JP2015529255A - 治療薬の持続放出のための多層の生体分解可能なマイクロ粒子 - Google Patents

治療薬の持続放出のための多層の生体分解可能なマイクロ粒子 Download PDF

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Publication number
JP2015529255A
JP2015529255A JP2015533228A JP2015533228A JP2015529255A JP 2015529255 A JP2015529255 A JP 2015529255A JP 2015533228 A JP2015533228 A JP 2015533228A JP 2015533228 A JP2015533228 A JP 2015533228A JP 2015529255 A JP2015529255 A JP 2015529255A
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composition
polymer
solvent
molecular weight
layer
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JP2015533228A
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Japanese (ja)
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JP2015529255A5 (enExample
Inventor
クリス ローズ，
クリス ローズ，
ニキータ マラビア，
ニキータ マラビア，
ロバート ジェニングス，
ロバート ジェニングス，
レディ ラクスマ，
レディ ラクスマ，
ベティー ノーマン，
ベティー ノーマン，
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OHR Pharma LLC
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OHR Pharma LLC
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Publication of JP2015529255A publication Critical patent/JP2015529255A/ja
Publication of JP2015529255A5 publication Critical patent/JP2015529255A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015533228A 2012-09-20 2013-09-20 治療薬の持続放出のための多層の生体分解可能なマイクロ粒子 Pending JP2015529255A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261703743P 2012-09-20 2012-09-20
US61/703,743 2012-09-20
PCT/US2013/060987 WO2014047477A2 (en) 2012-09-20 2013-09-20 Multilayer biodegradable microparticles for sustained release of therapeutic agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019021923A Division JP2019089824A (ja) 2012-09-20 2019-02-08 治療薬の持続放出のための多層の生体分解可能なマイクロ粒子

Publications (2)

Publication Number Publication Date
JP2015529255A true JP2015529255A (ja) 2015-10-05
JP2015529255A5 JP2015529255A5 (enExample) 2016-10-27

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JP2015533228A Pending JP2015529255A (ja) 2012-09-20 2013-09-20 治療薬の持続放出のための多層の生体分解可能なマイクロ粒子
JP2019021923A Pending JP2019089824A (ja) 2012-09-20 2019-02-08 治療薬の持続放出のための多層の生体分解可能なマイクロ粒子

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JP2019021923A Pending JP2019089824A (ja) 2012-09-20 2019-02-08 治療薬の持続放出のための多層の生体分解可能なマイクロ粒子

Country Status (9)

Country Link
US (2) US20140093552A1 (enExample)
EP (1) EP2897597B1 (enExample)
JP (2) JP2015529255A (enExample)
KR (1) KR20150083841A (enExample)
AU (3) AU2013317842A1 (enExample)
BR (1) BR112015006141A2 (enExample)
HK (1) HK1213178A1 (enExample)
MX (1) MX2015003658A (enExample)
WO (1) WO2014047477A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2974348A1 (en) * 2015-01-19 2016-07-28 The Regents Of The University Of Michigan Multiphasic particles fabricated by wettability engendered templated self-assembly (wets) methods
CN115920125B (zh) * 2022-11-30 2024-07-26 爱美客技术发展股份有限公司 一种复合凝胶及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003517446A (ja) * 1998-11-11 2003-05-27 フアーマシア・アー・ベー 新規制御放出ビーズ、その製造方法、およびそれを含む多重ユニット製剤
US20040115279A1 (en) * 2002-09-06 2004-06-17 The Ohio State University Microfabrication of polymer microparticles
JP2005112825A (ja) * 2003-10-10 2005-04-28 Ono Pharmaceut Co Ltd 胃内浮遊性固形製剤
JP2010001248A (ja) * 2008-06-20 2010-01-07 Bioserentack Co Ltd 酢酸リュープロレインの徐放性ミリ、マイクロカプセル
JP2010540533A (ja) * 2007-09-27 2010-12-24 アキナ、インコーポレイテッド ゾル−ゲル相可逆的ヒドロゲルテンプレート及びその用途
US20110256218A1 (en) * 2010-01-04 2011-10-20 Eurand, Inc. Controlled release compositions comprising meclizine or related piperazine derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5490962A (en) * 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
US8697117B2 (en) * 2010-08-02 2014-04-15 Ramot At Tel-Aviv University Ltd. Drug-eluting films

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003517446A (ja) * 1998-11-11 2003-05-27 フアーマシア・アー・ベー 新規制御放出ビーズ、その製造方法、およびそれを含む多重ユニット製剤
US20040115279A1 (en) * 2002-09-06 2004-06-17 The Ohio State University Microfabrication of polymer microparticles
JP2005112825A (ja) * 2003-10-10 2005-04-28 Ono Pharmaceut Co Ltd 胃内浮遊性固形製剤
JP2010540533A (ja) * 2007-09-27 2010-12-24 アキナ、インコーポレイテッド ゾル−ゲル相可逆的ヒドロゲルテンプレート及びその用途
JP2010001248A (ja) * 2008-06-20 2010-01-07 Bioserentack Co Ltd 酢酸リュープロレインの徐放性ミリ、マイクロカプセル
US20110256218A1 (en) * 2010-01-04 2011-10-20 Eurand, Inc. Controlled release compositions comprising meclizine or related piperazine derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF CONTROLLED RELAESE, vol. 141, no. 3, JPN6018009204, 2010, pages 314 - 319, ISSN: 0003758993 *

Also Published As

Publication number Publication date
AU2020202040A1 (en) 2020-04-09
WO2014047477A2 (en) 2014-03-27
BR112015006141A2 (pt) 2019-11-19
EP2897597B1 (en) 2020-07-08
US20140093552A1 (en) 2014-04-03
AU2018205060A1 (en) 2018-07-26
US20170354611A1 (en) 2017-12-14
EP2897597A4 (en) 2016-05-11
EP2897597A2 (en) 2015-07-29
HK1213178A1 (zh) 2016-06-30
KR20150083841A (ko) 2015-07-20
AU2013317842A1 (en) 2015-04-30
WO2014047477A3 (en) 2014-06-19
JP2019089824A (ja) 2019-06-13
MX2015003658A (es) 2015-09-25

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