JP2015528472A5 - - Google Patents

Info

Publication number

JP2015528472A5

JP2015528472A5 JP2015531408A JP2015531408A JP2015528472A5 JP 2015528472 A5 JP2015528472 A5 JP 2015528472A5 JP 2015531408 A JP2015531408 A JP 2015531408A JP 2015531408 A JP2015531408 A JP 2015531408A JP 2015528472 A5 JP2015528472 A5 JP 2015528472A5

Authority

JP

Japan

Prior art keywords

composition

xanthene

eosin

biophotonic

fluorescein

Prior art date

2013-09-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000001018 xanthene dye Substances 0.000 claims 17
• SEACYXSIPDVVMV-UHFFFAOYSA-L eosin Y Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 SEACYXSIPDVVMV-UHFFFAOYSA-L 0.000 claims 7
• 230000003287 optical effect Effects 0.000 claims 7
• GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 6
• IICCLYANAQEHCI-UHFFFAOYSA-N 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodospiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C(C(=C(Cl)C(Cl)=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 IICCLYANAQEHCI-UHFFFAOYSA-N 0.000 claims 4
• 229930187593 rose bengal Natural products 0.000 claims 4
• 229940081623 rose bengal Drugs 0.000 claims 4
• STRXNPAVPKGJQR-UHFFFAOYSA-N rose bengal A Natural products O1C(=O)C(C(=CC=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 STRXNPAVPKGJQR-UHFFFAOYSA-N 0.000 claims 4
• 238000000862 absorption spectrum Methods 0.000 claims 3
• 238000000295 emission spectrum Methods 0.000 claims 3
• 230000004913 activation Effects 0.000 claims 2
• 230000031700 light absorption Effects 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 230000000699 topical effect Effects 0.000 claims 2
• 238000001429 visible spectrum Methods 0.000 claims 2
• 102100034871 C-C motif chemokine 8 Human genes 0.000 claims 1
• 101710155833 C-C motif chemokine 8 Proteins 0.000 claims 1
• 102100036150 C-X-C motif chemokine 5 Human genes 0.000 claims 1
• 102000008186 Collagen Human genes 0.000 claims 1
• 108010035532 Collagen Proteins 0.000 claims 1
• 101100441523 Homo sapiens CXCL5 gene Proteins 0.000 claims 1
• 101001013150 Homo sapiens Interstitial collagenase Proteins 0.000 claims 1
• 101000990908 Homo sapiens Neutrophil collagenase Proteins 0.000 claims 1
• 101000990915 Homo sapiens Stromelysin-1 Proteins 0.000 claims 1
• 101000577874 Homo sapiens Stromelysin-2 Proteins 0.000 claims 1
• 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 claims 1
• 102100030411 Neutrophil collagenase Human genes 0.000 claims 1
• 241000220317 Rosa Species 0.000 claims 1
• 102100030416 Stromelysin-1 Human genes 0.000 claims 1
• 102100028848 Stromelysin-2 Human genes 0.000 claims 1
• 206010052428 Wound Diseases 0.000 claims 1
• 208000027418 Wounds and injury Diseases 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 230000003213 activating effect Effects 0.000 claims 1
• 230000033115 angiogenesis Effects 0.000 claims 1
• SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical group C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 229920001436 collagen Polymers 0.000 claims 1
• AEUKDPKXTPNBNY-XEYRWQBLSA-N mcp 2 Chemical compound C([C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)C1=CC=CC=C1 AEUKDPKXTPNBNY-XEYRWQBLSA-N 0.000 claims 1
• GVKCHTBDSMQENH-UHFFFAOYSA-L phloxine B Chemical compound [Na+].[Na+].[O-]C(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 GVKCHTBDSMQENH-UHFFFAOYSA-L 0.000 claims 1
• 230000001737 promoting effect Effects 0.000 claims 1
• 230000003716 rejuvenation Effects 0.000 claims 1
• 208000017520 skin disease Diseases 0.000 claims 1
• 230000017423 tissue regeneration Effects 0.000 claims 1