JP2015525784A5 - - Google Patents
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- Publication number
- JP2015525784A5 JP2015525784A5 JP2015525632A JP2015525632A JP2015525784A5 JP 2015525784 A5 JP2015525784 A5 JP 2015525784A5 JP 2015525632 A JP2015525632 A JP 2015525632A JP 2015525632 A JP2015525632 A JP 2015525632A JP 2015525784 A5 JP2015525784 A5 JP 2015525784A5
- Authority
- JP
- Japan
- Prior art keywords
- vaccine
- vaccine according
- alkyl
- antigen
- fusion polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960005486 vaccine Drugs 0.000 claims 58
- 239000000427 antigen Substances 0.000 claims 23
- 102000036639 antigens Human genes 0.000 claims 23
- 108091007433 antigens Proteins 0.000 claims 23
- 201000008827 tuberculosis Diseases 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 208000015181 infectious disease Diseases 0.000 claims 15
- 230000004927 fusion Effects 0.000 claims 14
- 229920001184 polypeptide Polymers 0.000 claims 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims 14
- 208000036981 active tuberculosis Diseases 0.000 claims 12
- 241000124008 Mammalia Species 0.000 claims 9
- 241000186359 Mycobacterium Species 0.000 claims 6
- 239000002246 antineoplastic agent Substances 0.000 claims 6
- 229940127089 cytotoxic agent Drugs 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 241000187488 Mycobacterium sp. Species 0.000 claims 4
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 241001467552 Mycobacterium bovis BCG Species 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 229960000190 bacillus calmette–guérin vaccine Drugs 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002685 pulmonary effect Effects 0.000 claims 2
- 238000010186 staining Methods 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 206010008479 Chest Pain Diseases 0.000 claims 1
- 206010011224 Cough Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 208000000616 Hemoptysis Diseases 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 208000022531 anorexia Diseases 0.000 claims 1
- 230000004596 appetite loss Effects 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000007821 culture assay Methods 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 229960003350 isoniazid Drugs 0.000 claims 1
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 claims 1
- 208000019017 loss of appetite Diseases 0.000 claims 1
- 235000021266 loss of appetite Nutrition 0.000 claims 1
- 210000003097 mucus Anatomy 0.000 claims 1
- 201000009671 multidrug-resistant tuberculosis Diseases 0.000 claims 1
- 206010029410 night sweats Diseases 0.000 claims 1
- 230000036565 night sweats Effects 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 claims 1
- 229960001225 rifampicin Drugs 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
- 208000016261 weight loss Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261679612P | 2012-08-03 | 2012-08-03 | |
| US61/679,612 | 2012-08-03 | ||
| US201361791213P | 2013-03-15 | 2013-03-15 | |
| US61/791,213 | 2013-03-15 | ||
| PCT/US2013/053482 WO2014042780A1 (en) | 2012-08-03 | 2013-08-02 | Compositions and methods for treating an active mycobacterium tuberculosis infection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015525784A JP2015525784A (ja) | 2015-09-07 |
| JP2015525784A5 true JP2015525784A5 (https=) | 2016-09-23 |
Family
ID=50278593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015525632A Pending JP2015525784A (ja) | 2012-08-03 | 2013-08-02 | 活動性結核菌感染を治療するための組成物及び方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20150182612A1 (https=) |
| EP (2) | EP2879701B1 (https=) |
| JP (1) | JP2015525784A (https=) |
| CN (1) | CN104812404A (https=) |
| BR (1) | BR112015002483A2 (https=) |
| ES (1) | ES2969734T3 (https=) |
| HR (1) | HRP20240164T1 (https=) |
| HU (1) | HUE065746T2 (https=) |
| MX (1) | MX385774B (https=) |
| PT (1) | PT2879701T (https=) |
| RU (1) | RU2659149C2 (https=) |
| WO (1) | WO2014042780A1 (https=) |
| ZA (2) | ZA201501242B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190009308A (ko) * | 2016-05-21 | 2019-01-28 | 인펙셔스 디지즈 리서치 인스티튜트 (아이디알아이) | 2차 결핵 및 비결핵성 마이코박테리아 감염을 치료하기 위한 조성물 및 방법 |
| GB201909953D0 (en) * | 2019-07-11 | 2019-08-28 | Sec Dep For Environment Food And Rural Affairs Acting Through The Animal And Plant Health Agency | Diagnostic reagents |
| US11679163B2 (en) | 2019-09-20 | 2023-06-20 | Hdt Bio Corp. | Compositions and methods for delivery of RNA |
| CA3172489A1 (en) | 2020-03-23 | 2021-09-30 | Amit KHANDHAR | Nanoemulsion compositions and methods for delivery of nra |
| CN117120087A (zh) | 2020-12-23 | 2023-11-24 | 高级健康研究所 | 茄尼醇疫苗助剂及其制备方法 |
| EP4404919A4 (en) | 2021-09-22 | 2025-08-20 | Hdt Bio Corp | DRIED NANOPARTICLE COMPOSITIONS |
| JP2024535354A (ja) | 2021-09-22 | 2024-09-30 | エイチディーティー バイオ コーポレーション | がん治療組成物およびその使用 |
| EP4405372A4 (en) | 2021-09-22 | 2026-01-14 | Hdt Bio Corp | SARS-CoV-2 RNA VACCINE COMPOSITIONS AND METHODS OF USE |
| KR20240096468A (ko) | 2021-09-22 | 2024-06-26 | 에이치디티 바이오 코포레이션 | 감염병에 대한 rna 백신 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US4866034A (en) | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
| US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
| US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5725871A (en) | 1989-08-18 | 1998-03-10 | Danbiosyst Uk Limited | Drug delivery compositions comprising lysophosphoglycerolipid |
| US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| US5466468A (en) | 1990-04-03 | 1995-11-14 | Ciba-Geigy Corporation | Parenterally administrable liposome formulation comprising synthetic lipids |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| US5756353A (en) | 1991-12-17 | 1998-05-26 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol-and liposome-based delivery |
| ES2105262T3 (es) | 1992-05-18 | 1997-10-16 | Minnesota Mining & Mfg | Dispositivo de suministro de farmaco a traves de las mucosas. |
| DK0671948T3 (da) | 1992-06-25 | 1997-09-01 | Smithkline Beecham Biolog | Vaccinepræparat indeholdende adjuvanser |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| ATE509102T1 (de) | 1994-07-15 | 2011-05-15 | Univ Iowa Res Found | Immunomodulatorische oligonukleotide |
| IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US5856462A (en) | 1996-09-10 | 1999-01-05 | Hybridon Incorporated | Oligonucleotides having modified CpG dinucleosides |
| GB9727262D0 (en) | 1997-12-24 | 1998-02-25 | Smithkline Beecham Biolog | Vaccine |
| IL138000A0 (en) | 1998-04-09 | 2001-10-31 | Smithkline Beecham Biolog | Adjuvant compositions |
| US7049302B1 (en) | 1998-08-10 | 2006-05-23 | Antigenics Inc. | Compositions of CPG and saponin adjuvants and uses thereof |
| US7472098B2 (en) | 2000-02-14 | 2008-12-30 | Ubs Financial Services, Inc. | System and method for execution of trades made pursuant to stock option and purchase plans |
| RU2262950C2 (ru) * | 2001-03-23 | 2005-10-27 | Каунсил Оф Сайентифик Энд Индастриал Рисерч | Способ получения вакцины для лечения туберкулеза и других внутриклеточных инфекционных заболеваний и вакцина, полученная по названному способу |
| GB0125535D0 (en) * | 2001-10-24 | 2001-12-12 | Microbiological Res Authority | Mycobacterial genes down-regulated during latency |
| EP2426141B1 (en) * | 2005-04-29 | 2014-10-01 | GlaxoSmithKline Biologicals S.A. | Method for preventing or treating M tuberculosis infection |
| EP1991213A2 (en) * | 2006-02-08 | 2008-11-19 | Fasgen, Inc. | Anti-mycobacterial formulation comprising octanesulphonylacetamide (osa), nonanesulphonylacetamide (nsa) and decanesulphonylacetamide (dsa) |
| PT2468300T (pt) | 2006-09-26 | 2018-01-30 | Infectious Disease Res Inst | Composição para vacina contendo adjuvante sintético |
| ES2621211T3 (es) * | 2007-04-04 | 2017-07-03 | Infectious Disease Research Institute | Composiciones inmunogénicas que comprenden polipéptidos de mycobacterium tuberculosis y fusiones de los mismos |
| WO2010010178A1 (en) * | 2008-07-25 | 2010-01-28 | Glaxosmithkline Biologicals S.A | The tuberculosis rv2707c protein, compositions and uses thereof |
| CA2732750A1 (en) * | 2008-09-22 | 2010-03-25 | The Government Of The United States Of America D.B.A.The Department Of V Eterans Affairs | Methods for detecting a mycobacterium tuberculosis infection |
| GB201008512D0 (en) * | 2010-05-21 | 2010-07-07 | Health Prot Agency | Mycobacterial antigen composition |
| EP2618838A1 (en) * | 2010-09-20 | 2013-07-31 | Crucell Holland B.V. | Therapeutic vaccination against active tuberculosis |
-
2013
- 2013-08-02 MX MX2015001557A patent/MX385774B/es unknown
- 2013-08-02 JP JP2015525632A patent/JP2015525784A/ja active Pending
- 2013-08-02 EP EP13836324.7A patent/EP2879701B1/en active Active
- 2013-08-02 CN CN201380051732.7A patent/CN104812404A/zh active Pending
- 2013-08-02 HR HRP20240164TT patent/HRP20240164T1/hr unknown
- 2013-08-02 PT PT138363247T patent/PT2879701T/pt unknown
- 2013-08-02 BR BR112015002483A patent/BR112015002483A2/pt not_active Application Discontinuation
- 2013-08-02 HU HUE13836324A patent/HUE065746T2/hu unknown
- 2013-08-02 US US14/419,477 patent/US20150182612A1/en not_active Abandoned
- 2013-08-02 WO PCT/US2013/053482 patent/WO2014042780A1/en not_active Ceased
- 2013-08-02 ES ES13836324T patent/ES2969734T3/es active Active
- 2013-08-02 RU RU2015107435A patent/RU2659149C2/ru active
- 2013-08-02 EP EP23206775.1A patent/EP4299138A3/en active Pending
-
2015
- 2015-02-24 ZA ZA2015/01242A patent/ZA201501242B/en unknown
-
2017
- 2017-03-24 ZA ZA2017/02091A patent/ZA201702091B/en unknown
-
2018
- 2018-09-10 US US16/126,285 patent/US11369672B2/en active Active
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