JP2016135755A5 - - Google Patents
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- Publication number
- JP2016135755A5 JP2016135755A5 JP2015231235A JP2015231235A JP2016135755A5 JP 2016135755 A5 JP2016135755 A5 JP 2016135755A5 JP 2015231235 A JP2015231235 A JP 2015231235A JP 2015231235 A JP2015231235 A JP 2015231235A JP 2016135755 A5 JP2016135755 A5 JP 2016135755A5
- Authority
- JP
- Japan
- Prior art keywords
- carbonate
- medoxomil
- basic inorganic
- inorganic acid
- prodrug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011780 sodium chloride Substances 0.000 claims 6
- -1 inorganic acid salt Chemical class 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrugs Drugs 0.000 claims 4
- 239000007888 film coating Substances 0.000 claims 3
- 238000009501 film coating Methods 0.000 claims 3
- 239000010410 layer Substances 0.000 claims 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M NaHCO3 Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N Silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 2
- 235000012239 silicon dioxide Nutrition 0.000 claims 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 2
- UQGKUQLKSCSZGY-UHFFFAOYSA-N (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate Chemical compound C=1C=C(C=2C(=CC=CC=2)C2=NNN=N2)C=CC=1CN1C(CCC)=NC(C(C)(C)O)=C1C(=O)OCC=1OC(=O)OC=1C UQGKUQLKSCSZGY-UHFFFAOYSA-N 0.000 claims 1
- PRKQVKDSMLBJBJ-UHFFFAOYSA-N Ammonium carbonate Chemical compound N.N.OC(O)=O PRKQVKDSMLBJBJ-UHFFFAOYSA-N 0.000 claims 1
- 239000002051 C09CA08 - Olmesartan medoxomil Substances 0.000 claims 1
- 239000003861 C09CA09 - Azilsartan medoxomil Substances 0.000 claims 1
- 229960003563 Calcium Carbonate Drugs 0.000 claims 1
- JHLNERQLKQQLRZ-UHFFFAOYSA-N Calcium silicate Chemical compound [Ca+2].[Ca+2].[O-][Si]([O-])([O-])[O-] JHLNERQLKQQLRZ-UHFFFAOYSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N Carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L Dipotassium phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L Magnesium carbonate Chemical group [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims 1
- 229960001199 Olmesartan medoxomil Drugs 0.000 claims 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M Potassium bicarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims 1
- FKHIFSZMMVMEQY-UHFFFAOYSA-N Talc Chemical compound [Mg+2].[O-][Si]([O-])=O FKHIFSZMMVMEQY-UHFFFAOYSA-N 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 claims 1
- 239000001099 ammonium carbonate Substances 0.000 claims 1
- 235000012501 ammonium carbonate Nutrition 0.000 claims 1
- 229940059913 ammonium carbonate Drugs 0.000 claims 1
- 229960001211 azilsartan medoxomil Drugs 0.000 claims 1
- QJFSABGVXDWMIW-UHFFFAOYSA-N azilsartan medoxomil Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C=3NC(=O)ON=3)C(OCC)=NC2=CC=CC=1C(=O)OCC=1OC(=O)OC=1C QJFSABGVXDWMIW-UHFFFAOYSA-N 0.000 claims 1
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 1
- 235000010216 calcium carbonate Nutrition 0.000 claims 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims 1
- 239000000378 calcium silicate Substances 0.000 claims 1
- 229910052918 calcium silicate Inorganic materials 0.000 claims 1
- 235000019700 dicalcium phosphate Nutrition 0.000 claims 1
- 239000001095 magnesium carbonate Substances 0.000 claims 1
- 239000011776 magnesium carbonate Substances 0.000 claims 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims 1
- 235000014380 magnesium carbonate Nutrition 0.000 claims 1
- 239000000391 magnesium silicate Substances 0.000 claims 1
- 229910052919 magnesium silicate Inorganic materials 0.000 claims 1
- 235000019792 magnesium silicate Nutrition 0.000 claims 1
- VPBIQXABTCDMAU-UHFFFAOYSA-N magnesium;oxido(oxo)alumane Chemical compound [Mg+2].[O-][Al]=O.[O-][Al]=O VPBIQXABTCDMAU-UHFFFAOYSA-N 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000011736 potassium bicarbonate Substances 0.000 claims 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims 1
- 235000015497 potassium bicarbonate Nutrition 0.000 claims 1
- 239000001184 potassium carbonate Substances 0.000 claims 1
- 229910000027 potassium carbonate Inorganic materials 0.000 claims 1
- 229940093956 potassium carbonate Drugs 0.000 claims 1
- 235000015320 potassium carbonate Nutrition 0.000 claims 1
- 229940086066 potassium hydrogencarbonate Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N silicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 1
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 1
- 239000001187 sodium carbonate Substances 0.000 claims 1
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 1
- 229940001593 sodium carbonate Drugs 0.000 claims 1
- 235000017550 sodium carbonate Nutrition 0.000 claims 1
Claims (5)
- メドキソミル基を有するプロドラッグを含有する素錠の外側に、メドキソミル基を有するプロドラッグ１００重量部に対して０．１〜５．０重量部の塩基性の無機酸塩を含有するフィルムコーティング層を有する錠剤。
- メドキソミル基を有するプロドラッグがオルメサルタンメドキソミル又はアジルサルタンメドキソミルである、請求項１に記載の錠剤。
- 塩基性の無機酸塩が、炭酸、ケイ酸、又は燐酸の金属塩である、請求項１又は２に記載の錠剤。
- 塩基性の無機酸塩が、炭酸マグネシウム、炭酸水素ナトリウム、炭酸ナトリウム、炭酸水素カリウム、炭酸カリウム、炭酸カルシウム、炭酸アンモニウム、無水リン酸水素カルシウム、リン酸水素二カリウム、ケイ酸カルシウム、ケイ酸マグネシウム、ケイ酸アルミン酸マグネシウム、メタケイ酸アルミン酸マグネシウム、軽質無水ケイ酸から選ばれる、請求項１又は２に記載の錠剤。
- メドキソミル基を有するプロドラッグを含有する素錠と塩基性の無機酸塩を含有するフィルムフィルムコーティング層との間に、塩基性の無機酸塩を含有しないフィルムコーティング層が存在する、請求項１〜４のいずれかに記載の錠剤。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015005618 | 2015-01-15 | ||
| JP2015005618 | 2015-01-15 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017074205A Division JP2017119714A (ja) | 2015-01-15 | 2017-04-04 | メドキソミル基を有するプロドラッグを含有するフィルムコーティング製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016135755A JP2016135755A (ja) | 2016-07-28 |
| JP2016135755A5 true JP2016135755A5 (ja) | 2016-10-06 |
| JP6188091B2 JP6188091B2 (ja) | 2017-08-30 |
Family
ID=56405574
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015231235A Active JP6188091B2 (ja) | 2015-01-15 | 2015-11-27 | メドキソミル基を有するプロドラッグを含有するフィルムコーティング製剤 |
| JP2017074205A Pending JP2017119714A (ja) | 2015-01-15 | 2017-04-04 | メドキソミル基を有するプロドラッグを含有するフィルムコーティング製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017074205A Pending JP2017119714A (ja) | 2015-01-15 | 2017-04-04 | メドキソミル基を有するプロドラッグを含有するフィルムコーティング製剤 |
Country Status (2)
| Country | Link |
|---|---|
| JP (2) | JP6188091B2 (ja) |
| WO (1) | WO2016114017A1 (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7209555B2 (ja) * | 2019-01-18 | 2023-01-20 | 日本ジェネリック株式会社 | ラメルテオン含有フィルムコーティング錠剤 |
| WO2024049155A1 (ko) * | 2022-08-31 | 2024-03-07 | (주)셀트리온 | 이중 냄새 차폐 약학 조성물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH092976A (ja) * | 1995-06-20 | 1997-01-07 | Lion Corp | 被覆組成物 |
| JP4512265B2 (ja) * | 2000-12-26 | 2010-07-28 | 株式会社ヤクルト本社 | 乳酸菌培養上清およびその製造方法並びに当該上清を利用する皮膚外用剤 |
| JP2002201418A (ja) * | 2000-12-28 | 2002-07-19 | Nonogawa Shoji Kk | コーティング剤及びこれを用いたコーティング錠 |
| EP2253318B1 (en) * | 2008-03-13 | 2014-08-06 | Daiichi Sankyo Company, Limited | Improvement of dissolvability of preparation containing olmesartan medoxomil |
| WO2010018777A1 (ja) * | 2008-08-11 | 2010-02-18 | 第一三共株式会社 | におい抑制方法 |
| WO2014188728A1 (ja) * | 2013-05-24 | 2014-11-27 | 持田製薬株式会社 | フィルムコーティング用組成物 |
-
2015
- 2015-11-27 WO PCT/JP2015/083347 patent/WO2016114017A1/ja active Application Filing
- 2015-11-27 JP JP2015231235A patent/JP6188091B2/ja active Active
-
2017
- 2017-04-04 JP JP2017074205A patent/JP2017119714A/ja active Pending
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