JP2015534809A5 - - Google Patents
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- JP2015534809A5 JP2015534809A5 JP2015539923A JP2015539923A JP2015534809A5 JP 2015534809 A5 JP2015534809 A5 JP 2015534809A5 JP 2015539923 A JP2015539923 A JP 2015539923A JP 2015539923 A JP2015539923 A JP 2015539923A JP 2015534809 A5 JP2015534809 A5 JP 2015534809A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- matrix
- ternary
- concentration
- cartilage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011159 matrix material Substances 0.000 claims 17
- 210000000845 cartilage Anatomy 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 8
- 210000001612 chondrocyte Anatomy 0.000 claims 7
- 102000000503 Collagen Type II Human genes 0.000 claims 5
- 108010041390 Collagen Type II Proteins 0.000 claims 5
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 3
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 3
- 229940059329 chondroitin sulfate Drugs 0.000 claims 3
- 229920002674 hyaluronan Polymers 0.000 claims 3
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims 3
- 229940099552 hyaluronan Drugs 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- 101100096242 Mus musculus Sox9 gene Proteins 0.000 claims 2
- 229920000954 Polyglycolide Polymers 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 230000007547 defect Effects 0.000 claims 2
- 239000004744 fabric Substances 0.000 claims 2
- 239000007943 implant Substances 0.000 claims 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 2
- 210000000963 osteoblast Anatomy 0.000 claims 2
- 210000004663 osteoprogenitor cell Anatomy 0.000 claims 2
- 239000004633 polyglycolic acid Substances 0.000 claims 2
- 239000011148 porous material Substances 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 241000283690 Bos taurus Species 0.000 claims 1
- 229920000742 Cotton Polymers 0.000 claims 1
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 239000007640 basal medium Substances 0.000 claims 1
- 210000004207 dermis Anatomy 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000004745 nonwoven fabric Substances 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 239000004626 polylactic acid Substances 0.000 claims 1
- 229940117828 polylactic acid-polyglycolic acid copolymer Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261719902P | 2012-10-29 | 2012-10-29 | |
| US61/719,902 | 2012-10-29 | ||
| PCT/US2013/067349 WO2014070796A1 (en) | 2012-10-29 | 2013-10-29 | Methods of transplanting chondrocytes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015534809A JP2015534809A (ja) | 2015-12-07 |
| JP2015534809A5 true JP2015534809A5 (enExample) | 2016-11-10 |
| JP6324395B2 JP6324395B2 (ja) | 2018-05-16 |
Family
ID=50628009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015539923A Active JP6324395B2 (ja) | 2012-10-29 | 2013-10-29 | 軟骨細胞を移植する方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US9974885B2 (enExample) |
| EP (1) | EP2911709B1 (enExample) |
| JP (1) | JP6324395B2 (enExample) |
| WO (1) | WO2014070796A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10724005B2 (en) | 2012-09-28 | 2020-07-28 | Scripps Health | Methods of differentiating stem cells into chondrocytes |
| WO2014070797A1 (en) | 2012-10-29 | 2014-05-08 | Scripps Health | Methods of producing pluripotent stem cells from chondrocytes |
| JP6324395B2 (ja) | 2012-10-29 | 2018-05-16 | スクリップス ヘルス | 軟骨細胞を移植する方法 |
| KR20180103818A (ko) * | 2015-08-31 | 2018-09-19 | 코르메딕스, 인코포레이티드 | 관절 치료용 조성물 |
| JP2022514298A (ja) * | 2018-12-19 | 2022-02-10 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | オルガノイドおよびその組織を作製および使用するための方法 |
| US20220064592A1 (en) * | 2020-09-03 | 2022-03-03 | Tokai University Educational System | Cell microsheet, syringe containing the cell microsheet, and production and use of the cell microsheet |
| DE102021202830A1 (de) * | 2021-03-23 | 2022-09-29 | Gelita Ag | Rekombinantes Typ II-Kollagen zur therapeutischen Verwendung |
| US20230330149A1 (en) * | 2022-04-14 | 2023-10-19 | Creative Medical Technologies, Inc. | Enhancement of cartilage regenerative activity of stem cell populations based on reduction of intra-articular cellular material |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399347A (en) * | 1987-06-24 | 1995-03-21 | Autoimmune, Inc. | Method of treating rheumatoid arthritis with type II collagen |
| CA2060223C (en) * | 1991-02-12 | 1999-07-20 | Clarence C. Lee | Injectable medical lubricating fluid composition and method of use |
| US5645851A (en) * | 1994-02-28 | 1997-07-08 | Moore; Eugene R. | Product for alleviating the symptons of arthritis in mammals |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| GB9503492D0 (en) | 1995-02-22 | 1995-04-12 | Ed Geistlich S Hne A G F R Che | Chemical product |
| US6025327A (en) * | 1997-08-08 | 2000-02-15 | Biocell Technology, Llc | Hydrolyzed collagen type II and use thereof |
| US6511958B1 (en) * | 1997-08-14 | 2003-01-28 | Sulzer Biologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
| US20030026786A1 (en) | 1999-06-04 | 2003-02-06 | Mark F. Pittenger | Chondrogenic differentiation of human mesenchymal stem cells |
| EP1254670A1 (en) | 2001-05-03 | 2002-11-06 | Stichting Katholieke Universiteit | Type II collagen matrices for use in cartilage engineering |
| US6780841B2 (en) * | 2001-11-13 | 2004-08-24 | Biocell Technology, Llc | Hyaluronic acid and chondroitin sulfate based hydrolyzed collagen type II and method of making same |
| CA2412012C (en) | 2001-11-20 | 2011-08-02 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Resorbable extracellular matrix containing collagen i and collagen ii for reconstruction of cartilage |
| US6852331B2 (en) | 2002-02-11 | 2005-02-08 | Taipei Biotechnology Ltd., Inc. | Fabrication of a cartilage implant |
| ES2265199B1 (es) | 2003-06-12 | 2008-02-01 | Cellerix, S.L. | Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones. |
| WO2006015209A2 (en) | 2004-07-29 | 2006-02-09 | Stem Cell Innovations, Inc. | Differentiation of stem cells |
| AU2005287855B2 (en) | 2004-09-24 | 2011-06-16 | Mesoblast, Inc. | Method of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC) |
| US20080260694A1 (en) | 2004-09-24 | 2008-10-23 | Angioblast Systems, Inc. | Multipotential Expanded Mesenchymal Precursor Cell Progeny (Memp) and Uses Thereof |
| US20060189840A1 (en) * | 2005-02-18 | 2006-08-24 | Acorn Cardiovascular, Inc. | Transmyocardial delivery of cardiac wall tension relief |
| ES2329636B2 (es) | 2006-02-17 | 2010-07-26 | Universitat De Valencia, Estudi General (Participa Con El 70%) | Uso del factor pedf para inducir la auto-renovacion de celulas madre. |
| FR2900155B1 (fr) * | 2006-04-21 | 2008-06-27 | Diana Naturals Sa | Hydrolisat de cartilage aviaire, procede d'obtention et utilisations |
| CN101721349B (zh) * | 2008-10-16 | 2011-07-20 | 常州百瑞吉生物医药有限公司 | 可注射原位交联水凝胶及其制备方法和用途 |
| KR101091028B1 (ko) * | 2009-07-02 | 2011-12-09 | 아주대학교산학협력단 | 체내 주입형 하이드로젤 및 이의 생의학적 용도 |
| JP5636174B2 (ja) | 2009-07-10 | 2014-12-03 | 学校法人近畿大学 | 間葉系細胞または軟骨細胞の製法ならびに発癌性の抑制方法 |
| JP6263329B2 (ja) | 2009-11-24 | 2018-01-17 | ザ ユニバーシティ オブ コネチカット | ヒト胚性および人工多能性幹細胞の分化 |
| KR100990436B1 (ko) | 2009-11-30 | 2010-10-29 | 동국대학교 산학협력단 | 중간엽 줄기세포를 ＤＫＫ-1 또는 ｓＦＲＰ-1을 이용하여 연골세포로 분화시키는 방법 |
| EP2529009A4 (en) | 2010-01-28 | 2013-11-13 | Univ Queensland | METHOD OF STEM CELL DIFFERENTIATION |
| AU2011235212B2 (en) * | 2010-03-31 | 2014-07-31 | The Scripps Research Institute | Reprogramming cells |
| CN102933704A (zh) | 2010-04-08 | 2013-02-13 | 爱丁堡大学管理处 | 软骨祖细胞、用于细胞衍生的方案和其用途 |
| CN101810855B (zh) * | 2010-05-20 | 2012-06-13 | 广州创尔生物技术有限公司 | 一种ⅱ型胶原关节软骨修复液及其制备方法 |
| WO2012013969A1 (en) | 2010-07-26 | 2012-02-02 | The University Of Manchester | Targeted differentiation of stem cells |
| CN101934092A (zh) | 2010-08-27 | 2011-01-05 | 中国人民解放军第三军医大学第一附属医院 | 用于软骨再生修复的注射型软骨仿生基质材料及使用方法 |
| KR101340458B1 (ko) * | 2010-11-02 | 2013-12-11 | 서울대학교산학협력단 | 하이드로겔을 포함하는 연골 이식용 조성물 |
| US8663675B2 (en) * | 2010-11-18 | 2014-03-04 | Jalaledin Ghanavi | Injectable matrix having a polymer and a stem cell niche composed of cup-shaped nanoparticles containing growth factors or physiological agents for organ reconstruction |
| WO2012126824A1 (en) | 2011-03-18 | 2012-09-27 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Chondrogenic differentiation media and methods for inducing chondrogenic differentiation of cells |
| US10724005B2 (en) | 2012-09-28 | 2020-07-28 | Scripps Health | Methods of differentiating stem cells into chondrocytes |
| WO2014070797A1 (en) | 2012-10-29 | 2014-05-08 | Scripps Health | Methods of producing pluripotent stem cells from chondrocytes |
| JP6324395B2 (ja) | 2012-10-29 | 2018-05-16 | スクリップス ヘルス | 軟骨細胞を移植する方法 |
| WO2014157257A1 (ja) | 2013-03-25 | 2014-10-02 | 公益財団法人先端医療振興財団 | 細胞の選別方法 |
-
2013
- 2013-10-29 JP JP2015539923A patent/JP6324395B2/ja active Active
- 2013-10-29 EP EP13852195.0A patent/EP2911709B1/en active Active
- 2013-10-29 WO PCT/US2013/067349 patent/WO2014070796A1/en not_active Ceased
- 2013-10-29 US US14/438,583 patent/US9974885B2/en active Active
-
2018
- 2018-01-16 US US15/872,667 patent/US10179193B2/en active Active
- 2018-12-07 US US16/213,790 patent/US20190143000A1/en not_active Abandoned
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