JP2016520068A5 - - Google Patents
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- Publication number
- JP2016520068A5 JP2016520068A5 JP2016513108A JP2016513108A JP2016520068A5 JP 2016520068 A5 JP2016520068 A5 JP 2016520068A5 JP 2016513108 A JP2016513108 A JP 2016513108A JP 2016513108 A JP2016513108 A JP 2016513108A JP 2016520068 A5 JP2016520068 A5 JP 2016520068A5
- Authority
- JP
- Japan
- Prior art keywords
- scaffold
- stem cells
- abcb5
- wound healing
- population
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000130 stem cell Anatomy 0.000 claims 16
- 230000029663 wound healing Effects 0.000 claims 12
- 102100021501 ATP-binding cassette sub-family B member 5 Human genes 0.000 claims 11
- 101000677872 Homo sapiens ATP-binding cassette sub-family B member 5 Proteins 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 7
- 206010052428 Wound Diseases 0.000 claims 5
- 208000027418 Wounds and injury Diseases 0.000 claims 5
- 210000001519 tissue Anatomy 0.000 claims 5
- 102000008186 Collagen Human genes 0.000 claims 4
- 108010035532 Collagen Proteins 0.000 claims 4
- 229920001436 collagen Polymers 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 2
- 229920001296 polysiloxane Polymers 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 239000002407 tissue scaffold Substances 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 1
- 206010056340 Diabetic ulcer Diseases 0.000 claims 1
- 230000000975 bioactive effect Effects 0.000 claims 1
- 230000002500 effect on skin Effects 0.000 claims 1
- 238000012407 engineering method Methods 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 210000002510 keratinocyte Anatomy 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 238000009581 negative-pressure wound therapy Methods 0.000 claims 1
- 238000010899 nucleation Methods 0.000 claims 1
- -1 polysiloxane Polymers 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 210000002435 tendon Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361822134P | 2013-05-10 | 2013-05-10 | |
| US61/822,134 | 2013-05-10 | ||
| PCT/US2014/037435 WO2014182994A1 (en) | 2013-05-10 | 2014-05-09 | Wound healing and tissue engineering |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520068A JP2016520068A (ja) | 2016-07-11 |
| JP2016520068A5 true JP2016520068A5 (enExample) | 2017-06-22 |
| JP6600299B2 JP6600299B2 (ja) | 2019-10-30 |
Family
ID=51867763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513108A Active JP6600299B2 (ja) | 2013-05-10 | 2014-05-09 | 創傷治癒および組織工学 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11446331B2 (enExample) |
| EP (2) | EP4008369A1 (enExample) |
| JP (1) | JP6600299B2 (enExample) |
| KR (1) | KR102319899B1 (enExample) |
| CN (1) | CN105517587B (enExample) |
| AU (1) | AU2014262590B2 (enExample) |
| BR (1) | BR112015028193B8 (enExample) |
| CA (1) | CA2911232C (enExample) |
| DK (1) | DK2994173T3 (enExample) |
| ES (1) | ES2892403T3 (enExample) |
| MX (1) | MX378814B (enExample) |
| WO (1) | WO2014182994A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2411101C (en) | 2000-06-05 | 2018-01-16 | Brigham And Women's Hospital, Inc. | A gene encoding a multidrug resistance human p-glycoprotein homologue on chromosome 7p15-21 and uses thereof |
| WO2007143139A1 (en) | 2006-05-31 | 2007-12-13 | The Brigham And Women's Hospital, Inc. | Abcb5 positive mesenchymal stem cells as immunomodulators |
| PT2155248E (pt) | 2007-04-12 | 2015-10-23 | Brigham & Womens Hospital | Direcionamento a abcb5 para tratameto do cancro |
| US11542328B2 (en) | 2008-11-14 | 2023-01-03 | The Brigham And Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
| ES2796111T3 (es) | 2008-11-14 | 2020-11-25 | Brigham & Womens Hospital Inc | Métodos terapéuticos relacionados con células madre cancerosas |
| US9801912B2 (en) | 2013-02-19 | 2017-10-31 | Va Boston Healthcare System | ABCB5(+) stem cells for treating ocular disease |
| BR112015028193B8 (pt) | 2013-05-10 | 2023-04-18 | Childrens Medical Center | Suporte para cicatrização de feridas |
| CA2966431C (en) * | 2014-10-31 | 2023-02-14 | The Administrators Of The Tulane Educational Fund | Surgical grafts for replacing the nipple and areola or damaged epidermis |
| US20200038248A1 (en) * | 2016-10-05 | 2020-02-06 | Temple University- Of The Commonwealth System Of Higher Education | Negative Pressure Enhanced Cellular Infiltration |
| CN107050521B (zh) * | 2017-04-27 | 2020-10-09 | 天新福（北京）医疗器材股份有限公司 | 一种双层胶原真皮支架及其制备方法 |
| KR20210005118A (ko) * | 2018-04-25 | 2021-01-13 | 칠드런'즈 메디컬 센터 코포레이션 | Abcb5 리간드 및 기질 |
| US11090412B2 (en) | 2018-12-21 | 2021-08-17 | Zavation Medical Products Llc | Bone repair composition and kit |
| KR20220007596A (ko) * | 2019-03-28 | 2022-01-18 | 칠드런'즈 메디컬 센터 코포레이션 | 고도로 기능적인 제조된 abcb5+ 중간엽 줄기 세포 |
| US20220241339A1 (en) * | 2019-04-24 | 2022-08-04 | Children's Medical Center Corporation | Abcb5+ stem cell therapeutics for liver disease |
| CN110314252A (zh) * | 2019-05-22 | 2019-10-11 | 嘉兴市爵拓科技有限公司 | 胶原蛋白植入物在制备青光眼手术辅助复原物中的用途 |
| EP4125960A4 (en) * | 2020-03-30 | 2024-04-03 | Children's Medical Center Corporation | USING STEM CELLS TO TREAT EXCESSIVE INFLAMMATION |
| GB2605969A (en) * | 2021-04-19 | 2022-10-26 | The Griffin Inst | Skin membranes |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4280954A (en) | 1975-07-15 | 1981-07-28 | Massachusetts Institute Of Technology | Crosslinked collagen-mucopolysaccharide composite materials |
| US4060081A (en) | 1975-07-15 | 1977-11-29 | Massachusetts Institute Of Technology | Multilayer membrane useful as synthetic skin |
| US4382441A (en) | 1978-12-06 | 1983-05-10 | Svedman Paul | Device for treating tissues, for example skin |
| US4505266A (en) | 1981-10-26 | 1985-03-19 | Massachusetts Institute Of Technology | Method of using a fibrous lattice |
| GB8509978D0 (en) | 1985-04-18 | 1985-05-30 | Juhasz L | Wound dressings |
| US5434075A (en) | 1992-03-20 | 1995-07-18 | Board Of Trustees Of The University Of Illinois | Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses |
| US5837258A (en) | 1991-08-30 | 1998-11-17 | University Of South Florida | Induction of tissue, bone or cartilage formation using connective tissue growth factor |
| US6231881B1 (en) | 1992-02-24 | 2001-05-15 | Anton-Lewis Usala | Medium and matrix for long-term proliferation of cells |
| GB2272645B8 (en) | 1992-11-23 | 2010-02-10 | Johnson & Johnson Medical | Wound dressing |
| GB9403135D0 (en) | 1994-02-18 | 1994-04-06 | Univ Glasgow | Wound healing device |
| US5489304A (en) * | 1994-04-19 | 1996-02-06 | Brigham & Women's Hospital | Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft |
| US5906934A (en) | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
| ATE439849T1 (de) | 1996-04-19 | 2009-09-15 | Osiris Therapeutics Inc | Die wiederherstellung und verstärkung von knochen mittels mesenchymalen stammzellen |
| US5904659A (en) | 1997-02-14 | 1999-05-18 | Exogen, Inc. | Ultrasonic treatment for wounds |
| US6152142A (en) | 1997-02-28 | 2000-11-28 | Tseng; Scheffer C. G. | Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries |
| DE19722075C1 (de) | 1997-05-27 | 1998-10-01 | Wilhelm Dr Med Fleischmann | Vorrichtung zur Applikation von Wirkstoffen an einer Wundoberfläche |
| EP1062321B1 (en) | 1998-03-13 | 2004-12-29 | Osiris Therapeutics, Inc. | Uses for humane non-autologous mesenchymal stem cells |
| US6368636B1 (en) | 1998-03-18 | 2002-04-09 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
| US6797269B2 (en) | 1998-04-03 | 2004-09-28 | Osiris Therapeutics, Inc. | Mesenchymal stem cells as immunosuppressants |
| EP1082410B1 (en) | 1998-05-29 | 2007-08-01 | Osiris Therapeutics, Inc. | Human cd45+ and/or fibroblast + mesenchymal stem cells |
| WO2001037922A2 (en) | 1999-11-29 | 2001-05-31 | Hill-Rom Services, Inc. | Wound treatment apparatus |
| US6673606B1 (en) | 2000-04-12 | 2004-01-06 | The Children's Hospital Of Philadelphia | Therapeutic uses for mesenchymal stromal cells |
| CA2411101C (en) | 2000-06-05 | 2018-01-16 | Brigham And Women's Hospital, Inc. | A gene encoding a multidrug resistance human p-glycoprotein homologue on chromosome 7p15-21 and uses thereof |
| EP1322936A2 (en) | 2000-10-03 | 2003-07-02 | California Institute Of Technology | Microfluidic devices and methods of use |
| WO2002083046A1 (en) | 2001-04-16 | 2002-10-24 | Pamela Howard | Wound dressing system |
| US6905678B2 (en) | 2001-07-07 | 2005-06-14 | Crucell Holland B.V. | Gene delivery vectors with cell type specificity for mesenchymal stem cells |
| US8034904B2 (en) | 2002-06-14 | 2011-10-11 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| US20040175366A1 (en) | 2003-03-07 | 2004-09-09 | Acell, Inc. | Scaffold for cell growth and differentiation |
| CA2629330C (en) | 2004-11-12 | 2018-05-22 | Cambridge University Technical Services Ltd. | Methods and means related to cancer stem cells |
| AU2006304392B2 (en) | 2005-10-18 | 2014-05-01 | National Jewish Health | Conditionally immortalized long-term stem cells and methods of making and using such cells |
| WO2007143139A1 (en) | 2006-05-31 | 2007-12-13 | The Brigham And Women's Hospital, Inc. | Abcb5 positive mesenchymal stem cells as immunomodulators |
| GB0610778D0 (en) | 2006-05-31 | 2006-07-12 | Het Nl Kanker I | Phosphatidylinositol phospahte and apoptosis |
| WO2008064244A2 (en) | 2006-11-20 | 2008-05-29 | The Trustees Of Columbia University In The City Of New York | Phosphoinositide modulation for the treatment of neurodegenerative diseases |
| PT2155248E (pt) | 2007-04-12 | 2015-10-23 | Brigham & Womens Hospital | Direcionamento a abcb5 para tratameto do cancro |
| US9011840B2 (en) * | 2008-03-14 | 2015-04-21 | The Board Of Trustees Of The University Of Illinois | Activated mesenchymal stem cells for wound healing and impaired tissue regeneration |
| US11542328B2 (en) | 2008-11-14 | 2023-01-03 | The Brigham And Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
| ES2796111T3 (es) | 2008-11-14 | 2020-11-25 | Brigham & Womens Hospital Inc | Métodos terapéuticos relacionados con células madre cancerosas |
| WO2010065711A1 (en) | 2008-12-04 | 2010-06-10 | Adimab, Inc. | An abcb5 epitope and antibodies thereto for the treatment of cancer |
| GB0908927D0 (en) | 2009-05-22 | 2009-07-01 | Univ Reading The | Synthetic graft |
| US9814744B2 (en) * | 2009-12-22 | 2017-11-14 | University of Pittsburg—Of the Commonwealth System of Higher Education | Decellularized adipose cell growth scaffold |
| WO2013002953A1 (en) * | 2011-06-01 | 2013-01-03 | The Board Of Trustees Of The University Of Illinois | Membrane-scaffold composites for tissue engineering applications |
| KR101138091B1 (ko) | 2011-08-31 | 2012-04-24 | 세원셀론텍(주) | 중간엽 줄기세포 기본 배양 배지 조성방법, 중간엽 줄기세포 기본 배양 배지 및 이를 이용하여 배양분화된 세포치료제 |
| US9801912B2 (en) | 2013-02-19 | 2017-10-31 | Va Boston Healthcare System | ABCB5(+) stem cells for treating ocular disease |
| BR112015028193B8 (pt) | 2013-05-10 | 2023-04-18 | Childrens Medical Center | Suporte para cicatrização de feridas |
| US20180134771A1 (en) | 2015-05-07 | 2018-05-17 | Bioxcel Corporation | Novel immunomodulatory therapeutic strategies targeting tumors in cancer |
| KR20210005118A (ko) | 2018-04-25 | 2021-01-13 | 칠드런'즈 메디컬 센터 코포레이션 | Abcb5 리간드 및 기질 |
| KR20220007596A (ko) | 2019-03-28 | 2022-01-18 | 칠드런'즈 메디컬 센터 코포레이션 | 고도로 기능적인 제조된 abcb5+ 중간엽 줄기 세포 |
-
2014
- 2014-05-09 BR BR112015028193A patent/BR112015028193B8/pt active IP Right Grant
- 2014-05-09 ES ES14795146T patent/ES2892403T3/es active Active
- 2014-05-09 US US14/890,251 patent/US11446331B2/en active Active
- 2014-05-09 AU AU2014262590A patent/AU2014262590B2/en active Active
- 2014-05-09 MX MX2015015536A patent/MX378814B/es unknown
- 2014-05-09 CA CA2911232A patent/CA2911232C/en active Active
- 2014-05-09 JP JP2016513108A patent/JP6600299B2/ja active Active
- 2014-05-09 WO PCT/US2014/037435 patent/WO2014182994A1/en not_active Ceased
- 2014-05-09 EP EP21183958.4A patent/EP4008369A1/en not_active Withdrawn
- 2014-05-09 EP EP14795146.1A patent/EP2994173B1/en active Active
- 2014-05-09 CN CN201480034115.0A patent/CN105517587B/zh active Active
- 2014-05-09 DK DK14795146.1T patent/DK2994173T3/da active
- 2014-05-09 KR KR1020157034739A patent/KR102319899B1/ko active Active
-
2022
- 2022-09-19 US US17/947,360 patent/US20230149469A1/en active Pending
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