JP2015529132A - 医療用塗布器 - Google Patents
医療用塗布器 Download PDFInfo
- Publication number
- JP2015529132A JP2015529132A JP2015532572A JP2015532572A JP2015529132A JP 2015529132 A JP2015529132 A JP 2015529132A JP 2015532572 A JP2015532572 A JP 2015532572A JP 2015532572 A JP2015532572 A JP 2015532572A JP 2015529132 A JP2015529132 A JP 2015529132A
- Authority
- JP
- Japan
- Prior art keywords
- applicator
- dispenser
- predetermined amount
- drug
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims abstract description 101
- 239000007788 liquid Substances 0.000 claims abstract description 49
- 239000012530 fluid Substances 0.000 claims abstract description 9
- 238000004891 communication Methods 0.000 claims abstract description 7
- 229940079593 drug Drugs 0.000 claims description 73
- 206010040882 skin lesion Diseases 0.000 claims description 46
- 231100000444 skin lesion Toxicity 0.000 claims description 46
- 238000000034 method Methods 0.000 claims description 16
- 230000035515 penetration Effects 0.000 claims description 10
- 230000007246 mechanism Effects 0.000 claims description 9
- 238000012546 transfer Methods 0.000 claims description 8
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 6
- 201000004624 Dermatitis Diseases 0.000 claims description 6
- 206010000496 acne Diseases 0.000 claims description 6
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 6
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims description 5
- 230000006378 damage Effects 0.000 claims description 4
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 3
- 206010020649 Hyperkeratosis Diseases 0.000 claims description 3
- 201000004681 Psoriasis Diseases 0.000 claims description 3
- 206010039796 Seborrhoeic keratosis Diseases 0.000 claims description 3
- 208000000260 Warts Diseases 0.000 claims description 3
- 208000009621 actinic keratosis Diseases 0.000 claims description 3
- 208000010668 atopic eczema Diseases 0.000 claims description 3
- 235000019253 formic acid Nutrition 0.000 claims description 3
- 208000007098 intradermal nevus Diseases 0.000 claims description 3
- 230000003211 malignant effect Effects 0.000 claims description 3
- 201000003385 seborrheic keratosis Diseases 0.000 claims description 3
- 201000010153 skin papilloma Diseases 0.000 claims description 3
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 2
- 206010027145 Melanocytic naevus Diseases 0.000 claims description 2
- 238000001467 acupuncture Methods 0.000 claims description 2
- 201000008937 atopic dermatitis Diseases 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 description 34
- 210000003491 skin Anatomy 0.000 description 10
- 239000000463 material Substances 0.000 description 7
- 230000003902 lesion Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 239000004417 polycarbonate Substances 0.000 description 4
- 229920000515 polycarbonate Polymers 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 229920002725 thermoplastic elastomer Polymers 0.000 description 4
- 239000004063 acid-resistant material Substances 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 239000004812 Fluorinated ethylene propylene Substances 0.000 description 2
- 239000002033 PVDF binder Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 2
- 239000005038 ethylene vinyl acetate Substances 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 230000036074 healthy skin Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920009441 perflouroethylene propylene Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- -1 polytetrafluoroethylene Polymers 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 2
- 208000008742 seborrheic dermatitis Diseases 0.000 description 2
- 206010059313 Anogenital warts Diseases 0.000 description 1
- 206010003645 Atopy Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000002681 cryosurgery Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
- A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Medicinal Preparation (AREA)
- Coating Apparatus (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (20)
- 薬剤を投与するための塗布器であって、
ディスペンサと流体連通した容器を備え、
前記ディスペンサが、前記容器から送達される所定量の液体薬剤を保持するように構成された複数の非変形構造体を有し、
前記ディスペンサが、ある表面に接触すると、前記所定量の前記液体薬剤の少なくとも一部を前記表面に送達可能である、塗布器。 - 前記複数の非変形構造体が、毛細管力によって前記所定量の前記液体薬剤を保持するように構成されている、請求項1に記載の塗布器。
- 前記表面に接触したときの前記所定量の前記薬剤の少なくとも一部の前記表面への送達が、毛細管移送によって行われる、請求項2に記載の塗布器。
- 前記複数の非変形構造体が溝又は凹部である、請求項1に記載の塗布器。
- 前記ディスペンサの組織接触面が、組織浸透又は破壊を行うように構成されている、請求項1に記載の塗布器。
- 前記容器から前記ディスペンサへの前記所定量の前記薬剤の放出を作動させるように構成された機構を更に備える、請求項1に記載の塗布器。
- 前記薬剤の前記所定量が約1μL〜約100μLである、請求項6に記載の塗布器。
- 前記薬剤の前記所定量が約5μLである、請求項6に記載の塗布器。
- 前記容器が変形可能な容器である、請求項1に記載の塗布器。
- 前記容器内に前記薬剤を更に備える、請求項1に記載の塗布器。
- 前記薬剤がトリクロロ酢酸を含む、請求項10に記載の塗布器。
- 前記薬剤がギ酸を更に含む、請求項11に記載の塗布器。
- 皮膚病変を治療する方法であって、
(a)所定量の液体薬剤を、容器から、前記所定量の前記液体薬剤を保持するように構成された複数の非変形構造体を有する流体接続されたディスペンサへと流通させることと、
(b)前記ディスペンサを前記皮膚病変に接触させることによって、前記所定量の前記液体薬剤の少なくとも一部を前記皮膚病変へと送達することと
を含む方法。 - 前記複数の非変形構造体が、毛細管力によって前記所定量の前記液体薬剤を保持するように構成されている、請求項13に記載の方法。
- 前記送達が毛細管移送によって実施される、請求項14に記載の方法。
- 前記ディスペンサを前記皮膚病変に押し付けることによって前記薬剤の前記皮膚病変組織への浸透を促進させることを更に含む、請求項15に記載の方法。
- 前記複数の非変形構造体が溝又は凹部である、請求項13に記載の方法。
- 前記ディスペンサの組織接触面が、組織浸透又は破壊を行うように構成されており、更に、前記接触の結果、前記送達に付随して前記皮膚病変の表面の浸透又は破壊が生じる、請求項13に記載の方法。
- 前記皮膚病変が良性又は悪性の皮膚病変である、請求項13に記載の方法。
- 前記皮膚病変が、脂漏性角化症、光線性角化症、真皮内母斑、いぼ、尖圭コンジローム、脂漏性皮膚炎、アトピー性皮膚炎、湿疹、過角化症、座瘡(尋常性座瘡)及び乾癬からなる群から選択される、請求項13に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261702752P | 2012-09-19 | 2012-09-19 | |
US61/702,752 | 2012-09-19 | ||
PCT/IL2013/050783 WO2014045277A1 (en) | 2012-09-19 | 2013-09-15 | Medical applicator |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019091814A Division JP2019166336A (ja) | 2012-09-19 | 2019-05-15 | 医療用塗布器 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2015529132A true JP2015529132A (ja) | 2015-10-05 |
JP2015529132A5 JP2015529132A5 (ja) | 2016-11-10 |
JP6609183B2 JP6609183B2 (ja) | 2019-11-20 |
Family
ID=49485772
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015532572A Active JP6609183B2 (ja) | 2012-09-19 | 2013-09-15 | 医療用塗布器 |
JP2019091814A Pending JP2019166336A (ja) | 2012-09-19 | 2019-05-15 | 医療用塗布器 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019091814A Pending JP2019166336A (ja) | 2012-09-19 | 2019-05-15 | 医療用塗布器 |
Country Status (19)
Country | Link |
---|---|
US (1) | US10449342B2 (ja) |
EP (1) | EP2897681B1 (ja) |
JP (2) | JP6609183B2 (ja) |
CN (1) | CN104755127B (ja) |
AU (1) | AU2013319782B2 (ja) |
CA (1) | CA2884586A1 (ja) |
CY (1) | CY1123544T1 (ja) |
DK (1) | DK2897681T3 (ja) |
EA (1) | EA030718B1 (ja) |
ES (1) | ES2795448T3 (ja) |
HR (1) | HRP20200879T1 (ja) |
HU (1) | HUE049313T2 (ja) |
IL (1) | IL237776B (ja) |
LT (1) | LT2897681T (ja) |
NZ (1) | NZ706047A (ja) |
PT (1) | PT2897681T (ja) |
RS (1) | RS60435B1 (ja) |
SI (1) | SI2897681T1 (ja) |
WO (1) | WO2014045277A1 (ja) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170100575A1 (en) * | 2015-10-08 | 2017-04-13 | Clixit, Llc | Pre-filled Pen Type Applicator with Novel Topical Acne Preparations |
EP3538196A1 (en) * | 2016-11-08 | 2019-09-18 | Medical Brands Research B.V. | Applicator device |
US10179678B2 (en) | 2017-04-26 | 2019-01-15 | The Hartz Mountain Corporation | Applicator with breakaway cap |
USD939696S1 (en) * | 2019-05-14 | 2021-12-28 | Medline Industries, Lp | Applicator |
US11590018B2 (en) | 2019-05-14 | 2023-02-28 | Medline Industries, Lp | Fecal management applicator and assembly |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56135451U (ja) * | 1980-03-14 | 1981-10-14 | ||
JP2003509164A (ja) * | 1999-09-22 | 2003-03-11 | ビー・ロン・ジョンソン | 単純疱疹のような障害組織を治療するための、振動させて抗感染性組成物を送達させるシステム |
JP2005537058A (ja) * | 2002-08-29 | 2005-12-08 | ベクトン・ディキンソン・アンド・カンパニー | 回転マイクロ剥離面による物質送達 |
US20070110506A1 (en) * | 2005-11-12 | 2007-05-17 | Conopco, Inc., D/B/A Unilever | Capillary dispenser |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
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SE333624B (ja) * | 1969-07-28 | 1971-03-22 | Perpedos Ab | |
US4583982A (en) * | 1984-08-24 | 1986-04-22 | Vlock D G | Fluid dispenser |
FR2633187A1 (fr) | 1988-06-23 | 1989-12-29 | Gafner Paul Felix | Dispositif applicateur cutane d'une solution medicamenteuse pour le traitement dermatologique |
US5851079A (en) * | 1996-10-25 | 1998-12-22 | The Procter & Gamble Company | Simplified undirectional twist-up dispensing device with incremental dosing |
US8173709B2 (en) * | 1999-09-22 | 2012-05-08 | Quadex Pharmaceuticals, Llc | Anti-infective methods for treating pathogen-induced disordered tissues |
ES2325951T3 (es) * | 2001-08-29 | 2009-09-25 | Pharmakodex Limited | Dispositivo de administracion topica. |
US7128903B2 (en) * | 2001-10-03 | 2006-10-31 | Innovative Pharmaceutical Concepts (Ipc) Inc. | Pharmaceutical preparations useful for treating tumors and lesions of the skin and the mucous membranes and methods and kits using same |
US6869421B2 (en) * | 2002-12-09 | 2005-03-22 | Gary L. Hanley | Device for non-gravity presentation of a liquid droplet |
US7658728B2 (en) * | 2006-01-10 | 2010-02-09 | Yuzhakov Vadim V | Microneedle array, patch, and applicator for transdermal drug delivery |
CA2705550A1 (en) * | 2007-11-12 | 2009-05-22 | Antares Pharma Ipl Ag | Metered gel dispenser |
US9056193B2 (en) * | 2008-01-29 | 2015-06-16 | Edge Systems Llc | Apparatus and method for treating the skin |
CA2736884A1 (en) * | 2008-09-17 | 2010-03-25 | Patrick D. Mcgrath | Antimicrobial sucralfate paste methods and compositions |
US9427560B2 (en) | 2010-08-11 | 2016-08-30 | Innovative Pharmaceutical Comcepts (Ipc) Inc. | Active agent delivery device |
-
2013
- 2013-09-15 EP EP13782857.0A patent/EP2897681B1/en active Active
- 2013-09-15 NZ NZ706047A patent/NZ706047A/en unknown
- 2013-09-15 SI SI201331734T patent/SI2897681T1/sl unknown
- 2013-09-15 US US14/429,593 patent/US10449342B2/en active Active
- 2013-09-15 JP JP2015532572A patent/JP6609183B2/ja active Active
- 2013-09-15 RS RS20200655A patent/RS60435B1/sr unknown
- 2013-09-15 AU AU2013319782A patent/AU2013319782B2/en active Active
- 2013-09-15 EA EA201500242A patent/EA030718B1/ru not_active IP Right Cessation
- 2013-09-15 PT PT137828570T patent/PT2897681T/pt unknown
- 2013-09-15 HU HUE13782857A patent/HUE049313T2/hu unknown
- 2013-09-15 CA CA 2884586 patent/CA2884586A1/en not_active Abandoned
- 2013-09-15 DK DK13782857.0T patent/DK2897681T3/da active
- 2013-09-15 WO PCT/IL2013/050783 patent/WO2014045277A1/en active Application Filing
- 2013-09-15 LT LTEP13782857.0T patent/LT2897681T/lt unknown
- 2013-09-15 ES ES13782857T patent/ES2795448T3/es active Active
- 2013-09-15 CN CN201380048904.5A patent/CN104755127B/zh active Active
-
2015
- 2015-03-16 IL IL237776A patent/IL237776B/en active IP Right Grant
-
2019
- 2019-05-15 JP JP2019091814A patent/JP2019166336A/ja active Pending
-
2020
- 2020-06-02 HR HRP20200879TT patent/HRP20200879T1/hr unknown
- 2020-06-04 CY CY20201100498T patent/CY1123544T1/el unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56135451U (ja) * | 1980-03-14 | 1981-10-14 | ||
JP2003509164A (ja) * | 1999-09-22 | 2003-03-11 | ビー・ロン・ジョンソン | 単純疱疹のような障害組織を治療するための、振動させて抗感染性組成物を送達させるシステム |
JP2005537058A (ja) * | 2002-08-29 | 2005-12-08 | ベクトン・ディキンソン・アンド・カンパニー | 回転マイクロ剥離面による物質送達 |
US20070110506A1 (en) * | 2005-11-12 | 2007-05-17 | Conopco, Inc., D/B/A Unilever | Capillary dispenser |
Also Published As
Publication number | Publication date |
---|---|
JP6609183B2 (ja) | 2019-11-20 |
SI2897681T1 (sl) | 2020-10-30 |
CN104755127A (zh) | 2015-07-01 |
HUE049313T2 (hu) | 2020-09-28 |
DK2897681T3 (da) | 2020-06-15 |
PT2897681T (pt) | 2020-06-17 |
ES2795448T3 (es) | 2020-11-23 |
LT2897681T (lt) | 2020-07-10 |
IL237776B (en) | 2020-03-31 |
NZ706047A (en) | 2017-09-29 |
CA2884586A1 (en) | 2014-03-27 |
JP2019166336A (ja) | 2019-10-03 |
CN104755127B (zh) | 2019-01-15 |
IL237776A0 (en) | 2015-05-31 |
EA201500242A1 (ru) | 2016-03-31 |
RS60435B1 (sr) | 2020-07-31 |
EA030718B1 (ru) | 2018-09-28 |
US10449342B2 (en) | 2019-10-22 |
CY1123544T1 (el) | 2022-03-24 |
AU2013319782B2 (en) | 2018-07-05 |
EP2897681A1 (en) | 2015-07-29 |
EP2897681B1 (en) | 2020-03-04 |
WO2014045277A1 (en) | 2014-03-27 |
US20150246212A1 (en) | 2015-09-03 |
HRP20200879T1 (hr) | 2020-09-04 |
AU2013319782A1 (en) | 2015-04-02 |
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