JP2015523098A5 - - Google Patents
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- JP2015523098A5 JP2015523098A5 JP2015525450A JP2015525450A JP2015523098A5 JP 2015523098 A5 JP2015523098 A5 JP 2015523098A5 JP 2015525450 A JP2015525450 A JP 2015525450A JP 2015525450 A JP2015525450 A JP 2015525450A JP 2015523098 A5 JP2015523098 A5 JP 2015523098A5
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- JP
- Japan
- Prior art keywords
- eif4g
- animal
- modified
- protein
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 101710091919 Eukaryotic translation initiation factor 4G Proteins 0.000 claims 58
- 241001465754 Metazoa Species 0.000 claims 32
- 241000710198 Foot-and-mouth disease virus Species 0.000 claims 17
- 238000000034 method Methods 0.000 claims 17
- 108091005804 Peptidases Proteins 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 102000004190 Enzymes Human genes 0.000 claims 10
- 108090000790 Enzymes Proteins 0.000 claims 10
- 238000003776 cleavage reaction Methods 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 230000007017 scission Effects 0.000 claims 10
- 102000035195 Peptidases Human genes 0.000 claims 8
- 235000019833 protease Nutrition 0.000 claims 8
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 claims 7
- 108700028369 Alleles Proteins 0.000 claims 6
- 210000001161 mammalian embryo Anatomy 0.000 claims 5
- 239000004365 Protease Substances 0.000 claims 4
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 4
- 235000019419 proteases Nutrition 0.000 claims 4
- 241000894007 species Species 0.000 claims 4
- 241000251468 Actinopterygii Species 0.000 claims 3
- 241000283690 Bos taurus Species 0.000 claims 3
- 241000283707 Capra Species 0.000 claims 3
- 241000287828 Gallus gallus Species 0.000 claims 3
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 3
- 241001494479 Pecora Species 0.000 claims 3
- 108010029485 Protein Isoforms Proteins 0.000 claims 3
- 102000001708 Protein Isoforms Human genes 0.000 claims 3
- 241000282887 Suidae Species 0.000 claims 3
- 235000013330 chicken meat Nutrition 0.000 claims 3
- 238000010362 genome editing Methods 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 101710163270 Nuclease Proteins 0.000 claims 2
- 238000010459 TALEN Methods 0.000 claims 2
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 2
- 238000010367 cloning Methods 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 230000037442 genomic alteration Effects 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 108091033409 CRISPR Proteins 0.000 claims 1
- 238000010354 CRISPR gene editing Methods 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 210000002257 embryonic structure Anatomy 0.000 claims 1
- 230000014509 gene expression Effects 0.000 claims 1
- 235000003869 genetically modified organism Nutrition 0.000 claims 1
- 244000144972 livestock Species 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- -1 nucleic acid compound Chemical class 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261677904P | 2012-07-31 | 2012-07-31 | |
| US61/677,904 | 2012-07-31 | ||
| US13/836,860 US10058078B2 (en) | 2012-07-31 | 2013-03-15 | Production of FMDV-resistant livestock by allele substitution |
| US13/836,860 | 2013-03-15 | ||
| PCT/US2013/051222 WO2014022120A1 (en) | 2012-07-31 | 2013-07-19 | Production of fmdv-resistant livestock by allele substitution |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015523098A JP2015523098A (ja) | 2015-08-13 |
| JP2015523098A5 true JP2015523098A5 (https=) | 2016-09-08 |
| JP6446360B2 JP6446360B2 (ja) | 2018-12-26 |
Family
ID=50026918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015525450A Expired - Fee Related JP6446360B2 (ja) | 2012-07-31 | 2013-07-19 | 対立遺伝子置換によるｆｍｄｖ抵抗性家畜の産生 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10058078B2 (https=) |
| EP (2) | EP2880153A4 (https=) |
| JP (1) | JP6446360B2 (https=) |
| KR (1) | KR20150036792A (https=) |
| CN (1) | CN104837989A (https=) |
| AR (1) | AR091948A1 (https=) |
| AU (1) | AU2013296901B2 (https=) |
| BR (1) | BR112015002280A2 (https=) |
| CA (1) | CA2880616A1 (https=) |
| CL (1) | CL2015000248A1 (https=) |
| MX (1) | MX366723B (https=) |
| NZ (1) | NZ629582A (https=) |
| PH (1) | PH12015500213A1 (https=) |
| RU (1) | RU2015106818A (https=) |
| WO (1) | WO2014022120A1 (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2533629B1 (en) * | 2010-02-11 | 2018-11-28 | Recombinetics, Inc. | Methods and materials for producing transgenic artiodactyls |
| US10920242B2 (en) | 2011-02-25 | 2021-02-16 | Recombinetics, Inc. | Non-meiotic allele introgression |
| US9528124B2 (en) | 2013-08-27 | 2016-12-27 | Recombinetics, Inc. | Efficient non-meiotic allele introgression |
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US10058078B2 (en) | 2012-07-31 | 2018-08-28 | Recombinetics, Inc. | Production of FMDV-resistant livestock by allele substitution |
| CN105683376A (zh) * | 2013-05-15 | 2016-06-15 | 桑格摩生物科学股份有限公司 | 用于治疗遗传病状的方法和组合物 |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US10779518B2 (en) | 2013-10-25 | 2020-09-22 | Livestock Improvement Corporation Limited | Genetic markers and uses therefor |
| CN106459995B (zh) | 2013-11-07 | 2020-02-21 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| US20180142307A1 (en) * | 2014-02-11 | 2018-05-24 | California Institute Of Technology | Recording and mapping lineage information and molecular events in individual cells |
| MX375361B (es) * | 2014-03-26 | 2025-03-06 | Univ Maryland | Edicion de genoma dirigida en cigotos de animales grandes domesticos. |
| BR112016024945A2 (pt) | 2014-04-28 | 2017-10-24 | Recombinetics Inc | edição de gene multiplex em suínos |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| GB201617559D0 (en) | 2016-10-17 | 2016-11-30 | University Court Of The University Of Edinburgh The | Swine comprising modified cd163 and associated methods |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| WO2019216338A1 (ja) * | 2018-05-08 | 2019-11-14 | 国立大学法人大阪大学 | ホモ接合型細胞の作製方法 |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| CN108998406B (zh) * | 2018-08-03 | 2022-05-10 | 福州大学 | 一种人类原代培养细胞基因组编辑、定点基因敲入方法 |
| CN108998540A (zh) * | 2018-08-18 | 2018-12-14 | 兰州大学 | 绵羊eif2s3y基因的单核苷酸多态性标记及其检测引物、试剂盒、方法及应用 |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| CN111534519B (zh) * | 2020-05-26 | 2021-12-14 | 中国农业科学院北京畜牧兽医研究所 | 识别猪eIF4G1基因的sgRNA及其编码DNA和应用 |
| CN111944770B (zh) * | 2020-08-27 | 2022-04-15 | 中国农业科学院兰州兽医研究所 | 一种口蹄疫病毒致弱突变株及其制备方法和应用 |
| GB202118058D0 (en) | 2021-12-14 | 2022-01-26 | Univ Warwick | Methods to increase yields in crops |
| IL316038A (en) | 2022-04-04 | 2024-11-01 | Univ California | Preparations and methods for genetic complementation |
| KR102871704B1 (ko) * | 2022-06-16 | 2025-10-17 | 대한민국 | 구제역 바이러스에 저항성을 갖는 lc3 단백질을 암호화하는 유전자 편집 세포 및 이의 용도 |
| GB2621813A (en) | 2022-06-30 | 2024-02-28 | Univ Newcastle | Preventing disease recurrence in Mitochondrial replacement therapy |
| GB202314578D0 (en) | 2023-09-22 | 2023-11-08 | Univ Manchester | Methods of producing homoplasmic modified plants or parts thereof |
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| US10058078B2 (en) | 2012-07-31 | 2018-08-28 | Recombinetics, Inc. | Production of FMDV-resistant livestock by allele substitution |
-
2013
- 2013-03-15 US US13/836,860 patent/US10058078B2/en active Active
- 2013-07-19 MX MX2015001299A patent/MX366723B/es active IP Right Grant
- 2013-07-19 KR KR1020157005357A patent/KR20150036792A/ko not_active Ceased
- 2013-07-19 BR BR112015002280A patent/BR112015002280A2/pt not_active Application Discontinuation
- 2013-07-19 AU AU2013296901A patent/AU2013296901B2/en not_active Ceased
- 2013-07-19 RU RU2015106818A patent/RU2015106818A/ru not_active Application Discontinuation
- 2013-07-19 EP EP13825988.2A patent/EP2880153A4/en not_active Ceased
- 2013-07-19 CA CA2880616A patent/CA2880616A1/en not_active Abandoned
- 2013-07-19 EP EP19159141.1A patent/EP3540050A1/en not_active Withdrawn
- 2013-07-19 JP JP2015525450A patent/JP6446360B2/ja not_active Expired - Fee Related
- 2013-07-19 WO PCT/US2013/051222 patent/WO2014022120A1/en not_active Ceased
- 2013-07-19 NZ NZ629582A patent/NZ629582A/en not_active IP Right Cessation
- 2013-07-19 CN CN201380048009.3A patent/CN104837989A/zh active Pending
- 2013-07-31 AR ARP130102723A patent/AR091948A1/es unknown
-
2015
- 2015-01-30 PH PH12015500213A patent/PH12015500213A1/en unknown
- 2015-01-30 CL CL2015000248A patent/CL2015000248A1/es unknown
-
2018
- 2018-07-13 US US16/035,411 patent/US20180310536A1/en not_active Abandoned
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