JP2015523326A5 - - Google Patents
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- Publication number
- JP2015523326A5 JP2015523326A5 JP2015510839A JP2015510839A JP2015523326A5 JP 2015523326 A5 JP2015523326 A5 JP 2015523326A5 JP 2015510839 A JP2015510839 A JP 2015510839A JP 2015510839 A JP2015510839 A JP 2015510839A JP 2015523326 A5 JP2015523326 A5 JP 2015523326A5
- Authority
- JP
- Japan
- Prior art keywords
- moiety
- tissue targeting
- complex according
- targeting moiety
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000008685 targeting Effects 0.000 claims 15
- 238000000034 method Methods 0.000 claims 8
- 239000003446 ligand Substances 0.000 claims 7
- 230000008878 coupling Effects 0.000 claims 6
- 238000010168 coupling process Methods 0.000 claims 6
- 238000005859 coupling reaction Methods 0.000 claims 6
- 239000007864 aqueous solution Substances 0.000 claims 5
- SNUSZUYTMHKCPM-UHFFFAOYSA-N 1-hydroxypyridin-2-one Chemical compound ON1C=CC=CC1=O SNUSZUYTMHKCPM-UHFFFAOYSA-N 0.000 claims 4
- ZSLUVFAKFWKJRC-IGMARMGPSA-N 232Th Chemical compound [232Th] ZSLUVFAKFWKJRC-IGMARMGPSA-N 0.000 claims 4
- 229910052776 Thorium Inorganic materials 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- GQZXNSPRSGFJLY-UHFFFAOYSA-N hydroxyphosphanone Chemical group OP=O GQZXNSPRSGFJLY-UHFFFAOYSA-N 0.000 claims 4
- 150000002500 ions Chemical class 0.000 claims 4
- 230000002285 radioactive effect Effects 0.000 claims 4
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 3
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 230000003381 solubilizing effect Effects 0.000 claims 3
- 201000009030 Carcinoma Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010039491 Sarcoma Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 206010020718 hyperplasia Diseases 0.000 claims 2
- 230000002390 hyperplastic effect Effects 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- BUXKULRFRATXSI-UHFFFAOYSA-N 1-hydroxypyrrole-2,5-dione Chemical compound ON1C(=O)C=CC1=O BUXKULRFRATXSI-UHFFFAOYSA-N 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000005604 azodicarboxylate group Chemical group 0.000 claims 1
- 150000001718 carbodiimides Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201208309A GB201208309D0 (en) | 2012-05-11 | 2012-05-11 | Complexes |
| GB1208309.3 | 2012-05-11 | ||
| PCT/EP2013/059840 WO2013167755A1 (en) | 2012-05-11 | 2013-05-13 | Radio-pharmaceutical complexes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015523326A JP2015523326A (ja) | 2015-08-13 |
| JP2015523326A5 true JP2015523326A5 (https=) | 2016-06-16 |
Family
ID=46458687
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015510838A Expired - Fee Related JP6211066B2 (ja) | 2012-05-11 | 2013-05-13 | 放射性医薬錯体 |
| JP2015510839A Pending JP2015523326A (ja) | 2012-05-11 | 2013-05-13 | 放射性医薬錯体 |
| JP2015510840A Expired - Fee Related JP6219372B2 (ja) | 2012-05-11 | 2013-05-13 | 放射性医薬錯体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015510838A Expired - Fee Related JP6211066B2 (ja) | 2012-05-11 | 2013-05-13 | 放射性医薬錯体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015510840A Expired - Fee Related JP6219372B2 (ja) | 2012-05-11 | 2013-05-13 | 放射性医薬錯体 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9827336B2 (https=) |
| EP (3) | EP2846842A1 (https=) |
| JP (3) | JP6211066B2 (https=) |
| KR (3) | KR20150092702A (https=) |
| CN (3) | CN104619355A (https=) |
| CA (3) | CA2873144C (https=) |
| GB (1) | GB201208309D0 (https=) |
| HK (3) | HK1206982A1 (https=) |
| WO (3) | WO2013167754A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2511266B1 (en) | 2006-07-10 | 2019-09-04 | The Regents of The University of California | Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides |
| EP2816038B8 (en) | 2009-08-24 | 2019-12-25 | Lumiphore, Inc. | Hopo chelators |
| GB201002508D0 (en) | 2010-02-12 | 2010-03-31 | Algeta As | Product |
| GB201208309D0 (en) | 2012-05-11 | 2012-06-27 | Algeta As | Complexes |
| US11453652B2 (en) | 2013-03-15 | 2022-09-27 | Lumiphore, Inc. | Di-macrocycles |
| MA41176A (fr) * | 2014-12-17 | 2017-10-24 | Bayer As | Complexes radio-pharmaceutiques |
| US10821195B2 (en) * | 2015-09-10 | 2020-11-03 | Memorial Sloan Kettering Cancer Center | Compositions for therapeutics, targeted PET imaging and methods of their use |
| GB201600154D0 (en) * | 2016-01-05 | 2016-02-17 | Bayer As | Isotope preparation method |
| GB201600158D0 (en) * | 2016-01-05 | 2016-02-17 | Bayer As | Purification method |
| PE20190168A1 (es) * | 2016-03-24 | 2019-02-01 | Bayer Pharma AG | Complejos radiofarmaceuticos |
| WO2017211809A1 (en) | 2016-06-10 | 2017-12-14 | Bayer Pharma Aktiengesellschaft | Radio-pharmaceutical complexes |
| EP3585436A1 (en) | 2017-02-24 | 2020-01-01 | Bayer AS | Combination therapy comprising a radiopharmaceutical and a dna-repair inhibitor |
| CN111918877A (zh) * | 2018-03-14 | 2020-11-10 | 美国卫生和人力服务部 | 抗cd33嵌合抗原受体及其用途 |
| EP3843743A1 (en) | 2018-08-28 | 2021-07-07 | Bayer AS | Combination of pi3k-inhibitors and targeted thorium conjugates |
| US11279698B2 (en) * | 2018-11-20 | 2022-03-22 | Cornell University | Macrocyclic complexes of alpha-emitting radionuclides and their use in targeted radiotherapy of cancer |
| USD885822S1 (en) | 2018-12-14 | 2020-06-02 | Whirlpool Corporation | Food grinder |
| CA3130747A1 (en) | 2019-02-21 | 2020-08-27 | Bayer Aktiengesellschaft | Combination of pd-1/pd-l1 inhibitors and targeted thorium conjugates |
| CA3130809A1 (en) | 2019-02-22 | 2020-08-27 | Bayer Aktiengesellschaft | Combination of ar antagonists and targeted thorium conjugates |
| EP4003959A1 (en) | 2019-07-25 | 2022-06-01 | Bayer AS | Targeted radiopharmaceuticals for the diagnosis and treatment of prostate cancer |
| BR112022013678A2 (pt) * | 2020-01-10 | 2022-11-16 | Fusion Pharmaceuticals Inc | Quelatos macrocíclicos e seus usos |
| AU2020424030B2 (en) * | 2020-01-23 | 2025-05-29 | Radtran Llc | Systems and methods for preparing tailored radioactive isotope solutions |
| US20240000838A1 (en) * | 2020-11-30 | 2024-01-04 | Simcere Innovation, Inc. | Universal chimeric antigen receptor-expressing immune cells for allogeneic cell therapy |
| AU2022210371A1 (en) | 2021-01-22 | 2023-07-20 | Bayer Aktiengesellschaft | Lrrc15 antibodies and conjugates thereof |
| AU2024339683A1 (en) | 2023-09-13 | 2026-03-26 | Toray Industries, Inc. | Pharmaceutical composition for treating, preventing and/or diagnosing cancer |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4698431A (en) * | 1985-11-12 | 1987-10-06 | The United States Of America As Represented By The United States Department Of Energy | Hydroxypyridonate chelating agents |
| US5624901A (en) | 1994-04-15 | 1997-04-29 | The Regents Of The University Of California | 3-hydroxy-2(1H)-pyridinone chelating agents |
| US8383081B2 (en) * | 1999-05-10 | 2013-02-26 | Immunomedics, Inc. | Anti-CD74 immunoconjugates and methods of use |
| NO312708B1 (no) | 2000-02-21 | 2002-06-24 | Anticancer Therapeutic Inv Sa | Radioaktive liposomer til terapi |
| NO313180B1 (no) | 2000-07-04 | 2002-08-26 | Anticancer Therapeutic Inv Sa | Bensökende alfapartikkel emitterende radiofarmasöytika |
| GB0308731D0 (en) | 2003-04-15 | 2003-05-21 | Anticancer Therapeutic Inv Sa | Method of radiotherapy |
| EP2497501B1 (en) * | 2004-06-25 | 2019-05-01 | The European Union, represented by the European Commission | Radionuclides for medical use |
| US7794691B2 (en) * | 2004-06-25 | 2010-09-14 | The European Community, Represented By The European Commission | Radionuclides for medical use |
| WO2008063721A2 (en) | 2006-08-15 | 2008-05-29 | The Regents Of The University Of California | Luminescent macrocyclic lanthanide complexes |
| US8158804B2 (en) | 2007-01-11 | 2012-04-17 | Ge Healthcare As | Chelating agents |
| CA2768658C (en) * | 2009-07-22 | 2018-04-03 | Actinium Pharmaceuticals, Inc. | Methods for generating radioimmunoconjugates |
| WO2011079291A1 (en) * | 2009-12-24 | 2011-06-30 | Lumiphore, Inc. | Radiopharmaceutical complexes |
| EP2359802B1 (en) * | 2010-02-12 | 2014-06-18 | Evonik Degussa GmbH | Cosmetic composition containing polyglycerol partial ester |
| GB201002508D0 (en) | 2010-02-12 | 2010-03-31 | Algeta As | Product |
| GB201208309D0 (en) | 2012-05-11 | 2012-06-27 | Algeta As | Complexes |
-
2012
- 2012-05-11 GB GB201208309A patent/GB201208309D0/en not_active Ceased
-
2013
- 2013-05-13 US US14/400,026 patent/US9827336B2/en not_active Expired - Fee Related
- 2013-05-13 US US14/400,020 patent/US20150104385A1/en not_active Abandoned
- 2013-05-13 EP EP13721784.0A patent/EP2846842A1/en not_active Withdrawn
- 2013-05-13 KR KR1020147034743A patent/KR20150092702A/ko not_active Withdrawn
- 2013-05-13 CA CA2873144A patent/CA2873144C/en not_active Expired - Fee Related
- 2013-05-13 EP EP13725586.5A patent/EP2846844B1/en active Active
- 2013-05-13 US US14/400,031 patent/US20150147272A1/en not_active Abandoned
- 2013-05-13 JP JP2015510838A patent/JP6211066B2/ja not_active Expired - Fee Related
- 2013-05-13 CN CN201380036807.4A patent/CN104619355A/zh active Pending
- 2013-05-13 CN CN201380036905.8A patent/CN104540530A/zh active Pending
- 2013-05-13 KR KR1020147034742A patent/KR20150092701A/ko not_active Withdrawn
- 2013-05-13 WO PCT/EP2013/059839 patent/WO2013167754A1/en not_active Ceased
- 2013-05-13 WO PCT/EP2013/059840 patent/WO2013167755A1/en not_active Ceased
- 2013-05-13 CN CN201380035189.1A patent/CN104602716A/zh active Pending
- 2013-05-13 KR KR1020147034741A patent/KR20150092700A/ko not_active Withdrawn
- 2013-05-13 WO PCT/EP2013/059841 patent/WO2013167756A1/en not_active Ceased
- 2013-05-13 JP JP2015510839A patent/JP2015523326A/ja active Pending
- 2013-05-13 HK HK15107609.1A patent/HK1206982A1/xx unknown
- 2013-05-13 CA CA2873142A patent/CA2873142A1/en not_active Abandoned
- 2013-05-13 EP EP13721975.4A patent/EP2846843A1/en not_active Withdrawn
- 2013-05-13 HK HK15108017.5A patent/HK1207307A1/xx unknown
- 2013-05-13 HK HK15107608.2A patent/HK1206981A1/xx unknown
- 2013-05-13 CA CA 2873143 patent/CA2873143A1/en not_active Abandoned
- 2013-05-13 JP JP2015510840A patent/JP6219372B2/ja not_active Expired - Fee Related
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