JP2015532289A5 - - Google Patents
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- JP2015532289A5 JP2015532289A5 JP2015534772A JP2015534772A JP2015532289A5 JP 2015532289 A5 JP2015532289 A5 JP 2015532289A5 JP 2015534772 A JP2015534772 A JP 2015534772A JP 2015534772 A JP2015534772 A JP 2015534772A JP 2015532289 A5 JP2015532289 A5 JP 2015532289A5
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- 229940002612 prodrug Drugs 0.000 claims description 129
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019004203A JP6913698B2 (ja) | 2012-09-28 | 2019-01-15 | ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261707568P | 2012-09-28 | 2012-09-28 | |
| US61/707,568 | 2012-09-28 | ||
| US201361780171P | 2013-03-13 | 2013-03-13 | |
| US61/780,171 | 2013-03-13 | ||
| PCT/US2013/062413 WO2014052896A1 (en) | 2012-09-28 | 2013-09-27 | Uridine diphosphate derivatives, prodrugs, compositions and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019004203A Division JP6913698B2 (ja) | 2012-09-28 | 2019-01-15 | ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015532289A JP2015532289A (ja) | 2015-11-09 |
| JP2015532289A5 true JP2015532289A5 (cg-RX-API-DMAC7.html) | 2016-10-20 |
| JP6523958B2 JP6523958B2 (ja) | 2019-06-05 |
Family
ID=50389029
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015534772A Expired - Fee Related JP6523958B2 (ja) | 2012-09-28 | 2013-09-27 | ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用 |
| JP2019004203A Expired - Fee Related JP6913698B2 (ja) | 2012-09-28 | 2019-01-15 | ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019004203A Expired - Fee Related JP6913698B2 (ja) | 2012-09-28 | 2019-01-15 | ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (6) | US9913855B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2900680A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6523958B2 (cg-RX-API-DMAC7.html) |
| AU (2) | AU2013323188B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2885369A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014052896A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6162125B2 (ja) * | 2011-09-30 | 2017-07-12 | タフツ・ユニバーシティ | 神経変性障害を処置するためのウリジン二リン酸誘導体、組成物および方法 |
| AU2013323188B2 (en) | 2012-09-28 | 2018-04-19 | Tufts University | Uridine diphosphate derivatives, prodrugs, compositions and uses thereof |
| CA2904180C (en) | 2013-03-13 | 2022-05-10 | Tufts University | Uridine nucleoside derivatives, compositions and methods of use |
| AR095442A1 (es) | 2013-03-13 | 2015-10-14 | Univ Tufts | Derivados de nucleósido de uridina, composiciones y métodos de uso |
| CA2937548C (en) * | 2014-02-13 | 2022-10-25 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
| US10526287B2 (en) | 2015-04-23 | 2020-01-07 | Constellation Pharmaceuticals, Inc. | LSD1 inhibitors and uses thereof |
| JP7121731B2 (ja) | 2016-09-26 | 2022-08-18 | タフツ・ユニバーシティ | ウリジンヌクレオシド誘導体、組成物及び使用方法 |
| NZ752587A (en) | 2016-10-26 | 2025-09-26 | Constellation Pharmaceuticals Inc | Lsd1 inhibitors and medical uses thereof |
| WO2018236221A2 (en) * | 2017-06-03 | 2018-12-27 | Can Holding B.V. | Neurodegenerative peptide deposit dissolution |
| WO2019112383A1 (ko) * | 2017-12-08 | 2019-06-13 | 윤주석 | 금속 미네랄 디아미네이트 및 이의 제조방법 |
| KR102010558B1 (ko) * | 2017-12-08 | 2019-08-13 | 윤주석 | 금속 미네랄 디아미네이트 및 이의 제조방법 |
| WO2020037275A1 (en) * | 2018-08-17 | 2020-02-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Purine and pyrimidine nucleotides as ecto-5'-nucleotidase inhibitors |
| CN117700468B (zh) * | 2024-02-05 | 2024-05-03 | 深圳赛陆医疗科技有限公司 | 一种核苷酸类似物的制备方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0621073B2 (ja) | 1986-03-06 | 1994-03-23 | 日水製薬株式会社 | 中枢抑制剤 |
| JP3032053B2 (ja) | 1991-09-06 | 2000-04-10 | 日水製薬株式会社 | ウリジン誘導体及びこれを含有する医薬 |
| KR100253515B1 (ko) * | 1992-05-22 | 2000-05-01 | 요시다 쇼지 | 녹내장 치료용 의약 조성물 |
| US5962459A (en) | 1996-05-28 | 1999-10-05 | Polifarma S.P.A. | Therapeutic active agent for treatment of neuron degenerative diseases |
| ID29198A (id) | 1997-08-29 | 2001-08-09 | Univ North Carolina | Pemakaian uridin 5'-difosfat dan persamaannya untuk mengobati penyakit paru-paru |
| US20050203053A1 (en) | 1999-07-30 | 2005-09-15 | Wurtman Richard J. | Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function |
| US8143234B2 (en) | 1998-07-31 | 2012-03-27 | Massachusetts Institute Of Technology | Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function |
| US8518882B2 (en) | 1998-07-31 | 2013-08-27 | Massachusetts Institute Of Technology | Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same |
| PT2322187E (pt) | 1998-07-31 | 2014-07-24 | Massachusetts Inst Technology | Utilização de uridina em combinação com colina para o tratamento de disfunções de memória |
| US20070004670A1 (en) | 1998-07-31 | 2007-01-04 | Richard Wurtman | Compositions containing citicoline, and methods of use thereof |
| US20060069061A1 (en) | 1998-07-31 | 2006-03-30 | Dick Wurtman | Compositions containing uridine and choline, and methods utilizing same |
| US8314064B2 (en) | 1998-07-31 | 2012-11-20 | Massachusetts Institute Of Technology | Uridine administration stimulates membrane production |
| GB0004297D0 (en) | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| US6875751B2 (en) | 2000-06-15 | 2005-04-05 | Idenix Pharmaceuticals, Inc. | 3′-prodrugs of 2′-deoxy-β-L-nucleosides |
| US20050074819A1 (en) | 2003-10-01 | 2005-04-07 | Japan Health Sciences Foundation | Screening method of drug for treatment of neuropathic pain |
| WO2005122767A1 (en) | 2004-06-10 | 2005-12-29 | Mclean Hospital Corporation | Pyrimidines, such as uridine, in treatments for patients with bipolar disorder |
| US7851456B2 (en) | 2005-06-29 | 2010-12-14 | Inspire Pharmaceuticals, Inc. | P2Y6 receptor agonists for treating lung diseases |
| WO2008113072A2 (en) * | 2007-03-15 | 2008-09-18 | Board Of Regents, The University Of Texas System | Gpcr enhanced neuroprotection to treat brain injury |
| EP2136626A4 (en) | 2007-03-19 | 2011-02-23 | Oregon State | Mannich base n-oxide drugs |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| WO2010039548A2 (en) | 2008-09-23 | 2010-04-08 | Alnylam Pharmaceuticals, Inc. | Chemical modifications of monomers and oligonucleotides with cycloaddition |
| IT1398378B1 (it) * | 2010-02-22 | 2013-02-22 | Omikron Italia S R L | Citicolina per il trattamento del glaucoma e dell'ipertensione oculare. |
| CN103339136A (zh) | 2010-12-01 | 2013-10-02 | 巴伊兰大学 | 尿苷二-或三-磷酸衍生物以及其用途 |
| JP6162125B2 (ja) | 2011-09-30 | 2017-07-12 | タフツ・ユニバーシティ | 神経変性障害を処置するためのウリジン二リン酸誘導体、組成物および方法 |
| AU2013323188B2 (en) | 2012-09-28 | 2018-04-19 | Tufts University | Uridine diphosphate derivatives, prodrugs, compositions and uses thereof |
| CA2904180C (en) | 2013-03-13 | 2022-05-10 | Tufts University | Uridine nucleoside derivatives, compositions and methods of use |
| AR095442A1 (es) | 2013-03-13 | 2015-10-14 | Univ Tufts | Derivados de nucleósido de uridina, composiciones y métodos de uso |
-
2013
- 2013-09-27 AU AU2013323188A patent/AU2013323188B2/en not_active Ceased
- 2013-09-27 US US14/432,104 patent/US9913855B2/en active Active
- 2013-09-27 US US14/039,748 patent/US9163055B2/en not_active Expired - Fee Related
- 2013-09-27 EP EP13842176.3A patent/EP2900680A4/en not_active Withdrawn
- 2013-09-27 WO PCT/US2013/062413 patent/WO2014052896A1/en not_active Ceased
- 2013-09-27 JP JP2015534772A patent/JP6523958B2/ja not_active Expired - Fee Related
- 2013-09-27 CA CA2885369A patent/CA2885369A1/en not_active Abandoned
-
2015
- 2015-10-16 US US14/885,773 patent/US9750760B2/en not_active Expired - Fee Related
-
2018
- 2018-02-20 US US15/900,570 patent/US10632138B2/en not_active Expired - Fee Related
- 2018-04-05 AU AU2018202405A patent/AU2018202405A1/en not_active Abandoned
-
2019
- 2019-01-15 JP JP2019004203A patent/JP6913698B2/ja not_active Expired - Fee Related
-
2020
- 2020-04-15 US US16/849,946 patent/US11241450B2/en active Active
-
2022
- 2022-01-31 US US17/589,864 patent/US20230012655A1/en not_active Abandoned