hand, popular varieties of barley change on the basis of yield, disease and insect damage resistance standards, and thus problems such as difficulty in obtaining seeds and difficulty in stable supply of barley stems and leaves arise. Furthermore, an enormous number of varieties of 30,000 or more are known for barley (Non-Patent Document 1), and it has not been easy to search for specific barley varieties that can solve the above problems.

JP 2010-47605 A

Search results for barley scientific name "Hordeum vulgare" in the Germplasm Resources Information Network under the jurisdiction of the US Department of Agriculture <https://npgsweb.ars-grin.gov/gringlobal/view2.aspx?dv=web_taxonomyspecies_view_accessionlist&params=: taxonomyid = 19333>

An object of the present invention is to provide an intestinal preparation containing a substance exhibiting a more excellent bowel movement improving action than a substance having a conventional bowel movement improving action.

In order to solve the above-mentioned problems, the present applicant has conducted extensive studies on various substances. Surprisingly, the present applicant has come from a group consisting of Shun Lai, Fiber Snow and Silky Snow (hereinafter also referred to as “specific varieties”). The at least one kind of barley stalks and powders selected has a bowel environment improvement effect as well as an intestinal environment improvement action compared to the stalks and leaves of Ichibanboshi, a kind of barley. It was found to show an action. The present invention is a completed invention based on such findings.

The gist of the present invention is as follows.
[1] An intestinal regulating agent containing at least one barley stem and / or leaf pulverized powder selected from the group consisting of Shunrai, Fiber Snow and Silky Snow.
[2] The intestinal regulating agent according to [1], wherein the content of the barley stem and / or leaf pulverized powder in the solid content of the intestinal regulating agent is 20% by mass or more in terms of dry mass.
[3] The content of the crushed powder of the barley stem and / or leaf in the solid content of the intestinal adjuster is 80% by mass or less in terms of dry mass, either [1] or [2] The intestinal regulating agent according to crab.

According to the intestinal regulating agent of the present invention, by containing the pulverized powder of barley stems and leaves of a specific variety, fecal improvement such as increase in stool volume, shortening intestinal transit time; and increase in intestinal mucosa; It can be expected to have an intestinal regulating action such as an increase or activation of useful bacteria that inhabit the accompanying intestines and an improvement of the intestinal environment such as an increase in fecal bulk. In addition, since the intestinal preparation of the present invention can exhibit an intestinal regulating action even by oral administration, the intestinal preparation of the present invention can be used in a daily use mode.

The intestinal regulating agent of the present invention can be expected to have various effects such as improvement of constipation, immunostimulation, harmful microorganism metabolites, suppression of harmful enzymes, prevention of lifestyle-related diseases, improvement of allergic constitutions and the like.

FIG. 1 is a graph showing the measurement results of the dry fecal weight (g) of the control according to Examples of the intestinal preparation, Comparative Example 1 and Examples 1 to 3. The numerical value represents an average value.

Hereinafter, the present invention will be described in detail.

[1. Barley Stem and / or Leaf Crush Powder]
As it is known that there are actually more than 30,000 varieties as barley varieties, in the present invention, at least one selected from Fiber Snow, Silky Snow, Shunrai, Ichibanboshi, and Harushizuku (specific varieties). Use the barley stem and / or leaf grind powder. In the present specification, “stems and / or leaves” may be called stems and leaves.

Specific varieties of barley are, for example, generally used as raw materials for wheat, such as barley miso, barley tea, shochu, and beer. In the present invention, one of these varieties can be used alone, or two or more can be used in combination. The pulverized powder of barley stalks and leaves may be barley leaves, stems, or both, and the leaves and stems may be part or all of them.

The barley stalks and leaves of a specific variety are preferably harvested before the maturity period, that is, from the beginning of the splitting to the early stage of heading. Barley foliage is preferably processed immediately after harvesting. When processing takes time, it is stored by storage means commonly used by those skilled in the art, such as low-temperature storage, to prevent barley foliage alteration.

A conventionally known method can be used to pulverize barley foliage. As such a method, a method combining drying treatment and pulverization treatment on barley foliage can be used. Either the drying process or the pulverization process may be performed first, but the drying process is preferably performed first. For pulverization, this method may be combined with one or more treatments selected from treatments such as blanching treatment and sterilization treatment as necessary. In addition, the number of times of pulverization may be one time or a combination of two or more processes, but it is preferable to combine a fine pulverization process that finely pulverizes after the coarse pulverization process.

The blanching process is a process for keeping the green color of the foliage vivid, and examples of the blanching process include a hot water process and a steaming process.

Examples of the hot water treatment include a method of treating barley foliage in hot water or steam at 80 to 100 ° C., preferably 90 to 100 ° C. for 60 to 180 seconds, preferably 90 to 120 seconds. Further, in the hot water treatment, it is preferable to use a carbonate such as magnesium carbonate or a hydrogen carbonate such as sodium hydrogen carbonate. By dissolving the hydrogen carbonate salt in hot water, the green color of the barley foliage is more vivid. can do.

The steaming treatment is preferably an intermittent steaming treatment in which barley stems and leaves are steamed and steamed under normal pressure or pressure. In the intermittent steaming process, the steaming process is performed, for example, for 20 to 40 seconds, preferably 30 seconds. The cooling treatment after the steaming treatment is preferably performed immediately, and the method is not particularly limited, but it is immersed in cold water, refrigerated, cooling with cold air, evaporative cooling with hot air, evaporative cooling combining hot air and cold air Etc. are used. Among these, evaporative cooling combining hot air and cold air is preferable. Such cooling treatment is performed such that the barley foliage has an article temperature of preferably 60 ° C. or lower, more preferably 50 ° C. or lower, and even more preferably 40 ° C. or lower. In order to produce barley stalk and leaf powder rich in nutrients such as vitamins, minerals, and chlorophyll, it is preferable to repeat the intermittent steaming treatment 2 to 5 times.

The sterilization treatment is not particularly limited as long as it is a treatment generally known to those skilled in the art. For example, the sterilization treatment is a treatment that physically or chemically kills microorganisms using temperature, pressure, electromagnetic waves, chemicals, or the like. it can. When the branching process is performed in addition to the drying process and the pulverization process, the branching process is preferably performed before the drying process. Moreover, when performing a sterilization treatment in addition to the drying treatment and the pulverization treatment, the sterilization treatment is preferably performed after the drying treatment or before or after the pulverization treatment.

Although a drying process is not specifically limited, For example, the process dried so that the moisture content of barley foliage may be 10% or less, Preferably it is 5% or less is mentioned. The drying treatment can be performed by any method known to those skilled in the art, such as hot air drying, high pressure steam drying, electromagnetic wave drying, freeze drying, and the like. Drying by heating can be performed, for example, at a temperature and a time at which the foliage is not discolored by heating at 40 ° C to 140 ° C, preferably 80 ° C to 130 ° C.

The pulverization process is not particularly limited, and examples thereof include a process of pulverizing a plant body by an arbitrary method commonly used by those skilled in the art using a crusher, a mill, a blender, a millstone, or the like. The crushed barley foliage is sieved as necessary. For example, it is preferable to use a barley foliage powder that passes through 30 to 250 mesh. By making the particle size below 250 mesh, the barley foliage powder becomes easier to handle during further processing, and by making the particle size above 30 mesh, the barley foliage powder and other materials Uniform mixing with is easy.

As a specific method for producing a pulverized powder, for example, after cutting barley foliage, it is subjected to a blanching treatment, and then dried so that the water content is 10% by mass or less, preferably 5% by mass or less. The method of grind | pulverizing is mentioned (refer Unexamined-Japanese-Patent No. 2004-000210). In addition to this, for example, after cutting barley stalks and leaves, a branching treatment is performed, followed by twisting, and then drying and pulverization (see Japanese Patent Application Laid-Open No. 2002-0665204 and Japanese Patent No. 3428956). A method in which barley foliage is dried and coarsely pulverized, heated at 110 ° C. or higher, and further finely pulverized (see Japanese Patent Application Laid-Open Nos. 2003-033151 and 3277181).

Although the characteristics of the pulverized powder of barley foliage are not particularly limited, for example, the angle of repose is preferably 20 ° to 80 °, more preferably 30 ° to 70 °, still more preferably 40 ° to 60 °, and more preferably 45 ° to Even more preferred is 55 °. The angle of repose is measured using an angle of repose measuring instrument (As One, ASK-01) by dropping about 50 g of sample into the center of a petri dish having an altitude of 12 cm to a radius of 4.3 cm, and then depositing the sample in a mountain shape. After measuring the height, the angle of repose can be calculated by the following formula from the radius of the petri dish and the height of the deposited sample.
Angle of repose = tan−1 (b / a) × 180 ÷ π (where, a = the petri dish radius, b = the height of the deposited sample)

The pulverized powder of barley stalks of a specific variety used in the present invention may contain water-insoluble dietary fiber. The water-insoluble dietary fiber contained in the pulverized powder is contained in an amount of 20% by mass or more, preferably 30% by mass or more in terms of dry mass, preferably 20 to 80% by mass, preferably 30 to 70% by mass, more preferably 35%. It is more preferable to contain -60 mass%.
[2. Intestinal adjuster]
The present invention relates to an intestinal preparation containing pulverized powder of barley foliage.

The intestinal regulating agent of the present invention contains at least pulverized powder of barley stalks and leaves of any one or more of Shun Lai, Fiber Snow and Silky Snow (specific varieties) as a substance having an intestinal regulating action.

The intestinal regulating agent of the present invention contains not only a bowel regulating action but also a beautiful appearance due to vivid color and a good flavor by containing a pulverized powder of barley stems and leaves of a specific variety. It is something that can be done.

In the intestinal regulating agent of the present invention, the content of the pulverized powder of barley foliage is not particularly limited as long as the problems of the present invention can be solved, but for example, 0.1 wt% or more in terms of the dry mass of the crushed powder of barley foliage 100 wt% or less, preferably 5 wt% or more and 90 wt% or less, more preferably 8 wt% or more and 80 wt% or less, and further preferably 10 wt% or more and 70 wt% or less. If the content of the pulverized powder of barley foliage is less than 5 wt%, the desired intestinal regulating action may not be obtained.

The pulverized powder of barley foliage used in the intestinal regulating agent of the present invention has an excellent intestinal regulating action. The technical scope of the present invention is not limited to any inference, but for example, the use of a barley stalk and leaf powder increases the total amount of feces (dried feces) and further the moisture in the feces. The water retention effect of increasing the content to form a stool suitable for defecation increases the amount of wet feces and improves the bowel movement improving excretion. Moreover, when the intestinal fermentation is promoted by increasing the weight of the cecal tissue and the weight of the cecum, the short-chain fatty acid in the cecal content is increased, and the pH of the cecal content tends to be lowered. The short-chain fatty acid produced by intestinal fermentation suppresses the increase in cancer cells, and when the intestinal pH is lowered, it suppresses infection with pathogenic bacteria, thereby obtaining an intestinal environment improving effect.

Moreover, by improving the bowel movement, the growth of bad bacteria in the intestine due to constipation can be suppressed, and the intestinal environment can be normally maintained and improved. If the intestinal environment is improved, the movement of intestines can be activated and the bowel movement can be improved by the action of useful bacteria in the intestines. Thus, when the intestinal regulating agent of the present invention is used, the bowel movement improving action and the intestinal environment improving action are interactively exhibited, and as a result, the bowel regulating action can be achieved. The water retention effect and smooth excretion are also effective for preventing wrinkles, for example. Therefore, another aspect of the present invention is a pharmaceutical composition for preventing and treating a disease caused by a bowel movement disorder, comprising a powder of barley stalks and leaves of a specific variety.

Since the intestinal regulating agent of the present invention has a bowel movement improving action and an intestinal environment improving action, it can be used in various forms aimed at obtaining such an action. The intestinal preparation of the present invention may be used for various purposes without adding any special treatment. The amount of the pulverized powder of barley foliage contained in the intestinal regulating agent of the present invention is not particularly limited, and is appropriately set according to, for example, the use form of the intestinal regulating agent.

In the solid content of the intestinal adjusting agent of the present invention, the content of barley stalks and leaves is dry mass, and the lower limit is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and 1% by mass. % Or more, more preferably 10% by weight or more, still more preferably 20% by weight or more, and the upper limit is preferably 99.9% by weight or less, more preferably 90% by weight or less, and 80% by weight or less. Further preferred. In order to sufficiently exert the intestinal regulating action, the content of barley stalks and leaves is preferably 0.1% by mass.

The daily use amount of the intestinal regulating agent of the present invention is not particularly limited, and may be appropriately set according to the use mode or the use contents of the user. For example, in terms of the mass of the crushed powder of barley foliage, Based on body weight, it is 1 to 6000 mg / kg, preferably 1 to 4000 mg / kg, more preferably 10 to 3000 mg / kg, and further preferably 10 to 2000 mg / kg. Similarly, the amount of the intestinal adjuster of the present invention used is not particularly limited as well, and is, for example, 0.5 to 3000 mg / kg based on the weight of the user in terms of mass of the pulverized powder of barley foliage, Preferably it is 1-2000 mg / kg, More preferably, it is 5-1000 mg / kg.

In addition, the amount of the intestinal adjuster of the present invention used at one time is, for example, 0.01 to 30 g, preferably 0.05 to 20 g, more preferably 0.1 to 10 g in terms of the mass of barley stalks and leaves. Most preferably, it can be 0.3-7 g. Similarly, the daily use amount of the intestinal regulating agent of the present invention is, for example, 0.01 to 100 g, preferably 0.05 to 70 g, more preferably 0.5 to 50 g in terms of the mass of barley stalks and leaves. Especially preferably, it can be 1-30 g.

The intestinal regulating agent of the present invention may contain only the crushed powder of barley foliage, or may contain other components in addition to the crushed powder of barley foliage. Examples of other components include various excipients, binders, lubricants, stabilizers, diluents, extenders, thickeners, emulsifiers, colorants, fragrances, additives, and the like. The content of other components can be appropriately selected according to the use form of the intestinal regulating agent of the present invention.

The intestinal regulating agent of the present invention can be used in various forms for the purpose of obtaining an intestinal regulating action. The intestinal regulating agent of the present invention can be, for example, an oral or parenteral intestinal regulating agent.

The form of the intestinal regulating agent of the present invention is not particularly limited, and can be any form. As the form of the oral intestinal preparation, for example, a form suitable for oral use, specifically, a powder form, a granular form, a granular form, a tablet form, a liquid form, a paste form, a capsule form such as a hard capsule or a soft capsule, Examples include a caplet shape and a tablet shape.

The packaging form of the intestinal regulating agent of the present invention is not particularly limited, and can be appropriately selected according to the dosage form, for example, blister pack such as PTP; strip packaging; heat sealing; aluminum pouch; film packaging using plastic or synthetic resin A glass container such as a vial; a plastic container such as an ampoule.

The intestinal regulating agent of the present invention is preferably in the form of powder (in the form of powder such as powder or granule) and used in the oral form of a mixture mixed with water, since it prevents spoilage and is suitable for long-term storage. Further, when the intestinal preparation of the present invention is in a solid form such as powder or tablet, as described above, it can be mixed with water to form a liquid and can be used orally. Depending on the preference, it may be used orally as a solid.

The intestinal preparation of the present invention contains a large amount of vitamins, minerals and the like derived from the pulverized powder of barley foliage of a specific variety in addition to the intestinal regulating action of the conventional pulverized powder of barley shoots. It is very useful for maintaining health.

Hereinafter, the present invention will be described in more detail with reference to examples. However, the present invention is not limited to these examples, and the present invention can take various modes as long as the problems of the present invention can be solved. .

It was demonstrated as follows that the ground powders of Shun Lai, Fiber Snow, and Silky Snow show a particularly remarkable intestinal regulating action by having a bowel movement improving action.

1. As test substance examples 1 to 3, Shun Lai, fiber snow and silky snow were used. Further, as Comparative Example 1, Ichibanboshi was used.

2. Preparation of test feed The barley foliage of Examples 1 to 3 and Comparative Example 1 were used as test samples. This was washed with water to remove adhering mud and the like, and a pretreatment was performed to cut it to a size of about 5 to 10 cm. The pretreated stalks and leaves were blanched only once with hot water at 90 to 100 ° C. for 90 to 120 seconds, and then cooled with cold water. Subsequently, the obtained foliage was dried with warm air at 80 ° C. to 130 ° C. for 20 minutes to 180 minutes in a dryer until the water content became 5% by mass or less. The dried foliage was pulverized to a size of about 1 mm using a mixer. The obtained barley stalks and leaves were pulverized using a pulverizer such that 90% or more of the 200 mesh sections passed through to obtain pulverized powder of barley stalks and leaves.

According to the composition shown in Table 1 below, each component of the crushed powder of barley foliage and the non-fiber high-fat diet (NFHF) based on AIN-76 is used in each feed using a pestle and mortar. The ingredients were prepared to be uniform, and a 10 wt% barley stalk-containing NFHF powder feed was obtained. Moreover, NFHF powder feed was obtained as what does not contain the pulverized powder of barley stalks and leaves.

3. Test animals 6-week-old male Wistar rats (Kudo Co., Ltd.) were allowed to freely ingest MF solid feed (Oriental Yeast Co., Ltd.) and water for 5 days. For the 7-week-old male Wistar rats after acclimatization, they were grouped as shown in Table 2 below so that the average value of the body weight was almost uniform. Breeding freely. However, in grouping, it was considered that there was no significant difference in the number of feces before the start of the test (from -1 to 0 days) in each group (priority order: body weight value> number of feces).

4). Evaluation method and result Before the start of the test (-1 to 0 days), 6 to 7, 13 to 14, 20 to 21, and 27 to 28 days after the start of the test, the stool for each day of each group was collected. The number was measured every measurement day. The obtained stool was dried in an incubator at 100 ° C. for 3 days or more. The stool weight after drying was measured and used as the dry stool weight. A summary of the dry fecal weight of each group is shown in FIG.

As shown in FIG. 1, the dry stool weight was generally higher in Examples 1 to 3 and Comparative Example 1 group than in the control group. Furthermore, surprisingly, the Examples 1 to 3 groups had a higher dry stool weight than the Comparative Example 1 group. Therefore, Shunrai, Fiber Snow, and Silky Snow barley stalks and leaves have the effect of promoting the increase in fecal volume and improving bowel movement, and the effect is shown by the barley stalks of Ichibanboshi, which is a comparative example. It was shown that it was much better than that. From these results, it was found that the barley foliage of Shunrai, Fiber Snow and Silky Snow showed a remarkable intestinal regulating effect through the bowel movement improving effect on the subject used.

The intestinal regulating agent of the present invention contains a pulverized powder of barley stalks and leaves of a specific variety, so that it is safer than conventional substances having an effect of improving bowel movement, and has an excellent bowel regulating action including an effect of improving bowel movement. It can be expected to have various effects such as treatment and prevention of defecation disorders.

The present invention includes specific health foods and drinks, nutritional foods and drinks, health functional foods and drinks, special purpose foods and drinks, nutritional supplements and foods, health supplements and foods, supplements, beauty foods and beverages, other health foods and beverages, and pharmaceutical parts. It can be used as foreign products, cosmetics, and pharmaceuticals.

Claims (3)

An intestinal regulating agent comprising at least one barley stem and / or leaf pulverized powder selected from the group consisting of Shun Lai, Fiber Snow and Silky Snow. 2. The intestinal regulating agent according to claim 1, wherein the content of the pulverized powder of the barley stem and / or leaves in the solid content of the intestinal regulating agent is 20% by mass or more in terms of dry mass. The intestinal adjuster according to claim 1 or 2, wherein a content of the pulverized powder of the barley stem and / or leaves in the solid content of the intestinal adjuster is 80% by mass or less in terms of dry mass. .

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