JP2016079138A - Amino acid-containing composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition containing branched chain amino acid which is excellent in dissolution/dispersibility into milk in high concentration.SOLUTION: A powder composition is obtained by coating the surface of a particle containing amino acid powders containing branched chain amino acid, and citrate with an emulsifying agent; and mixing it with calcium carbonate powders.SELECTED DRAWING: None

Description

  The present invention relates to an amino acid-containing composition.

  In older people, a characteristic skeletal muscle loss, often called sarcopenia, occurs. And skeletal muscle loss reduces the amount of activity of the elderly, and falls into a vicious circle in which this reduction in activity amount leads to further muscular weakness. Reduced activity also reduces basal energy metabolism. This state is particularly noticeable in the bedridden state.

A series of musculoskeletal disorders associated with skeletal muscle loss is called locomotive syndrome ("locomo" for short). The causes of “motor disorder”, which is the cause of locomotive, can be broadly classified into “disease of the motor itself” and “motor dysfunction due to aging”. Diseases of the musculoskeletal itself (musculoskeletal musculoskeletal system) include various musculoskeletal diseases associated with aging, such as osteoarthritis, dorsum of the osteoporosis, easy fracture, osteoarthritis, and spinal stenosis In rheumatoid arthritis, etc., balance ability, physical strength, movement ability are reduced due to pain, limited range of motion, muscle weakness, paralysis, fracture, spasticity, etc.
In addition, musculoskeletal dysfunction due to aging mainly originates from the aforementioned skeletal muscle loss. With aging, physical function decreases, and muscle strength, endurance, extended reaction time, reduced exercise speed, skill, deep sense, and balance ability appear.
Locomo has been pointed out to be the main cause of “nettaki” and “need nursing care”, and along with “metabo” and “dementia” It is said to be one of the three major factors of "state".

Muscle loss due to aging begins around the age of 40, but in order to suppress muscle loss, keep stressing muscles with moderate exercise, and intake nutrients that are muscle materials such as proteins and amino acids. Is said to be necessary. Amino acids are essential for muscle synthesis and are being actively consumed. Among amino acids, branched chain amino acids such as leucine, isoleucine, and valine are important. Among them, leucine is said to be particularly important.
Furthermore, it is said that it is important to prevent the deterioration of the bone due to aging and to strengthen the joint function after the decrease of the skeletal muscle. In order to strengthen bones, it is said that ingestion of “vitamin D”, ingestion of mucopolysaccharides such as hyaluronic acid and chondroitin sulfate, or its precursor N-acetylglucosamine is effective for strengthening joint function. ing. Calcium is an essential nutrient for bone formation. Together with phosphorus and magnesium, it forms bones and teeth and maintains strength, but if chronic calcium deficiency continues, so-called osteoporosis results in low back pain. , The risk of fracture increases. Calcium deficiency is directly linked to Locomo.

A patent application has been filed for a technique for suppressing muscle loss that causes locomotives. Patent Document 1 discloses a composition that suppresses muscle lowering in elderly people, including branched chain amino acids leucine, isoleucine, valine, and lysine.
Patent Document 2 discloses a granule containing leucine, isoleucine, valine and an organic acid.
Each of these prior arts is a technique for a preparation for taking a large amount of amino acid at a time. Further, these branched chain amino acids are known to be hardly soluble in water and difficult to be blended in beverages.
Moreover, in order to reinforce the function of bones and joints, as described above, taking N-acetylglucosamine and calcium in combination has become widespread. However, calcium and N-acetylglucosamine for strengthening bone are both tablets and granules.
The present inventor has also tried to add a branched chain amino acid to a beverage, but it has been difficult to prepare a preferred beverage due to low solubility and flavor problems.
Moreover, when a branched chain amino acid is added to milk, in addition to the amino acid constituting the milk protein, a branched chain amino acid useful for measures against locomo can be easily enhanced. There is a problem that the branched chain amino acid cannot be efficiently ingested even if a desired amount is blended because it does not dissolve in a mamaco state and precipitates.

WO2012 / 141316 WO2009 / 028649

The present inventor is researching a technique for blending a branched chain amino acid and calcium into a food as a measure against locomo. Branched chain amino acids are hydrophobic, are not easily dissolved in water, and are not easily wetted with water. Therefore, when they are dissolved in water or milk, they are in a so-called “mamako” state and are not easily dissolved or dispersed. For this reason, granulation with a soluble saccharide is usually performed. However, when it coexists with a saccharide or calcium carbonate, a new problem of browning or solidification due to an aminocarbonyl reaction appears. Moreover, when N-acetylglucosamine which keeps joint function healthy is mix | blended, there exists a subject of browning with the coexisting glucosamine. In addition, calcium carbonate, which is widely used as calcium, has a problem of being easily precipitated in milk.
The problem to be solved by the present invention is a composition that is dissolved in milk for drinking against locomotive, and is easily dissolved and dispersed in milk, is not easily browned during storage, and is difficult to solidify. It is to provide a granular composition containing calcium carbonate.

  As a result of various studies to solve the above problems, a mixture of amino acids containing branched chain amino acids, saccharides and citric acid powder is granulated, and further, calcium carbonate powder is mixed with granules obtained by spraying an emulsifier on the surface of the particles. Thus, it is found that browning is suppressed, and when dissolved in milk, calcium carbonate and citric acid interact to foam, disperse the powder particles, and easily dissolve and disperse the composition. Was completed.

That is, the present invention has the following configuration.
(1) A powder composition comprising an amino acid powder containing a branched chain amino acid, particles obtained by coating the surface of particles containing citric acid with an emulsifier, and calcium carbonate powder.
(2) The composition according to (1), wherein the calcium carbonate powder is scallop shell powder.
(3) The composition as described in (1) or (2) which contains 3-7 mass% of citric acid.
(4) The composition according to any one of (1) to (3), which contains 50% by mass or more of branched chain amino acids in all amino acids.
(5) The composition according to (4), further comprising sodium gluconate and N-acetylglucosamine.
(6) The composition according to any one of (1) to (5), wherein 10% by mass or more of branched chain amino acid is contained.
(7) The composition according to (6), wherein 5% by mass or more of calcium carbonate is contained.
(8) The composition according to any one of (1) to (7), which is used after being dissolved and dispersed in milk.

The composition according to the present invention dissolves and disperses quickly in milk, and no precipitation occurs. Moreover, the milk in which the powder of the present invention is dissolved has no off-flavors and off-flavors derived from branched chain amino acids, and is a beverage that is extremely easy to drink. Furthermore, it is stable without browning or solidification when the powder is stored.
In addition, the composition of the present invention can be expected to strengthen and prevent inhibition of muscle with branched chain amino acids, strengthen bone with calcium, and strengthen joint function with N-acetylglucosamine.

The present invention relates to a composition for drinking after being dissolved or dispersed in milk, and comprising an amino acid powder containing a branched chain amino acid and particles containing citric acid coated with an emulsifier, and a powder containing calcium carbonate powder It relates to the composition.
The composition according to the present invention preferably contains 10 to 40% by mass of a total amount of one or more branched chain amino acids selected from the group consisting of valine, leucine and isoleucine per composition.

  The branched chain amino acid used in the composition according to the present invention includes one or more selected from the group consisting of valine, leucine and isoleucine. The form of these branched chain amino acids is not particularly limited, and for example, any form such as a protein form, a peptide form, a salt form, and a free form can be used. The free amino acid form is most preferred. In this case, any of L-form, D-form, and DL-form can be used. However, L-form is most preferably used. In addition, as the branched chain amino acid, any of those extracted and purified from animals and plants containing them, or those obtained by chemical synthesis, fermentation, or genetic recombination may be used.

The branched chain amino acids used in the composition of the present invention may all be in a single form or may be in two or more different forms. For example, the branched chain amino acid may be composed only of a free form of a branched chain amino acid, or may include a free form of a branched chain amino acid and a protein form of a branched chain amino acid. . When the composition according to the present invention contains a free-form branched-chain amino acid, the content is preferably 10% by mass or more, particularly preferably 10 to 15% by mass, based on the total amount of the composition.
In the present specification, the amount of the branched chain amino acid is a free form equivalent amount.

  The branched chain amino acid used in the composition of the present invention preferably contains valine, leucine and isoleucine. In that case, the blending ratio of leucine, isoleucine and valine is usually in a weight ratio of leucine: isoleucine: valine = 4: 1: 1 to 3: 1: 1.

In the present invention, in addition to branched-chain amino acids, other amino acids can be included. In particular, for the countermeasure against locomo of the present invention, it is preferable to add essential amino acids such as threonine, phenylalanine, methionine, tryptophan, lysine and non-essential amino acids such as histidine.
The form of these other amino acids is not particularly limited in the same manner as the branched chain amino acid, and can be used in any form such as a protein form, a peptide form, a salt form, and a free form. The free amino acid form is most preferred. In this case, any of L-form, D-form, and DL-form can be used. However, L-form is most preferably used. The branched chain amino acid is preferably contained in an amount of 10 to 40% by mass and 40 to 60% by mass per total amino acid.
When the composition according to the present invention contains the above-mentioned other amino acids in a free form, the content is preferably about 30% by mass with respect to the total amino acid content and about 10% by mass per composition.

Citric acid used in the composition according to the present invention may be natural citric acid extracted from citrus fruits, produced by microbial fermentation, or chemically synthesized. The content of citric acid is 1 to 10% by mass, preferably 3 to 7% by mass, based on the composition of the present invention. When citric acid dissolves in milk, it reacts with calcium carbonate to form minute carbon dioxide bubbles, promotes amino acid dispersion, and further contains sedimentation particles such as calcium carbonate to suppress sedimentation.
Citric acid is mixed with branched chain amino acids and other amino acids and granulated.

  In addition to the above-mentioned amino acid powder and citric acid, the granulated particles can contain acceptable additives such as excipients, binders and disintegrants. As the excipient, those known in the art can be widely used. For example, lactose, sucrose, glucose, D-mannitol, maltitol, xylitol, erythritol, D-sorbitol, maltose, starch and starch Derivatives, aspartame, glycyrrhizic acid and its salts, saccharin and its salts, stevia and its salts, sucralose, acesulfame potassium, calcium hydrogen phosphate and the like. In the present invention, reduced maltose or erythritol is preferred.

  As the binder, those known in the art can be widely used. For example, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinylpyrrolidone, methylcellulose, dextrin, starch and starch derivatives, starch degradation products, guar gum, gum arabic , Tragacanth, alginic acid and salts thereof, pullulan, carrageenan, gelatin, agar, and the like. In the present invention, starch degradation products are preferred.

The production method for granulating the granule is not particularly limited, and a wide variety of methods known in the art can be used. Specifically, extrusion granulation, rolling granulation, stirring granulation , Fluidized granulation method, rolling fluidized granulation method, kneading granulation method and the like. Among these, fluid granulation method and stirring granulation method are preferable.
The bulk density (bulk specific gravity) of the granulated amino acid / citric acid granules is not particularly limited, but is preferably 0.30 to 0.60 g / mL, more preferably 0.35 to 0.55 g / mL, and 35 to 0.40 g / mL is particularly preferable.
In the granulation, the glycerin fatty acid ester is sprayed as a binder and coating agent by using a fluid flow apparatus, and granulation and coating are performed simultaneously. Examples of the glycerin ester include acetic acid monoglyceride, lactic acid monoglyceride, citric acid monoglyceride, diacetyltartaric acid monoglyceride, succinic acid monoglyceride, polyglycerin fatty acid ester, polyglycerin condensed ricinoleic acid ester and the like. In the present invention, any glycerin fatty acid ester permitted as a food additive can be used. Particularly preferred is a glycerin ester marketed as a noodle loosening agent. Specific examples of such products include Ematec W-700 manufactured by Riken Vitamin Co., Ltd.
The coating amount is 0.1% by mass or more per granule containing amino acids. Considering the dispersibility of the composition of the present invention in milk and the coating effect, it is particularly preferably about 0.5 to 1% by mass.

  In addition, it is preferable to perform the drying process of the water | moisture content of the obtained granule. The drying treatment is preferably performed until the moisture content of the original granule becomes 2% or less. The drying method is not particularly limited, and any method can be adopted as long as it is a drying method used for ordinary granule drying, but the vacuum drying method and the air drying method are preferable. The vacuum drying method and the blast drying method may be carried out independently or in combination. However, it is particularly preferable to use a vacuum drying method because the moisture of the granules can be removed as much as possible.

The granules thus obtained are further mixed with calcium carbonate powder to obtain the composition of the present invention.
The calcium carbonate used in the composition according to the invention can be of any origin as long as it is of food or pharmaceutical standards. Examples thereof include limestone powder, eggshell powder, oyster shell powder, and scallop shell lime (scallop shell powder). Particularly preferred is scallop shell powder. Scallop shell powder is a crushed shell of scallop shell and has a fine porous structure. It reacts with an acidic aqueous solution to generate carbon dioxide. In the present invention, it is particularly preferable since sedimentation at the bottom is suppressed. Examples of such commercially available calcium carbonate include scallop powder and scallop powder S manufactured by NC Corporation. The calcium carbonate powder is 1 to 10% by mass, preferably 3 to 7% per composition of the present invention. % By mass, particularly preferably 5% by mass or more.
The composition according to the present invention contains vitamins, sweeteners, and other flavor-improving ingredients required to improve locomo when mixing the granulated amino acid / citrate granules and calcium carbonate powder. can do. Examples of vitamins include vitamin K-containing powder and vitamin D-containing powder. Examples of sweeteners include sucralose, acesulfame potassium, reduced palatinose, and neotame.

  The composition thus obtained is expected to dissolve and disperse quickly in milk, impart a favorable flavor to milk, and further improve the symptoms of patients with locomotive syndrome.

  Next, this invention is demonstrated based on an Example and a comparative example.

1. Preparation of Powder Composition In consideration of the nutritional effect of optimal countermeasures against locomotive syndrome for the elderly, a nutritional composition containing branched chain amino acids with the composition shown in Table 1 was prepared. The amino acid mixture was prepared by previously mixing amino acid powder in accordance with the specifications shown in Table 2.

When granulating the granulation part of Table 1, using a flow flow apparatus MP-01 manufactured by POWREC Co., Ltd., the batch amount is 300 g, the intake temperature is 60 ° C., the exhaust temperature is 40 ° C., the spray air pressure The test was performed under the conditions of 0.4 MPa, a spray air flow rate of 25 L / hour, and a spray rate of 16 g / minute. In the granulation, Ematech W-700 described above was used as a binder and coating agent.
The bulk density of the obtained amino acid / citric acid granules was 0.35 to 0.38 g / mL. The particle size was 18 mesh PASS with a JIS sieve.

  The granules were added to the post-addition so as to have the composition shown in Table 3 below, and mixed to obtain a product of the present invention. In addition, the following edible scallop shell powder used was “Scallop powder, 500 mesh pass 95% or more” manufactured by NC Corporation.

2. Comparative Example In order to compare with the product of the present invention, a granule having the composition shown in Table 4 below was prepared in the same manner, and this was mixed with the post-added component to obtain Comparative Examples 1, 2, and 3 having the same powder composition. It was.

3. Solubility test, flavor test 9.6 g each of the products of Example 1 and Comparative Examples 1 to 3 were weighed, added to 180 ml of milk at room temperature, stirred with a spatula for 1 minute, and the powder solubility was visually confirmed. In addition, the flavor of milk in which each product was dissolved was evaluated by a specialized panel. The evaluation standard of solubility was evaluated by the presence or absence of occurrence of “mamako” which is expected to be derived from amino acids.
The evaluation results are shown in Table 5 below.

  The flavor was good. However, Comparative Examples 1 and 2 in which calcium carbonate was previously granulated were clearly inferior in solubility and dispersibility.

4). Storage Stability Test Each of the compositions of Examples and Comparative Examples 1 to 3 was weighed and placed in a sealable aluminum bag, stored at 40 ° C. and 75% humidity for 7 days, then opened, and then the composition The state of browning and solidification of the powder was confirmed.
The results are shown in Table 6.

  In the examples of the present invention, neither browning nor consolidation occurred.

5. Effect confirmation test by citric acid blending In producing the product of the example, the product was prepared without blending citric acid, and this was designated as Comparative Example 4. The product of Example and Comparative Example 4 was dissolved in milk under the same conditions as in the solubility test, and 100 ml of this was collected and centrifuged at 1500 × g for 1 minute to forcibly precipitate insoluble matter. When the precipitate in the centrifuge tube was collected and 0.05 M aqueous citric acid solution was added dropwise thereto, foaming of the precipitate of Comparative Example 4 was observed. On the other hand, no such foaming phenomenon was observed in the precipitates of Examples.
From this test, it was revealed that scallop shell powder (calcium carbonate) was precipitated when the composition of Comparative Example 4 containing no citric acid was dissolved in milk. On the other hand, since the foaming phenomenon was not observed in the products of the examples, it was judged that precipitation of scallop shell powder was suppressed.

Claims (8)

  A powder composition comprising an amino acid powder containing a branched chain amino acid, particles having the surface of particles containing citric acid coated with an emulsifier, and calcium carbonate powder.   The composition according to claim 1, wherein the calcium carbonate powder is scallop shell powder.   The composition of Claim 1 or 2 containing 3-7 mass% of citric acid.   The composition according to any one of claims 1 to 3, which contains 50% by mass or more of branched chain amino acids in all amino acids.   Furthermore, the composition of Claim 4 containing sodium gluconate and N-acetylglucosamine.   The composition according to any one of claims 1 to 5, comprising 10% by mass or more of branched chain amino acids.   The composition according to claim 6, wherein calcium carbonate is contained in an amount of 5% by mass or more.   The composition according to any one of claims 1 to 7, which is used after being dissolved and dispersed in milk.