JP2015521041A - Ｐｋｎ３阻害剤投与のためのバイオマーカーとしてのｖｅｇｆｒ１の使用 - Google Patents

Ｐｋｎ３阻害剤投与のためのバイオマーカーとしてのｖｅｇｆｒ１の使用 Download PDF

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Publication number
JP2015521041A
JP2015521041A JP2015511948A JP2015511948A JP2015521041A JP 2015521041 A JP2015521041 A JP 2015521041A JP 2015511948 A JP2015511948 A JP 2015511948A JP 2015511948 A JP2015511948 A JP 2015511948A JP 2015521041 A JP2015521041 A JP 2015521041A
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JP
Japan
Prior art keywords
vegfr1
nucleic acid
pkn3
subject
acid encoding
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Pending
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JP2015511948A
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Japanese (ja)
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JP2015521041A5 (enExample
Inventor
ギーゼ，クラウス
カウフマン，イェルク
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Silence Therapeutics GmbH
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Atugen AG
Silence Therapeutics GmbH
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Application filed by Atugen AG, Silence Therapeutics GmbH filed Critical Atugen AG
Publication of JP2015521041A publication Critical patent/JP2015521041A/ja
Publication of JP2015521041A5 publication Critical patent/JP2015521041A5/ja
Pending legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • G01N33/575—
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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JP2015511948A 2012-05-16 2013-05-15 Ｐｋｎ３阻害剤投与のためのバイオマーカーとしてのｖｅｇｆｒ１の使用 Pending JP2015521041A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12003888 2012-05-16
EP12003888.0 2012-05-16
PCT/EP2013/001441 WO2013170960A1 (en) 2012-05-16 2013-05-15 Use of vegfr1 as a biomarker for pkn3 inhibitor administration

Publications (2)

Publication Number Publication Date
JP2015521041A true JP2015521041A (ja) 2015-07-27
JP2015521041A5 JP2015521041A5 (enExample) 2016-07-07

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JP2015511948A Pending JP2015521041A (ja) 2012-05-16 2013-05-15 Ｐｋｎ３阻害剤投与のためのバイオマーカーとしてのｖｅｇｆｒ１の使用

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US (2) US9133515B2 (enExample)
EP (1) EP2849771A1 (enExample)
JP (1) JP2015521041A (enExample)
WO (1) WO2013170960A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016083623A1 (en) * 2014-11-28 2016-06-02 Silence Therapeutics Gmbh Means for the treatment of pre-eclampsia
CN110177544A (zh) 2016-11-29 2019-08-27 普尔泰克健康有限公司 用于递送治疗剂的外泌体

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040220128A1 (en) * 1995-10-26 2004-11-04 Sirna Therapeutics, Inc. Nucleic acid based modulation of female reproductive diseases and conditions

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
EP0533838B1 (en) 1990-06-11 1997-12-03 NeXstar Pharmaceuticals, Inc. Nucleic acid ligands
DE59708838D1 (de) 1996-08-30 2003-01-09 Jens Peter Fuerste Spiegelselektion und spiegelevolution von nucleinsäuren
US5849902A (en) 1996-09-26 1998-12-15 Oligos Etc. Inc. Three component chimeric antisense oligonucleotides
US6958239B2 (en) 1996-11-21 2005-10-25 Oligos Etc Inc. Three component chimeric antisense oligonucleotides
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
KR101215789B1 (ko) 2000-03-30 2012-12-26 화이트헤드 인스티튜트 포 바이오메디칼 리서치 Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체
IL166718A0 (en) 2002-08-14 2006-01-15 Atugen Ag Further use of protein kinase n beta
KR101670085B1 (ko) 2006-07-21 2016-10-28 사일런스 테라퓨틱스 게엠베하 단백질 키나아제 3의 발현을 억제하기 위한 수단

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040220128A1 (en) * 1995-10-26 2004-11-04 Sirna Therapeutics, Inc. Nucleic acid based modulation of female reproductive diseases and conditions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CANCER RESEARCH, vol. 68, JPN6017004475, 2008, pages 9788 - 9798, ISSN: 0003497206 *
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, vol. 50, JPN6017004476, January 2012 (2012-01-01), pages 76 - 78, ISSN: 0003497207 *

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WO2013170960A1 (en) 2013-11-21
US9133515B2 (en) 2015-09-15
US20140179755A1 (en) 2014-06-26
EP2849771A1 (en) 2015-03-25
US20150368650A1 (en) 2015-12-24

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